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Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease
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作者 Li-Ming Chen Min Kang +12 位作者 Jun-Yi wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou yi-xin wang Xu Chen Ping Ying Hui Huang Yi Shao Rui Wu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第10期1869-1879,共11页
AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography ... AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal eyes.METHODS:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD group.The 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control group.The macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual eye.The densities of retinal microvascular(MIR),macrovascular(MAR),and total microvascular(TMI)were calculated and compared.Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis.RESULTS:The OCTA data demonstrated a statistically significant difference(P<0.05)in macular retinal microvessel density between the two groups.Specifically,in the SRL and DRL analyses,the ILD group exhibited significantly lower surface density of MIR and TMI compared to the HCs group(P<0.05).Furthermore,using the hemispheric segmentation method,the ILD group showed notable reductions in SL,SR,and IL in the superficial retina(P<0.05),as well as marked decreases in SL and IR in the deep retina(P<0.05).Similarly,when employing the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation method,the ILD group exhibited a significant decrease in the superficial retinal C2-4 region(P<0.05),whereas the deep retina showed a notable reduction in the C3-5 region(P<0.05).Additionally,there was an observed higher positive likelihood ratio in the superficial SR region and deep MIR.Furthermore,there was a negative correlation between conjunctival vascular density and both deep and superficial retinal TMI(P<0.001).CONCLUSION:Patients with CTD-ILD exhibits a significantly higher conjunctival vascular density compared to the HCs group.Conversely,their fundus retinal microvascular density is significantly lower.Furthermore,CTD-ILD patients display notably lower superficial and deep retinal vascular density in comparison to the HCs group.The inverse correlation between conjunctival vascular density and both superficial and deep retinal TMI suggests that detecting subtle changes in ocular microcirculation could potentially serve as an early diagnostic indicator for connective tissue diseases,thereby enhancing disease management. 展开更多
关键词 connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface RETINA
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Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations:a functional magnetic resonance imaging study
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作者 Xue-Lin wang Xu-Jun Zheng +8 位作者 Li-Juan Zhang Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen yi-xin wang Xu Chen Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第9期1665-1674,共10页
AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHO... AIM:To study functional brain abnormalities in patients with hypertensive retinopathy(HR)and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations(fALFFs)method.METHODS:Twenty HR patients and 20 healthy controls(HCs)were respectively recruited.The age,gender,and educational background characteristics of the two groups were similar.After functional magnetic resonance imaging(fMRI)scanning,the subjects’spontaneous brain activity was evaluated with the fALFF method.Receiver operating characteristic(ROC)curve analysis was used to classify the data.Further,we used Pearson’s correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR.RESULTS:The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus(RO-MFG)and right lingual gyrus.In contrast,the values of fALFFs in the left middle temporal gyrus(MTG),left superior temporal pole(STP),left middle frontal gyrus(MFG),left superior marginal gyrus(SMG),left superior parietal lobule(SPL),and right supplementary motor area(SMA)were higher in the HR group.The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group(P<0.001).The fALFF values of the left middle frontal gyrus in HR patients were positively correlated with anxiety scores(r=0.9232;P<0.0001)and depression scores(r=0.9682;P<0.0001).CONCLUSION:fALFF values in multiple brain regions of HR patients are abnormal,suggesting that these brain regions in HR patients may be dysfunctional,which may help to reveal the pathophysiological mechanisms of HR. 展开更多
关键词 hypertensive retinopathy fractional amplitude of low-frequency fluctuation brain region magnetic resonance imaging
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Effect of ultrasound-guided lumbar square muscle block on stress response in patients undergoing radical gastric cancer surgery 被引量:1
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作者 Xin-Ran wang Dan-Dan Xu +3 位作者 Meng-Jiao Guo yi-xin wang Meng Zhang Dong-Xiao Zhu 《World Journal of Gastrointestinal Oncology》 SCIE 2023年第12期2093-2100,共8页
BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier dysfunction.Ultrasound-guided quadratus lumborum block is oft... BACKGROUND Radical surgery is a common treatment for patients with gastric cancer;however,it can lead to postoperative complications and intestinal barrier dysfunction.Ultrasound-guided quadratus lumborum block is often used for postoperative analgesia,but its effects on stress response and intestinal barrier function are not well understood.AIM To investigate the effects of an ultrasound-guided quadratus lumborum block on stress response and intestinal barrier function in patients undergoing radical surgery for gastric cancer.METHODS A total of 100 patients undergoing radical surgery for gastric cancer were randomly categorized into observation and control groups.Plasma adrenaline and cortisol levels,intestinal mucosal barrier indexes,and complication rates were compared between the two groups before,during,and 1 day after surgery.RESULTS The observation group had significantly lower plasma adrenaline and cortisol levels during surgery and at 1 day postoperatively than that of the control group(P<0.05).Additionally,intestinal barrier indexes(endotoxin and D-dimer)at 1 day postoperatively were significantly lower in the observation group than in the control group(P<0.05).CONCLUSION Ultrasound-guided quadratus lumborum block could reduce stress response,protect intestinal barrier function,and decrease the incidence of complications in patients undergoing radical surgery for gastric cancer.This technique has the potential for clinical applications. 展开更多
关键词 Ultrasound-guided quadratus lumborum block Radical gastric cancer surgery Stress response Intestinal barrier function Postoperative analgesia Rehabilitation
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Extracting angle-domain common-image gathers in VTI media using ansiotropic-Helmholtz P/S wave-mode decomposition
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作者 Le-Le Zhang Yang Zhao +4 位作者 Lu Liu Ke Chen Jia-Hui Zuo yi-xin wang Ji-Dong Yang 《Petroleum Science》 SCIE EI CAS CSCD 2023年第3期1546-1561,共16页
Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transfor... Common-image gathers are extensively used in amplitude versus angle(AVA)and migration velocity analysis(MVA).The current state of methods for anisotropic angle gathers extraction use slant-stack,local Fourier transform or low-rank approximation,which requires much computation.Based on an anisotropic-Helmholtz P/S wave-mode decomposition method,we propose a novel and efficient approach to produce angle-domain common-image gathers(ADCIGs)in the elastic reverse time migration(ERTM)of VTI media.To start with,we derive an anisotropic-Helmholtz decomposition operator from the Christoffel equation in VTI media,and use this operator to derive the decomposed formulations for anisotropic P/S waves.Second,we employ the first-order Taylor expansion to calculate the normalized term of decomposed formulations and obtain the anisotropic-Helmholtz decomposition method,which generates the separated P/S wavefields with correct amplitudes and phases.Third,we develop a novel way that uses the anisotropic-Helmholtz decomposition operator to define the polari-zation angles for anisotropic P/S waves and substitute these angles to decomposing formulations.The polarization angles are then calculated directly from the separated vector P-and S-wavefields and converted to the phase angles.The ADCIGs are thusly produced by applying the phase angles to VTI ERTM.In addition,we develop a concise approximate expression of residual moveout(RMO)for PP-reflections of flat reflectors in VTI media,which avoids the complex transformations between the group angles and the phase angles.The approximate RMO curves show a good agreement with the exact solution and can be used as a tool to assess the migration velocity errors.As demonstrated by two selected examples,our ADCIGs not only produce the correct kinematic responses with regards to different velocity pertubatation,but also generate the reliable amplitude responses versus different angle.The final stacking images of ADCIGs data exhibit the identical imaging effect as that of VTI ERTM. 展开更多
关键词 Helmholtz decomposition Angle gathers Anisotropy Elastic-RTM
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Retinal microvascular and microstructural alterations in the diagnosis of meibomian gland dysfunction in severely obese population:a new approach
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作者 Hai Huang Xiao-Yu wang +9 位作者 Hong Wei Min Kang Jie Zou Qian Ling San-Hua Xu Hui Huang Xu Chen yi-xin wang Yi Shao Yao Yu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第12期1977-1985,共9页
AIM:To study retinal microvascular and microstructural alterations in meibomian gland dysfunction(MGD)in severely obese population using optical coherence tomography angiography(OCTA).METHODS:Twelve MGD patients with ... AIM:To study retinal microvascular and microstructural alterations in meibomian gland dysfunction(MGD)in severely obese population using optical coherence tomography angiography(OCTA).METHODS:Twelve MGD patients with severely obese population(PAT group;24 eyes)and 12 healthy controls(HC group;24 eyes)were recruited.OCTA images were segmented into five[superior(S),nasal(N),inferior(I),temporal(T),and central foveal(C)]or nine[inner superior(IS),outer superior(OS),inner nasal(IN),outer nasal(ON),inner inferior(II),outer inferior(OI),inner temporal(IT),outer temporal(OT),and C]subregions.The superficial vessel density(SVD),retinal thickness(RT),foveal avascular zone(FAZ)parameters,and retinal volume were measured.RESULTS:Visual acuity was significantly different between two groups(0.8±0.17 in PAT group vs 0.2±0.06 in HC group).SVD was significantly lower in PATs in N,T,OS,IN,OT,and ON.The area under the receiver operating characteristic curve(AUC)for T was 0.961[95% confidence interval(CI):0.908 to 1.000],for OS was 0.962(95%CI:0.915 to 1.000).RT was significantly lower in PATs in IS,OS,OI,OT,ON,IT,IN,and II.AUC for OT was 0.935(95%CI:0.870 to 0.999),for IS was 0.915(95%CI:0.838 to 0.992).Angiography results showed significantly lower area and perimeter of FAZ,SVD of the inner retina and both retinal volume and the average volume thickness in the PAT group.CONCLUSION:Vision may be affected in patients with MGD due to changes in retinal microvessels and microstructures.These changes detected by OCTA may be a potential marker for diagnosing MGD in severe obesity. 展开更多
关键词 superficial vessel density retinal thickness severely obesity meibomian gland dysfunction optical coherence tomography angiography
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Sexual and reproductive health service needs of university/ college students: updates from a survey in Shanghai, China 被引量:20
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作者 Bin Chen Yong-Ning Lu +7 位作者 Hong-Xiang wang Qing-Liang Ma Xiao-Ming Zhao Jian-Hua Guo Kai Hu yi-xin wang Yi-Ran Huang Pei Chen 《Asian Journal of Andrology》 SCIE CAS CSCD 2008年第4期607-615,共9页
Aim: To promote the provision of reproductive health services to young people by exploring the attitudes and perceptions of university students in Shanghai, China, toward reproductive health. Methods: From July 2004... Aim: To promote the provision of reproductive health services to young people by exploring the attitudes and perceptions of university students in Shanghai, China, toward reproductive health. Methods: From July 2004 to May 2006, 5 243 students from 14 universities in Shanghai took part in our survey. Topics covered the demands of reproductive health-care services, attitudes towards and experience with sex, exposure to pornographic material, and knowledge on sexual health and sexually transmitted infections (STIs)/AIDS. Results: Of the 5 067 students who provided valid answer sheets, 50.05% were female and 49.95% were male, 14.86% were medical students, and 85.14% had non-medical backgrounds. A total of 38.4% of respondents had received reproductive health education previously. The majority of students supported school-based reproductive health education, and also acquired information about sex predominantly from books, schoolmates, and the Internet. Premarital sexual behavior was opposed by 17.7% of survey participants, and 37.5% could identify all the three types of STIs listed in the questionnaire. Although 83.7% knew how HIV is transmitted, only 55.7% knew when to use a condom and 57.8% knew that the use of condoms could reduce the risk of HIV infection. Conclusion: The reproductive health service is lagging behind current attitudes and demands of university students. Although students' attitudes towards sexual matters are liberal, their knowledge about reproductive health and STIs/AIDS is still limited. It is therefore necessary to provide effective and confidential reproductive health services to young people. 展开更多
关键词 reproductive health reproductive health services safe sex sexual behavior SEXUALITY
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Effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives sensitized by glass microballoons 被引量:3
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作者 Ji-ping Chen Hong-hao Ma +2 位作者 yi-xin wang Liang-liang Huang Zhao-wu Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第5期747-754,共8页
In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the explosives.The effect of hydrogen-storage pressure on the detonation characteris... In this study,hydrogen-storage glass microballoons were introduced into emulsion explosives to improve the detonation performance of the explosives.The effect of hydrogen-storage pressure on the detonation characteristics of emulsion explosives was systematically investigated.Detonation velocity experiments shows that the change of sensitizing gas and the increase of hydrogen pressure have different effects on the detonation velocity.The experimental parameters of underwater explosion increase first and then decreases with the increase of hydrogen pressure.The decrease of these parameters indicates that the strength of glass microballoons is the limiting factor to improve the detonation performance of hydrogen-storage emulsion explosives.Compared with the traditional emulsion explosives,the maximum peak pressure of shock wave of hydrogen-storage emulsion explosives increases by 10.6%at 1.0 m and 10.2%at 1.2 m,the maximum values of shock impulse increase by 5.7%at 1.0 m and 19.4%at 1.2 m.The stored hydrogen has dual effects of sensitizers and energetic additives,which can improve the energy output of emulsion explosives. 展开更多
关键词 Emulsion explosives Hydrogen-storage pressure Glass microballoons Underwater explosion
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Xeno-free culture of human spermatogonial stem cells supported by human embryonic stem cell-derived fibroblast-like cells 被引量:3
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作者 Bin Chen Yu-Bin wang +8 位作者 Zhi-Ling Zhang Wei-Liang Xia Hong-Xiang wang Zu-Qiong Xiang Kai Hu Yin-Fa Han yi-xin wang Yi-Ran Huang Zheng wang 《Asian Journal of Andrology》 SCIE CAS CSCD 2009年第5期557-565,I0002,共10页
Spermatogonial stem cells (SSCs) divide continuously to support spermatogenesis throughout postnatal life and transmit genetic information to the next generation. Here, we report the successful establishment of the ... Spermatogonial stem cells (SSCs) divide continuously to support spermatogenesis throughout postnatal life and transmit genetic information to the next generation. Here, we report the successful establishment of the method for the isolation and identification of human SSCs from testicular tissue, and to determine the culture conditions required to expand SSCs on human embryonic stem cell-derived fibroblast-like cells (hdFs). Large-scale cultures of SSCs were maintained on hdF feeder layers and expanded in the presence of a combination of cytokines and glial cell line-derived neurotrophic factor for at least 2 months. Cell surface marker analysis showed that SSCs retained high levels of alkaline phosphatase activity and stained strongly for anti-stage-specific embryonic antigen (SSEA)-1, OCT4 and CD49f. They also expressed the genes OCT4, SOX3 and STRA8 as detected by reverse transcription polymerase chain reaction (RT-PCR) analysis. These data clearly illustrate a novel approach for the growth of human SSCs using hdFs as feeder cells, potentially eliminating xenogeneic contaminants. This system provides a new opportunity for the study of the regulatory mechanism of the ‘niche' that governs SSC self-renewal, and will be a valuable source of SSCs for potential clinical applications. 展开更多
关键词 human embryonic stem cell-derived fibroblast-like cells (hdFs) spermatogonial stem cells (SSCs) xeno-free culture
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Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury 被引量:1
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作者 yi-xin wang Jin-Zhu Bai +2 位作者 Zhen Lyu Guang-Hao Zhang Xiao-Lin Huo 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第6期1318-1323,共6页
Oscillating field stimulation(OFS)is a potential method for treating spinal cord injury.Although it has been used in spinal cord injury(SCI)therapy in basic and clinical studies,its underlying mechanism and the correl... Oscillating field stimulation(OFS)is a potential method for treating spinal cord injury.Although it has been used in spinal cord injury(SCI)therapy in basic and clinical studies,its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood.In this study,we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS.The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks.The underlying mechanism may be related to the effects of OFS on promoting axon regeneration,inhibiting astrocyte proliferation,and improving the linear arrangement of astrocytes.This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University(supplemental approval No.AEEI-2021-204)on July 26,2021. 展开更多
关键词 astrocyte orientation astrocyte proliferation axonal regeneration locomotor recovery neural regeneration neural repair oscillating field stimulation spinal cord injury stimulus duration
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Study on the blood-borne virus co-infection and T lymphocyte subset among intravenous drug users 被引量:1
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作者 Jian-Rong Li Rui-Yu Gong +3 位作者 Kun-Lun Tian Jing wang yi-xin wang Han-Ju Huang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第16期2357-2362,共6页
AIM: To investigate the features of various blood- borne virus infections and co-infection in intravenous drug users (IDUs), and to examine the correlation of T lymphocyte subsets with virus co-infection. METHODS:... AIM: To investigate the features of various blood- borne virus infections and co-infection in intravenous drug users (IDUs), and to examine the correlation of T lymphocyte subsets with virus co-infection. METHODS: Four hundred and six IDUs without any clinical manifestation of hepatitis and 102 healthy persons were enrolled in this study. HBV-DNA and HCV-RNA were detected by fluorescence quantitative PCR. HBsAg, HBeAg, anti-HBc, anti-HCV, HDV-Ag, anti-HGV, anti-HIV, and HCMV-IgM were assayed by enzyme-linked immunosorbent assay (ELISA) and immunochromatographic tests. The levels of Th1 and Th2 cytokines were measured by ELISA and radioactive immune assay (RIA). The T lymphocyte subpopulation was detected by using fluorescence immunoassay. The similar indices taken from the healthy persons served as controls. RESULTS: The viral infection rate among IDUs was 36.45% for HBV, 69.7% for HCV, 47.3% for HIV, 2.22% for HDV, 1.97% for HGV, and 3.45% for HCMV. The co- infection rate of blood-borne virus was detected in 255 of 406 (62.81%) IDUs. More than 80% (161/192) of subjects infected with HIV were co-infected with the other viruses, such as HBV, HCV. In contrast, among the controls, the infection rate was 17.65% for HBV and 0% for the other viruses. Our investigation showed that there was a profound decrease in the proportion of CD4/CD8 and the percentage of CD3 and CD4, but not in the percentage of CD8. The levels of PHA-induced cytokines (IFN-γ and IL-4) and serum IL-2 were obviously decreased in IDUs. On the other hand, the level of serum IL-4 was increased. The level of IFN-γ and the percentage of CD4 were continuously decreased when the IDUs were infected with HIV or HIV co-infection. IDUs with HIV and HBV co-infection was 15.1% (29/192). Of those 29 IDU with HIV and HBV co-infection, 51.72% (15/29) and 37.93% (11/29) were HBV-DNA-positive and HBeAg-positive, respectively. But, among IDUs without HIV infection, only 1.68% (2/119) of cases were HBV- DNA-positive.CONCLUSION: HCV, HBV and HIV infections are common in this population of IDU, leading to a high incidence of impaired Thl cytokine levels and CD4 lymphocyte. IDUs with HIV and HBV/HCV co-infection have lower expression of Th1 cytokine with enhancement of the Th2 response. HIV may be causing HBV replication by decreasing Thl function. 展开更多
关键词 Intravenous drug users T lymphocyte subpopulation Blood-borne virus CO-INFECTION CYTOKINE
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Modulation of Schottky barrier in XSi_(2)N_(4)/graphene(X=Mo and W)heterojunctions by biaxial strain 被引量:1
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作者 Qian Liang Xiang-Yan Luo +2 位作者 yi-xin wang Yong-Chao Liang Quan Xie 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第8期578-586,共9页
Reducing the Schottky barrier height(SBH)and even achieving the transition from Schottky contacts to Ohmic contacts are key challenges of achieving high energy efficiency and high-performance power devices.In this pap... Reducing the Schottky barrier height(SBH)and even achieving the transition from Schottky contacts to Ohmic contacts are key challenges of achieving high energy efficiency and high-performance power devices.In this paper,the modulation effects of biaxial strain on the electronic properties and Schottky barrier of Mo Si_(2)N_(4)(MSN)/graphene and WSi_(2)N_(4)(WSN)/graphene heterojunctions are examined by using first principles calculations.After the construction of heterojunctions,the electronic structures of MSN,WSN,and graphene are well preserved.Herein,we show that by applying suitable external strain to a heterojunction stacked by MSN or WSN—an emerging two-dimensional(2D)semiconductor family with excellent mechanical properties—and graphene,the heterojunction can be transformed from Schottky ptype contacts into n-type contacts,even highly efficient Ohmic contacts,making it of critical importance to unleash the tremendous potentials of graphene-based van der Waals(vd W)heterojunctions.Not only are these findings invaluable for designing high-performance graphene-based electronic devices,but also they provide an effective route to realizing dynamic switching either between n-type and p-type Schottky contacts,or between Schottky contacts and Ohmic contacts. 展开更多
关键词 MoSi_(2)N_(4) Schottky barrier height HETEROJUNCTION biaxial strain
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An effective snakebite first aid training method for medics in the Chinese troops: a RCT
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作者 Chen Qiu Xiao-Feng Qiu +2 位作者 Jing-Jing Liu yi-xin wang Li Gui 《Military Medical Research》 SCIE CAS CSCD 2020年第1期55-62,共8页
Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Th... Background:Snakebites can lead to lifelong consequences and is one of the main causes of death among military troops worldwide.However,few Chinese military medics know the proper first aid procedures for snakebites.Therefore,this study aimed to explore the impact of the Standard Operation Procedure(SOP)and checklist on Chinese military medics’ability to manage snakebite first aid.Methods:This study was a prospective single-blind randomized controlled trial conducted in a military medical university of China from May to June 2017.A questionnaire-based survey was performed to collect the participants’socio-demographic profiles before the baseline measurement.During the baseline measurement,participants were requested to provide corresponding first aid that was responsive to the simulative situation portrayed by the standardized patients(SPs)and the evaluators then scored their performances according to a checklist for snakebite first aid scoring table.After the baseline measurement,they were randomly assigned to one of three intervention groups after stratification according to their baseline performance scores:group A received a self-learning course with textbooks(n=27),group B received a self-learning training on the SOP and checklist(n=27)and group C was engaged in an interactive discussion panel regarding the SOP and checklist(n=26).After the interventions,participants received outcome measurements about snakebite first aid key points capability from the same evaluator and SP for each group to avoid observational error.The reviewers were blinded about the grouping in the trial.Results:The baseline measurement yielded no significant difference(H=1.647,P=0.439)among the three groups.The post-intervention scores were higher than the pre-intervention scores for all three(A,B and C)groups(P=0.008,P<0.001 and P<0.001,respectively).There was significant difference of the post-intervention scores among the three groups(F=8.841,P<0.001).Both post-intervention scores of group B and group C were higher than that of group A(P<0.001 and P=0.001,respectively),but no difference was found between group B and C(P=0.695).The acceptance questionnaire score of SOP and checklist was mostly very satisfied,as the final scores of group B and group C were 4.62±0.61 and 4.82±0.45,respectively.Conclusions:In this study,the implementation of an SOP and checklist for snakebite first aid was shown to update and improve first aid treatment concepts in military medics.These intervention methods played an important role in improving the medics’cognition and understanding of snakebite first aid.Therefore,this finding suggests that SOP and checklist training should be further implemented in Chinese troops for snakebite care. 展开更多
关键词 SNAKEBITE Standard operation procedure(SOP) CHECKLIST Medic TRAINING
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The association of intraocular pressure with metabolic syndrome and its components: a Meta-analysis and systematic review
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作者 yi-xin wang Jian-Xin Tao Yong Yao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第3期510-516,共7页
AIM: To perform a Meta-analysis to explore the correlation between metabolic syndrome and intraocular pressure(IOP).METHODS: We searched PubMed and Embase in November 2017 for studies discussing the relationship betwe... AIM: To perform a Meta-analysis to explore the correlation between metabolic syndrome and intraocular pressure(IOP).METHODS: We searched PubMed and Embase in November 2017 for studies discussing the relationship between metabolic syndrome components and IOP in patients. Pearson correlation coefficients, odds ratios and standardized betas were extracted from inclusive studies. Heterogeneity and publication bias were checked.RESULTS: Of 295 articles, 10 met inclusion criteria and provided sufficient data for Meta-analysis. Results showed a significant positive relation between metabolic syndrome and IOP(Z=0.47, 95%CI: 0.15-0.79, P=0.005). The five components [waist circumference, hypertriglyceridemia, high blood pressure, high fasting glucose and low high density lipoprotein(HDL)-cholesterol] of metabolic syndrome all showed positive correlation with IOP except the low HDL-cholesterol which had no statistical significance. The pooled Z was 0.08(95%CI: 0.04-0.12), 0.16(95%CI: 0.11-0.21), 0.16(95%CI: 0.10-0.22), 0.30(95%CI: 0.20-0.40) and 0.12(95%CI: 0.08-0.16), respectively. Begg's test and Egger's test showed no evidence of significant publication bias of this Meta-analysis.CONCLUSION: Our findings suggest that metabolic syndrome and its components are significantly associated with IOP, besides the HDL-cholesterol. This association may be used to control IOP by intervening the occurrence of metabolic syndrome. 展开更多
关键词 INTRAOCULAR pressure METABOLIC SYNDROME META-ANALYSIS
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Consensus statement on layout and delivery of automatic external defibrillator in China
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作者 Yu Cao Song Chen +132 位作者 Yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-Jiang Fang Mai-Ying Fan Li Gui Ping Gong Wei Guo Shu-Bin Guo Liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun Jiang wang-Xiang Jiang Jia-Liang Liu Xiao-Ran Liu Zhi Liu Chuan-Zhu Lv Feng Lu Tan-Shi Li Xin Li Yong Li Shang-Lun Li Shuang-Ming Li Xiao-Gang Li Bao-Jun Li Pei-Wu Li Chun-Sheng Li Zhi-Jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing Liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma Lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao Pei Shu-Ming Pan Guo-Zhong Qing Li-Jie Qin Wu-Ying Qiao Fei Shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian Jian-Guang Tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao wang Xin wang Peng wang Zhong wang Tong wang Ri-Xing wang yi-xin wang Xiao-Dan wang Ling Wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi Li-Shan Yang Shi-Jiao Yan Jin-Jian Yao Shou-Chun Yan Xue-Zhong Yu Xian-Zhi Ye Xian-Liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang Yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou 《Journal of Hainan Medical University》 2020年第15期18-23,共6页
1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symp... 1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2]. 展开更多
关键词 CARDIAC DEATH RESPIRATORY
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Unique Azolyl Acylhydrazonyl Hybridization of Aloe Emodins to Access Potential Antibacterial Agents
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作者 yi-xin wang Zhao Deng +2 位作者 Aisha Bibi Bo Fang Cheng-He Zhou 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第15期1741-1758,共18页
A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial infections.Some target AAEs showed strong antibacterial activities,especially,tetra... A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial infections.Some target AAEs showed strong antibacterial activities,especially,tetrazolylthioether AAE 27a exhibited broad antibacterial spectrum with 16-256 folds and 8-64 folds more active antibacterial efficacy than the reference drugs aloe emodin and norfloxacin,respectively.Tetrazolylthioether AAE 27a also gave low hemolysis and cytotoxicity,as well as favorable bioavailability.Preliminary mechanism explorations revealed that tetrazolylthioether AAE 27a could cause bacterial membrane depolarization and damage the cell membrane,resulting in nucleic acid leakage.Moreover,compound 27a could intercalate into DNA to impede its replication and form supramolecular 27a-DNA gyrase complex to disturb the function of DNA gyrase.These findings would provide valuable insights for the further exploration of azolyl acylhydrazonyl aloe emodins as new potential antibacterial candidates. 展开更多
关键词 Aloe emodin Hydrazone HETEROCYCLE ANTIBACTERIAL Membrane damage
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Protein separation using a novel silica-based RPLC/IEC stationary phase modified with N-methylimidazolium ionic liquid 被引量:1
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作者 yi-xin wang Kai-Lou Zhao +3 位作者 Fan Yang Lei Tian Ying Yang Quan Bai 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第8期988-992,共5页
Ionic liquids(ILs) immobilized on silica as novel high performance liquid chromatography(HPLC)stationary phases have attracted considerable attention. However, it has not been applied to protein separation. In thi... Ionic liquids(ILs) immobilized on silica as novel high performance liquid chromatography(HPLC)stationary phases have attracted considerable attention. However, it has not been applied to protein separation. In this paper, N-methylimidazolium IL-modified silica-based stationary phase(Silpr Mim)was prepared and investigated as a novel multi-interaction stationary phase charged positively for protein separation. The results indicate that all of the basic proteins tested cannot be absorbed on this novel stationary phase, whereas all of the acidic proteins tested can be retained, and the baseline separation of eight kinds of acidic protein standards can be achieved when performed in reversed phase/ion-exchange chromatography(RPLC/IEC) mode. Compared with commonly used commercial octadecylated silica(ODS) column, the novel stationary phase can show selectivity and good resolution to acidic proteins, which has a promising application in the separation and analyses of acidic proteins from the complex samples in proteomics. In addition, the chromatographic behavior of proteins, the effect of the ligand structure and the retention mechanism on this stationary phase were also investigated. 展开更多
关键词 stationary silica ionic selectivity acidic retention proteomics liquids separated Ionic
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Association of handgrip strength with semen characteristics:a study with repeated measurements among healthy Chinese men
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作者 Bin Sun Heng-Gui Chen +6 位作者 Peng Duan Zhou-Zheng Tu Ying-Jun Chen Tian-Qing Meng Cheng-Liang Xiong yi-xin wang An Pan 《Asian Journal of Andrology》 SCIE CAS CSCD 2022年第6期594-600,共7页
Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen character... Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen characteristics have not been explored.We recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month period.Semen characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were assessed.Mixed-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen characteristics.After adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),respectively.These positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous variable.Handgrip strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner. 展开更多
关键词 EPIDEMIOLOGY handgrip strength repeated measurements semen characteristics
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Present Researching Approaches and Future Prospects for Treatment of Cardiac Diseases-Integrative Medicine
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作者 Yan Feng Hao Xu +2 位作者 yi-xin wang Li-Ping Ma Da-Zhuo Shi 《World Journal of Traditional Chinese Medicine》 2015年第2期56-60,共5页
The pathogenesis of cardiac diseases is very complex and involved in many gene transcription and protein expression. How to effectively treat the diseases has become the hotspot of modern medicine. Accumulating eviden... The pathogenesis of cardiac diseases is very complex and involved in many gene transcription and protein expression. How to effectively treat the diseases has become the hotspot of modern medicine. Accumulating evidences over the past decades on integrative medicine have shown us hopeful future prospects. With the development of modern biomedicine, such as sketch mapping genomic sequence, functional genomics,proteomics and pharmacogenetics, more advanced techniques could be applied in elucidating the possibly complicated biological networks, or complex pathological and physiological mechanisms underlying cardiac diseases, by which integrative medicine will also bring out some new and more effective strategies in the treatment of cardiac diseases. 展开更多
关键词 Future prospects Cardiac diseases Integrative medicine TREATMENT
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