Servile Straw Mat and Precious Memory——Impression of Huang Ming's Still Life

Almost in the same period of time, I was acquainted with Huang Ming, Fan Bo and Lei Bo. Five years ago, Huang Ming was a neighbor of Fan Bo when he lived in Beijing. So, if I visited one of them, the other one would be called to join the gathering. It was interesting to discover although they had totally different personality and style of painting, they had one single commonality in the form of expression, which gave me the deepest impression. Their paintings showed two core elements. In many paintings of Fan, you would see a withered tree and a man under the tree; while in many of Huang's paintings, you would see an aged object and a straw mat underneath.

Zhuang Zhong's "Perplexities" and "Free-from-Perplexities"

No More Perplexities at Forty Confucius says:'At forty,I no longer sufferedfromperplexities.'Although the 39-year-old painter Zhuang Zhong is about to be'free from perplexities',he is still suffering from'perplexities.'Fortumately,his'perplexities'are not the fear of being lost and confused,but a desire for knowledge,a passion for creativity and courage to surpass himself.. The painter sitting opposite me seemed to be more interested in music than painting. He said he is learning Guqin(a seven-string plucked instrument).To begin with,he kept listening to the music played by masters. Meanwhile,he had collected some

The Application and Practice of TBL Method in the Teaching of “Zhuang Medical Prescriptions”

The application of TBL teaching method to"Zhuang Medical Prescriptions"is an actual practice of group cooperative learning mode.Through this method,a more active learning atmosphere can be constructed,and it is also an activity to jointly achieve the teaching goals.From the perspective of the practice of basic teaching,it is a creative teaching strategy.Let students develop the awareness and habit of using team groups for cooperative inquisitive learning,so as to gradually improve students'level of comprehensive application analysis.This paper discusses in detail from the perspective of practical research and building,and compares data under different teaching methods with test results to prove that TBL teaching method is superior to traditional teaching method.

Application of three-dimensional speckle tracking technique in measuring left ventricular myocardial function in patients with diabetes

BACKGROUND Diabetic cardiomyopathy is considered as a chronic complication of diabetes mellitus(DM).Therefore,early detection of left ventricular systolic function(LVSF)damage in DM is essential.AIM To explore the use of the three-dimensional speckle tracking technique(3D-STI)for measuring LVSF in DM patients via meta-analysis.METHODS The electronic databases were retrieved from the initial accessible time to 29 April 2023.The current study involved 9 studies,including 970 subjects.We carried out this meta-analysis to estimate myocardial function in DM compared with controls according to myocardial strain attained by 3D-STI.RESULTS Night articles including 970 subjects were included.No significant difference was detected in the left ventricular ejection fraction between the control and the diabetic group(P>0.05),while differences in global longitudinal strain,global circumferential strain,global radial strain,and global area strain were markedly different between the controls and DM patients(all P<0.05).CONCLUSION The 3D-STI could be applied to accurately measure early LVSF damage in patients with DM.

Bioactivated polyetheretherketone scaffold able to generate mild heat for promoting bone regeneration via activating MAPK/ERK signaling pathway

Photothermal therapy(PTT)is a desirable way to attain on-demand hyperthermia owing to the heat gen-erated by photothermal materials absorbing near-infrared light.The mild heat(42±0.5℃)can not only accelerate bone tissue regeneration but also promote the release of bioactive ions from biomaterials.Based on this one-stone-two-birds strategy,a 3D printed PEEK-graphene composite scaffold(PG)with hydroxyapatite(HA)coating(PGH)for photothermally remote control of bone regeneration was well de-signed in this study.The results showed that the HA coating on PGH could release Ca^(2+)and PO_(4)^(3-)ions easily under NIR irradiation,which was ascribed to the mild heat generated from graphene in the com-posite scaffold.The mild heat and the boosted Ca^(2+)/PO_(4)^(3-)release could synergistically enhance the bone regeneration ability both in vitro and in vivo.The underlying mechanism was further explored and con-firmed to be closely related to the upregulation of HSP 70,by which the MAPK/ERK signaling pathway was activated selectively.The favorable results demonstrate that the 3D-printed PEEK/graphene composite scaffold is promising in the applications of bone defect repair.

Effects of vitrectomy combined with internal limiting membrane peeling in patients with diabetic macular edema

BACKGROUND Diabetic macular edema(DME),a chronic microvascular complication of diabetes,is a leading cause of visual impairment and blindness.Pars plana vitrectomy(PPV)can restore the normal macular structure and reduce macular edema,whereas internal limiting membrane(ILM)peeling is used to treat tractional macular diseases.Despite the advantages,there is limited research on the combined effects of PPV with ILM peeling.AIM To observe the effects of PPV combined with ILM peeling on postoperative central macular thickness(CMT),best-corrected visual acuity(BCVA),cystoid macular edema(CME)volume,and complications in patients with DME.METHODS Eighty-one patients(92 eyes)diagnosed with DME at the Beijing Shanqu Liangxiang Hospital between January and December 2022 were randomly divided to undergo PPV alone(control group:41 patients,47 eyes)or PPV+ILM peeling(stripping group:40 patients,45 eyes);a single surgeon performed all surgeries.The two groups were compared preoperatively and 1 and 3 months postoperatively.RESULTS Preoperatively,both groups had comparable values of CMT,BCVA,and CME volume(P>0.05).After surgery(both 1 and 3 months),both groups showed significant reductions in CMT,BCVA,and CME volume compared to preoperative levels,with the stripping group showing more significant reductions compared to the control group(P<0.05).Further repeated-measures ANOVA analysis for within-group differences revealed significant effects of group and time,and interaction effects for CMT,BCVA,and CME volume(P<0.05).There were no significant differences in the incidence of complications between the groups(retinal detachment:control=2,stripping=1;endophthalmitis:Control=4,stripping=1;no cases of secondary glaucoma or macular holes;χ^(2)=0.296,P=0.587).CONCLUSION PPV with ILM peeling can significantly improve the visual acuity of patients with DME,reduce CMT,and improve CME with fewer complications.

热消融治疗肺部亚实性结节专家共识(2021年版)

局部热消融技术在肺部结节治疗领域正处在起步与发展阶段,为了肺结节热消融治疗的临床实践和规范发展,由"中国医师协会肿瘤消融治疗技术专家组""中国医师协会介入医师分会肿瘤消融专业委员会""中国抗癌协会肿瘤消融治疗专业委员会""中国临床肿瘤学会消融专家委员会"组织多学科国内有关专家,讨论制定了"热消融治疗肺部亚实性结节专家共识(2021年版)"。主要内容包括:(1)肺部亚实性结节的临床评估;(2)热消融治疗肺部亚实性结节技术操作规程、适应证、禁忌证、疗效评价和相关并发症;(3)存在的问题和未来发展方向。

以创新人才培养为导向的无机及分析化学实验课程体系建设与实践

以培养创新型人才为出发点,针对一年级本科生在无机及分析化学实验教学中存在的问题,探讨了从“以教为主”转变为“以学为主”的课程体系建设与实施情况。通过优化课程体系、拓展培养模式、强化平台建设等手段,在引导学生主动探究、独立思考、掌握科学研究方法等方面取得了一定的成效。

Antibacterial and angiogenic dual-functional fibrous membrane dressing for infected wound healing

Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental factors.Healing full-thickness skin defects becomes especially challenging when infections and vascular injuries are involved.Traditional wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound healing.To address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic properties.Methods:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic agent.Results:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air permeability.It not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo assays.Conclusion:These findings highlight the immense potential of this wound dressing material for future clinical applications.

Comparison of Cell Morphology and Flow Cytometry in the Diagnosis of Multiple Myeloma

Objective: To investigate the value of cell morphology and flow cytometry in the diagnosis of Multiple myeloma (MM). Methods: 166 newly diagnosed MM patients were retrospectively analyzed, and the proportion of plasma cells detected by flow cytometry and cell morphology in these patients was statistically analyzed. Results: All patients were divided into three groups according to the proportion of plasma cells detected by cell morphology: group A (≥30%), group B (≥10% and <30%), and group C (<10%). 1) In all patients and group A, B and C, the proportion of plasma cells detected by cell morphology was all correlated with that detected by flow cytometry. 2) The proportion of plasma cells detected by cell morphology in group A and group B was higher than that by flow cytometry, while there was no significant difference in group C. 3) The sensitivity of plasma cells detected by flow cytometry in group A, B and C was 88.7%, 51.2% and 10%, respectively. 4) According to the immunophenotypic analysis, the immunophenotypic characteristics were similar, all of them were CDl9 - CD38 + CDl38 + CD56 +/- CD45dim ~ -. Conclusion: There is a certain correlation between the two detection methods. The quantitative detection of myeloma cells by cell morphology is better, and the qualitative detection by flow cytometry is better. Combined with the two detection methods, the detection rate of multiple myeloma can be significantly improved.

股骨假体颈干角、前倾角变化对全髋关节置换术后预后的影响

目的研究全髋关节置换手术前后股骨解剖改变,测量颈干角、股骨前倾角等解剖参数,对比上述参数差异对关节置换术后的功能预后、疼痛及患者满意度的影响。方法选取2011~2014年55例患者行全髋关节置换术并随访1年,收集患者基本资料,手术前后行CT检查以及常规X射线检查,利用三维重建软件构建髋关节三维模型,测量股骨颈干角、前倾角、股骨偏心距及髋关节旋转中心的解剖参数,利用Harris关节评分评估患者关节功能,利用视觉模拟评分评估术后关节疼痛程度,评估患者满意度,通过亚组分析上述解剖参数变化与术后预后的相关性。结果共有44例患者完成随访,平均年龄为(65.3±7.0)岁,术后颈干角为(131.6±2.1)°,手术前后颈干角比较有差异(P<0.05),术后平均颈干角较术前大。术前股骨前倾角为(24.9±8.0)°,术后前倾角为(7.4±7.3)°,手术前后股骨前倾角比较有差异(P<0.05)。亚组患者Harris关节评分、视觉模拟评分及患者满意度评分均无差异(P>0.05)。结论患者对手术前后的颈干角以及前倾角差异耐受能力较强,上述解剖参数改变对术后关节功能、疼痛以及患者满意度无显著影响。

聚丁二酸丁二醇酯/聚乙二醇硬脂酸酯共混物结晶行为

用溶液共混的方法制备了聚丁二酸丁二醇酯(PBS)/聚乙二醇硬脂酸酯(PEOST)共混物。采用差示扫描量热法(DSC)表征了共混物的结晶熔融行为。研究结果表明,加入质量分数5%的PEOST能使PBS结晶温度(T_c)降低约10℃,但使熔融温度(T_m)升高约3℃,继续增加PEOST用量对PBS的T_c和T_m影响不大;PBS的结晶焓(ΔH_c)随PEOST含量的增加呈上升趋势,而熔融焓(ΔH_m)先降低再上升;PEOST的结晶属于受限结晶,当其质量分数低于10%,DSC曲线中没有出现PEOST的结晶峰和熔融峰;当质量分数大于20%时,才出现PEOST结晶峰和相应的熔融峰。傅里叶变换红外(FT-IR)谱图中也才出现相应的结晶红外响应峰(1107 cm^(-1)和841 cm^(-1))。广角X射线衍射显示加入PEOST未改变PBS的晶体结构。偏光显微镜分析表明,PEOST含量较高的共混物晶体尺寸更大,具有更清晰的周期性明暗相间的环带花纹。

鼻内镜下扁桃体腺样体等离子切除术对重度鼾症所致发育不良的治疗效果

目的探讨扁桃体腺样体重度肥大阻塞气道、引起睡眠鼾症而致身高和(或)体重发育不达标的患儿,进行鼻内镜下等离子扁桃体腺样体切除术后1年,其生长发育达标的情况。方法随访因扁桃体腺样体重度肥大引起睡眠鼾症导致身高和(或)体重发育不达标的患儿47名,收集其术前病史,包括睡眠质量、有无缺氧、发育情况、精神注意力和手术情况,并记录术前和术后6个月、术后1年身高和体重达标情况,统计分析身高体重术前术后的增长情况和达标率。结果患儿年龄2～5岁,平均月龄(48.45±11.36)个月,术前均有严重的睡眠打鼾,伴有张口呼吸和睡眠呼吸暂停41例(87.2%),白天注意力不集中35例(74.5%),进行鼻内镜扁桃体腺样体等离子切除术,术后6个月和1年身高增长平均为(6.27±1.73)和(11.88±2.35)cm,体重增长分别为(1.96±0.42)和(3.58±0.79)kg。术后1年身高体重按标准,身高达标40例(85.11%),体重达标36例(76.60%),均达标32例(68.09%)。结论儿童鼾症会影响患儿身高体重发育,尤其是重度阻塞,经鼻内镜扁桃体腺样体等离子切除术后,可促进恢复生长发育,有手术指征的患儿应尽早手术,以免耽误儿童黄金生长发育期。

Acupuncture for ischemic stroke:cerebellar activation may be a central mechanism following Deqi

The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magnetic resonance imaging（f MRI）on the effects of acupuncture at Waiguan（SJ5）in pathological and physiological states is controversial.In this study,12 patients with ischemic stroke received acupuncture at Waiguan（SJ5）and simultaneously underwent f MRI scanning of the brain,with imaging data of the activated areas obtained.Based on the patient＇s sensation,imaging data were allocated to either the Deqi group or non-Deqi group.In the Deqi group,the activated/deactivated areas were the left superior temporal gyrus（BA39）/right anterior lobe of the cerebellum and left thalamus.In the non-Deqi group,the activated areas included the medial frontal gyrus of the right frontal lobe（BA11）,right limbic lobe（BA30,35）,and left frontal lobe（BA47）,while the only deactivated area was the right parietal lobe（BA40）.Compared with the non-Deqi group,the Deqi group exhibited marked activation of the right anterior lobe of the cerebellum and right limbic lobe（BA30）.These findings confirm that the clinical effect of Deqi during acupuncture is based on brain functional changes.Cerebellar activation may be one of the central mechanisms of acupuncture in the treatment of ischemic stroke.

Late Triassic sedimentary records in the northern Tethyan Himalaya:Tectonic link with Greater India

The Upper Triassic flysch sediments(Nieru Formation and Langjiexue Group)exposed in the Eastern Tethyan Himalayan Sequence are crucial for unraveling the controversial paleogeography and paleotectonics of the Himalayan orogen.This work reports new detrital zircon U-Pb ages and whole-rock geochemical data for clastic rocks from flysch strata in the Shannan area.The mineral modal composition data suggest that these units were mainly sourced from recycled orogen provenances.The chemical compositions of the sandstones in the strata are similar to the chemical composition of upper continental crust.These rocks have relatively low Chemical Index of Alteration values(with an average of 62)and Index of Compositional Variability values(0.69),indicating that they experienced weak weathering and were mainly derived from a mature source.The geochemical compositions of the Upper Triassic strata are similar to those of graywackes from continental island arcs and are indicative of an acidicintermediate igneous source.Furthermore,hornblende and feldspar experienced decomposition in the provenance,and the sediment became enriched in zircon and monazite during sediment transport.The detrital zircons in the strata feature two main age peaks at 225-275 Ma and 500-600 Ma,nearly continuous Paleoproterozoic to Neoproterozoic ages,and a broad inconspicuous cluster in the Tonian-Stenian(800-1200 Ma).The detrital zircons from the Upper Triassic sandstones in the study area lack peaks at 300-325 Ma(characteristic of the Lhasa block)and 1150-1200 Ma(characteristic of the Lhasa and West Australia blocks).Therefore,neither the Lhasa block nor the West Australia blocks likely acted as the main provenance of the Upper Triassic strata.Newly discovered Permian-Triassic basalt and mafic dikes in the Himalayas could have provided the 225-275 Ma detrital zircons.Therefore,Indian and Himalayan units were the main provenances of the flysch strata.The Tethyan Himalaya was part of the northern passive margin and was not an exotic terrane separated from India during the Permian to Early Cretaceous.This evidence suggests that the Neo-Tethyan ocean opened prior to the Late Triassic and that the Upper Triassic deposits were derived from continental crustal fragments adjacent to the northern passive continental margin of Greater India.

Acupuncture at Waiguan(SJ5) and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study

Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group （true acupuncture at right Waiguan （SJ5）） and sham point group （sham acupuncture）. Results of functional magnetic resonance imaging revealed activation in right parietal lobe （Brodmann areas 7 and 19）, the right temporal lobe （Brodmann area 39）, the right limbic lobe （Brodmann area 23） and bilateral oc-cipital lobes （Brodmann area 18）. Furthermore, inhibition of bilateral frontal lobes （Brodmann area 4, 6, and 45）, right parietal lobe （Brodmann areas 1 and 5） and left temporal lobe （Brodmann area 21 ） were observed in the true point group. Activation in the precuneus of right parietal lobe （Brodmann area 7） and inhibition of the left superior frontal gyrus （Brodmann area 10） was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex （Brodmann area 5） is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients.

聚α-甲基苯乙烯的热降解研究进展

聚α-甲基苯乙烯(PAMS)是一种典型的α,α-双取代乙烯基的高分子材料,由于其优异的热降解性能,已被广泛用于制备多种激光惯性约束聚变靶丸。文中综述了PAMS的热降解机理及热降解动力学,介绍了相对分子质量、端基、引发剂等因素对PAMS热降解温度的影响,并对各种影响因素进行了分析与总结。最后提出了从相对分子质量分布、立构规整性、引发剂降低PAMS热降解温度及优化升温程序的研究方向。

Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people A functional MRI study

In the present study, 10 patients with ischemic stroke in the left hemisphere and six healthy controls were subjected to acupuncture at right Waiguan （TE5）. In ischemic stroke subjects, functional MRI showed enhanced activation in Broadmann areas 5, 6, 7, 18, 19, 24, 32, the hypothalamic inferior lobe, the mamiilary body, and the ventral posterolateral nucleus of the left hemisphere, and Broadmann areas 4, 6, 7, 18, 19 and 32 of the right hemisphere, but attenuated activation of Broadmann area 13, the hypothalamic inferior lobe, the posterior lobe of the tonsil of cerebellum, and the culmen of the anterior lobe of hypophysis, in the left hemisphere and Broadmann area 13 in the right hemisphere. In ischemic stroke subjects, a number of deactivated brain areas were enhanced, including Broadmann areas 6, 11,20, 22, 37, and 47, the culmen of the anterior lobe of hypophysis, alae lingulae cerebella, and the posterior lobe of the tonsil of cerebellum of the left hemisphere, and Broadmann areas 8, 37, 45 and 47, the culmen of the anterior lobe of hypophysis, pars tuberalis adenohypophyseos, inferior border of lentiform nucleus, lateral globus pallidus, inferior temporal gyrus, and the parahippocampal gyrus of the right hemisphere. These subjects also exhibited attenuation of a number of deactivated brain areas, including Broadmann area 7. These data suggest that acupuncture at Waiguan specifically alters brain function in regions associated with sensation, vision, and motion in ischemic stroke patients. By contrast, in normal individuals, acupuncture at Waiguan generally activates brain areas associated with insomnia and other functions.

Brain activation and inhibition after acupuncture at Taichong and Taixi: resting-state functional magnetic resonance imaging

Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture atTaichong （LR3） andTaixi （KI3） using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture atTaichong andTaixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic res-onance imaging, which revealed that the amplitude of low-frequency lfuctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus （Brodmann area 18/19）, inferior occipital gyrus （Brodmann area 18） and cuneus （Brodmann area 18）, but decreased mainly in the gyrus rectus of the frontal lobe （Brodmann area 11）, inferi-or frontal gyrus （Brodmann area 44） and the center of the posterior lobe of the cerebellum. The present ifndings indicate that acupuncture atTaichong andTaixi speciifcally promote blood lfow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.

In-situ sulfur isotope and trace element of pyrite constraints on the formation and evolution of the Nibao Carlin-type gold deposit in SW China

The fault-controlled Nibao Carlin-type gold deposit,together with the strata-bound Shuiyindong deposit,comprise a significant amount of the disseminated gold deposits in southwestern Guizhou Province,China.Five main types and two sub-types of pyrite at the Nibao deposit(Py1a/Py1b,Py2,Py3,Py4,Py5)were distinguished based on detailed mineralogical work.Py1,Py2and Py3 are Au-poor,whereas Py4 and Py5 are Au-rich,corresponding to a sedimentary and hydrothermal origin,respectively.Through systematic in situ analyses of NanoSIMS sulfur isotopes,the framboid pyrite Py1a with negative δ^34S values(-53.3 to-14.9%)from the Nibao deposit were found to originate from bacterial sulfate reduction(BSR)processes in an open and sulfate-sufficient condition while the superheavy pyrite Py1b(73.7–114.8%)is probably due to the potential influence of closed-system Rayleigh fractionation or the lack of preservation of deepsea sediments.Data of Py2 and Py3 plot within the area of S isotope compositions from biogenic and abiogenic sulfate reduction.In view of few coeval magmatic rocks in the mining district,the near zero δ^34S values of the Au-rich pyrites(Py4 and Py5)may discount the potential involvement of magmatic but metamorphic or sedimentary origin.LA-ICP-MS and TEM work show that Au in ore-related pyrite is present as both nanoparticles and structurally bound.LA-ICP-MS analyses show that the Au-rich pyrite also contains higher As,Cu,Sb,Tl and S than other types of pyrite,which inferred a distal manifestation of deep hydrothermal mineralization systems.