Effect of Huanglian Jiedu Decoction on the Behavior of Zebrafish with Alzheimer's Disease

[Objectives]To study the effect of Huanglian Jiedu Decoction on the behavior of zebrafish with Alzheimer's disease caused by AlCl 3.[Methods]Each portion of Huanglian Jiedu Decoction was prepared according to the proportion of Coptis chinensis∶Phellodendron chinense Rupr.∶Scutellaria baicalensis Georgi∶Gardenia jasminoides Ellis=63 g∶42 g∶42 g∶63 g.After that,each portion of Huanglian Jiedu Decoction was soaked in 6.3 L water for 30 min and boiled twice at 100℃.The extracts were combined twice and filtered,then concentrated to 308 g/L and put into refrigerator for later use.Before training,zebrafishes were put into T-maze to adapt for 2 d,and then behavioral training was carried out for 7 d.After video recording,the behavior of zebrafish was analyzed by Smart 3.0,and qualified zebrafishes were selected for follow-up experiments.Then 60 successfully trained zebrafishes were randomly divided into control group,model group,positive group,low-dose group,medium-dose group and high-dose group of Huanglian Jiedu Decoction.Except for the control group,all the other groups were exposed to 100μg/L AlCl 3 for 7 d.After that,video was recorded,and behavioral analysis was carried out with behavioral record and analysis software Smart 3.0.And then the zebrafishes in the other four groups except the model group were treated with Huperzine A(4μg/L)and Huanglian Jiedu Decoction(154,308,616 mg/L)for 6 d,respectively.After that,it was recorded and the behavior of each group was analyzed.[Results]There was a significant difference in the time spent in the left area and the percentage of time in the left area between the control group and the model group(P<0.001).The time spent in the left area and the percentage of time in the left area in the model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction decreased significantly(P<0.05,P<0.01,P<0.001).The swimming distance in the left area and the percentage of swimming distance in the left area in the model group were significantly higher than those in the control group(P<0.001).There was a significant difference in swimming distance between model group and positive group,low,medium and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).In the percentage of swimming distance in the left area,there was a significant difference between the model group and the low and high dose groups of Huanglian Jiedu Decoction(P<0.01,P<0.001).[Conclusions]Huanglian Jiedu Decoction can improve the behavior of zebrafish with Alzheimer's disease.

水性双组分底面合一防腐蚀涂料的研究

介绍一种能兼顾耐腐蚀性与耐老化性能的水性双组分底面合一防腐蚀涂料新体系,阐述其制备工艺并探讨了水性羟丙树脂、异氰酸酯固化剂、防锈颜料、涂料体系的颜基比(P/B)和膜厚等变化对水性双组分底面合一防腐蚀涂料的涂膜外观及性能的影响。最终实现“1C1B”工艺施工,单道涂层膜厚≥45μm,耐盐雾性能可达到360 h,氙灯耐老化性能达到600 h。

Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversible risk factor for glaucoma,the leading cause of irreversible blindness.We previously demonstrated that casein kinase-2 inhibition can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve injury.To investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhibitor(4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole)by intravitreal injection.We found that intravitreal injection of 4,5,6,7-tetrabromo-2-azabenzimidazole or 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole promoted retinal ganglion cell survival and reduced the number of infiltrating macrophages.Transcriptomic analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation but was not modulated by the casein kinase-2 inhibitors.Furthermore,casein kinase-2 inhibition downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb,Prph,Chat,Slc18a3,Slc5a7,Scn1b,Crybb2,Tsga10ip,and Vstm21)involved in intraocular pressure elevation.Our data indicate that inhibition of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

Effect of overheating-induced minor addition on Zr-based metallic glasses

Melt treatment is well known to have an important influence on the properties of metallic glasses(MGs).However,for the MGs quenched from different melt temperatures with a quartz tube,the underlying physical origin responsible for the variation of properties remains poorly understood.In the present work,we systematically studied the influence of melt treatment on the thermal properties of a Zr50Cu36Al14 glass-forming alloy and unveiled the microscopic origins.Specifically,we quenched the melt at different temperatures ranging from 1.1Tl to 1.5Tl(Tl is the liquidus temperature)to obtain melt-spun MG ribbons and investigated the variation of thermal properties of the MGs upon heating.We found that glass transition temperature,Tg,increases by as much as 36 K,and the supercooled liquid region disappears in the curve of differential scanning calorimetry when the melt is quenched at a high temperature up to 1.5Tl.The careful chemical analyses indicate that the change in glass transition behavior originates from the incorporation of oxygen and silicon in the molten alloys.The incorporated oxygen and silicon can both enhance the interactions between atoms,which renders the cooperative rearrangements of atoms difficult,and thus enhances the kinetic stability of the MGs.

A Catalog of ^(13)CO Clumps from the MWISP in l=10°–20°

In this study, we present a catalog of molecular clumps extracted from ^(13)CO(J=1-0) emission data of the Milky Way Imaging Scroll Painting(MWISP) project. The data covers the inner Milky Way within the longitude range10°≤l≤20° and the latitude strip of |b|≤ 5°. 25. The workflow for the extraction of clumps, namely Facet-SS-3DClump, consists of two parts: the identification of clump candidates and their verification. First, Facet-SS-3DClump employs FacetClumps to identify clump candidates. Subsequently, high-confidence clumps are obtained by cross-matching with the clumps detected by other algorithms, such as dendrogram. Second, these high-confidence clumps are used as prior knowledge to train a semi-supervised deep clustering approach, SS-3D-Clump, which is applied to verify clump candidates detected by FacetClumps, providing confidence levels for the molecular clumps. Finally, the catalog comprising 18,757 molecular clumps was obtained using Facet-SS-3D-Clump, and the catalog is 90% complete above 37 K km s^(-1). We observe a significant deviation of the mean Galactic latitude for clumps within |b|≤ 2° from the midplane, with b=-0°.110. We found that 82.3% of the dust clumps correspond to ^(13)CO clumps by matching with Herschel infrared dust clumps. In the future, Facet-SS-3D-Clump will be applied to detect ^(13)CO clumps in the entire MWISP data.

Influence of liquid film shape on evaporation performance of agitated thin film evaporator

The agitated thin film evaporator(ATFE),which is known for its high efficiency,force the material to form a film through the scraping process of a scraper,followed by evaporation and purification.The complex shape of the liquid film inside the evaporator can significantly affect its evaporation capability.This work explores how change in shape of the liquid films affect the evaporation of the materials with non-Newtonian characteristics,achieved by changing the structure of the scraper.Examining the distribution of circumferential temperature,viscosity,and mass transfer of the flat liquid film shows that the film evaporates rapidly in shear-thinning region.Various wavy liquid films are developed by using shear-thinning theory,emphasizing the flow condition in the thinning area and the factors contributing to the exceptional evaporation capability.Further exploration is conducted on the spread patterns of the wavy liquid film and flat liquid film on the evaporation wall throughout the process.It is noted that breaking the wavy liquid film on the evaporating wall during evaporation is challenging due to its film-forming condition.For which the fundamental causes are demonstrated by acquiring the data regarding the flow rate and temperature of the liquid film.The definitive findings of the analysis reveal a significant improvement in the evaporation capability of the wavy liquid film.This enhancement is attributed to increasing the shear-thinning areas and maintaining the overall shape of the film throughout the entire evaporation process.

Magnetic diagnostics layout design for CFETR plasma equilibrium reconstruction

Plasma equilibrium reconstruction provides essential information for tokamak operation and physical analysis.An extensive and reliable set of magnetic diagnostics is required to obtain accurate plasma equilibrium.This study designs and optimizes the magnetic diagnostics layout for the reconstruction of the equilibrium of the plasma according to the scientific objectives,engineering design parameters,and limitations of the Chinese Fusion Engineering Test Reactor(CFETR).Based on the CFETR discharge simulation,magnetic measurement data are employed to reconstruct consistent plasma equilibrium parameters,and magnetic diagnostics'number and position are optimized by truncated Singular value decomposition,verifying the redundancy reliability of the magnetic diagnostics layout design.This provides a design solution for the layout of the magnetic diagnostics system required to control the plasma equilibrium of CFETR,and the developed design and optimization method can provide effective support to design magnetic diagnostics systems for future magnetic confinement fusion devices.

软土地区河道开挖对下方地铁隧道变形的影响及其控制措施

[目的]地铁盾构隧道因上方河道开挖卸荷产生隆起变形,可能会影响地铁隧道的正常运行。为此,应就软土地区河道开挖工程对下方地铁隧道的变形影响进行研究,并制定地铁隧道变形控制措施。[方法]介绍了案例工程的概况,采用有限元方法对其实测数据进行分析,验证了土体本构模型及参数的合理性。基于具有典型软土特征的宁波地区地层剖面和土层参数,建立了土体简化模型,依次分析了河道开挖宽度变化对下方地铁隧道变形的影响、河道开挖深度变化对下方地铁隧道变形的影响、软土层埋深对地铁隧道变形的影响。介绍了门架式土体加固措施及门架式梁板加固措施两种变形控制措施,将考虑了控制变形措施的计算模型与基准模型的有限元计算结果进行了比较分析。[结果及结论]在土体加固和河道开挖阶段,下方地铁隧道变形分别表现为沉降和隆起;河道开挖断面面积相同时,减小河道的开挖深度、增加河道开挖宽度,有利于减少下方地铁隧道变形;地铁隧道竖向位移主要由其下方土体回弹变形产生;门架式梁板加固措施对于地铁隧道隆起变形的控制效果明显。

Fuel recycling feedback control via real-time boron powder injection in EAST with full metal wall

A feedback control of fuel recycling via real-time boron powder injection,addressing the issue of continuously increasing recycling in long-pulse plasma discharges,has been successfully developed and implemented on EAST tokamak.The feedback control system includes four main parts:the impurity powder dropper(IPD),a diagnostic system measuring fuel recycling level represented by D_(α)emission,a plasma control system(PCS)implementing the Proportional Integral Derivative(PID)algorithm,and a signal converter connecting the IPD and PCS.Based on this control system,both active control and feedback control experiments have recently been performed on EAST with a full metal wall.The experimental results show that the fuel recycling can be gradually reduced to lower level as PCS control voltage increases.In the feedback control experiments,it is also observed that the D_(α)emission is reduced to the level below the target D_(α)value by adjusting boron injection flow rate,indicating successful implementation of the fuel recycling feedback control on EAST.This technique provides a new method for fuel recycling control of long pulse and high parameter plasma operations in future fusion devices.

水性单组分浸涂漆在汽车发动机缸体上的应用研究

针对汽车发动机缸体上涂装的防护涂层经超声波-化学清洗工艺容易被破坏和剥离的难题,研制了一种高性能水性单组分浸涂漆并研究其应用效果;探讨了浸涂漆的成膜物、润湿剂、催干剂和附着力促进剂对漆膜的附着力、耐水性、耐盐雾性和耐超声波-化学清洗性能的影响。结果表明:选择水性丙烯酸改性环氧酯树脂TH-8180和改性水性环氧分散体H-502-42W按照质量比6∶4作为成膜物,选择润湿剂BW-104E和HOS 2413按照质量比2∶3进行复配,同时,添加5%无钴环保催干剂OXY-Coat1101和1.5%附着力促进剂MOAP 1880,制备的水性单组分浸涂漆对发动机缸体的润湿性良好,漆膜的干燥速度快,耐水性、耐盐雾性和耐超声波-化学清洗性优异。

Long-Lifetime Optical Trapping of a ^(40)Ca^(+) Ion

We have experimentally achieved the all-optical trapping of a ^(40)Ca^(+)ion.An optical dipole trap was established using a high-power,far-detuned,tightly focused laser with a wavelength of 532 nm.The single ^(40)Ca^(+)ion was trapped without any RF fields and demonstrated a long lifetime of over 3 s.In this experiment,we implemented several measures to improve the optical trapping probability,including focusing the dipole beam waist near the diffraction limit,precisely compensating for stray electric fields,and mitigating electron shelving in metastable states.The optical trapping of a ^(40)Ca^(+)ion eliminates the influence of micromotion induced by RF fields,potentially paving the way for development of all-optical trapping ion optical clocks.

Unmanned aerial vehicles towards future Industrial Internet:Roles and opportunities

Unmanned Aerial Vehicles(UAVs)are gaining increasing attention in many fields,such as military,logistics,and hazardous site mapping.Utilizing UAVs to assist communications is one of the promising applications and research directions.The future Industrial Internet places higher demands on communication quality.The easy deployment,dynamic mobility,and low cost of UAVs make them a viable tool for wireless communication in the Industrial Internet.Therefore,UAVs are considered as an integral part of Industry 4.0.In this article,three typical use cases of UAVs-assisted communications in Industrial Internet are first summarized.Then,the state-of-the-art technologies for drone-assisted communication in support of the Industrial Internet are presented.According to the current research,it can be assumed that UAV-assisted communication can support the future Industrial Internet to a certain extent.Finally,the potential research directions and open challenges in UAV-assisted communications in the upcoming future Industrial Internet are discussed.

水性炭黑色浆的生产研磨工艺对水性涂料配方产业化的影响

对水性涂料产业化过程中,水性无树脂色浆研磨工艺进行系统性的研究,主要考察了水性无树脂炭黑色浆预分散的生产设备和工艺,研磨设备、研磨介质及其填充量,研磨过程的研磨流量、研磨时间、研磨温度、色浆黏度和预分散浆液静置时间等工艺参数对色浆研磨效率和稳定性影响。研究结果对水性涂料从实验室配方快速向产业化生产转化和对水性涂料生产企业完善生产质量管理体系具有指导意义。

一种S波段国产GaN固态雷达发射机

为了应对国产化需求,设计了一款工作频点在2.7到2.9 GHz的国产氮化镓(GaN)固态雷达发射机。设计的发射系统A、B两路发射机各自可以单独工作。当一路工作出现故障,能够自动切换到另外一路,不会造成中断停机。发射系统的组成部件位于发射机柜和电源机柜里,通过接收来自发射监控系统的控制命令,执行发射监控系统的命令并完成对发射电源及发射组件的控制,完成功率数据、电流电压等数据的采集,同时也将本系统中各主要部件的工作状态和故障信息回馈监控系统。

高端车桥用水性双组分环氧底面合一涂料的制备与研究

研制了一种高端车桥用水性双组分环氧底面合一涂料,研究了主要成膜物、防锈颜料、流变助剂和消泡剂对涂料性能和施工性的影响。结果表明,环氧乳液选用AQUAER-3015和3EE102W复配,按照3:1复配,固化剂选用硬度高、耐水好的AQUAEPO-3126,n(环氧)∶n(活泼氢)=1∶0.8,防锈颜料选择GA-4、WJ1711和APW-Ⅱ复配,流变助剂选择DeuRheo WT-102、HM-30S、Bentone LT和SCM-198复配,质量比为3∶3∶3∶5,消泡剂选择HOS 401W、HOS 420和HOS 402W复配,质量比为1∶2∶3时,该水性双组分环氧底面合一涂料的性能最优,可以适用现场施工工艺条件。

一种L波段国产GaN固态雷达发射机

为了应对国产雷达所有元器件均国产化需求,设计了一款工作频点在1.2GHZ~1.4 GHz的国产氮化镓(gallium nitride,GaN)固态雷达发射机。使用国产GaN功率模块对发射系统最大限度地进行小型化设计,降低组件的重量,加强设备的高可靠性及维护方便性设计,进一步完善GaN功率模块在线测试功能,使产品具有高可靠性和完善的雷达故障诊断功能。增加系统的监控、检测及显示功能,并将各种工作状态信号都传输到主监控上,使系统的各种工作状态都能够在终端上显示,使操作人员通过终端界面便可以检查发射系统的各种工作参数,判断发射机的工作状态。在电磁兼容方面通过谐波滤波器对二次谐波的抑制,测试结果表明,发射系统输出信号的二次谐波小于等于-66dB。

基于交联透明质酸的微针制备及性能

新型水凝胶微针具有安全包裹多相药物、药物持续、可控释放等优点,在微针透皮给药领域极具应用潜力。文中重点研究了交联透明质酸微针贴片的优化工艺,并对微针贴片进行了性能评价。在碱性条件下使用1,4-丁二醇二缩水甘油醚(BDDE)为交联剂对透明质酸进行交联,利用微浇注法制备交联透明质酸微针(cHA-MN),并优化其工艺。对所制备的微针贴片进行了外观形貌、力学性能、体外刺入性能及溶胀性能表征,验证其能否满足使用要求。实验结果表明,使用最优工艺制备的交联透明质酸微针贴片力学性能优良,可以顺利刺破皮肤,并实现溶胀功能。使用制备的微针搭载2.5%的右旋布洛芬药物,体外透皮扩散结果表明,微针在0~6 h释放出约38%药物,随后以一定速度缓慢释放至42 h,累计释放率约90%。

透皮给药实心微针阵列的紫外压印工艺方法

文中提出了一种紫外压印技术成型透皮给药实心微针的工艺方法,以C-coating光刻胶作为微针成型的原材料,采用微机电技术加工的聚二甲基硅氧烷(PDMS)微针模具,探究了紫外压印实验中影响微针成型质量的工艺条件。实验结果表明,利用C-coating光刻胶抽真空12 min以上,紫外曝光170~200 s时,制备的紫外压印微针的高度能达到230μm。通过纳米压痕力学测试和猪皮离体皮肤穿刺实验,证明这种紫外压印微针的针尖在承受50 mN的力时没有发生断裂破坏现象,并且能够顺利刺入猪皮达到良好的透皮给药效果,为紫外压印技术成型透皮给药微针提供了一定的技术参考。

Analysis of Eco-Tourism Climate Resources in Xingwen, China Based on the Comfort Index and the Negative Air (Oxygen) Ion

The present work investigates an analysis of Eco-Tourism Climate Resources in Xingwen, China based on the Comfort Index and Negative Air (Oxygen) Ion (“NAI” for short in this article) concentration. The daily temperature, precipitation, wind speed, sunshine hours, and relative humidity data of the Xingwen National Meteorological Station from 1999 to 2018, as well as the NAI data of Feiwu Cave station and Shoushan Lake station in Xingwen of 2018 were used in this study. Based on the analysis of the characteristics of basic meteorological elements, the index of climate comfort of human living environment and the NAI variation in Xingwen, the eco-tourism climate resources in this area were evaluated comprehensively. The results show that: The climate is mild, the precipitation is abundant and the seasonal variation trend of precipitation and heat is similar in the study area. The annual average temperature of this area is 17.8°C, the annual average precipitation is 1096 mm, the annual average precipitation days are 186 days, the annual average relative humidity is 81%, the annual average wind speed is 1.3 m/s, and the annual average sunshine hours are 999 h. The living environment comfort level reaches the “comfort” level for 6 months per year. In addition, the concentration of NAI in Xingwen remains at the highest level 7 throughout the year, and the rate of good air quality is extremely high. Overall, the study area has high-quality ecological climate resources that are conducive to the development of forest recuperation, leisure and vacation and other ecological tourism activities.

基于师生共建自制慕课的化学史信息化教学初探

针对化学史教学的现状和00后“移动学习”的特点,通过师生共建的方法自制化学MOOC,基于自制的MOOC,进行信息化教学。教师通过教学智慧工具超星学习通充分与学生互动,激活课堂;学生通过个人展示(分享),演绎“化学史小剧场”并制作小视频,自主学习了大量化学史的知识,提升了学习能力,培养了核心素养;结合超星学习通的直播功能,提高了学习兴趣。该教学方法为自制线上资源进行信息化教学提供了参考。