Micro,Small,and Medium Enterprises’Cross-Border Business Strategies

This paper explores the operational strategies of cross-border micro, small, and medium enterprises (MSMEs). Against the backdrop of globalization and digitalization, cross-border trade has become one of the important pathways for many MSMEs to achieve growth and competitive advantage. Firstly, the paper outlines the concept and characteristics of cross-border MSMEs, as well as the analysis of their operational environment in the context of globalization, including political, economic, social, technological, environmental, and legal factors. Secondly, the paper proposes operational strategies for cross-border MSMEs, including international market selection and positioning, cross-border marketing strategies, supply chain management, cross-border financial management, and cross-border risk management. Finally, the paper summarizes the importance of effectively implementing these strategies for cross-border MSMEs to seize international market opportunities, reduce operational risks, and enhance competitiveness and profitability.

A Study on the Factors Influencing Consumer Purchase Decision Under the Live-Streaming Sales Model

In recent years,with the rapid development and popularization of Internet information technology,many new media platforms have risen rapidly,and major e-commerce companies have begun to explore the mode of livestreaming.Especially during the COVID-19 pandemic,due to the lockdown,live-streaming has become an important means of economic development in many places.Owing to its remarkable characteristics of timeliness,entertainment,and interactivity,it has become the latest and trendiest sales mode of e-commerce channels,reflecting huge economic potential and commercial value.This article analyzes two models and their characteristics of live-streaming sales from a practical perspective.Based on this,it outlines consumer purchasing decisions and the factors that affect consumer purchasing decisions under the live-streaming sales model.Finally,it discusses targeted suggestions for using the live-streaming sales model to expand the consumer market,hoping to promote the healthy and steady development of the live-streaming sales industry.

Decoding the molecular landscape of keloids:new insights from single-cell transcriptomics

Keloids are a fibrotic disease caused by an excessive accumulation of extracellular matrix in the dermis;they have neoplasia-like properties of aggressive growth and high posttreatment recurrence rates.Therefore,it is imperative to gain additional insight into the pathobiology of keloid formation.Single-cell RNA sequencing(scRNA-seq)technology has brought data-driven innovation to understanding the pathogenesis of keloids by breaking the limitations of traditional sequencing technologies to resolve cell composition and to distinguish functional cell subtypes at an unprecedented resolution.The present review aims to cover the application of scRNAseq technology in keloids and its exploratory findings,including the depiction of the cellular landscape of keloids,fibroblast heterogeneity,the lineage development of Schwann cells and the mesenchymal-activation phenomenon of endothelial cells.Furthermore,scRNA-seq records the transcriptional profiles of fibroblasts and immune cells in a more refined manner,and this gene expression information provides excellent material for inferring intercellular communication networks and lays an important theoretical foundation for future studies.

Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid

Keloid scarring is a kind of pathological healing manifestation after skin injury and possesses various tumor properties,such as the Warburg effect,epithelial-mesenchymal transition(EMT),expression imbalances of apoptosis-related genes and the presence of stem cells.Abnormal expression of tumor signatures is critical to the initiation and operation of these effects.Although previous experimental studies have recognized the potential value of a single or several tumor biomolecules in keloids,a comprehensive evaluation system for multiple tumor signatures in keloid scarring is still lacking.This paper aims to summarize tumor biomolecules in keloids from the perspectives of liquid biopsy,genetics,proteomics and epigenetics and to investigate their mechanisms of action and feasibility from bench to bedside.Liquid biopsy is suitable for the early screening of people with keloids due to its noninvasive and accurate performance.Epigenetic biomarkers do not require changes in the gene sequence and their reversibility and tissue specificity make them ideal therapeutic targets.Nonetheless,given the ethnic specificity and genetic predisposition of keloids,more large-sample multicenter studies are indispensable for determining the prevalence of these signatures and for establishing diagnostic criteria and therapeutic efficacy estimations based on these molecules.