Education Technology Cloud Platform Framework Establishment and Security

With more educational business absorbed into information management system at universities, traditional information management platform seems unable to provide efficient service for teaching and research. Some universities then resort to cloud computing platform. In view of the problems existing in the traditional information platform, this study presented an information management framework designed with cloud technology, and introduced the security techniques for its protection.

大学生手机使用现状及对睡眠质量的影响

目的:探讨大学生手机使用现状及对睡眠质量的影响状况。方法:应用匹兹堡睡眠量表(PSQI)及手机成瘾量表对银川市某高校300名在校大学生进行调查分析。结果:睡眠量表结果显示,PSQI总分小于等于8的有171人,占84.2%;大于8的有32人,占15.8%。不同性别对睡眠质量影响差异无统计学意义;年级,夜晚使用手机时间,使用后身体状况及手机成瘾性对睡眠质量影响有统计学意义。结论:多数大学生晚上都有长时间使用手机的习惯,使用手机后睡眠质量有所下降。

CmWRKY6-1-CmWRKY15-like transcriptional cascade negatively regulates the resistance to fusarium oxysporum infection in Chrysanthemum morifolium

Chrysanthemum Fusarium wilt is a soil-borne disease that causes serious economic losses to the chrysanthemum industry.However,the molecular mechanism underlying the response of chrysanthemum WRKY to Fusarium oxysporum infection remains largely unknown.In this study,we isolated CmWRKY6–1 from chrysanthemum‘Jinba’and identified it as a transcriptional repressor localized in the nucleus via subcellular localization and transcriptional activation assays.We found that CmWRKY6–1 negatively regulated resistance to F.oxysporum and affected reactive oxygen species(ROS)and salicylic acid(SA)pathways using transgenic experiments and transcriptomic analysis.Moreover,CmWRKY6–1 bound to the W-box element on the CmWRKY15-like promoter and inhibited its expression.Additionally,we observed that CmWRKY15-like silencing in chrysanthemum reduced its resistance to F.oxysporum via transgenic experiments.In conclusion,we revealed the mechanism underlying the CmWRKY6–1–CmWRKY15-like cascade response to F.oxysporum infection in chrysanthemum and demonstrated that CmWRKY6–1 and CmWRKY15-like regulates the immune system.

Comparison of uniform resampling and nonuniform sampling direct-reconstruction methods in k-space for FD-OCT

The nonuniform distribution of interference spectrum in wavenumber k-space is a key issue to limit the imaging quality of Fourier-domain optical coherence tomography(FD-OCT).At present,the reconstruction quality at different depths among a variety of processing methods in k-space is still uncertain.Using simulated and experimental interference spectra at different depths,the effects of common six processing methods including uniform resampling(linear interpolation(LI),cubic spline interpolation(CSI),time-domain interpolation(TDI),and K-B window convolution)and nonuniform sampling direct-reconstruction(Lomb periodogram(LP)and nonuniform discrete Fourier transform(NDFT))on the reconstruction quality of FD-OCT were quantitatively analyzed and compared in this work.The results obtained by using simulated and experimental data were coincident.From the experimental results,the averaged peak intensity,axial resolution,and signal-to-noise ratio(SNR)of NDFT at depth from 0.5 to 3.0mm were improved by about 1.9 dB,1.4 times,and 11.8 dB,respectively,compared to the averaged indices of all the uniform resampling methods at all depths.Similarly,the improvements of the above three indices of LP were 2.0 dB,1.4 times,and 11.7 dB,respectively.The analysis method and the results obtained in this work are helpful to select an appropriate processing method in k-space,so as to improve the imaging quality of FD-OCT.

Quantification of Central and Eastern China's atmospheric CH_(4) enhancement changes and its contributions based on machine learning approach

Methane is the second largest anthropogenic greenhouse gas,and changes in atmospheric methane concentrations can reflect the dynamic balance between its emissions and sinks.Therefore,the monitoring of CH_(4) concentration changes and the assessment of underlying driving factors can provide scientific basis for the government’s policy making and evaluation.China is the world’s largest emitter of anthropogenic methane.However,due to the lack of ground-based observation sites,little work has been done on the spatial-temporal variations for the past decades and influencing factors in China,especially for areas with high anthropogenic emissions as Central and Eastern China.Here to quantify atmospheric CH_(4) enhancements trends and its driving factors in Central and Eastern China,we combined the most up-to-date TROPOMI satellite-based column CH_(4)(xCH_(4))concentration from 2018 to 2022,anthropogenic and natural emissions,and a random forest-based machine learning approach,to simulate atmospheric xCH_(4) enhancements from 2001 to 2018.The results showed that(1)the random forest model was able to accurately establish the relationship between emission sources and xCH_(4) enhancement with a correlation coefficient(R^(2))of 0.89 and a root mean-square error(RMSE)of 11.98 ppb;(2)The xCH_(4) enhancement only increased from 48.21±2.02 ppb to 49.79±1.87 ppb from the year of 2001 to 2018,with a relative change of 3.27%±0.13%;(3)The simulation results showed that the energy activities and waste treatment were the main contributors to the increase in xCH_(4) enhancement,contributing 68.00% and 31.21%,respectively,and the decrease of animal ruminants contributed-6.70% of its enhancement trend.

Source apportionment of VOCs in a typical medium-sized city in North China Plain and implications on control policy

Characteristics of atmospheric VOCs(volatile organic compounds) have been extensively studied in megacities in China, however, they are scarcely investigated in medium/smallsized cities in North China Plain(NCP).A comprehensive research on possible sources of VOCs was conducted in a medium-sized city of NCP, from May to September 2019.A total of 143 canister samples of 8 sites in Xuchang city were collected, and 57 VOC species were detected.The average VOC concentrations were 42.6 ± 31.6 μg/m3, with 53.7 ± 31.0 μg/m3 and 32.1 ± 27.8 μg/m^(3), in the morning and afternoon, respectively.Alkenes and aromatics contributed 80% of the total ozone formation potential(OFP).Aromatics accounted for more than 95% of secondary organic aerosol potential(SOAP).VOCs were dominated by the local emission with significant transport from the southeast direction.PMF analysis extracted 6 sources, which were combustion(33.1%), LPG usage(19.3%), vehicular exhaust & fuel evaporation(15.8%), solvent usage(15.2%), industrial(9.11%) and biogenic(7.51%), respectively and they contributed 33.4%, 17.6%, 12.9%, 18.6%, 9.28% and 8.22% to the OFP, respectively.Combustion and LPG usage were the dominant VOC sources;and combustion, solvent usage and LPG usage were the main sources of OFP in Xuchang city, which were different to megacities in China with a high contribution from vehicular exhaust, solvent usage and industry,suggesting specific control strategies on VOCs need to be implemented in medium-sized city such as Xuchang city.

Emerging phagocytosis checkpoints in cancer immunotherapy

Cancer immunotherapy,mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells,has revolutionized the oncology landscape as it utilizes patients’own immune systems in combating the cancer cells.Cancer cells escape immune surveillance by hijacking the corresponding inhibitory pathways via overexpressing checkpoint genes.Phagocytosis checkpoints,such as CD47,CD24,MHC-I,PD-L1,STC-1 and GD2,have emerged as essential checkpoints for cancer immunotherapy by functioning as“don’t eat me”signals or interacting with“eat me”signals to suppress immune responses.Phagocytosis checkpoints link innate immunity and adaptive immunity in cancer immunotherapy.Genetic ablation of these phagocytosis checkpoints,as well as blockade of their signaling pathways,robustly augments phagocytosis and reduces tumor size.Among all phagocytosis checkpoints,CD47 is the most thoroughly studied and has emerged as a rising star among targets for cancer treatment.CD47-targeting antibodies and inhibitors have been investigated in various preclinical and clinical trials.However,anemia and thrombocytopenia appear to be formidable challenges since CD47 is ubiquitously expressed on erythrocytes.Here,we review the reported phagocytosis checkpoints by discussing their mechanisms and functions in cancer immunotherapy,highlight clinical progress in targeting these checkpoints and discuss challenges and potential solutions to smooth the way for combination immunotherapeutic strategies that involve both innate and adaptive immune responses.

Objective visual performance evaluation with visual evoked potential measurements based on an adaptive optics system

An objective visual performance evaluation with visual evoked potential （VEP） measurements was first inte- grated into an adaptive optics （AO） system. The optical and neural limits to vision can be bypassed through this system. Visual performance can be measured electrophysiologically with VEP, which reflects the objective func- tion from the retina to the primary visual cortex. The VEP ts without and with AO correction were preliminarily carried out using this system, demonstrating the great potential of this system in the objective visual performance evaluation. The new system will provide the necessary technique and equipment support for the further study of human visual function.