Histone lactylation promotes cell proliferation,migration and invasion through targeting HMGB1 in endometriosis

Endometriosis is defined as a condition with endometrium-like tissues migrating outside of the pelvic cavity.However,the mechanism of endometriosis is still unclear.Lactate can be covalently modified to lysine residues of histones and other proteins,which is called lactylation.The results showed that the higher level of lactate and lactate dehydrogenase A enhanced the histone H3 lysine 18 lactylation(H3K18lac)in ectopic endometrial tissues and ectopic endometrial stromal cells than that in normal endometrial tissues and normal endometrial stromal cells.Lactate promoted cell proliferation,migration,and invasion in endometriosis.Mechanistically,lactate induced H3K18lac to promote the expression of high-mobility group box 1(HMGB1)in endometriosis,and HMGB1 knockdown significantly reduced the cell proliferation,migration,and invasion of the lactate-treated cells through the phosphorylation of AKT.In conclusion,lactate could induce histone lactylation to promote endometriosis progression by upregulating the expression of HMGB1,which may provide a novel target for the prevention and treatment of endometriosis.

Insights into the intrinsic interaction between series of C1 molecules and surface of NiO oxygen carriers involved in chemical looping processes

Understanding and modulating the interaction between various reactive molecules and oxygen carriers are the key issue to achieve process intensification of chemical looping technology.C1 chemical molecules play an important role in many reactions involved with chemical looping processes.However,up to now,there is still a lack of systematic and in-depth understanding of the adsorption mechanism of C1 molecules on the surface of oxygen carriers(OCs).In this work,the intrinsic interaction between a series of C1 molecules composed of CH4,CO,CO2,CH3OH,HCHO and HCOOH and surface of Ni O OCs in the chemical looping process have been studied using density functional theory calculations.Various adsorption configurations of C1 molecules and also different adsorption sites of Ni O have been considered.The structural features of stable configuration of C1 molecules on the surface of NiO OCs have been obtained.Further,the interacted sites,types and strengths of C1 molecules on the surface of NiO have been directly pictured by the independent gradient model methods.Also,the nature of the interaction between C1 molecule and Ni O surface has been investigated with the aid of energy decomposition analysis from a quantitative view.

Preparation and Characterization of Electrospun Polylactic Acid Micro/Nanofibers under Different Solvent Conditions

Electrospinning is a versatile and popular method for the fabrication of ultrafine fibers and many parameters in electrospinning can be adjusted when ideal micro/nanofibers are required.In particular,the selection of a proper solvent condition is a fundamental and crucial step to produce electrospun ultrafine fibers.In this study,a commonly used biomaterial,polylactic acid(PLA),was dissolved in 7 different solvents and PLA micro/nanofibers were prepared by electrospinning.The morphology,porosity,mechanical property and static contact angle were characterized to determine the quality of the obtained product.The results show that different solvent conditions have a significant effect on both the diameter,surface smooth degree of PLA micro/nanofibers and the properties of the fibrous membranes.

Study on Legal Issues of Ocean Fishing in China

“The 21st century is the century of the ocean.”In recent years,China has paid more and more attention to the promotion and development of the ma­rine industry,especially the ocean fishery has brought immeasurable eco­nomic benefits to China.The development of the marine field is becoming more and more important in the national political,economic and cultural development.All coastal countries have included marine development in their national development strategies and continuously improved their ma­rine legislation under the provisions of the United Nations Convention on the law of the sea.China’s pelagic fishing began in 1985,but because Chi­na’s pelagic fishing started too late,after the entry into force of the United Nations Convention on the law of the sea at the end of 1994,nearly 36%of the richest high seas on earth became the exclusive economic zone of coastal countries,and the development space of China’s pelagic fishing has become very limited.After just more than 30 years of development,***.However,before that,China’s pelagic fishing was still subject to the dual norms of international conventions and domestic laws,and China had not yet formulated a special law on pelagic fishing,and there were still many deficiencies in the legal system norms of pelagic fishing.Therefore,the biggest problem facing China’s pelagic fishery is how to better develop the marine industry under the system of laws and regulations,drive the coordi­nated economic development,provide legal guidance and help for pelagic fishermen,and provide solid technical support for building a marine power with Chinese characteristics.

The Design Strategy of High-Density Primary Schools in Shenzhen

The construction of high-density primary schools in Shenzhen is facing new challenges.Therefore,it is essential to look for ways to meet the demand for degrees,realize education and teaching reform,eliminate the shackles of design code,and adapt to the local climate.From the perspective of design methodology,this article discusses the design strategy of Shenzhen’s high-density primary school campus from four aspects:compact layout,multiple functions,open space,and personalized design,aiming to provide ideas for the construction of primary school campuses.

论高等教育的义务化

高等教育发展是一个复杂而充满不确定性的过程。伴随世界各国接受高等教育人数的普遍增加,普及化高等教育的力量依然存在,但普及化已难以解释以义务化为主要特征的高等教育发展现象。源于对义务、义务履行方式与驱动力的不同理解,形成了作为强迫教育的义务教育与非强迫性的“义务”教育两种概念,前者强调法律义务,后者反映事实义务。当后者具备向前者转变的义务化特征,“义务”教育就具备了向义务教育转化的可能。未来高等教育的发展将持续推进,透视高等教育普及化之后的发展适逢其时。通过认识高等教育义务化的发展态势,分析支撑高等教育义务化的社会条件,可以为促进高等教育由普及化向义务化的顺利过渡提供保障。

A Novel Strategy to Fabricate Core-Sheath Structure Piezoelectric Yarns for Wearable Energy Harvesters

Wearable and portable electronic devices based on textile structure have been widely used owing to their wearability and comfortableness.However,yarn fineness and the comfort of the fabric cannot satisfy the requirements of smart wearable devices.This work presents a novel strategy to prepare highly integrated PVDF/conductive nylon core-sheath structure piezoelectric yarns for wearable which is fabricated by combining electrospinning strategy with 2D braiding technology.The fineness of single yarns as well as strength are both improved significantly compared to previous works.The piezoelectric outputs of the yarn are still stable after 800 s fatigue test at a frequency of 4 Hz,and the cycle stability can maintain more than 3200 cycles.Furthermore,the piezoelectric yarns are further woven into piezoelectric plain fabric.According to the electrical performance,the length of the piezoelectric yarn and the thickness of the piezoelectric layer would both affect the output electrical performance.The yarn of the 10 cm in length and 600μm in fineness can produce an output voltage of 120 mV.Meanwhile,Both the piezoelectric yarn and the fabric could generate piezoelectric output signals through human movement,such as bending,walking.Therefore,the electrical and mechanical performance of the piezoelectric yarns prepared in our work could be improved significantly,and the comfortableness and durability performance of the piezoelectric fabric can satisfy most wearing requirements,which would provide some help in the field of piezoelectric wearable devices based on yarns and fabrics.