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Investigation of multi-step fast charging protocol and aging mechanism for commercial NMC/graphite lithium-ion batteries 被引量:2
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作者 yaqi li Jia Guo +2 位作者 Kjeld Pedersen Leonid Gurevich Daniel-Ioan Stroe 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第5期237-246,I0006,共11页
Fast charging is considered a promising protocol for raising the charging efficiency of electric vehicles.However,high currents applied to Lithium-ion(Li-ion)batteries inevitably accelerate the degradation and shorten... Fast charging is considered a promising protocol for raising the charging efficiency of electric vehicles.However,high currents applied to Lithium-ion(Li-ion)batteries inevitably accelerate the degradation and shorten their lifetime.This work designs a multi-step fast-charging method to extend the lifetime of LiNi0.5Co0.2Mn0.3O2(NMC)/graphite Li-ion batteries based on the studies of half cells and investigates the aging mechanisms for different charging methods.The degradation has been studied from both full cell behaviour and materials perspectives through a combination of non-destructive diagnostic methods and post-mortem analysis.In the proposed multi-step charging protocol,the state-of-charge(SOC)profile is subdivided into five ranges,and the charging current is set differently for different SOC ranges.One of the designed multi-step fast charging protocols is shown to allow for a 200 full equivalent cycles longer lifetime as compared to the standard charging method,while the charging time is reduced by 20%.From the incremental capacity analysis and electrical impedance spectroscopy,the loss of active materials and lithium inventory on the electrodes,as well as an increase in internal resistance for the designed multistep constant-current-constant-voltage(MCCCV)protocol have been found to be significantly lower than for the standard charging method.Post-mortem analysis shows that cells aged by the designed MCCCV fast charging protocol exhibit less graphite exfoliation and crystallization damage,as well as a reduced solid electrolyte interphase(SEI)layer growth on the anode,leading to a lower Rseiresistance and extended lifetime. 展开更多
关键词 Fast-charging Lithium-ion battery Aging mechanism ELECTRODE
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A Transient-Pressure-Based Numerical Approach for Interlayer Identification in Sand Reservoirs
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作者 Hao Luo Haibo Deng +4 位作者 Honglin Xiao Shaoyang Geng Fu Hou Gang Luo yaqi li 《Fluid Dynamics & Materials Processing》 EI 2024年第3期641-659,共19页
Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and ga... Almost all sandstone reservoirs contain interlayers. The identification and characterization of these interlayers iscritical for minimizing the uncertainty associated with oilfield development and improving oil and gas recovery.Identifying interlayers outside wells using identification methods based on logging data and machine learning isdifficult and seismic-based identification techniques are expensive. Herein, a numerical model based on seepageand well-testing theories is introduced to identify interlayers using transient pressure data. The proposed modelrelies on the open-source MATLAB Reservoir Simulation Toolbox. The effects of the interlayer thickness, position,and width on the pressure response are thoroughly investigated. A procedure for inverting interlayer parametersin the reservoir using the bottom-hole pressure is also proposed. This method uses only transient pressuredata during well testing and can effectively identify the interlayer distribution near the wellbore at an extremelylow cost. The reliability of the model is verified using effective oilfield examples. 展开更多
关键词 Sand reservoir interlayer identification transient pressure analysis numerical well test
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Identification of Hyperparasitic Fungal Species Associated with Coffee Leaf Rust
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作者 Xingfei FU Jianxin CHEN +4 位作者 Guiping li Haohao YU yaqi li Xiaofei BI Faguang HU 《Plant Diseases and Pests》 2024年第5期5-7,共3页
[Objectives]The paper was to elucidate the specific hyperparasitic fungal species that are associated with coffee leaf rust.[Methods]Tissue isolation,sample humidification,and three-point inoculation techniques were e... [Objectives]The paper was to elucidate the specific hyperparasitic fungal species that are associated with coffee leaf rust.[Methods]Tissue isolation,sample humidification,and three-point inoculation techniques were employed to isolate,culture,and purify the hyperparasitic fungi responsible for coffee leaf rust.The purified strains were identified using traditional morphological techniques and molecular biology methods.[Results]Four strains were isolated,specifically BS21(Cladosporium cladosporioides),BS34(C.tenuissimum),BS62(C.cladosporioides),and BS75(C.colombiae).[Conclusions]The findings of this research will contribute novel insights into the biological control of coffee leaf rust. 展开更多
关键词 Leaf rust Hyperparasitic fungi ISOLATION IDENTIFICATION
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Understanding the mechanism of capacity increase during early cycling of commercial NMC/graphite lithium-ion batteries 被引量:7
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作者 Jia Guo yaqi li +3 位作者 Jinhao Meng Kjeld Pedersen Leonid Gurevich Daniel-Ioan Stroe 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2022年第11期34-44,I0003,共12页
A capacity increase is often observed in the early stage of Li-ion battery cycling.This study explores the phenomena involved in the capacity increase from the full cell,electrodes,and materials perspective through a ... A capacity increase is often observed in the early stage of Li-ion battery cycling.This study explores the phenomena involved in the capacity increase from the full cell,electrodes,and materials perspective through a combination of non-destructive diagnostic methods in a full cell and post-mortem analysis in a coin cell.The results show an increase of 1%initial capacity for the battery aged at 100%depth of discharge(DOD)and 45℃.Furthermore,large DODs or high temperatures accelerate the capacity increase.From the incremental capacity and differential voltage(IC-DV)analysis,we concluded that the increased capacity in a full cell originates from the graphite anode.Furthermore,graphite/Li coin cells show an increased capacity for larger DODs and a decreased capacity for lower DODs,thus in agreement with the full cell results.Post-mortem analysis results show that a larger DOD enlarges the graphite dspace and separates the graphite layer structure,facilitating the Li+diffusion,hence increasing the battery capacity. 展开更多
关键词 Capacity increasing Lithium-ion battery Full cell Coin cell Graphite anode
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Relationship between hyperlipidemia and the gut microbiome of rats, characterized using high-throughput sequencing 被引量:4
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作者 yaqi li Quantao Ma +7 位作者 Jingkang Wang Pengfei li Long Cheng Yongcheng An Yuhui Duan Hongyu Dai Ting Wang Baosheng Zhao 《Journal of Traditional Chinese Medical Sciences》 2020年第2期154-161,共8页
Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for ... Objective:To determine the effects of a high-fat diet(HFD)on the gut microbiome in rats,to explore the relationship between the intestinal flora and blood lipid profile.Methods:SpragueeDawley rats were fed an HFD for four weeks to induce hyperlipidemia,then 16S rRNA sequencing was used to compare the intestinal flora between hyperlipidemic and control diet-fed rats.Results:The microbiome of rats fed an HFD for four weeks differed from that of control diet-fed rats.Bacterial species that were less abundant were most affected by HFD feeding,among which were many pathogenic species,which became significantly more abundant.Eighteen genera were present in significantly different numbers in hyperlipidemic and control rats,more than half of which have been linked to infection and inflammation,or energy intake and obesity.The results indicated a type of stress response of the flora to a high-fat environment.In addition,the age of the rats tended to influence the gut microbial composition.Conclusion:These findings suggest that HFD may induce hyperlipidemia by affecting the gut microbial composition.Changes in the abundance of pro-inflammatory and pathogenic bacteria,and those that influence energy intake and obesity,may be important mediators of this. 展开更多
关键词 HYPERLIPIDEMIA Gut microbiota 16S rRNA sequencing High-fat diet
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Ferroptosis molecular inducers:A future direction for malignant tumor chemotherapy 被引量:1
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作者 ZIQIAN WANG yaqi li +1 位作者 DONGYANG WANG YINGQIANG SHEN 《BIOCELL》 SCIE 2022年第7期1599-1611,共13页
Iron-dependent ferroptosis is a form of cell death dependent on iron levels.Cells that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxid... Iron-dependent ferroptosis is a form of cell death dependent on iron levels.Cells that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxidation,Mitochondria,lysosomes and many signal pathways are involved in the regulation of ferroptosis.More importantly,many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis.Moreover,over recent years,a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors.Therefore,the study of ferroptosis is of great significance for future cancer treatments.In this review,we discussed the metabolic process of ferroptosis,the role of different organelles,the typical signaling pathways involved in ferroptosis,as well as natural and synthetic compounds that can induce ferroptosis,aiming to point out new conceptual avenues for utilizing ferroptosis in future cancer treatments. 展开更多
关键词 Ferroptosis CANCER ORGANELLE PATHWAYS Ferroptosis-induced drugs
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Synergistic application of molecular docking and machine learning for improved binding pose 被引量:1
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作者 yaqi li Hongrui lin +5 位作者 He Yang Yannan Yuan Rongfeng Zou Gengmo Zhou linfeng Zhang Hang Zheng 《National Science Open》 2024年第2期36-45,共10页
Accurate prediction of protein-ligand complex structures is a crucial step in structure-based drug design.Traditional molecular docking methods exhibit limitations in terms of accuracy and sampling space,while relying... Accurate prediction of protein-ligand complex structures is a crucial step in structure-based drug design.Traditional molecular docking methods exhibit limitations in terms of accuracy and sampling space,while relying on machine-learning approaches may lead to invalid conformations.In this study,we propose a novel strategy that combines molecular docking and machine learning methods.Firstly,the protein-ligand binding poses are predicted using a deep learning model.Subsequently,position-restricted docking on predicted binding poses is performed using Uni-Dock,generating physically constrained and valid binding poses.Finally,the binding poses are re-scored and ranked using machine learning scoring functions.This strategy harnesses the predictive power of machine learning and the physical constraints advantage of molecular docking.Evaluation experiments on multiple datasets demonstrate that,compared to using molecular docking or machine learning methods alone,our proposed strategy can significantly improve the success rate and accuracy of protein-ligand complex structure predictions. 展开更多
关键词 binding pose molecular docking machine learning machine learning scoring function
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Association of insomnia with diet quality and eating behavior
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作者 Guliyeerke Jigeer Zhe Huang +7 位作者 Jiaojiao Zou Siwei Zhu yaqi li Shuohua Chen Qishan Yang liang Sun Shouling Wu Xiang Gao 《Chinese Medical Journal》 SCIE CAS CSCD 2024年第16期2002-2004,共3页
To the Editor:Insomnia affects 30%-50%of adults globally,leading to diminished quality of life and increased risks of developing physically and mentally demanding disorders.[1]Previous research,primarily in Western po... To the Editor:Insomnia affects 30%-50%of adults globally,leading to diminished quality of life and increased risks of developing physically and mentally demanding disorders.[1]Previous research,primarily in Western populations,reported the association between insomnia and poor diet quality,characterized by higher energy intake,lower vegetable consumption,and a preference for fatty foods,risk factors contributing to major chronic conditions.[2]This association,however,remains under-explored in Asian populations. 展开更多
关键词 INTAKE INS globally
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Image format pipeline and instrument diagram recognition method based on deep learning
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作者 Guanqun Su Shuai Zhao +4 位作者 Tao li Shengyong liu yaqi li Guanglong Zhao Zhongtao li 《Biomimetic Intelligence & Robotics》 EI 2024年第1期36-44,共9页
In this study,we proposed a recognition method based on deep artificial neural networks to identify various elements in pipelines and instrumentation diagrams(P&ID)in image formats,such as symbols,texts,and pipeli... In this study,we proposed a recognition method based on deep artificial neural networks to identify various elements in pipelines and instrumentation diagrams(P&ID)in image formats,such as symbols,texts,and pipelines.Presently,the P&ID image format is recognized manually,and there is a problem with a high recognition error rate;therefore,automation of the above process is an important issue in the processing plant industry.The China National Offshore Petrochemical Engineering Co.provided the image set used in this study,which contains 51 P&ID drawings in the PDF.We converted the PDF P&ID drawings to PNG P&IDs with an image size of 8410×5940.In addition,we used labeling software to annotate the images,divided the dataset into training and test sets in a 3:1 ratio,and deployed a deep neural network for recognition.The method proposed in this study is divided into three steps.The first step segments the images and recognizes symbols using YOLOv5+SE.The second step determines text regions using character region awareness for text detection,and performs character recognition within the text region using the optical character recognition technique.The third step is pipeline recognition using YOLOv5+SE.The symbol recognition accuracy was 94.52%,and the recall rate was 93.27%.The recognition accuracy in the text positioning stage was 97.26%and the recall rate was 90.27%.The recognition accuracy in the character recognition stage was 90.03%and the recall rate was 91.87%.The pipeline identification accuracy was 92.9%,and the recall rate was 90.36%. 展开更多
关键词 Deep learning Image processing Piping and instrumentation Object recognition Pipeline recognition
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Electrochemically-driven interphase conditioning of magnesium electrode for magnesium sulfur batteries 被引量:1
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作者 yaqi li Pengjian Zuo +6 位作者 Ruinan li Mengxue He Yulin Ma Yingxin Shi Xinqun Cheng Chunyu Du Geping Yin 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2019年第10期215-219,共5页
The earth-abundant magnesium metal is a kind of promising anode material due to its low reduction potential (-2.356V vs. SHE), high volumetric and gravimetric specific capacities of 3882 mAh cm-3 and 2234 mAh g_1 resp... The earth-abundant magnesium metal is a kind of promising anode material due to its low reduction potential (-2.356V vs. SHE), high volumetric and gravimetric specific capacities of 3882 mAh cm-3 and 2234 mAh g_1 respectively [1]. Moreover, the magnesium anode shows high safety due to the non-dentritic electrodeposition mechanism during cycling, which is related to the strong Mg-Mg bonding and the consequent high energy barrier between the crystal boundaries of different crystal orientation [2]. 展开更多
关键词 MAGNESIUM BATTERIES MAGNESIUM ELECTRODE DEPOLARIZATION Bis(trifluoromethanesulfonyl)imide anion In-situ electrochemical activation
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Modification and application of Fe_(3)O_(4) nanozymes in analytical chemistry:A review 被引量:2
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作者 Jiahe Ju Yitong Chen +5 位作者 Zhiqiang liu Cheng Huang yaqi li Dezhao Kong Wei Shen Sheng Tang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期46-56,共11页
In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials i... In recent years,Fe_(3)O_(4)nanomaterials have received much attention in analytical chemistry due to their excellent magnetic and peroxidase-like activity.As the catalytic characteristics of Fe_(3)O_(4)nanomaterials is similar to those of horseradish peroxidase(HRP),Fe_(3)O_(4)nanomaterials are also used as peroxidase mimics and have achieved a certain development in many fields based on latest research results.To improve the stability and catalytic ability of simple Fe_(3)O_(4)nanomaterials,various modification strategies of Fe_(3)O_(4)nanomaterials have been developed.The recent advances of these strategies have been presented and discussed.In addition,this paper introduces the application of Fe_(3)O_(4)nanozymes in the detection of food and industrial pollutants,as well as in the field of biosafety. 展开更多
关键词 Fe_(3)O_(4)nanomaterials Nanozyme Peroxidase-like activity MODIFICATION Application
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Temporospatial inhibition of Erk signaling is required for lymphatic valve formation 被引量:2
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作者 Yaping Meng Tong Lv +9 位作者 Junfeng Zhang Weimin Shen lifang li yaqi li Xin liu Xing Lei Xuguang lin Hanfang Xu Anming Meng Shunji Jia 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第10期4850-4866,共17页
Intraluminal lymphatic valves(LVs)and lymphovenous valves(LVs)are critical to ensure the unidirectional flow of lymphatic fluid.Morphological abnormalities in these valves always cause lymph or blood reflux,and result... Intraluminal lymphatic valves(LVs)and lymphovenous valves(LVs)are critical to ensure the unidirectional flow of lymphatic fluid.Morphological abnormalities in these valves always cause lymph or blood reflux,and result in lymphedema. 展开更多
关键词 LYMPHATIC MORPHOLOGICAL EDEMA
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2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents 被引量:58
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作者 Cheng Wang yaqi li +86 位作者 Ying liao Hong Tian Min Huang Xiangyu Dong lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong lin Feng lijun Fu Fangqi Gong Yonghao Gui ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo li Fen li Tao li Xiaohui li Xiaoyan liu Yan li Haitao Lv Tiewei Lv Zipu li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu 《Science Bulletin》 SCIE EI CAS CSCD 2018年第23期1558-1564,共7页
Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of eme... Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. 展开更多
关键词 CPCS CHILDREN ADOLESCENT SYNCOPE
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Organoid based personalized medicine:from bench to bedside 被引量:12
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作者 yaqi li Peiyuan Tang +2 位作者 Sanjun Cai Junjie Peng Guoqiang Hua 《Cell Regeneration》 2020年第1期226-258,共33页
Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic,phenotypic and behavioral trait of in vivo organs,which can be established from both pluripotent stem cells and... Three-dimensional cultured organoids have become a powerful in vitro research tool that preserves genetic,phenotypic and behavioral trait of in vivo organs,which can be established from both pluripotent stem cells and adult stem cells.Organoids derived from adult stem cells can be established directly from diseased epithelium and matched normal tissues,and organoids can also be genetically manipulated by CRISPR-Cas9 technology.Applications of organoids in basic research involve the modeling of human development and diseases,including genetic,infectious and malignant diseases.Importantly,accumulating evidence suggests that biobanks of patientderived organoids for many cancers and cystic fibrosis have great value for drug development and personalized medicine.In addition,organoids hold promise for regenerative medicine.In the present review,we discuss the applications of organoids in the basic and translational research. 展开更多
关键词 ORGANOIDS Stem cells Disease modeling BIOBANKS Personalized medicine
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Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma 被引量:4
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作者 yaqi li Jian li +22 位作者 Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu 《Protein & Cell》 SCIE CAS CSCD 2020年第4期292-298,共7页
Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,a... Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). 展开更多
关键词 al. COLORECTAL ADENOCARCINOMA
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Advances in bismuth-based topological quantum materials by scanning tunneling microscopy
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作者 yaqi li Jingwei Zhang +3 位作者 Xun Xu Weichang Hao Jincheng Zhuang Yi Du 《Materials Futures》 2022年第3期68-83,共16页
In recent years,topological quantum materials(TQMs)have attracted intensive attention in the area of condensed matter physics due to their novel topologies and their promising applications in quantum computing,spin el... In recent years,topological quantum materials(TQMs)have attracted intensive attention in the area of condensed matter physics due to their novel topologies and their promising applications in quantum computing,spin electronics and next-generation integrated circuits.Scanning tunneling microscopy/spectroscopy(STM/STS)is regarded as a powerful technique to characterize the local density of states with atomic resolution,which is ideally suited to the measurement of the bulk-boundary correspondence of TQMs.In this review,using STM/STS,we focus on recent research on bismuth-based TQMs,including quantum-spin Hall insulators,3D weak topological insulators(TIs),high-order TIs,topological Dirac semi-metals and dual TIs.Efficient methods for the modulation of the topological properties of the TQMs are introduced,such as interlayer interaction,thickness variation and local electric field perturbation.Finally,the challenges and prospects for this field of study are discussed. 展开更多
关键词 STM/STS topological quantum materials BISMUTH spin-orbit coupling
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Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth
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作者 Yongmei Shen yaqi li +5 位作者 Jiasong Cao Wen li Qimei lin Jianxi Wang Zhuo Wei Ying Chang 《Maternal-Fetal Medicine》 CSCD 2023年第4期229-237,共9页
In 2019,preterm births(PTB)accounted for approximately 0.66 million deaths globally.PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns.Long-term studies assoc... In 2019,preterm births(PTB)accounted for approximately 0.66 million deaths globally.PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns.Long-term studies associated several factors,including disruption of immune tolerance and inflammation,with PTB.However,the pathogenesis of PTB remains unclear.Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses.However,it is not clear how unbalanced gonadal steroid hormones,such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB.In this review,we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses,which are known to promote the occurrence of PTB,and provide insight into PTB prediction. 展开更多
关键词 Gonadal steroid hormones Immunity tolerance INFLAMMATION Premature birth
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The development and implementation of pathological parameters and molecular testing impact prognosis of colorectal adenocarcinoma
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作者 Midie Xu yaqi li +15 位作者 Yingxue liu Jinjia Chang Changming Zhou Weiwei Weng Hui Sun Cong Tan Xin Wang Xu Wang Meng Zhang Shujuan Ni Lei Wang Yu Yang Xiaoyan Zhou Junjie Peng Dan Huang Weiqi Sheng 《Journal of the National Cancer Center》 2024年第1期74-85,共12页
Objective:This study aims to analyze how changes in pathological diagnosis practice and molecular detection technology have affected clinical outcomes for colorectal cancer(CRC)patients in Fudan University Shanghai Ca... Objective:This study aims to analyze how changes in pathological diagnosis practice and molecular detection technology have affected clinical outcomes for colorectal cancer(CRC)patients in Fudan University Shanghai Cancer Center(FUSCC).Methods:This retrospective cohort study analyzed 21,141 pathologically confirmed CRC cases diagnosed at FUSCC from 2008 to 2020.Patients were divided into five groups for different analytical purposes:(1)the before vs.since 2014 groups to analyze the influence of the changes in the classification criteria of pT3 and pT4 staging on the survival of patients;(2)the partial vs.total mesorectal excision(TME)groups to analyze whether evaluation of completeness of the mesorectum have impact on the survival of patients;(3)the tumor deposit(TD)(+)N0 vs.TD(+)N1c groups to analyze the influence of the changes in the pN staging on the survival of patients with positive TD and negative regional lymph node metastasis(LNM);(4)the before vs.since 2013 groups to analyze the influence of the changes in the testing process of deficient mismatch repair on the survival of patients;and(5)the groups with vs.without RAS/BRAF gene mutation testing to analyze the influence of these testing on the survival of patients.Patients’clinicopathological parameters,including age at diagnosis,sex,tumor size,location,differentiation,mucinous subtype,TD,lymphovascular invasion,perineural invasion,tumor depth,LNM and distant metastasis,and tumor-node-metastasis(TNM)stage,were compared between groups.Kaplan-Meier analysis with log rank method was performed for patients’overall survival(OS)and disease-free survival(DFS)analyses.Results:In pathological reports,there were three parameter changes that impacted patient outcomes.Firstly,changes in the pT staging criteria led to a shift of the ratio of patients with stage pT3 to stage pT4 from 1:110.9 to 1:0.26.In comparison to patients admitted before 2014(n=4,754),a significant difference in prognosis between pT3 and pT4 stages was observed since 2014(n=9,965).Secondly,we began to evaluate the completeness of the mesorectum since 2016.As a result,91.0%of patients with low rectal cancer underwent TME(n=4,111)surgery,and patients with TME had significantly better OS compared with partial mesorectal excision(PME,n=409).Thirdly,we began to stage TD(+)LNM(-)as N1c since 2017.The results showed that N1c(n=127)but not N0(n=39)can improve the prognosis of patients without LNM and distal metastasis.In molecular testing,there have been three and five iterations of updates regarding mismatch repair(MMR)/microsatellite instability(MSI)status and RAS/BRAF gene mutation detection,respectively.The standardization of MMR status testing has sharply decreased the proportion of deficient MMR(dMMR)patients(from 32.5%to 7.4%)since 2013.The prognosis of patients underwent MMR status testing since 2013(n=867)were significantly better than patients before 2013(n=1,313).In addition,detection of RAS/BRAF gene mutation status(n=5,041)resulted in better DFS but not OS,for patients with stage I-III disease(n=16,557).Conclusion:Over the past few decades,updates in elements in pathological reports,as well as the development of standardized tests for MMR/MSI status and RAS/BRAF gene mutations have significantly improved patient outcomes. 展开更多
关键词 Colorectal adenocarcinoma Pathological features Molecular testing Trends Prognosis
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Characteristics of volatile organic compounds,NO_2,and effects on ozone formation at a site with high ozone level in Chengdu 被引量:34
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作者 Yuanyuan Deng Jing li +2 位作者 yaqi li Rongrong Wu Shaodong Xie 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第1期334-345,共12页
Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the... Chengdu is a megacity in the southwest of China with high ozone(O_3) mixing ratio.Observation of volatile organic compounds(VOCs), NO_2 and O_3 with high temporal resolution was conducted in Chengdu to investigate the chemical processes and causes of high O_3 levels. The hourly mixing ratios of VOCs, NO2, and O_3 were monitored by an online system from 28 August to 7 October, 2016. According to meteorological conditions,Chengdu, with relative warm weather and low wind speed, is favorable to O_3 formation.Part of the O_3 in Chengdu may be transported from the downtown area. In O_3 episodes,the average mixing ratios of NO_2 and O_3 were 20.20 ppbv and 47.95 ppbv, respectively. In non-O_3 episodes, the average mixing ratios of NO_2 and O_3 were 16.38 ppbv and 35.15 ppbv,respectively. The average mixing ratio of total VOCs(TVOCs) was 40.29 ppbv in non-O_3 episodes, which was lower than that in O_3 episodes(53.19 ppbv). Alkenes comprised51.7% of the total O_3 formation potential(OFP) in Chengdu, followed by aromatics which accounted for 24.2%. Ethylene, trans-pentene, propene, and BTEX(benzene, ethylbenzene,toluene, m/p-xylene, o-xylene) were also major contributors to the OFP in Chengdu. In O_3 episodes, intensive secondary formations were observed during the campaign. Oxygenated VOCs(OVOCs), such as acetone, Methylethylketone(MEK), and Methylvinylketone(MVK)were abundant. Isoprene rapidly converted to MVK and Methacrolein(MACR) during O_3 episodes. Acetone was mainly the oxidant of C3-C5 hydrocarbons. 展开更多
关键词 OZONE formation VOCS NO2 OFP DIURNAL VARIATION
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Elodexanthones A—J, Isoprenylated Xanthone Derivatives with Diverse Skeletons and Bioactivities from Hypericum elodeoides 被引量:1
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作者 Yanbing Mu yaqi li +6 位作者 Qiji li Wenjun Xu Yunpeng Sun Siyuan Wang Letian Cui lingyi Kong Jun Luo 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第24期2939-2946,共8页
Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropa... Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropanoid xanthones (10), were purified and enantio-separated from the whole plant of Hypericum elodeoides. Their structures including absolute configurations were characterized by the comprehensive analysis of NMR, HRESIMS, NMR calculations, and ECD calculations. Through Bayer-Villiger oxidation, Claisen condensation and electrophilic addition, the rearranged skeletons of elodexanthones A—B (1—2) were generated from isoprenylated xanthone precursors. The bioactivities evaluation exhibited that compounds 3, 5, 8—10 showed anti-inflammatory activity with the IC_(50) values in the range of 9.53—34.39 μmol/L, and compounds 3—7, and 9 showed notable α-glucosidase inhibitory activity (IC_(50): 6.02—257.11 μmol/L). 展开更多
关键词 Hypericum eldeoides Isoprenylated xanthones Structure elucidation Biological activity INFLAMMATORY
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