Bullous pemphigoid associated with acquired hemophilia A: A case report

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must improve.CASE SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 days.CONCLUSION AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

地铁车站软土深基坑开挖变形全过程数值模拟研究

软弱土层的深基坑施工会引起周边道路开裂及临近建(构)筑物沉降,如变形过大则会对周边建(构筑物产生不利影响。文章以南京地铁5号线虹桥站地铁车站为研究背景,基于有限元软件建立了地铁深基坑全过程开挖的三维数值模型,其中土体采用摩尔-库伦本构模拟其力学行为,结合特定断面对软弱土层基坑开挖施工过程的支护结构性状和基坑土体变形的情况进行分析。数值计算结果与实测对比表明:围护结构侧位移与实测比较一致,沉降值较实测偏小,分析其原因可知施工过程中的一些临时荷载,在数值模拟中并未体现,所以导致了两者的差异。因此,在实际施工中应着重控制基坑周边的地面超载,避免产生过大沉降和地表倾斜。

Ti_(3)C_(2)T_(x) MXene/carbon composites for advanced supercapacitors:Synthesis,progress,and perspectives

MXenes are a family of two-dimensional(2D)layered transition metal carbides/nitrides that show promising potential for energy storage applications due to their high-specific surface areas,excellent electron conductivity,good hydrophilicity,and tunable terminations.Among various types of MXenes,Ti_(3)C_(2)T_(x) is the most widely studied for use in capacitive energy storage applications,especially in supercapacitors(SCs).However,the stacking and oxidation of MXene sheets inevitably lead to a significant loss of electrochemically active sites.To overcome such challenges,carbon materials are frequently incorporated into MXenes to enhance their electrochemical properties.This review introduces the common strategies used for synthesizing Ti_(3)C_(2)T_(x),followed by a comprehensive overview of recent developments in Ti_(3)C_(2)T_(x)/carbon composites as electrode materials for SCs.Ti_(3)C_(2)T_(x)/carbon composites are categorized based on the dimensions of carbons,including 0D carbon dots,1D carbon nanotubes and fibers,2D graphene,and 3D carbon materials(activated carbon,polymer-derived carbon,etc.).Finally,this review also provides a perspective on developing novel MXenes/carbon composites as electrodes for application in SCs.

Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors

Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photoreceptors in rd1, a transgenic mouse model of retinitis pigmentosa. L. barbarum glycopeptide(Lb GP) is an immunoreactive glycoprotein extracted from LBP. In this study, we investigated the potential protective effect of Lb GP on a chemically induced photoreceptor-degenerative mouse model. Wild-type mice received the following: oral administration of Lb GP as a protective pre-treatment on days 1–7;intraperitoneal administration of 40 mg/kg N-methylN-nitrosourea to induce photoreceptor injury on day 7;and continuation of orally administered Lb GP on days 8–14. Treatment with Lb GP increased photoreceptor survival and improved the structure of photoreceptors, retinal photoresponse, and visual behaviors of mice with photoreceptor degeneration. Lb GP was also found to partially inhibit the activation of microglia in N-methyl-N-nitrosourea-injured retinas and significantly decreased the expression of two pro-inflammatory cytokines. In conclusion, Lb GP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.

Collaborative positioning for swarms:A brief survey of vision,LiDAR and wireless sensors based methods

As positioning sensors,edge computation power,and communication technologies continue to develop,a moving agent can now sense its surroundings and communicate with other agents.By receiving spatial information from both its environment and other agents,an agent can use various methods and sensor types to localize itself.With its high flexibility and robustness,collaborative positioning has become a widely used method in both military and civilian applications.This paper introduces the basic fundamental concepts and applications of collaborative positioning,and reviews recent progress in the field based on camera,LiDAR(Light Detection and Ranging),wireless sensor,and their integration.The paper compares the current methods with respect to their sensor type,summarizes their main paradigms,and analyzes their evaluation experiments.Finally,the paper discusses the main challenges and open issues that require further research.

Comparison of microwave- and thermal-assisted rock fragmentation methods at different temperatures and loading rates

Understanding the effects of microwave irradiation and thermal treatment on the dynamic compression and fragmentation properties of rocks is essential to quantify energy consumption in rock engineering.In this study,Fangshan granite(FG)specimens were exposed to microwave irradiation and heat treatment.The damage of FG specimens induced by these two methods was compared using X-ray CT scanning and ultrasonic wave method.The temperatures of FG after microwave irradiation and thermal treatment were effectively evaluated using a newly proposed technique.A novelty method for precisely determining the geometric features of fragments is developed to estimate the fragmentation energy.Thus,the dynamic uniaxial compressive strength(UCS),the dynamic fragmentation characteristics,and the fragmentation energy of FG after these two pretreatment methods can be reasonably compared.The noticeable distinction of loading rate effect on the dynamic UCS of FG between these two pretreatment methods is first observed.A relationship is established between the dynamic UCS and the damage induced by microwave irradiation and heat treatment.Moreover,fragmentation energy fan analysis is introduced to accurately compare the fragmentation properties of FG after two pretreatment methods in dynamic compression tests.

Stability mechanism and control of the pumpable supports in longwall recovery room

The load-bearing performance(LBP)of pumpable supports(PPS)is crucial for the stability of longwall pre-driven recovery room(PRR)surrounding rock.However,the unbalanced bearing coefficient(UBC)of the PPS(undertaking unequal load along the mining direction)has not been investigated.A mechanical model of the PRR was established,considering the main roof cantilever beam structure,to derive an assessment formula for the load,the failure criteria,and the UBC of the PPS.Subsequently,the generation mechanisms,and influencing factors of the UBC were revealed.Global sensitivity analysis shows that the main roof hanging length(l_(2))and the spacing between the PPS(r)significantly impact the UBC.A novel design of the PPS and the coupling control technology were proposed and applied to reduce the UBC of the PPS in the adjacent longwall PRR.Monitor results showed no failure of the PPS at the test site,with the UBC(ζ)reduced to 1.1 consistent with the design value(1.15)basically,fully utilizing the collaborative LBP of the PPS.Finally,the maximum roof-to-floor convergence of the PRR was 234 mm,effectively controlling the stability of the surrounding rock of the PRR and ensuring the mining equipment recovery.

粉砂与粉土固结蠕变特性对比的试验研究

为了解释基坑预降水引发的基坑周边地面沉降的滞后性,依托某地铁车站基坑预降水工程,开展场地中典型粉砂和粉土的一维固结蠕变试验。通过试验结果分析,得到土的压缩指数、回弹指数和次固结系数,给出了回弹指数与压缩指数和次固结系数与压缩指数的经验关系。蠕变试验结果表明,粉砂和粉土的次固结系数与固结荷载之间呈现良好的线性关系,提出了次固结系数与固结压力的经验公式。从固结压力下砂土天然结构破坏的角度,解释了次固结系数随着固结压力的增加而增大的原因,为解释预降水引起的基坑周边地面沉降滞后效应和地面沉降合理估算提供了实验依据。

基于内聚力单元法的船舶与重叠冰碰撞数值模拟研究

The gradual increase in shipping and drilling activities in the Arctic regions has resulted in the increased importance of studying the structural safety of polar ships in various ice conditions.Rafted ice refers to a type of accumulated and overlapped sea ice;it is driven by external forces,such as wind and waves,and may exert high loads on ships and threaten their structural safety.Therefore,the properties of rafted ice and the construction of numerical models should be studied before exploring the interaction and collision between ships and rafted ice.Based on the nonlinear finite-element method,this paper introduces the cohesive element model for the simulation of rafted ice.The interaction between ships and rafted ice is studied,and the ice force of the hull is obtained.Numerical simulation results are compared with model test findings,and the effectiveness of the cohesive element method in the construction of the model of rafted ice materials is verified.On this basis,a multilayer rafted ice model is constructed,and its interaction with the ship is studied.The research unveils that rafted ice parts impede crack generation and slow down crack propagation to a certain extent.

Effect of strain on structure and electronic properties of monolayer C_(4)N_(4)

The first-principles calculations are performed to examine structural,mechanical,and electronic properties at large strain for a monolayer C_(4)N_(4),which has been predicted as an anchoring promising material to attenuate shuttle effect in Li–S batteries stemming from its large absorption energy and low diffusion energy barrier.Our results show that the ideal strengths of C_(4)N_(4)under tension and pure shear deformation conditions reach 13.9 GPa and 12.5 GPa when the strains are 0.07 and 0.28,respectively.The folded five-membered rings and diverse bonding modes between carbon and nitrogen atoms enhance the ability to resist plastic deformation of C_(4)N_(4).The orderly bond-rearranging behaviors under the weak tensile loading path along the[100]direction cause the impressive semiconductor–metal transition and inverse semiconductor–metal transition.The present results enrich the knowledge of the structure and electronic properties of C_(4)N_(4)under deformations and shed light on exploring other two-dimensional materials under diverse loading conditions.

Research on Sarcasm Detection Technology Based on Image-Text Fusion

The emergence of new media in various fields has continuously strengthened the social aspect of social media.Netizens tend to express emotions in social interactions,and many people even use satire,metaphors,and other techniques to express some negative emotions,it is necessary to detect sarcasm in social comment data.For sarcasm,the more reference data modalities used,the better the experimental effect.This paper conducts research on sarcasm detection technology based on image-text fusion data.To effectively utilize the features of each modality,a feature reconstruction output algorithm is proposed.This algorithm is based on the attention mechanism,learns the low-rank features of another modality through cross-modality,the eigenvectors are reconstructed for the corresponding modality through weighted averaging.When only the image modality in the dataset is used,the preprocessed data has outstanding performance in reconstructing the output model,with an accuracy rate of 87.6%.When using only the text modality data in the dataset,the reconstructed output model is optimal,with an accuracy rate of 85.2%.To improve feature fusion between modalities for effective classification,a weight adaptive learning algorithm is used.This algorithm uses a neural network combined with an attention mechanism to calculate the attention weight of each modality to achieve weight adaptive learning purposes,with an accuracy rate of 87.9%.Extensive experiments on a benchmark dataset demonstrate the superiority of our proposed model.

A Unified Model Fusing Region of Interest Detection and Super Resolution for Video Compression

High-resolution video transmission requires a substantial amount of bandwidth.In this paper,we present a novel video processing methodology that innovatively integrates region of interest(ROI)identification and super-resolution enhancement.Our method commences with the accurate detection of ROIs within video sequences,followed by the application of advanced super-resolution techniques to these areas,thereby preserving visual quality while economizing on data transmission.To validate and benchmark our approach,we have curated a new gaming dataset tailored to evaluate the effectiveness of ROI-based super-resolution in practical applications.The proposed model architecture leverages the transformer network framework,guided by a carefully designed multi-task loss function,which facilitates concurrent learning and execution of both ROI identification and resolution enhancement tasks.This unified deep learning model exhibits remarkable performance in achieving super-resolution on our custom dataset.The implications of this research extend to optimizing low-bitrate video streaming scenarios.By selectively enhancing the resolution of critical regions in videos,our solution enables high-quality video delivery under constrained bandwidth conditions.Empirical results demonstrate a 15%reduction in transmission bandwidth compared to traditional super-resolution based compression methods,without any perceivable decline in visual quality.This work thus contributes to the advancement of video compression and enhancement technologies,offering an effective strategy for improving digital media delivery efficiency and user experience,especially in bandwidth-limited environments.The innovative integration of ROI identification and super-resolution presents promising avenues for future research and development in adaptive and intelligent video communication systems.

Advances in dynamic test of deep rocks considering in-situ mechanical and hydraulic conditions

Determining the dynamic behaviors of deep rocks is important but challenging for deep underground rock engineering.Recently,great advances have been made by researchers in dynamic tests of deep rocks considering insitu mechanical and hydraulic conditions.It is thus imperative to systematically review the progress in this field.This paper focuses on the dynamic experiments of deep rocks using the modified split Hopkinson pressure bar(SHPB),including new advances in experimental apparatuses,methodologies,and results.A comprehensive introduction to the principles of the triaxial confinement SHPB,the true triaxial SHPB,and SHPB with a coupled hydraulic-mechanical device is provided.The development of these systems for conducting dynamic tests of deep rocks is briefly presented.Moreover,the experimental methods and results for quantifying dynamic compressive,tensile,flexure,and shear strengths and mode I/II fracture toughness of rocks under axial preload,hydrostatic pressure,triaxial stress state,and coupled hydraulic-mechanical condition are systematically discussed,and the rate-dependent characteristics and mechanisms of deep rocks under various geological occurrence conditions are also summarized.

新疆某铁矿选矿厂破碎工艺改造应用

新疆某磁铁矿选矿厂破碎工段采用三段一闭路破碎、干磁预选工艺流程,生产过程中存在破碎系统循环负荷大的问题。为达到减少破碎循环时间、提高矿石入破量、减小入磨粒度、提高磨矿处理量和磨矿效率的目的,需要对选厂破碎流程进行优化。将原有的圆振筛筛孔增大,降低细碎循环负荷;在原有的干磁预选后增加高压辊磨合振动筛,将入磨粒度减小,多碎少磨;将高压辊系统前增加磁滚筒抛废,脉石矿物能抛早抛。此次破碎工艺流程优化后,入破量有所增加,入磨粒度变小,入磨品位得以提高,产能也获得了提升。

The Research of Chinese Words Semantic Similarity Calculation with Multi-Information

Text similarity has a relatively wide range of applications in many fields, such as intelligent information retrieval, question answering system, text rechecking, machine translation, and so on. The text similarity computing based on the meaning has been used more widely in the similarity computing of the words and phrase. Using the knowledge structure of the and its method of knowledge description, taking into account the other factor and weight that influenced similarity, making full use of depth and density of the Concept-Sememe tree, an improved method of Chinese word similarity calculation based on semantic distance was provided in this paper. Finally the effectiveness of this method was verified by the simulation results.

Bioinformatics Identification of ZNFs/LINC00520/miR-181d/BCL2 Axis as a Novel Network in Cisplatin-Resistant Lung Adenocarcinoma Cells

Background: Resistance to cisplatin (DDP) leads to poor prognosis in patients with Lung Adenocarcinoma (LUAD) and limits its clinical application. It has been confirmed that autophagy promotes chemoresistance and, therefore, novel strategies to reverse chemoresistance by regulating autophagy are desperately needed. Methods: The differentially expressed lncRNAs (DElncRNAs), miRNAs (DEmiRNAs), and mRNAs (DEmRNAs) between A549 and A549/DDP cell lines were identified using the limma package in R, after gene expression profiles were obtained from Gene Expression Omnibus (GEO) database. By combining Autophagy-Related Genes (ARGs) from Human Autophagy Database (HADb), the interactions lncRNA-miRNAs and the interactions miRNAs-mRNAs respectively predicted by miRcode and miRDB/Targetscan database, the autophagy-related ceRNA network was constructed. Then, extraction of ceRNA subnetwork and Cox regression analyses were performed. A prognosis-related ceRNA subnetwork was constructed, and the upstream Transcription Factors (TFs) regulating lncRNAs were predicted by the JASPAR database. Finally, the expression patterns of candidate genes were further verified by quantitative real-time polymerase chain reaction (qRT-PCR) experiments. Results: A total of 3179 DEmRNAs, 180 DEmiRNAs, and 160 DElncRNAs were identified, and 35 DEmRNAs were contained in the HADb. Based on the ceRNA hypothesis, we established a ceRNA network, including 10 autophagy-related DEmRNAs, 9 DEmiRNAs, and 14 DElncRNAs. Then, LINC00520, miR-181d, and BCL2 were identified to construct a risk score model, which was confirmed to be a well-predicting prognostic factor. Furthermore, 5 TF ZNF family members were predicted to regulate LINC00520, whereas the RT-PCR results showed that the 5 ZNFs were consistent with the bioinformatics analysis. Finally, a ZNF regulatory LINC00520/miR-181d/BCL2 ceRNA subnetwork was constructed. Conclusions: An ZNFs/LINC00520/miR-181d/BCL2 axis as a novel network in DDP-resistant LUAD has been constructed successfully, which may provide potential therapeutic targets for LUAD.

Identification of Driver Genes in Primary Liver Cancer by Integrating NGS and TCGA Mutation Data

Background: This study is aimed towards an exploration of mutant genes in primary liver cancer (PLC) patients by using bioinformatics and data mining techniques. Methods: Peripheral blood or paraffin-embedded tissues from 8 patients with PLC were analyzed using a 551 cancer-related gene panel on an Illumina NextSeq500 Sequencer (Illumina). Meanwhile, the data of 396 PLC cases were downloaded from The Cancer Genome Atlas (TCGA) database. The common mutated genes were obtained after integrating the mutation information of the above two cohorts, followed by functional enrichment and protein-protein interaction (PPI) analyses. Three well-known databases, including Vogelstein’s list, the Network of Cancer Gene (NCG), and the Catalog of Somatic Mutations in Cancer (COSMIC) database were used to screen driver genes. Furthermore, the Chi-square and logistic analysis were performed to analyze the correlation between the driver genes and clinicopathological characteristics, and Kaplan-Meier (KM) method and multivariate Cox analysis were conducted to evaluate the overall survival outcome. Results: In total, 84 mutation genes were obtained after 8 PLC patients undergoing gene mutation detection with next-generation sequencing (NGS). The top 100 most mutate gene data from PLC patients in TCGA database were downloaded. After integrating the above two cohorts, 17 common mutated genes were identified. Next, 11 driver genes were screened out by analyzing the intersection of the 17 mutation genes and the genes in the three well-known databases. Among them, RB1, TP53, and KRAS gene mutations were connected with clinicopathological characteristics, while all the 11 gene mutations had no relationship with overall survival. Conclusion: This study investigated the mutant genes with significant clinical implications in PLC patients, which may improve the knowledge of gene mutations in PLC molecular pathogenesis.

静脉采血中快速小角度直刺法对减轻疼痛的作用

目的 探讨静脉采血中快速小角度直刺法对减轻疼痛的作用。方法 选取2021年10月至2022年10月在南阳市中心医院行静脉采血的120例患者为研究对象,分为观察组和对照组,每组60例。对照组采取常规采血,观察组采取快速小角度直刺法采血,比较两组患者疼痛程度、采血成功率、不良反应发生率、按压止血时间、进针时间及对护士采血技术满意度。结果 观察组无痛率高于对照组(83.33%vs.31.67%,P<0.001),轻度、中度、重度疼痛发生率均低于对照组(P <0.05);观察组一次采血成功率高于对照组(100.00%vs.76.67%,P <0.001);观察组不良反应发生率显著低于对照组(6.67%vs.20.00%,P=0.032);观察组对护士操作技术、服务态度、工作流程满意度及满意度总分均高于对照组(P <0.001);与对照组相比,观察组按压止血时间、进针时间均较短(P <0.001)。结论 对静脉采血患者采取快速小角度直刺法,可显著减轻患者疼痛程度,提高一次采血成功率,缩短其进针时间,不良反应发生率较低。

小儿气管支气管异物存留位置的相关因素分析

目的分析小儿气管支气管异物存留位置的相关因素,为病情评估、手术风险和预后提供帮助。方法回顾性分析2015年1月-2015年12月1060例小儿气管支气管异物患儿的临床资料,分析异物存留位置与年龄、性别、肉芽形成、胸部CT及三维重建、术前并发症、手术时间和住院时间的相关性。结果异物存留位置与年龄、性别、手术时间和住院时间不存在相关性,异物存留位置与肉芽形成、胸部CT及三维重建以及术前并发症存在关联。结论异物存留位置与肉芽形成、胸部CT的异物部位显示及术前并发症存在关联。

肠神经胶质细胞与胃肠道运动功能研究进展

肠神经胶质细胞(enteric glial cells, EGCs)是肠神经系统的重要组成部分,在维持胃肠道功能方面发挥着重要作用.营养和支持胃肠神经元,参与胃肠道内神经活动的整合和调节以及参与肠道炎症反应,直接或间接调节胃肠道运动功能.研究肠神经胶质细胞对胃肠神经的影响以及在肠道炎症所致胃肠道运动障碍中的作用,有助于揭示肠神经胶质细胞对胃肠道动力影响的作用机制.在临床上, EGCs具有作为多种胃肠道运动功能障碍性疾病的治疗靶点的应用前景.本文将对EGCs对胃肠道运动功能的影响进行综述.