Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on ant...Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS.展开更多
Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was f...Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to(1) compare the levels of plasma leptin between schizophrenia(n=74) and healthy controls(n=50); and(2)investigate the relationship between plasma leptin levels and depressive subscores.Results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls.(2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale(PANSS).(3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia.展开更多
INTRODUCTION Gender dysphoria(GD),or gender identity disorder,is defined as persistent distress stemming from the incongruence between one's assigned sex at birth and gender identity.'GD has traditionally been...INTRODUCTION Gender dysphoria(GD),or gender identity disorder,is defined as persistent distress stemming from the incongruence between one's assigned sex at birth and gender identity.'GD has traditionally been introduced as a rare condition predominant in assigned males at birth(AMABs).2 However,recent studies have shown an upward trend in assigned females at birth(AFABs)with a dramatic reversal of the AMAB:AFAB ratio-.5-The actual AMAB:AFAB ratio varies by age group and study population.4-Questions have been raised concerning the increasing number of youth who seek professional care for GD,especially adolescent AFABs.展开更多
Viral encephalitis is a common clinical condition.Its clinical manifestations are variable and include neurological symptoms and psychiatric abnormalities,which makes clinical diagnosis and treatment difficult.To date...Viral encephalitis is a common clinical condition.Its clinical manifestations are variable and include neurological symptoms and psychiatric abnormalities,which makes clinical diagnosis and treatment difficult.To date,there are only a few reported cases on mental symptoms of chronic viral encephalitis.We present a case of a 16-year old male patient who was previously hospitalised and diagnosed with schizophrenia and treated with aripiprazole 15 mg/day but failed to respond.The patient was then given antiviral therapy and recovered after 2 weeks.Clinicians should be aware of the possbility that chronic mental disorders could be caused by viral encephalitis.In the future,diagnosis of chronic functional mental disorders should include viral encephalitis in the differential diagnosis.展开更多
基金This case report was funded by Psychosomatic Medicine Project of Key Developing Disciplines of Shanghai Municipal Health Commission(2019ZB0202)in China.
文摘Restless legs syndrome(RLS)is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity.Although there have been many case reports on antipsychotic-induced RLS,ziprasidone has never been reported as a cause of RLS.We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate.The patient’s symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg,and were relieved upon reducing the dose to 120 mg/day.Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded.Clinicians should be aware of the potential for ziprasidone-induced RLS.Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS.
基金The National Key Research and Development Program(2017YFC0909200)National Natural Science Foundation of China(NSFC,81171266,81271481,81571326,81500976)+2 种基金Ministry of Science and Technology Precision Medicine ProjectShanghai Key Laboratory of Psychotic Disorders(13dz2260500)Shanghai Municipal Planning Commission of Science and Research Fund(20154Y0194)
基金supported by grants from the National Key R&D Program of China(2017YFC0909200)the National Science Foundation of China(NSFC+4 种基金81171266,81271481,81671336 and 81500976)the China and National Key Research and Development Program(2017YFC0909200)the Shanghai Key Laboratory of Psychotic Disorders(13dz2260500)the Shanghai Municipal Planning Commission of Science and Research Fund(20154Y0194)the Canadian Institutes of Health Research(project grant PJT-156116)
文摘Background Depressive symptoms are often seen in schizophrenia. The overlap in presentation makes it difficult to distinguish depressive symptoms from the negative symptoms of schizophrenia. The adipokine leptin was found to be altered in both depression and schizophrenia. There are few studies focusing on the prediction of leptin in diagnosis and evaluation of depressive symptoms in schizophrenia.ObjectiveAims To assess the plasma leptin level in patients with schizophrenia and its relationships with depressive symptoms.Methods Cross-sectional studies were applied to(1) compare the levels of plasma leptin between schizophrenia(n=74) and healthy controls(n=50); and(2)investigate the relationship between plasma leptin levels and depressive subscores.Results(1) Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls.(2) Correlation analysis revealed a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale(PANSS).(3) Stepwise multiple regression analyses identified leptin as an influencing factor for depressed factor score on PANSS.Conclusion Leptin may serve as a predictor for the depressive symptoms of chronic schizophrenia.
文摘INTRODUCTION Gender dysphoria(GD),or gender identity disorder,is defined as persistent distress stemming from the incongruence between one's assigned sex at birth and gender identity.'GD has traditionally been introduced as a rare condition predominant in assigned males at birth(AMABs).2 However,recent studies have shown an upward trend in assigned females at birth(AFABs)with a dramatic reversal of the AMAB:AFAB ratio-.5-The actual AMAB:AFAB ratio varies by age group and study population.4-Questions have been raised concerning the increasing number of youth who seek professional care for GD,especially adolescent AFABs.
基金This case report was funded by Shanghai Key Laboratory of Psychotic Disorders Open Grant(grant number:13dz2260500).
文摘Viral encephalitis is a common clinical condition.Its clinical manifestations are variable and include neurological symptoms and psychiatric abnormalities,which makes clinical diagnosis and treatment difficult.To date,there are only a few reported cases on mental symptoms of chronic viral encephalitis.We present a case of a 16-year old male patient who was previously hospitalised and diagnosed with schizophrenia and treated with aripiprazole 15 mg/day but failed to respond.The patient was then given antiviral therapy and recovered after 2 weeks.Clinicians should be aware of the possbility that chronic mental disorders could be caused by viral encephalitis.In the future,diagnosis of chronic functional mental disorders should include viral encephalitis in the differential diagnosis.
