Lesions of the left triangular ligament of the liver are rare,and there are even fewer cases of vascular tumors misdiagnosed as gastrointestinal stromal tumors.We comment on the two cases reported in the article.The a...Lesions of the left triangular ligament of the liver are rare,and there are even fewer cases of vascular tumors misdiagnosed as gastrointestinal stromal tumors.We comment on the two cases reported in the article.The article did not include pictures of laparoscopic surgery,making it unconvincing.For gastric submucosal lesions,enhanced computed tomography venous phase imaging may be beneficial for differential diagnosis.Although endoscopic ultrasound is an effective tool for diagnosing submucosal lesions of the stomach,due to various factors,it cannot achieve an accurate diagnosis.During endoscopic examination,a more accurate diagnosis can be made depending on the personal experience of the operators.展开更多
Extremely heavy rainfall occurred over both Northwest India and North China in September 2021.The precipitation anomalies were 4.1 and 6.2 times interannual standard deviation over the two regions,respectively,and bro...Extremely heavy rainfall occurred over both Northwest India and North China in September 2021.The precipitation anomalies were 4.1 and 6.2 times interannual standard deviation over the two regions,respectively,and broke the record since the observational data were available,i.e.,1901 for India and 1951 for China.In this month,the Asian uppertropospheric westerly jet was greatly displaced poleward over West Asia,and correspondingly,an anomalous cyclone appeared over India.The anomalous cyclone transported abundant water vapor into Northwest India,leading to the heavy rainfall there.In addition,the Silk Road pattern,a teleconnection pattern of upper-level meridional wind over the Eurasian continent and fueled by the heavy rainfall in Northwest India,contributed to the heavy rainfall in North China.Our study emphasizes the roles of atmospheric teleconnection patterns in concurrent rainfall extremes in the two regions far away from each other,and the occurrence of rainfall extremes during the post-or pre-monsoon period in the northern margins of monsoon regions.展开更多
Translational therapy refers to a combination of chemotherapy,radiotherapy,targeted therapy,and immunotherapy for patients with advanced gastric cancer who are initially unable to undergo R0 resection.This treatment c...Translational therapy refers to a combination of chemotherapy,radiotherapy,targeted therapy,and immunotherapy for patients with advanced gastric cancer who are initially unable to undergo R0 resection.This treatment can achieve partial or complete remission of the unresectable tumors to meet the criteria for R0 resection,thus enabling the patients to prolong their survival time and improve their quality of life.In gastric cancer,translational therapy has been tried and improved.At present,there are a large number of patients with locally advanced gastric cancer in China,and the selection of suitable patients for transla-tional therapy to prolong objective survival and improve survival quality is one of the hot spots in the field of gastric cancer research.展开更多
Extreme heat over the North China Plain is typically induced by anomalous descending flows associated with anticyclonic circulation anomalies. However, an extreme heat event that happened in the North China Plain regi...Extreme heat over the North China Plain is typically induced by anomalous descending flows associated with anticyclonic circulation anomalies. However, an extreme heat event that happened in the North China Plain region on 12–13 July 2015,with maximum temperature higher than 40℃ at some stations, was characterized by only a weak simultaneous appearance of an anomalous anticyclone and descending flow, suggesting that some other factor(s) may have induced this heat event. In this study, we used the forecast data produced by the Beijing Rapid Updated Cycling operational forecast system, which predicted the heat event well, to investigate the formation mechanism of this extreme heat event. We calculated the cumulative heat in the mixed-layer air column of North China to represent the change in surface air temperature. The cumulative heat was composed of sensible heat flux from the ground surface and the horizontal heat flux convergence. The results indicated that the horizontal heat flux in the mixed layer played a crucial role in the temporal and spatial distribution of high temperatures.The horizontal heat flux was found to be induced by distinct distributions of air temperatures and horizontal winds at low levels during the two days, implying a complexity of the low-level atmosphere in causing the extreme heat.展开更多
The Tibetan Plateau(TP)is a prevalent region for convection systems due to its unique thermodynamic forcing.This study investigated isolated deep convections(IDCs),which have a smaller spatial and temporal size than m...The Tibetan Plateau(TP)is a prevalent region for convection systems due to its unique thermodynamic forcing.This study investigated isolated deep convections(IDCs),which have a smaller spatial and temporal size than mesoscale convective systems(MCSs),over the TP in the rainy season(June-September)during 2001–2020.The authors used satellite precipitation and brightness temperature observations from the Global Precipitation Measurement mission.Results show that IDCs mainly concentrate over the southern TP.The IDC number per rainy season decreases from around 140 over the southern TP to around 10 over the northern TP,with an average 54.2.The initiation time of IDCs exhibits an obvious diurnal cycle,with the peak at 1400–1500 LST and the valley at 0900–1000 LST.Most IDCs last less than five hours and more than half appear for only one hour.IDCs generally have a cold cloud area of 7422.9 km^(2),containing a precipitation area of approximately 65%.The larger the IDC,the larger the fraction of intense precipitation it contains.IDCs contribute approximately 20%–30%to total precipitation and approximately 30%–40%to extreme precipitation over the TP,with a larger percentage in July and August than in June and September.In terms of spatial distribution,IDCs contribute more to both total precipitation and extreme precipitation over the TP compared to the surrounding plain regions.IDCs over the TP account for a larger fraction than MCSs,indicating the important role of IDCs over the region.展开更多
目的通过监测肾小球足细胞相关分子podocin和nephrin的mRNA比值(podocin mRNA:nephrin mRNA ratio,PNR)在大鼠糖尿病肾脏疾病(diabetic kidney disease,DKD)早期模型中的变化,并将其与尿白蛋白-肌酐比值(urinary albumin to creatinine ...目的通过监测肾小球足细胞相关分子podocin和nephrin的mRNA比值(podocin mRNA:nephrin mRNA ratio,PNR)在大鼠糖尿病肾脏疾病(diabetic kidney disease,DKD)早期模型中的变化,并将其与尿白蛋白-肌酐比值(urinary albumin to creatinine ratio,U-ACR)对比,评价PNR作为DKD早期诊断指标的可行性;并比较缬沙坦和福辛普利钠对DKD的早期干预作用。方法采用尾静脉注射链脲霉素(streptozotocin,STZ)(60 mg/kg)建立DKD大鼠模型,监测对比PNR与U-ACR的早期变化,适时给予缬沙坦和福辛普利钠干预;采用苏木精-伊红(hematoxylin and eosin staining,HE)染色观察肾小球结构形态,透射电子显微镜观察肾小球足细胞超微结构。结果造模后PNR在第9天达临界值(≥1),较U-ACR在第15天达临界值(≥30 mg/g)更早;造模后第9天给予缬沙坦和福辛普利钠干预,发现其对U-ACR均有显著降低作用(P<0.05),且缬沙坦低剂量优于高剂量(P>0.05),而福辛普利钠高剂量优于低剂量(P>0.05);低剂量的缬沙坦和福辛普利钠均对PNR有明显降低作用(P<0.05),高剂量未见明显影响;缬沙坦和福辛普利钠干预对肾小球结构及足细胞排布均具有一定的改善和维持作用。结论PNR较U-ACR更早变化,对大鼠DKD早期诊断具有一定的提示作用,缬沙坦和福辛普利钠早期干预对大鼠DKD有一定的治疗作用。展开更多
文摘Lesions of the left triangular ligament of the liver are rare,and there are even fewer cases of vascular tumors misdiagnosed as gastrointestinal stromal tumors.We comment on the two cases reported in the article.The article did not include pictures of laparoscopic surgery,making it unconvincing.For gastric submucosal lesions,enhanced computed tomography venous phase imaging may be beneficial for differential diagnosis.Although endoscopic ultrasound is an effective tool for diagnosing submucosal lesions of the stomach,due to various factors,it cannot achieve an accurate diagnosis.During endoscopic examination,a more accurate diagnosis can be made depending on the personal experience of the operators.
基金supported by the National Natural Science Foundation of China(Grant No.42105064)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(Grant No.2019QZKK0102)China Meteorological Administration program(Grant No.CXFZ2021J030)。
文摘Extremely heavy rainfall occurred over both Northwest India and North China in September 2021.The precipitation anomalies were 4.1 and 6.2 times interannual standard deviation over the two regions,respectively,and broke the record since the observational data were available,i.e.,1901 for India and 1951 for China.In this month,the Asian uppertropospheric westerly jet was greatly displaced poleward over West Asia,and correspondingly,an anomalous cyclone appeared over India.The anomalous cyclone transported abundant water vapor into Northwest India,leading to the heavy rainfall there.In addition,the Silk Road pattern,a teleconnection pattern of upper-level meridional wind over the Eurasian continent and fueled by the heavy rainfall in Northwest India,contributed to the heavy rainfall in North China.Our study emphasizes the roles of atmospheric teleconnection patterns in concurrent rainfall extremes in the two regions far away from each other,and the occurrence of rainfall extremes during the post-or pre-monsoon period in the northern margins of monsoon regions.
文摘Translational therapy refers to a combination of chemotherapy,radiotherapy,targeted therapy,and immunotherapy for patients with advanced gastric cancer who are initially unable to undergo R0 resection.This treatment can achieve partial or complete remission of the unresectable tumors to meet the criteria for R0 resection,thus enabling the patients to prolong their survival time and improve their quality of life.In gastric cancer,translational therapy has been tried and improved.At present,there are a large number of patients with locally advanced gastric cancer in China,and the selection of suitable patients for transla-tional therapy to prolong objective survival and improve survival quality is one of the hot spots in the field of gastric cancer research.
基金sponsored by the Ministry of Science and Technology of China (Grant No.2015DFA20870)
文摘Extreme heat over the North China Plain is typically induced by anomalous descending flows associated with anticyclonic circulation anomalies. However, an extreme heat event that happened in the North China Plain region on 12–13 July 2015,with maximum temperature higher than 40℃ at some stations, was characterized by only a weak simultaneous appearance of an anomalous anticyclone and descending flow, suggesting that some other factor(s) may have induced this heat event. In this study, we used the forecast data produced by the Beijing Rapid Updated Cycling operational forecast system, which predicted the heat event well, to investigate the formation mechanism of this extreme heat event. We calculated the cumulative heat in the mixed-layer air column of North China to represent the change in surface air temperature. The cumulative heat was composed of sensible heat flux from the ground surface and the horizontal heat flux convergence. The results indicated that the horizontal heat flux in the mixed layer played a crucial role in the temporal and spatial distribution of high temperatures.The horizontal heat flux was found to be induced by distinct distributions of air temperatures and horizontal winds at low levels during the two days, implying a complexity of the low-level atmosphere in causing the extreme heat.
基金supported by the National Natural Science Foundation of China[grant number 42105064]the Second Tibetan Plateau Scientific Expedition and Research(STEP)program[grant number 2019QZKK0102]the special fund of the Yunnan University“double first-class”construction.
文摘The Tibetan Plateau(TP)is a prevalent region for convection systems due to its unique thermodynamic forcing.This study investigated isolated deep convections(IDCs),which have a smaller spatial and temporal size than mesoscale convective systems(MCSs),over the TP in the rainy season(June-September)during 2001–2020.The authors used satellite precipitation and brightness temperature observations from the Global Precipitation Measurement mission.Results show that IDCs mainly concentrate over the southern TP.The IDC number per rainy season decreases from around 140 over the southern TP to around 10 over the northern TP,with an average 54.2.The initiation time of IDCs exhibits an obvious diurnal cycle,with the peak at 1400–1500 LST and the valley at 0900–1000 LST.Most IDCs last less than five hours and more than half appear for only one hour.IDCs generally have a cold cloud area of 7422.9 km^(2),containing a precipitation area of approximately 65%.The larger the IDC,the larger the fraction of intense precipitation it contains.IDCs contribute approximately 20%–30%to total precipitation and approximately 30%–40%to extreme precipitation over the TP,with a larger percentage in July and August than in June and September.In terms of spatial distribution,IDCs contribute more to both total precipitation and extreme precipitation over the TP compared to the surrounding plain regions.IDCs over the TP account for a larger fraction than MCSs,indicating the important role of IDCs over the region.
文摘目的通过监测肾小球足细胞相关分子podocin和nephrin的mRNA比值(podocin mRNA:nephrin mRNA ratio,PNR)在大鼠糖尿病肾脏疾病(diabetic kidney disease,DKD)早期模型中的变化,并将其与尿白蛋白-肌酐比值(urinary albumin to creatinine ratio,U-ACR)对比,评价PNR作为DKD早期诊断指标的可行性;并比较缬沙坦和福辛普利钠对DKD的早期干预作用。方法采用尾静脉注射链脲霉素(streptozotocin,STZ)(60 mg/kg)建立DKD大鼠模型,监测对比PNR与U-ACR的早期变化,适时给予缬沙坦和福辛普利钠干预;采用苏木精-伊红(hematoxylin and eosin staining,HE)染色观察肾小球结构形态,透射电子显微镜观察肾小球足细胞超微结构。结果造模后PNR在第9天达临界值(≥1),较U-ACR在第15天达临界值(≥30 mg/g)更早;造模后第9天给予缬沙坦和福辛普利钠干预,发现其对U-ACR均有显著降低作用(P<0.05),且缬沙坦低剂量优于高剂量(P>0.05),而福辛普利钠高剂量优于低剂量(P>0.05);低剂量的缬沙坦和福辛普利钠均对PNR有明显降低作用(P<0.05),高剂量未见明显影响;缬沙坦和福辛普利钠干预对肾小球结构及足细胞排布均具有一定的改善和维持作用。结论PNR较U-ACR更早变化,对大鼠DKD早期诊断具有一定的提示作用,缬沙坦和福辛普利钠早期干预对大鼠DKD有一定的治疗作用。
