In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine, Immunofluorescence and western bl...In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine, Immunofluorescence and western blotting revealed an increase in adenosine A1 receptor expression and a decrease in adenosine A2a receptor expression in the brain tissues of epileptic rats 3 months after transplantation. Moreover, the imbalance in the A1 adenosine receptor/A2a adenosine receptor ratio was improved. Electroencephalograms showed that frequency and amplitude of spikes in the hippocampus and frontal lobe were reduced. These results suggested that mesenchymal stem cell transplantation can reconstruct the normal function of the adenosine system in the brain and greatly improve epileptiform discharges.展开更多
High resolution satellite images are becoming increasingly available for urban multi-temporal semantic understanding.However,few datasets can be used for land-use/land-cover(LULC)classification,binary change detection...High resolution satellite images are becoming increasingly available for urban multi-temporal semantic understanding.However,few datasets can be used for land-use/land-cover(LULC)classification,binary change detection(BCD)and semantic change detection(SCD)simultaneously because classification datasets always have one time phase and BCD datasets focus only on the changed location,ignoring the changed classes.Public SCD datasets are rare but much needed.To solve the above problems,a tri-temporal SCD dataset made up of Gaofen-2(GF-2)remote sensing imagery(with 11 LULC classes and 60 change directions)was built in this study,namely,the Wuhan Urban Semantic Understanding(WUSU)dataset.Popular deep learning based methods for LULC classification,BCD and SCD are tested to verify the reliability of WUSU.A Siamese-based multi-task joint framework with a multi-task joint loss(MJ loss)named ChangeMJ is proposed to restore the object boundaries and obtains the best results in LULC classification,BCD and SCD,compared to the state-of-the-art(SOTA)methods.Finally,a large spatial-scale mapping for Wuhan central urban area is carried out to verify that the WUsU dataset and the ChangeMJ framework have good application values.展开更多
The Middle Permian Lucaogou Formation is the source rock and the main oil shale producing formation in the southeastern Junggar Basin.This study focused on the Lucaogou Formation exposed in two outcrop sections on the...The Middle Permian Lucaogou Formation is the source rock and the main oil shale producing formation in the southeastern Junggar Basin.This study focused on the Lucaogou Formation exposed in two outcrop sections on the northern flank of the Bogda Mountain,namely the Jingjingzigou and Dalongkou sections.Here,we present integrated analysis of the sedimentology,major and trace elements,mineral components and total organic carbon contents.The paleo-environment was reconstructed including provenance,redox conditions,paleo-salinity,chemical weathering intensity and primary organic matter productivity.The results showed that the upper and lower units were deposited in distinct depositional environments with different organic matter accumulation mechanisms.The lower unit was characterized by low lake level,dry climate,fresh-brackish and well-oxygenated water.While during the deposition of the upper unit the lake level rose,climate turned wetter and the bottom water became less oxidized and much saltier.The mechanism of the organic matter accumulation is different for these two units.The preserved organic matters were mainly controlled by the primary productivity in the lower unit and by the redox conditions in the upper unit.展开更多
In the process of pyrolysis and combustion of coal particles, coal structure evolution will be affected by the ash behavior, which will further affect the char reactivity, especially in the ash melting temperature zon...In the process of pyrolysis and combustion of coal particles, coal structure evolution will be affected by the ash behavior, which will further affect the char reactivity, especially in the ash melting temperature zone. Lu’an bituminous char and ash samples were prepared at the N_(2) and air atmospheres respectively across ash melting temperature. A scanning electron microscope (SEM) was used to observe the morphology of char and ash. The specific surface area (SSA) analyzer and thermogravimetric analyzer were respectively adopted to obtain the pore structure characteristics of the coal chars and combustion parameters. Besides, an X-ray diffractometer (XRD) was applied to investigate the graphitization degree of coal chars prepared at different pyrolysis temperatures. The SEM results indicated that the number density and physical dimension of ash spheres exuded from the char particles both gradually increased with the increasing temperature, thus the coalescence of ash spheres could be observed obviously above 1100℃. Some flocculent materials appeared on the surface of the char particles at 1300℃, and it could be speculated that β-Si_(3)N_(4) was generated in the pyrolysis process under N_(2). The SSA of the chars decreased with the increasing pyrolysis temperature. Inside the char particles, the micropore area and its proportion in the SSA also declined as the pyrolysis temperature increased. Furthermore, the constantly increasing pyrolysis temperature also caused the reactivity of char decrease, which is consistent with the results obtained by XRD. The higher combustion temperature resulted in the lower porosity and more fragments of the ash.展开更多
文摘In the present study, we transplanted bone marrow-derived mesenchymal stem cells into the CA3 area of the hippocampus of chronic epilepsy rats kindled by lithium chloride-pilocarpine, Immunofluorescence and western blotting revealed an increase in adenosine A1 receptor expression and a decrease in adenosine A2a receptor expression in the brain tissues of epileptic rats 3 months after transplantation. Moreover, the imbalance in the A1 adenosine receptor/A2a adenosine receptor ratio was improved. Electroencephalograms showed that frequency and amplitude of spikes in the hippocampus and frontal lobe were reduced. These results suggested that mesenchymal stem cell transplantation can reconstruct the normal function of the adenosine system in the brain and greatly improve epileptiform discharges.
基金supported by National Key Research and Development Program of China under grant number 2022YFB3903404National Natural Science Foundation of China under grant number 42325105,42071350LIESMARS Special Research Funding.
文摘High resolution satellite images are becoming increasingly available for urban multi-temporal semantic understanding.However,few datasets can be used for land-use/land-cover(LULC)classification,binary change detection(BCD)and semantic change detection(SCD)simultaneously because classification datasets always have one time phase and BCD datasets focus only on the changed location,ignoring the changed classes.Public SCD datasets are rare but much needed.To solve the above problems,a tri-temporal SCD dataset made up of Gaofen-2(GF-2)remote sensing imagery(with 11 LULC classes and 60 change directions)was built in this study,namely,the Wuhan Urban Semantic Understanding(WUSU)dataset.Popular deep learning based methods for LULC classification,BCD and SCD are tested to verify the reliability of WUSU.A Siamese-based multi-task joint framework with a multi-task joint loss(MJ loss)named ChangeMJ is proposed to restore the object boundaries and obtains the best results in LULC classification,BCD and SCD,compared to the state-of-the-art(SOTA)methods.Finally,a large spatial-scale mapping for Wuhan central urban area is carried out to verify that the WUsU dataset and the ChangeMJ framework have good application values.
基金financially supported by the Petro China Science and Technology Major Project(Nos.2016B-0302 and 2019B-0302)。
文摘The Middle Permian Lucaogou Formation is the source rock and the main oil shale producing formation in the southeastern Junggar Basin.This study focused on the Lucaogou Formation exposed in two outcrop sections on the northern flank of the Bogda Mountain,namely the Jingjingzigou and Dalongkou sections.Here,we present integrated analysis of the sedimentology,major and trace elements,mineral components and total organic carbon contents.The paleo-environment was reconstructed including provenance,redox conditions,paleo-salinity,chemical weathering intensity and primary organic matter productivity.The results showed that the upper and lower units were deposited in distinct depositional environments with different organic matter accumulation mechanisms.The lower unit was characterized by low lake level,dry climate,fresh-brackish and well-oxygenated water.While during the deposition of the upper unit the lake level rose,climate turned wetter and the bottom water became less oxidized and much saltier.The mechanism of the organic matter accumulation is different for these two units.The preserved organic matters were mainly controlled by the primary productivity in the lower unit and by the redox conditions in the upper unit.
基金This work was financial supported by the National Natural Science Foundation of China(Grant No.51576158).
文摘In the process of pyrolysis and combustion of coal particles, coal structure evolution will be affected by the ash behavior, which will further affect the char reactivity, especially in the ash melting temperature zone. Lu’an bituminous char and ash samples were prepared at the N_(2) and air atmospheres respectively across ash melting temperature. A scanning electron microscope (SEM) was used to observe the morphology of char and ash. The specific surface area (SSA) analyzer and thermogravimetric analyzer were respectively adopted to obtain the pore structure characteristics of the coal chars and combustion parameters. Besides, an X-ray diffractometer (XRD) was applied to investigate the graphitization degree of coal chars prepared at different pyrolysis temperatures. The SEM results indicated that the number density and physical dimension of ash spheres exuded from the char particles both gradually increased with the increasing temperature, thus the coalescence of ash spheres could be observed obviously above 1100℃. Some flocculent materials appeared on the surface of the char particles at 1300℃, and it could be speculated that β-Si_(3)N_(4) was generated in the pyrolysis process under N_(2). The SSA of the chars decreased with the increasing pyrolysis temperature. Inside the char particles, the micropore area and its proportion in the SSA also declined as the pyrolysis temperature increased. Furthermore, the constantly increasing pyrolysis temperature also caused the reactivity of char decrease, which is consistent with the results obtained by XRD. The higher combustion temperature resulted in the lower porosity and more fragments of the ash.
