Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer:A bidirectional Mendelian randomization study

BACKGROUND Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-lowdensity lipoprotein(VLDL)and the occurrence of peptic ulcers(PU).However,the precise causal relationship between these factors remains ambiguous.Consequently,this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic ulcer.AIM To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein(VLDL)association with PU via genetic methods,guiding future clinical research.METHODS Genome-wide association study(GWAS)datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project(https://gwas.mrcieu.ac.uk).For the forward Mendelian randomization(MR)analysis,72 single nucleotide polymorphisms(SNPs)were identified as instrumental variables.These SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL,with peptic ulcer as the outcome variable.Conversely,for the inverse MR analysis,no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the outcome.All MR analyses utilized inverse variance weighted(IVW)as the primary analytical method.Additionally,weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal effects.Egger regression was used as a supplementary method to evaluate potential directional pleiotropy.Heterogeneity and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple testing.RESULTS The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer(IVW:OR=2.557,95%CI=1.274-5.132,P=0.008).However,no causal association of peptic ulcer with the ratio of cholesterol to total lipids in medium VLDL was observed in the inverse Mendelian randomization analysis.CONCLUSION In conclusion,our study reveals a significant association between the ratio of cholesterol to total lipids in medium VLDL and an elevated risk of peptic ulcers.However,further validation through laboratory investigations and larger-scale studies is warranted to strengthen the evidence and confirm the causal relationship between these factors.

Weakly nonlinear multi-mode Bell-Plesset growth in cylindrical geometry

Bell-Plesset(BP)effect caused perturbation growth plays an important role in better understanding of characteristics of the convergence effect.Governing equations for multi-mode perturbation growth on a cylindrically convergent interface are derived.The second-order weakly nonlinear(WN)solutions for two-mode perturbations at the interface which is subject to uniformly radical motion are obtained.Our WN theory is consistent with the numerical result in terms of mode-coupling effect in converging Richtmyer-Meshkov instability.Nonlinear mode-coupling effects will cause irregular deformation of the convergent interface.The mode-coupling behavior in convergent geometry depends on the mode number,Atwood number A and convergence ratio Cr.The A=-1.0 at the interface results in larger perturbation growth than A=1.0.The growth of generated perturbation modes from two similar modes at the initial stage are smaller than that from two dissimilar modes.

Magnetohydrodynamic Kelvin-Helmholtz instability for finite-thickness fluid layers

We have derived the analytical formulas for the Kelvin-Helmholtz instability(KHI)of two superposed finite-thickness fluid layers with the magnetic field effect into consideration.The linear growth rate of KHI will be reduced when the thickness of the fluid with large density is decreased or the thickness of fluid with small density is increased.When the thickness and the magnetic field act together on the KHI,the effect of thickness is more obvious when the magnetic field intensity is weak.The magnetic field transition layer destabilizes(enforces)the KHI,especially in the case of small thickness of the magnetic field transition layer.When considering the effect of magnetic field,the linear growth rate of KHI always decreases after reaching the maximum with the increase of total thickness.The stronger the magnetic field intensity is,the more obvious the growth rate decreases with the total thickness.Thus,it should be included in applications where the effect of fluid thickness on the KHI cannot be ignored,such as in double-cone ignition scheme for inertial confinement fusion.

Mechanical and microstructural response of densified silica glass under uniaxial compression: Atomistic simulations

We investigate the mechanical and microstructural changes of the densified silica glass under uniaxial loading-unloading via atomistic simulations with a modified BKS potential. The stress–strain relationship is found to include three respective stages: elastic, plastic and hardening regions. The bulk modulus increases with the initial densification and will undergo a rapid increase after complete densification. The yield pressure varies from 5 to 12 GPa for different densified samples. In addition, the Si–O–Si bond angle reduces during elastic deformation under compression, and 5-fold Si will increase linearly in the plastic deformation. In the hardening region, the peak splitting and the new peak are both found on the Si–Si and O–O pair radial distribution functions, where the 6-fold Si is increased. Instead, the lateral displacement of the atoms always varies linearly with strain, without evident periodic characteristic. As is expected, the samples are permanently densified after release from the plastic region, and the maximum density of recovered samples is about 2.64 g/cm^3, which contains 15 % 5-fold Si, and the Si–O–Si bond angle is less than the ordinary silica glass. All these findings are of great significance for understanding the deformation process of densified silica glass.

Effect of initial phase on the Rayleigh–Taylor instability of a finite-thickness fluid shell

Rayleigh–Taylor instability(RTI) of finite-thickness shell plays an important role in deep understanding the characteristics of shell deformation and material mixing. The RTI of a finite-thickness fluid layer is studied analytically considering an arbitrary perturbation phase difference on the two interfaces of the shell. The third-order weakly nonlinear(WN) solutions for RTI are derived. It is found the main feature(bubble-spike structure) of the interface is not affected by phase difference. However, the positions of bubble and spike are sensitive to the initial phase difference, especially for a thin shell(kd < 1), which will be detrimental to the integrity of the shell. Furthermore, the larger phase difference results in much more serious RTI growth, significant shell deformation can be obtained in the WN stage for perturbations with large phase difference. Therefore, it should be considered in applications where the interface coupling and perturbation phase effects are important, such as inertial confinement fusion.

Analytical model for Rayleigh-Taylor instability in conical target conduction region

This work builds an isobaric steady-state fluid analytical-physical model of the plasma conduction region in a conical target. The hydrodynamic instability in the double-cone ignition scheme^([21]) for inertial confinement fusion(ICF) proposed by Zhang is studied with the built model. With this idealized model, the relevant parameters, such as density, temperature,and length of the plasma in the conduction region of the conical target under long-pulse conditions are given. The solution of the proposed analytical model dovetails with the trend of the numerical simulation. The model and results in this paper are beneficial for discussing how to attenuate Rayleigh-Taylor instability in ICF processes with conical and spherical targets.

A model for fast electron-driven high-density plasma in the double-cone ignition scheme

A model for fast electron-driven high-density plasma is proposed to describe the effect of injected fast electrons on the temperature and inner pressure of the plasma in the fast heating process of the double-cone ignition(DCI)scheme.Due to the collision of the two low-density plasmas,the density and volume of the high-density plasma vary.Therefore,the ignition temperature and energy requirement of the high-density plasma vary at different moments,and the required energy for hot electrons to heat the plasma also changes.In practical experiments,the energy input of hot electrons needs to be considered.To reduce the energy input of hot electrons,the optimal moment and the shortest time for injecting hot electrons with minimum energy are analyzed.In this paper,it is proposed to inject hot electrons for a short time to heat the high-density plasma to a relatively high temperature.Then,the alpha particles with the high heating rate and PdV work heat the plasma to the ignition temperature,further reducing the energy required to inject hot electrons.The study of the injection time of fast electrons can reduce the energy requirement of fast electrons for the high-density plasma and increase the probability of successful ignition of the high-density plasma.

Ultrafast structural dynamics using time-resolved x-ray diffraction driven by relativistic laser pulses

Based on a femtosecond laser plasma-induced hard x-ray source with a high laser pulse energy(>100 mJ)at 10 Hz repetition rate,we present a time-resolved x-ray diffraction system on an ultrafast time scale.The laser intensity is at relativistic regime(2×10^(19)W/cm^(2)),which is essential for effectively generating K_(α)source in high-Z metal material.The produced copper K_(α)radiation yield reaches to 2.5×10^(8)photons/sr/shot.The multilayer mirrors are optimized for monochromatizating and two-dimensional beam shaping of Kαemission.Our experiment exhibits its ability of monitoring the transient structural changes in a thin film SrCoO_(2.5)crystal.It is demonstrated that this facility is a powerful tool to perform dynamic studies on samples and adaptable to the specific needs for different particular applications with high flexibility.

Physical modeling of multiphase flow via lattice Boltzmann method： Numerical effects, equation of state and boundary conditions

The aims of the present paper are threefold. First, we further study the fast Fourier transform thermal lattice Boltzmann （FFT-TLB） model for van der Waals （VDW） fluids proposed in Phys. Rev. E, 2011, 84（4）： 046715. We analyze the merits of the FFT approach over the traditional finite difference scheme and investigate the effects of smoothing factors on accuracy and stability in detail. Second, we incorporate the VDW equation of state with flexible parameters into the FFT- TLB model. As a result, the revised model may be used to handle multiphase flows with various critical densities and temperatures. Third, we design appropriate boundary conditions for systems with solid walls. These improvements, from the views of numerics and physics, significantly extend the application scope of the model in science and engineering.