“诗意唯美”还是“简陋本真”?扶贫宣传风格对农产品质量感知的影响

理论界鲜有研究关注扶贫宣传风格是否影响消费者对扶贫农产品质量感知。基于常人理论和线索利用理论,本研究聚焦消费扶贫中宣传者、受助者、消费者三方的互动关系,通过二手数据分析、田野研究、在线实验和情景实验,验证了新媒体时代下不同类型扶贫宣传风格影响农产品质量感知的作用机制,研究发现诗意唯美的扶贫宣传风格会提升消费者对农产品质量的感知水平,简陋本真的扶贫宣传风格则效果相反,而心理意象起到了中介作用。研究还证实了受助者脱贫态度以及消费者对农产品价值的关注焦点对扶贫宣传风格影响农产品质量感知的调节作用。研究结论为优化精准扶贫宣传策略、助力乡村振兴提供了理论指导和管理启示。

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

Origin of the Yueguang gold deposit in Xinhua, Hunan Province, South China: insights from fl uid inclusion and hydrogen–oxygen stable isotope analysis

The Yueguang gold deposit is located in Fengjia,Xinhua County,Hunan Province,South China.It represents a recently discovered small-scale gold deposit situated in the southwestern region of the Jiangnan Orogenic Belt,west of the Baimashan granitic batholith.In order to discern the characteristics of the ore-formingfluids,the underlying mineralization processes,and establish a foundation for the origin of the Yueguang gold depositfluid inclusion micro-thermometry,as well as quartz hydrogen and oxygen isotope analysis,have been carried out on samples obtained from various stages of mineralization.The hydrothermal miner-alization stages within the Yueguang gold deposit can be categorized into three stages:(i)the barren,pre-ore quartz-pyrite stage(Stage Ⅰ),the quartz-pyrite-gold stage(Stage Ⅱ),and the post-ore quartz-carbonate stage(Stage Ⅲ),with the second stage being the main mineralization stage.Thefluid inclusions identified in samples from the main min-eralization stage can predominantly be described with the NaCl–H_(2)O and CO_(2)–NaCl–H_(2)O systems.These inclusions display homogenization temperatures ranging from 158.8 to 334.9℃,and thefluid salinity ranges from 0.3%to 4.0%(wt.%NaCl equiv.).Laser Raman spectroscopy analysis of individual inclusions further reveals the presence of gas-phases such as CO_(2),CH_(4),and N_(2).Isotopic analysis indicatesδ^(18)Ofluid values ranging from 3.95 to 6.7‰ and δDH_(2)O values ranging from-71.9 to-55.7‰.These results indi-cate that the ore-formingfluid of the Yueguang gold deposit belongs to metamorphic hydrothermalfluids of middle-low temperature and low salinity.In the process of ore formation,gold is transported in the form of Au(HS)2-complexes,with gold deposition being driven byfluid immiscibility.Therefore,the Yueguang gold deposit is categorized as an orogenic gold deposit dominated by metamorphic hydrother-malfluid.It may become a new target for gold exploration in the Baimashan region,central Hunan Province.

传统建筑地域性的衍化与传承——以吉安至兴国古道沿线家族祠堂为例

吉安至兴国古道是连接古时吉安地区与赣州地区重要的陆上通道,跨越两个不同文化背景的地区。受不同自然环境与多元文化的影响,古道沿线区域的传统建筑有着丰富的地域特征。文章以吉安至兴国古道沿线的7座家族祠堂为研究对象,通过文献分析与田野考察等方法,从选址、平面布局、梁架结构方面分析其共性与差异性,总结地域性衍化和传承特征。

基于文本内容分析的互联网医疗平台信息质量评价研究

目的/意义借助文本内容分析法对互联网医疗平台用户发布的信息质量进行评价研究。方法/过程通过Python爬虫获取国内典型互联网医疗平台的文本内容,进行自然语言处理和聚类分析,提取特征指标设计逻辑回归模型并进行灰色关联度修正,从而构建信息质量评价指标体系。结果/结论互联网医疗平台可重点从信息丰富度、信息发布者特征及用户交流互动方面加强信息的发布与呈现,引导用户发布高质量信息并快速识别有价值信息,促进互联网医疗平台的可持续发展。

Seamless Prediction in China: A Review

Seamless prediction is a weather-climate integrated prediction covering multiple time scales that include days,weeks,months,seasons,years,and decades.Seamless prediction can provide different industries with information such as weather conditions and climate variations from the next few days to years,which have important impacts on economic and social development and important reference value for short-,medium-and long-term decision-making and planning of the country.Therefore,seamless prediction has received widespread attention from the international scientific community recently.As Chinese scientists have also carried out relevant research,this paper reviews the research in China on developments and applications of seamless prediction methods and prediction systems in recent years.Among them,the main progress of seamless prediction methods studies is reviewed from four aspects:short-and medium-range weather forecasting,subseasonal-to-seasonal,seasonal-to-interannual,and decadal climate prediction.In terms of development and application of seamless prediction systems,the main achievements made by meteorological operational departments,scientific institutes,and universities in China in recent years are reviewed.Finally,some of the issues in seamless prediction that need further study are discussed.

An overview on CV2/CRMP5 antibody-associated paraneoplastic neurological syndromes

Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis.Patients with this syndrome produce multiple antibodies,each targeting a different antigen and causing different symptoms and signs.The CV2/collapsin response mediator protein 5(CRMP5)antibody is a major antibody of this type.It damages the nervous system,which often manifests as limbic encephalitis,chorea,ocular manifestation,cerebellar ataxia,myelopathy,and peripheral neuropathy.Detecting CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome,and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis.However,because of the low incidence of this disease,few repo rts and no reviews have been published about it so far.This article intends to review the research on CV2/CRMP5antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease.Additionally,this review discusses the curre nt challenges that this disease poses,and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrom e,including CV2/CRMP5-associated paraneoplastic neurological syndrome,in recent years.

A novel cerebrovascular drug-coated balloon catheter for treating symptomatic intracranial atherosclerotic stenosis lesions:Study protocol for a prospective,multicenter,single-arm,target-value clinical trial

Background:Previous single-center studies have demonstrated that drug-coated balloons(DCBs)may reduce restenosis rates,which is an important factor affecting the prognosis for intracranial interventional therapy.However,currently available cardiac DCBs are not always suitable for the treatment of intracranial atherosclerotic stenosis(ICAS).This study aimed to evaluate the safety and efficacy of a novel DCB catheter designed for patients with severely symptomatic ICAS.Methods:This prospective,multicenter,single-arm,target-value clinical trial was conducted in 9 Chinese stroke centers to evaluate the safety and efficacy of a novel DCB catheter for treating symptomatic severe ICAS.Primary metrics and other indicators were collected and analyzed using SAS version 9.4(SAS Institute,Cary,NC,USA).Results:A total of 155 patients were enrolled in this study.The preliminary collection of follow-up data has been completed,while data quality control is ongoing.Conclusion:Results of this study demonstrated the patency rate,safety,and effectiveness of a novel on-label paclitaxel DCB designed for the treatment of ICAS.Ethics and dissemination:This study,involving human participants,was reviewed and approved by the Ethics Committee of Drugs(Devices)Clinical Experiment at Henan Provincial People’s Hospital(reference number:2020-145-03)and other research centers participating in the clinical trial.The results of this study will be presented at international conferences and sent to peer-reviewed journals for publication.Standard protocol items:The Recommendations for Interventional Trials checklist was used when drafting the study protocol.Trial registration number:Registered with the Chinese Clinical Trial Registry on June 11,2021(Chi CTR2100047223).

堂祀与横居:一种江西客家建筑的典型空间模式

广泛分布于中国东南诸省的客家建筑既有显著共性,又随地域变化产生出多种不同特征。文章综合运用建筑学、文化人类学和类型学的方法,对江西客家建筑分布、形态及其核心空间的使用方式开展长期田野调查并进行比较研究,在此基础上提出堂横式建筑是江西客家移民区内分布最普遍和基本的民居建筑类型,其关键特征是祭祀空间与生活空间存在于同一座建筑之中,祭祀空间位于中心位置,生活空间在其周围,但两者完全分离,形成居祀合一而又分立的空间关系,并由此形成以祭祀功能为主的堂屋和以居住功能为主的横屋组合而成的空间模式。堂横式建筑的具体组合既受到风水理论的影响又寻求与特定自然环境的平衡,通过多种方式与周边自然环境对话,从而在不同地区基于同一的空间模式发展出多种多样的建筑形态,并成为围垅屋①、围屋等其他客家民居类型空间组织的基础。

Factors Affecting the Duration between Symptom Onset and Diagnosis in Patients with Gastric Cancer

Background: The prognosis of patients with tumors is partly influenced by the stage when patients are diagnosed. Therefore, the time of confirmed diagnosis after onset can be considered as a prognostic predictor. Although a few of studies work on it, factors that influence the duration remain poorly understood in different areas. Methods: This retrospective study involved patients with gastric cancer. Participants completed questionnaires by either phone or face-to-face interviews. Results: Females are with a longer interval than males. Farms lived in rural area and with New Rural Cooperative Medical Scheme are associated with a longer time interval. Patients whose income is mainly from their spouses also have a longer interval. Abdominal pain seems to be associated with longer interval time, while vomiting leads to a shorter time interval. Taking medicine after symptoms appear is associated with longer time intervals, especially those take medicine nonstandardly and more than 2 weeks. Conclusions: The results demonstrate that the medical resource in rural area should still be enhanced;meanwhile taking medicine without doctor’s advice should be cut down. Additional efforts must be made to devise strategies to properly guide patients’ behavior.

结伴购物情境下消费者冲动购买行为发生机理

冲动性购买是生活中的常见现象,也是消费者行为研究的重要子领域。围绕单人购物情境下的冲动购买研究成果较多,而对结伴购物情境下的冲动购买行为研究明显不足。聚焦结伴购物情境下消费者的冲动购买现象,基于"欲望-意志力"模型,在情绪感染理论、归因理论等理论基础之上,采用焦点访谈法、实验法、问卷调查法等研究方法,从欲望和意志力两个方面,深入探讨结伴购物消费者冲动购买行为发生的内部决策机理。研究结论将丰富现有结伴购物情境下的冲动购买行为研究内容,也为企业营销实践、个人冲动购买行为管理以及政府部门开展消费者教育提供理论指导。

Application of 3 dimension-printed injection-molded polyether ether ketone lunate prosthesis in the treatment of stage Ⅲ Kienböck’s disease: A case report

BACKGROUND Polyether ether ketone(PEEK)is a high-performance medical polymer,and there are some clinical cases of PEEK prosthesis implantation.However,application of 3D-printed injection-molded PEEK lunate prosthesis for treatment of stage Ⅲ Kienböck’s disease has not been reported.This study’s purpose was to analyze the clinical efficacy of 3D-printed injection-molded PEEK lunate prosthesis in the treatment of stage Ⅲ Kienböck’s disease and thus provide a good therapeutic choice for Kienböck’s disease.CASE SUMMARY We report a patient with stage Ⅲ Kienböck’s disease.With the healthy lunate bone as reference,3D lunate reconstruction was performed using a mirroring technique.A PEEK lunate prosthesis was prepared by 3D printing and injection molding,and then it was inserted into the original anatomical position after removing the necrotic lunate bone.Wrist pain and function,anatomical suitability of the lunate prosthesis,and complications were evaluated and analyzed postoperatively.At the last visit(one year after surgery),the range of motion,grasp force,visual analog scale score and Cooney score of the affected wrist were significantly improved,and postoperative X-ray examination indicated that the lunate prosthesis had good anatomical suitability for adjacent bony structures.CONCLUSION The 3D-printed injection-molded PEEK lunate prosthesis demonstrated definite efficacy in treating stage Ⅲ Kienböck’s disease.

特殊整平剂甲基橙在通孔电镀铜的应用(英文)

甲基橙具有两种基团,可以同时起到加速和抑制作用,可作为特殊的整平剂应用与通孔电镀铜实验中。通过分子动力学模拟和量子化学计算来表征甲基橙在通孔电镀铜中的作用,结果表明甲基橙可以很好地吸附在阴极表面并抑制铜的电沉积。通过恒电流测试和循环伏安测试结果显示,甲基橙由于同时具有磺酸基的去极化和其分子结构部分的极化作用,形成协同分子内对铜加速还原和阻碍传质的竞争效应,所以几乎不影响电位。在板厚孔径为10:1的通孔电镀铜实验中,仅以甲基橙和环氧乙烷和环氧丙烷嵌段共聚物作为添加剂,TP值可达到92.34%。

A kinetic model for predicting shelf-life of fresh extruded rice-shaped kernels(FER)

Fresh extruded rice-shaped kernels(FER) are remoulded rice products from cereals or seed flours, which have the advantages of safety, nutrition, health and time saving. However, the finished products are easy to react with oxygen, so it is necessary to develop a fast, simple and reliable approach to monitor and predict the shelf-life of FER. A comprehensive mathematical model of FER shelf-life prediction was developed using a dynamic modelling approach based on real supply chain conditions. This predictive model was developed to determine four key indexes including acid value, iodine blue value, water uptake ratio and peroxide value. The results showed that when the peroxide value was 1.6849, the FER lost its edible value, nutritional value and commodity value. Moreover, the acid value and peroxide value of FER were used to establish a first-order kinetic model, and the iodine blue value of FER was suited for a zero-order kinetic model. The validation experiment of predicted and measured shelf life showed that the relative error was 3.12%, which was less than 5%. Therefore, this kinetic model could be used to predict the shelf-life of FER quickly and conveniently. The kinetic-based shelf-life prediction model proposed in this study is rapid and practical, providing theoretical basis and guidance for the establishment of quality monitoring and quality evaluation systems of FER during the production, storage, transport and marketing.

Research progress on the regulation of androgen receptor signaling pathway in the treatment of prostate cancer by traditional Chinese medicine monomers

The prevalence of prostate cancer in males worldwide is increasing every year.Androgen and androgen receptor drive the development of prostate cancer and are important targets for the treatment of prostate cancer.A growing number of reports indicate that the traditional Chinese medicine has a clear advantage in the prevention and treatment of prostate cancer.This article provides an overview of the in vitro and in vivo studies of different traditional Chinese medicine monomers acting on the androgen receptor-signaling pathway in prostate cancer.

A study on the frequency of thyroid nodules and uterine fibroids in Chinese breast cancer patients

Background:Single or multiple thyroid nodules and uterine fibroids are the most common benign gynecologic disease.An increasing number of breast cancer are accompanied with thyroid nodules or uterine fibroids or both of them.However,the incidence of thyroid nodules or uterine fibroids in patients with different subtypes of breast cancer is unclear.Objective:To study the incidence of thyroid nodules or uterine fibroids in patients with different subtypes of breast cancer.Methods:A retrospective cohort study conducted in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(China)that included 1,322 female cancer survivors who went to our hospital from January 2014 to November 2019.In this study,we evaluated the frequency of thyroid nodules and uterine fibroids in breast cancer survivors in comparison with other cancer survivors.Besides,we compare the frequency of thyroid nodules and uterine fibroids among different luminal breast cancer.Results:In this study,there were 245 breast cancer survivors,including 58 cases with thyroid nodule,52 cases with uterine fibroids,17 cases with both,152 cases with none.And 1,077 other cancer survivors were collected,including 142 cases with thyroid nodule,172 cases with uterine fibroids,25 cases with both,788 cases with none.According to statistical analysis,the incidence of thyroid nodule and uterine fibroids in breast cancer patients is significantly higher than that in non-breast cancer patients(P<0.01 and P<0.05).Between the molecular classification of breast cancer,among 245 BC patients,58 were combined with thyroid nodule,including 57 cases of luminal-A type BC and 22 cases of combined thyroid nodule;101 cases of luminal-B type BC and 20 cases of combined thyroid nodule;50 cases of HER2-positive over expression type BC and 13 cases of combined thyroid nodule;37 cases of TNBC and 3 cases of combined thyroid nodule,Patients with luminal-A BC have a higher incidence of thyroid nodules compared to other types of BC.Among 245 BC patients,there were 52 cases with uterine fibroids,including 57 cases of luminal-A type BC,5 cases with uterine fibroids;101 cases of luminal-B type BC,32 cases with uterine fibroids;50 cases of HER2-positive over expression type BC,11 cases with uterine fibroids;37 cases of TNBC,4 cases with uterine fibroids.Luminal-B breast cancer is more likely to suffer from uterine fibroids than other types of breast cancer.In addition,breast cancer patients with both thyroid nodules and uterine fibroids had significantly higher luminal-B than other subtypes.Conclusions:This study demonstrates that breast cancer women have a significantly greater incidence rate of thyroid nodules and uterine fibroids,and is higher at Luminal A or Luminal B.We consider these findings may contribute to the identification of liver channel of foot jueyin following underlying this disease association.

A low-melting-point metal doping strategy for the synthesis of small-sized intermetallic Pt_(5)Ce fuel cell catalysts

Carbon-supported platinum-lanthanum(Pt-Ln)intermetallic compound(IMC)nanoparticles with high activity and robust stability have been demonstrated as promising cathode catalysts for proton-exchange membrane fuel cells.However,the preparation of Pt-Ln IMC catalysts needs high-temperature annealing treatment that inevitably causes nanoparticle sintering,resulting in significant reduction of the electrochemical surface area and mass-based activity.Here,we prepare small-sized M-doped Pt_(5)Ce(M=Ga,Cd,and Sb)IMCs catalysts via a low-melting-point metal doping strategy.We speculate that the doping of low-melting-point metals can facilitate the generation of vacancies in the crystal lattice through thermal activation and thus reduce the kinetic barriers for the formation of intermetallic Pt_(5)Ce catalysts.The prepared Ga-doped Pt_(5)Ce catalyst exhibits a higher electrochemical active surface area(81 m^(2)·gPt^(-1))and a larger mass activity(0.45 A·mgPt^(-1)at 0.9 V)over the undoped Pt_(5)Ce and commercial Pt/C catalysts.In the membrane electrode assembly test,the Ga-doped Pt_(5)Ce cathode delivers a power density of 0.98 W·cm^(-2)at 0.67 V,along with a voltage loss of only 27 mV at 0.8 A·cm^(-2)at the end of accelerated stability test.

Construction of Z-scheme Cu-CeO_(2)/BiOBr heterojunction for enhanced photocatalytic degradation of sulfathiazole

The utilization of an efficient photocatalyst is crucial for the photocatalytic degradation of antibiotics in water through visible light,which is an imperative requirement for the remediation of water environments.In this study,a novel Cu-CeO_(2)/BiOBr Z-type heterojunction was synthesized by calcination and hydrothermal methods,and the degradation rate of sulfathiazole(STZ)antibiotic solution was studied using simulated illumination(300 W xenon lamp).The results indicated that 3%Cu-CeO_(2)/BiOBr achieved a degradation rate of 92.3%within 90 min when treating 20 mg/L STZ solution,demonstrating its potential for practical water treatment applications.Characterization using various chemical instruments revealed that 3%Cu-CeO_(2)/Bi OBr exhibited the lowest electron-hole recombination rate and electron transfer resistance.Furthermore,the utilization of ESR data and quenching experiments has substantiated the involvement of hydroxyl radicals(·OH)and superoxide radicals(·O_(2)^(-))as the primary active species.Consequently,a plausible degradation mechanism has been inferred.These findings offer a prospective approach for the development of heterojunction materials with appropriate band matching.

LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant tumors.Nonetheless,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing uncertainty.Here we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor differentiation.HMGB1 knockdown could significantly inhibit wound closure and colony formation.The full-genome gene expression microarray was performed to investigate the mechanism.After knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for validation.Then,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation assay.LSM6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC tissues.Furthermore,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony formation.This study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of LSM6.We anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.