Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation

A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is addressed.This paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain nonlinearity.First,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the system.Second,the dynamical equation in the form of state space is established by designing the angular tracking error.Third,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of uncertainty.Finally,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is proposed.The feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental platform.This paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time.

Quality Evaluation of Fermented Mulberry Wine

[Objectives]This study to conducted to clarify various nutritional components and the composition and contents of aromatic substances in mulberry wine prepared by fermentation,and promote the quality improvement and product development of mulberry wine.[Methods]Mulberry wine was prepared with mulberry Shengguo 1 as the material using Saccharomyces cerevisiae,and its contents of total sugars,total phenols,total acids,resveratrol,protein,dry extract,ethanol content,Fe,methanol,sulfur dioxide,volatile acids,total flavonoids and proanthocyanidins were determined.Aromatic substances were extracted by n-hexane,and their components and relative contents were determined by gas chromatography-mass spectrometry(GC-MS).[Results]The physical and chemical indexes of the mulberry wine prepared by fermentation were in accordance with the national standards,and it was rich in resveratrol(10.5±0.6 mg/L),protein(381±11 mg/L),total flavonoids(406±18 mg/L)and proanthocyanidins(855±22 mg/L),which were 8.95,19.49,3.76 and 1.63 times higher than those of grape wine,respectively.The aromatic substances were mainly composed of ethyl formate(9.9%),ethyl acetate(7.6%),acetal(6.2%),propanol(5.7%),isobutanol(5.6%)and isoamyl acetate(5.3%).[Conclusions]The results of this study demonstrated that mulberry wine was rich in active substances,which suggested that mulberry wine has great potential in the fruit wine market.

腹腔镜辅助与开腹近端胃切除对SiewertⅡ型和Ⅲ型食管胃结合部腺癌疗效比较

目的:研究腹腔镜辅助近端胃切除术(laparoscopic-assisted proximal gastrectomy,LAPG)和开腹全胃切除术(open proximalgastrectomy,OPG)治疗SiewertⅡ型和Ⅲ型食管胃结合部腺癌(adenocarcinoma of the esophagogastric junction,AEG)的临床疗效。方法:回顾性分析蚌埠医学院第一附属医院2015年2月至2017年2月收治的116例行近端胃切除的SiewertⅡ型和Ⅲ型AEG患者的临床资料,其中LAPG组48例、OPG组68例。分析两组患者的临床病理特征、术中情况、根治效果与肿瘤复发情况。结果:两组患者手术均顺利完成,无围手术期死亡。LAPG组患者平均手术时间为(3.46±0.46)h,长于OPG组的(2.68±0.68)h;平均术中出血量为(108±46.8)mL,少于OPG组的(236±86.6)mL;胃肠功能恢复时间为(2.56±0.56)d,短于OPG组的(3.82±0.86)d;术后平均住院时间为(12.24±1.86)d,少于OPG组的(14.68±2.89)d;近端切缘(3.06±0.56)cm长于OPG组的(2.38±0.68)cm(均P<0.05)。两组患者的清扫淋巴结数目、远端切缘、术后并发症发生率,差异均无统计学意义(P>0.05)。结论:LAPG在治疗SiewertⅡ型和Ⅲ型AEG患者的根治效果、术后并发症及肿瘤复发方面与开放手术相当;LAPG具有术中出血少、胃肠功能恢复快、住院时间短的优势,近端切缘更长。

Application of Hydrazine Hydrate in the Synthesis of Octa(aminophenyl)silsesquioxane (OAPS) Poss

Octa(aminophenyl)silsesquioxane (OAPS) was prepared from octaphenyl silsesquioxane (OPS) in two steps, first nitration to obtain Octa(nitrophenyl)silsesquioxane (ONPS) then reduction by using the stable, inexpensive, and readily available hydrazine hydrate as the reducing agent in the presence of Iron(III)Chloride catalyst with a yield of around 87%. Hydrazine is a two-electron reducing agent whereas nitro group is a four-electron reduction process. The activated carbon serves as an adsorbent and electrical conductor enabling the reaction to occur by acting as a mediator between a two-electron reagent and a four-electron process. Adsorption provides a reducing potential and a supply of electrons from many hydrazines making possible the initial four-electron process even though each individual hydrazine is a two-electron donor. The product was characterized by FTIR and 1H NMR. The time period for preparation of ONPS from octaphenyl silsesquioxane was considerably shortened to avoid double nitration of the aromatic rings.

Microwave ablation of colorectal liver metastases adjacent to the cardiophrenic angle:Parallel versus non-parallel placement of the antenna relative to the diaphragm

Purpose:Microwave ablation(MWA)is difficult to perform in colorectal liver metastases(CRLMs)adjacent to the cardiophrenic angle.Therefore,a modified approach involving antenna array placement parallel to the diaphragm was initially attempted.Its safety and efficacy were compared with those involving non-parallel placement.Methods:Sixty-three patients with CRLMs adjacent to the cardiophrenic angle(lesions within 10 mm of the diaphragm)who underwent MWA were included in the study.All patients were further classified into parallel and non-parallel groups according to the method of antenna placement.The distance between the lesion and diaphragmatic surface before MWA,complications,and local tumor progression(LTP)at the last imaging follow-up were recorded.LTPs in the two groups were compared using the log-rank test.Prognostic factors for LTP were assessed using the Cox proportional hazards regression model.Results:Thirty and 33 lesions were ablated using parallel and non-parallel antenna placement,respectively.During the mean follow-up duration of 19.7±8.2 months,the LTP rate in the parallel and non-parallel placement groups were 3.3%(1/30)and 24.2%(8/33),respectively.The log-rank test showed that parallel antenna placement was associated with delayed LTP(p=0.018).Multivariate Cox regression analysis showed that parallel antenna placement was an independent predictor of delayed LTP after adjusting for possible risk factors,including age,sex,tumor size,and KRAS mutation(hazard ratio,0.1;95%confidence interval,0.00,0.80;p=0.034).Conclusion:The placement of the antenna parallel to the diaphragm is an alternative and effective method for MWA of CRLMs near the cardiophrenic angle and can contribute to the reduction of the LTP rate.

Surface Modification of Hollow Glass Microspheres

Hollow Glass Microspheres are high-strength, low-density additives made from water resistant and chemically-stable soda-lime-borosilicate glass. These hollow glass microspheres offer a variety of advantages over conventional irregularly-shaped mineral fillers or glass fiber. Their spherical shape helps reduce resin content in a variety of applications. They also create a ball bearing effect that can result in higher filler loading and improved flow. In this research, amine terminated hollow glass microspheres were prepared by adopting three different routes. The results were investigated using FT-IR and SEM to establish the formation of amine groups and observe the morphological structure of the modified HGMs. The results obtained were used to select a suitable less toxic and environmental friendly modification method based on the chemicals used.

Development of Whole Potato Flour Fish Noodles

[Objectives] This study was conducted to prepare a kind of traditional aquatic food―fish noodles in Hubei Province by replacing some wheat flour with whole potato flour. [Methods] With whole potato flour, wheat flour and minced fish as main raw materials, the effects of the ratio of whole potato flour to minced fish and the addition amounts of sodium alginate, egg white, salt and ginger juice on the quality of whole potato flour fish noodles were studied. An orthogonal experiment was conducted to confirm the optimal technical formula of the whole potato flour fish noodles. [Results] The best formula of the whole potato flour fish noodles was whole potato flour 30 g, wheat flour 20 g, minced fish(grass carp) 50 g, salt 2.00 g, egg white 4.00 g, sodium alginate 2.00 g, and ginger juice 5.00 g. [Conclusions] The whole potato flour fish noodles prepared according to this formula are not only nutritious and taste good, but also have the advantages of easy and convenient eating and storage. This kind of fish noodle has good development prospects.

The Effects of Naoxintong Capsule on the Vascular Endothelial Function and Inflammatory Factors in Spontaneously Hypertensive Rats

Objective:To investigate the effects of Naoxintong(NXT)capsule on vascular endothelial function and inflammatory mechanism in spontaneously hypertensive rats.Methods:A total of 100 spontaneously hypertensive rats were divided into model group,positive control group,NXT low-dose group,NXT medium-dose group and NXT high-dose group.Rats in the model group were given an equal dose of normal saline once a day;the positive control group was given telmisartan 50 mg/(kg·d)once a day;the low,middle and high dose groups were given the NTX 0.5,1.0,2.0 mg/(kg·d)once a day,respectively.Rats in each group were continuously intragastrically administered for 12 weeks.The vascular endothelial function index,inflammation index and blood pressure of each group were observed at the end of 8 weeks.Results:Endothelin(ET),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and systolic blood pressure levels were lower in the positive control group and NXT group compared with model group.In the model group,the NO level was lower than the positive control group and NXT group;the levels of ET,IL-6,TNF-α,CRP and systolic blood pressure in the middle-dose group and the high-dose group were lower than those in the positive control group and NXT low-dose group.Furthermore,the level of NO was higher in positive control group and NXT middle and high dose group compared with model group.The levels of ET,IL-6,TNF-α,CRP and systolic pressure in NXT high dose group were lower than in NXT middle dose group,while the level of NO was higher in NXT high group than in NXT middle dose group and the difference was statistically significant(p<0.05).Conclusions:NXT has obviously antihypertensive effect on spontaneously hypertensive rats,and its mechanism may be related to the improvement of vascular endothelial function and inflammatory factors.

两种预防新生仔猪大肠杆菌腹泻疫苗的猪场试验效果对比

1简介大肠杆菌引起的新生仔猪腹泻一直以来都是困扰猪场的顽疾。仔猪发病率高、传染性强、传播速度快,死亡率也高,一般可达20%~60%,严重时可达100%,给我国养猪业带来了严重的经济损失。以往,猪场在处理这些问题时多考虑使用抗生素,但是随着细菌耐药性不断增强,抗生素的效果大打折扣;国家新的禁抗、限抗的政策逐步落实,抗生素的使用范围也有了更严格的限制。

Copper-catalyzed tandem radical amination/1,2-carbon migration of allylic alcohols: Direct access to α-quaternary-β-amino ketones

A novel nitrogen‐centered radical‐induced1,2‐carbon migration reaction of allylic alcohols has been developed.This method provides easy access to a variety ofα‐quaternary‐β‐amino ketones under mild reaction conditions.The reaction has a wide substrate scope and operational simplicity.Mechanistic studies suggest that1,2‐carbon migration is induced by regioselective nitrogen‐centered radical addition to the alkene unit.?2018,Dalian Institute of Chemical Physics,Chinese Academy of Sciences.Published by Elsevier B.V.All rights reserved.

Development of a Fubaiju Compound Tea Beverage

[Objectives]This study was conducted to develop a compound tea beverage with local characteristics.[Methods]A chrysanthemum compound tea beverage was developed using Fubaiju and Yunwu tea as the main raw materials,supplemented by wolfberry,through single factor test and orthogonal test,combined with sensory evaluation.[Results]The final product formula was the volume ratio of Fubaiju extract and Yunwu tea extract 2∶1,wolfberry juice 15%,white sugar 4%,citric acid 0.04%,and xanthan gum 0.05%.The prepared compound chrysanthemum tea beverage had the aroma and taste of Fubaiju,Yunwu tea and wolfberry,and tasted good.[Conclusions]This study provides reference for the deep processing and application of the two local special resources,Fubaiju and Yunwu tea.

Triglycerides Isolated from <i>Streptomyces</i>sp. ZZ035 and Their Nuclear Magnetic Resonance Spectroscopic Characters

Streptomyces sp. ZZ035 isolated from a folk medicinal soil sample in China showed remarkable antimicrobial activities. During the isolation of secondary metabolites, a white crystal powder (1) was isolated from the broth of this strain. Its nuclear magnetic resonance (NMR) and infrared (IR) spectra indicated that it was a complex composed of triglycerides. Next, six C15-17 long- chain fatty acids derived from these triglycerides were respectively identified as n-pentadecanoyl, 12-methyltetradecanoyl, 14-methyl pentadecanoyl, palmitoyl, 15-methyl hexadecanoyl and 14-methyl hexadecanoyl using the gas chromatography-mass spectroscopy (GC-MS) technology. Finally, the 13C and 1H assignments of 1 were achieved through the analyses of NMR data. Based on above, their detailed NMR spectroscopic elucidation and meticulous 13C, 1H assignments, especially the split peaks and coupling correlation of protons attached on the glycerol carbons, were performed for distinguishing triglycerides from other glycerides and for the identification of the long-chain fatty acids, and which would be helpful to the qualitative and quantitative analyses of tri-, di-and mono-glycerides.

Role of Biochar Amendment on Soil Carbon Mineralization and Microbial Biomass

To understand the influence of biochar properties (pyrolysis temperature and types) on soil physicochemical properties, we investigated the changes of soil organic carbon mineralization, nutrient contents and microbial biomass after 135 d incubation. Results showed that both corn straw (CB) and rice straw (RB) derived biochars increase the mineralization of organic carbon and nitrogen in the soil, and these biochars pyrolysised at 500?C (CB500, RB500) significantly enhanced the mineralization of soil organic nitrogen. In comparison with control treatment, the application of biochar significantly increased the contents of soil organic carbon, available P and K in soil. Moreover, the activity of soil microbe was enhanced with biochar amendment. Among all treatments, RB500 significantly increased the content of soil microbial biomass carbon (379 ± 9 mg?kg?1) in soil. Our results suggested that the application of biochars to soil improve soil quality, while the biochar type and pyrolysis temperature should be taken into consideration before its application in agro-ecosystem.

Mutant Selection Windows of Azalomycin F5a in Combination with Vitamin K3 against Methicillin-Resistant Staphylococcus aureus

Azalomycin F5a, a 36-membered macrocyclic lactone isolated from several streptomyces strains, presented remarkable anti-methicillin-resistant Staphylococcus aureus (MRSA) activities. To improve its anti-MRSA potential and to evaluate the probability of MRSA resistant to it before development, the anti-MRSA activities of azalomycin F5a in combination with vitamin K3 were first evaluated using checkerboard assay. Then the minimal concentration inhibiting colony formation by 99% (MIC99) and mutant prevention concentration (MPC) of azalomycin F5a alone and in combination with vitamin K3 against MRSA were determined using agar plates with linear antimicrobial concentration decrease. The fractional inhibitory concentration indexes (FICIs) of 0.25 - 0.50 showed the synergistic activity of azalomycin F5a in combination with vitamin K3. The mutant selection windows (MSWs, MIC99-MPC) of azalomycin F5a alone against MRSA tested were 2.07 - 6.40 μg/mL, and the MPCs of azalomycin F5a in combination with vitamin K3 against MRSA tested were 1.60 - 3.20 μg/mL. These indicated that the MPCs of azalomycin F5a in combination could drop down to below its MIC99 alone. According to the hypothesis of MSW, the narrower MSWs of azalomycin F5a alone, even closed MSWs in combination with vitamin K3, together with their synergistic anti-MRSA activities, indicated that azalomycin F5a had a good potential to develop as a new antimicrobial agent.

Impact of inhaled corticosteroid use on elderly chronic pulmonary disease patients with community acquired pneumonia

To the Editor:With an aging global population,the incidences of community-acquired pneumonia(CAP)and chronic obstructive pulmonary disease(COPD)have signicantly increased.[1]Previous studies have conrmed that COPD and asthma are independently associated with the prevalence of CAP.The use of inhaled corticosteroid(ICS),the cornerstone of treatment for asthma,COPD with frequent acute exacerbations,and asthma-COPD overlap(ACO)may induce changes in the local lung microbiome and abnormal lung immunity,ultimately,causing a signicantly increased risk of pneumonia.However,in cases of pneumonia,the effect of the use of ICS on CAP mortality remains controversial.While data from one study favored the prior use of ICS,which was associated with a signicantly lower short-term mortality rate,[2]other studies have identied no impact on mortality.To date,data on the impact of the use of ICS on mortality,prehospitalization or during hospitalization,are scarce,particularly in the older population.Therefore,this multicenter,retrospective study explored the association between the use of ICS during hospitalization and short-term mortality in older patients with CAP and those with chronic pulmonary disease(CPD).

On the bramble way to Mg metal anodes in secondary Mg ion batteries

As a prospective alternative to lithium-ion batteries,rechargeable magnesium metal batteries(RMBs)have many unparalleled advantages,including direct use of Mg metal as the electrode;large nature abundance;intrinsically safe merits;high theoretical volumetric capacity.Nonetheless,there exist a large number of challenges on electrodes for their applications.Among them,surface passivation,uneven deposition/dissolution,and corrosion are critical issues that severely hinder the development of Mg anodes in RMBs.This review gives a specific comprehensive,and in-depth summary of mechanisms relative to these problems.Subsequently,it displays the protection progresses of the Mg metal anode via three-dimensional host nanostructure fabrication,Mg alloys anode design,current collector modification,artificial solid-electrolyte interphase construction,and electrolyte optimization.Finally,future perspectives and outlooks in developing the other blossom of these strategies for rechargeable Mg batteries are also discussed.This overview provides significant guidance for designing and fabricating high-performance Mg metal anodes in secondary Mg batteries and boosting their commercial applications.

Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis

The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available.

Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia

Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1βlevel(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase inα-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1βlevel were associated with patients’lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.

Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community

Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management.

Modifying the Autism Spectrum Rating Scale(6–18 years)to a Chinese Context:An Exploratory Factor Analysis

The purpose of this study was to explore the psychometric properties of the Chinese version of the autism spectrum rating scale（ASRS）. We recruited 1,625community-based children and 211 autism spectrum disorder（ASD） cases from 4 sites, and the parents of all participants completed the Chinese version of the ASRS. A robust weighted least squares means and variance adjusted estimator was used for exploratory factor analysis. The3-factor structure included 59 items suitable for the current sample. The item reliability for the modi？ed Chinese version of the ASRS（MC-ASRS） was excellent. Moreover,with 60 as the cut-off point, receiver operating characteristic analysis showed that the MC-ASRS had excellent discriminate validity, comparable to that of the unmodi？ed Chinese version（UC-ASRS）, with area under the curve values of 0.952（95% CI： 0.936–0.967） and 0.948（95% CI：0.930–0.965）, respectively. Meanwhile, the con？rm factor analysis revealed that MC-ASRS had a better construct validity than UC-ASRS based on the above factor solution in another children sample. In conclusion, the MC-ASRS shows better ef？cacy in epidemiological screening for ASD in Chinese children.