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不同毒力型的幽门螺旋杆菌对胃内微环境的影响
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作者 赵小青 肖嘉欣 +3 位作者 林勇 张剑锋 王文辉 张文杰 《昆明医科大学学报》 CAS 2024年第2期148-152,共5页
目的 通过观察不同毒力型的幽门螺旋杆菌(helicobacter pylori,Hp)感染对胃液、胃蛋白酶及炎症因子的影响。方法 收集2021年12月至2023年3月收治的110例患者,根据碳13呼气试验结果,分为Hp阳性组(n=79),Hp阴性组(n=31)。其中Hp阳性组根据... 目的 通过观察不同毒力型的幽门螺旋杆菌(helicobacter pylori,Hp)感染对胃液、胃蛋白酶及炎症因子的影响。方法 收集2021年12月至2023年3月收治的110例患者,根据碳13呼气试验结果,分为Hp阳性组(n=79),Hp阴性组(n=31)。其中Hp阳性组根据其Hp抗体分型,分为Ⅰ型组(n=52)、Ⅱ型组(n=11)、未定型组(n=16);Hp阴性组挑选抗体全阴者分为空白对照组(n=12)。所有患者均进行胃液pH值、钠离子(Na+)、钾离子(K+)、氯离子(Cl-)、白介素6 (Interleukin-6,IL-6)、白介素8 (Interleukin-8,IL-8)、胃泌素17 (Gastrin-17,G-17)、胃蛋白酶原Ⅰ(Pepsinogen I,PGⅠ)、胃蛋白酶原Ⅱ(Pepsinogen I,PGⅡ)检测。结果 Hp阳性组与Hp阴性组相比pH值、Na+、Cl-、K+,差异无统计学意义(P> 0.05);Hp阳性组相比Hp阴性组Cl-含量降低(P <0.05)。Hp阳性组较Hp阴性组相比IL-6、IL-8、G-17、PGⅠ、PGⅡ均有上升(P <0.05)。Ⅰ型组与Ⅱ型组、未定型组、空白对照组相比pH值、Na+、K+,差异均无统计学意义(P> 0.05)。Ⅰ型组、未定型组与空白对照组比较,Cl-含量均降低(P <0.05)。Ⅰ型组分别与Ⅱ型组、未定型组、空白对照组比较,IL-6、IL-8、PGⅠ均有上升(P <0.05)。空白对照组分别与其他各组之间PGⅡ存在明显差异(P <0.05)。Ⅰ型组与未定型组的G-17含量差异无统计学意义(P> 0.05)。Ⅰ型组与Ⅱ型组、空白对照组比较G-17均有上升(P <0.05)。结论 Ⅰ型Hp菌感染可能通过增加IL-6、IL-8、G-17的表达造成胃黏膜损伤,进而导致消化功能异常。 展开更多
关键词 幽门螺旋杆菌 胃蛋白酶原 IL-6 IL-8 胃泌素17 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ
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Real-Time Fracture Aperture Identification Using Mud Loss Data and Solution for LCM Combination
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作者 Hongpeng Yang yong lin Na Jiang 《Journal of Applied Mathematics and Physics》 2024年第4期1337-1351,共15页
Managing server lost circulation is a major challenge of drilling operation in naturally fractured formations and it causes much nonproductive rig time. When encountered with loss, the fracture aperture intersecting t... Managing server lost circulation is a major challenge of drilling operation in naturally fractured formations and it causes much nonproductive rig time. When encountered with loss, the fracture aperture intersecting the wellbore is not well-identified in time, which has a significant impact on the decision of drilling operation and the undesired result of loss curing. Therefore, the onset of fracture is identified in a timely manner and evaluated comprehensively to formulate an appropriate strategy over time. However, the mud loss date, which is the primary source of information retrieved from the drilling process, was not properly used in real-time prediction of fracture aperture. This article provides a detailed mathematical study to discuss the mechanism of mud invasion in the near-wellbore region and prediction of fracture aperture. The fracture aperture can be calculated from mud-loss data by solving a cubic equation with input parameters given by the well radius, the overpressure ratio, and the maximum mud-loss volume. It permits the proper selection of loss-circulation material (LCM) with respect to particle size distribution and fiber usage. The case study illustrates the applicability of this methodology with a discussion on LCM particle distribution in different scenarios and the result demonstrates the outcome of inappropriate LCM usage and the advantages of the novel fiber-based LCM treatment. 展开更多
关键词 Mud loss Fracture Aperture LCM Selection Particle-Size Distribution
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A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics 被引量:1
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作者 Qian Wang Yanyan Li +7 位作者 yong lin Yuping Sun Chong Bai Haorun Guo Ting Fang Gaohua Hu Yanqing Lu Desheng Kong 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第5期120-133,共14页
Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composite... Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human body.As the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured skin.Hybrid electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device interfaces.However,chemical modifications are typically needed for reliable bonding,which can alter their original properties.To overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid electrodes.In this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the hydrogel.The microfoam-enabled bonding strategy is generally compatible with various polymers.The resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked hybrids.These electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive hydrogels.They have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle contractions.Interlocked nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems. 展开更多
关键词 Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites HYDROGEL
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储层断裂高分辨预测及连通性评价方法研究与应用
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作者 雍林 程冰洁 徐天吉 《石油物探》 CSCD 北大核心 2024年第4期846-857,共12页
为了提高断裂预测精度和分辨率,分析储层断裂连通性,提出基于高斯滤波拉普拉斯(the Laplacian of a Gaussian filter,LoG)算子的断层增强方法、基于特征向量的断层细化方法和基于三维稳态饱和流动方程的断层连通性方法相结合的储层断裂... 为了提高断裂预测精度和分辨率,分析储层断裂连通性,提出基于高斯滤波拉普拉斯(the Laplacian of a Gaussian filter,LoG)算子的断层增强方法、基于特征向量的断层细化方法和基于三维稳态饱和流动方程的断层连通性方法相结合的储层断裂预测及连通性评价方法。将该方法应用于威远龙马溪组页岩储层断层增强和断层细化的处理,提高了地震资料的信噪比,改善了横向和垂向上的分辨率,突出了微、小断裂的细节特征,使目标储层的断裂特征刻画得更清楚、全面,增强和细化处理后的属性对断裂识别的分辨率和精度都明显优于相干属性;断层连通性评价方法的应用突出了目标储层段的连通断层,同时连接了小断层,并结合该储层段的孔隙度预测结果,将储层断裂连通性划分为3个区间,得到有效的评价认识,即:目标储层段断层、中小尺度断裂发育,储层断裂整体连通性较好,可以作为天然气的储集空间和运移通道。 展开更多
关键词 储层断裂 高分辨预测 连通性评价 断层增强 断层细化处理
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Alkali burn injury model of meibomian gland dysfunction in mice
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作者 yong Li Ya-Qiong Yang +6 位作者 yong lin Ke Yan Yu-Fei Lyu Zhao-Qiang Zhang Cai-Hong Huang Jiao-Yue Hu Zu-Guo Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第12期2158-2166,共9页
AIM:To establish a stable,short-time,low-cost and reliable murine model of meibomian gland dysfunction(MGD).METHODS:A filter paper sheet soaked in 1.0 mol/L sodium hydroxide(NaOH)solution was used to touch the eyelid ... AIM:To establish a stable,short-time,low-cost and reliable murine model of meibomian gland dysfunction(MGD).METHODS:A filter paper sheet soaked in 1.0 mol/L sodium hydroxide(NaOH)solution was used to touch the eyelid margin of C57BL/6J mice for 10s to establish the model.The other eye was left untreated as a control group.Eyelid margin morphological changes and the meibomian glands(MGs)were observed by slit lamp microscopy on days 5 and 10 post-burn.Hematoxylin-eosin(HE)staining and Oil red O staining were adopted in detecting the changes in MGs morphology and lipid deposition.Real-time polymerase chain reaction,Western blot,immunofluorescence staining and immunohistochemical staining were used to detect interleukin(IL)-6,IL-1β,IL-18,tumor necroses factor(TNF)-α,interferon(IFN)-γ,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase 4(NOX4),3-nitroturosine(3-NT),4-hydroxynonenal(4-HNE)and cytokeratin 10(K10)expression changes in MGs.RESULTS:MGs showed plugging of orifice,glandular deficiency,abnormal acinar morphology,ductal dilatation,and lipid deposition after alkali burn.The expressions of IL-6,IL-18,IL-1β,IFN-γ,and TNF-αindicators of inflammation and oxidative stress in MGs tissues were significantly increased.Abnormal keratinization increased in the MG duct.CONCLUSION:A murine model of MGD is established by alkali burn of the eyelid margin that matches the clinical presentation of MGD providing a stable,short-time,lowcost,and reliable MGD model.The new method suggests efficient avenues for future research. 展开更多
关键词 alkali burn meibomian gland dysfunction animal model oxidative stress
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Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure
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作者 yong lin Geng-Jie Yan +5 位作者 Mei-Yan Liu Yin Cao Kan Zhang Na Wang Fu-Li Long De-Wen Mao 《World Journal of Clinical Cases》 SCIE 2024年第27期6045-6056,共12页
Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor aff... Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality rates.The immune status is an important factor affecting LF prognosis.Interleukins(Ils)are a type of cytokine that act and interact with multiple cells,including immune cells.These signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory response.To date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of LF.This article reviews the potential use of Ils as the prognostic biomarkers of LF.Particularly,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to LF.Harnessing biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient survival.Thus,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF. 展开更多
关键词 INTERLEUKIN-21 INTERLEUKIN-22 Interleukin-31 Liver failure Biological markers Potential value
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MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding
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作者 Jun-Nan Hu Fei Xu +5 位作者 Ya-Rong Hao Chun-Yan Sun Kai-Ming Wu yong lin Lan Zhong Xin Zeng 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第3期790-806,共17页
BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment decisions.AIM To develop a new scoring system to predict its prognosis.METHODS ... BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment decisions.AIM To develop a new scoring system to predict its prognosis.METHODS In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction models.The en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during hos-pitalization.The models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)curves.RESULTS Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor outcomes.Based on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the model.Compared with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,respectively.According to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both cohorts.After removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was conducted.Similarly,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic scores.CONCLUSION The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies. 展开更多
关键词 Upper gastrointestinal bleeding Prognosis prediction Retrospective study NOMOGRAM Post-endoscopic model Pre-endoscopic model
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BLOW-UP PROBLEMS FOR NONLINEAR PARABOLIC EQUATIONS ON LOCALLY FINITE GRAPHS 被引量:3
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作者 yong lin Yiting WU +2 位作者 Department of Mathematics Renmin University of China 《Acta Mathematica Scientia》 SCIE CSCD 2018年第3期843-856,共14页
Let G =(V, E) be a locally finite connected weighted graph, and ? be the usual graph Laplacian. In this article, we study blow-up problems for the nonlinear parabolic equation ut = ?u + f(u) on G. The blow-up p... Let G =(V, E) be a locally finite connected weighted graph, and ? be the usual graph Laplacian. In this article, we study blow-up problems for the nonlinear parabolic equation ut = ?u + f(u) on G. The blow-up phenomenons for ut = ?u + f(u) are discussed in terms of two cases:(i) an initial condition is given;(ii) a Dirichlet boundary condition is given. We prove that if f satisfies appropriate conditions, then the corresponding solutions will blow up in a finite time. 展开更多
关键词 BLOW-UP parabolic equations locally finite graphs differential inequalities
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Prediction System for Diagnosis and Detection of Coronavirus Disease-2019(COVID-19):A Fuzzy-Soft Expert System
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作者 Wencong Liu Ahmed Mostafa Khalil +1 位作者 Rehab Basheer yong lin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第6期2715-2730,共16页
In early December 2019,a new virus named“2019 novel coronavirus(2019-nCoV)”appeared in Wuhan,China.The disease quickly spread worldwide,resulting in the COVID-19 pandemic.In the currentwork,we will propose a novel f... In early December 2019,a new virus named“2019 novel coronavirus(2019-nCoV)”appeared in Wuhan,China.The disease quickly spread worldwide,resulting in the COVID-19 pandemic.In the currentwork,we will propose a novel fuzzy softmodal(i.e.,fuzzy-soft expert system)for early detection of COVID-19.Themain construction of the fuzzy-soft expert systemconsists of five portions.The exploratory study includes sixty patients(i.e.,fortymales and twenty females)with symptoms similar to COVID-19 in(Nanjing Chest Hospital,Department of Respiratory,China).The proposed fuzzy-soft expert systemdepended on five symptoms of COVID-19(i.e.,shortness of breath,sore throat,cough,fever,and age).We will use the algorithm proposed by Kong et al.to detect these patients who may suffer from COVID-19.In this way,the present system is beneficial to help the physician decide if there is any patient who has COVID-19 or not.Finally,we present the comparison between the present system and the fuzzy expert system. 展开更多
关键词 Coronavirus disease-2019(COVID-19) fuzzy-soft expert system fuzzy expert system diagnosed results
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应用纤维支气管镜诊断和治疗小儿肺不张的效果探讨 被引量:17
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作者 林勇 彭静君 +5 位作者 赵兴艳 李颖 杨嫚 张翔 黄波 卢根 《中国内镜杂志》 2019年第4期84-87,共4页
目的探讨纤维支气管镜在小儿肺不张诊断和治疗中的临床价值。方法回顾性分析2013年1月-2016年12月在遵义市第一人民医院儿科行纤维支气管镜检查和治疗的86例肺不张患儿的临床资料,统计肺不张发生原因,观察治疗效果。结果 86例患儿的肺... 目的探讨纤维支气管镜在小儿肺不张诊断和治疗中的临床价值。方法回顾性分析2013年1月-2016年12月在遵义市第一人民医院儿科行纤维支气管镜检查和治疗的86例肺不张患儿的临床资料,统计肺不张发生原因,观察治疗效果。结果 86例患儿的肺不张病因以炎症和异物最多,分别有39例(45.35%)和34例(39.53%)。不同年龄肺不张病因分布:0~1岁患儿肺不张病因以异物最多,2~3岁及以上患儿中异物和炎症所占比例较高;结核感染主要分布在0~3岁患儿中;痰液堵塞集中在4~6岁和7~9岁患儿中,10~12岁肺不张分布最少,主要为炎症和支气管扩张。经纤维支气管镜支气管肺泡灌洗治疗1个月后,总复张率为88.37%;治疗3个月后,总复张率为97.67%。结论小儿肺不张病因复杂,其中炎症和异物是其主要病因,纤维支气管镜不仅能够帮助临床医生诊断小儿肺不张病因,还能够同时完成针对性治疗,在临床上具有应用价值。 展开更多
关键词 肺不张 小儿 纤维支气管镜 诊断 治疗
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MicroRNA-181a、SIRT1水平与新生儿急性呼吸窘迫综合征严重程度及预后的相关性 被引量:9
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作者 林勇 束国防 +2 位作者 陈名霞 孙晓玄 陆爱珍 《中国现代医学杂志》 CAS 北大核心 2021年第21期65-71,共7页
目的分析新生儿急性呼吸窘迫综合征(ARDS)血清microRNA-181a(miR-181a)、沉默信息调节因子2相关酶1(SIRT1)水平变化,探讨二者与其病情严重程度及预后的关系。方法选取2017年10月—2021年7月东南大学附属中大医院江北院区收治的162例ARD... 目的分析新生儿急性呼吸窘迫综合征(ARDS)血清microRNA-181a(miR-181a)、沉默信息调节因子2相关酶1(SIRT1)水平变化,探讨二者与其病情严重程度及预后的关系。方法选取2017年10月—2021年7月东南大学附属中大医院江北院区收治的162例ARDS患儿为ARDS组,根据氧合指数分为轻度组60例、中度组53例、重度组49例;根据预后情况分为预后不良组68例和预后良好组94例。另选取同期64名健康新生儿为对照组。实时荧光定量聚合酶链反应(qRT-PCR)检测血清miR-181a mRNA相对表达量,酶联免疫吸附试验(ELISA)检测血清SIRT1、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平。Pearson/Spearman相关性分析ARDS患儿血清miR-181a、SIRT1水平与氧合指数、炎症因子的相关性。ROC曲线分析血清miR-181a、SIRT1水平单独及联合对ARDS患儿预后不良的评估价值。结果ARDS组血清miR-181a mRNA相对表达量、IL-1β、IL-6、TNF-α水平均高于对照组(P<0.05);SIRT1水平低于对照组(P<0.05)。重度组和中度组患儿血清miR-181a mRNA相对表达量、IL-1β、IL-6、TNF-α水平高于轻度组,且重度组血清miR-181a mRNA相对表达量、IL-1β、IL-6、TNF-α水平高于中度组(P<0.05);而重度组和中度组患儿血清SIRT1水平低于轻度组,且重度组血清SIRT1水平低于中度组(P<0.05)。相关性分析显示,ARDS患儿血清miR-181a与SIRT1水平呈负相关(rs=-0.788,P<0.05),与氧合指数、IL-1β、IL-6、TNF-α水平呈正相关(r=0.780、0.833、0.776和0.804,均P<0.05);SIRT1与氧合指数、IL-1β、IL-6、TNF-α水平呈负相关(rs/r=-0.836、-0.716、-0.691和-0.754,均P<0.05)。预后不良组血清miR-181a mRNA相对表达量高于预后良好组,SIRT1水平低于预后良好组(P<0.05)。ROC曲线结果显示,miR-181a评估ARDS患儿预后不良的最佳截断值为1.59,敏感性为80.88%(95%CI:0.717,0.857),特异性为70.21%(95%CI:0.652,0.757);SIRT1评估ARDS患儿预后不良的最佳截断值为0.70 ng/ml,敏感性为76.47%(95%CI:0.712,0.796),特异性为87.23%(95%CI:0.832,0.917)。两者联合评估ARDS患儿预后不良的敏感性为85.29%(95%CI:0.788,0.902),特异性为81.91%(95%CI:0.774,0.886)。结论新生儿ARDS血清miR-181a、SIRT1水平与ARDS患儿病情严重程度及预后密切相关,可作为新生儿ARDS预后评估指标。 展开更多
关键词 急性呼吸窘迫综合征 新生儿 炎症 microRNA-181a 沉默信息调节因子2相关酶1 病情严重程度 预后
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再生育患者行IVF/ICSI双胎妊娠结局分析 被引量:3
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作者 万琪 李莹星 +3 位作者 梁雪霏 雍琳 刘敬 钟影 《实用妇科内分泌电子杂志》 2019年第3期92-94,100,共4页
目的探讨再生育患者行体外受精胚胎移植(IVF-ET)和卵胞浆内单精子显微注射(ICSI后双胎妊娠的临床结局。方法回顾性分析2011年1月~2016年5月在本院行IVF/ICSI的再生育患者妊娠后的临床资料,将患者分为两组,一组前次妊娠为顺产,另一组前... 目的探讨再生育患者行体外受精胚胎移植(IVF-ET)和卵胞浆内单精子显微注射(ICSI后双胎妊娠的临床结局。方法回顾性分析2011年1月~2016年5月在本院行IVF/ICSI的再生育患者妊娠后的临床资料,将患者分为两组,一组前次妊娠为顺产,另一组前次妊娠为剖宫产,以供再生育患者更清楚了解妊娠风险。结果无论是顺产后或剖宫产后的再生育患者,行IVF/ICSI助孕妊娠的单胎妊娠组的早期流产率均较双胎妊娠组高,但双胎妊娠组的早产率、新生儿体重<2500g比率、新生儿阿普加(Apgar)评分<8分比率、抱婴率均较单胎妊娠组高,平均妊娠天数较单胎妊娠组短,剖宫产后再生育患者双胎妊娠的晚期妊娠流产率较单胎妊娠高,差异均有统计学意义(P<0.05)。结论再生育患者行IVF/ICSI助孕后妊娠,双胎妊娠风险较单胎妊娠高,但双胎妊娠即使一个胎儿停育、流产、围生期死亡,另一个胎儿也有存活的可能,因此双胎妊娠具有更高的抱婴率。患者在行辅助生殖技术助孕时需了解双胎妊娠的风险,谨慎选择移植胚胎个数。 展开更多
关键词 再生育 体外受精胚胎移植(IVF-ET) 卵胞浆内单精子显微注射(ICSI) 双胎
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HEV汽车CAN总线短路故障分析
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作者 谭红川 雍林 肖举 《汽车实用技术》 2019年第19期187-188,共2页
文章对HEV汽车CAN总线短路的故障现象进行介绍,分析了故障存在的原因及诊断思路,给出了故障排除方法。
关键词 READY CAN-L 故障诊断
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Endoscopic ultrasound elastography for differentiating between pancreatic adenocarcinoma and inflammatory masses:A meta-analysis 被引量:6
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作者 Xiang Li Wei Xu +2 位作者 Jian Shi yong lin Xin Zeng 《World Journal of Gastroenterology》 SCIE CAS 2013年第37期6284-6291,共8页
AIM:To evaluate the accuracy of endoscopic ultrasound(EUS)elastography for differentiating between pancreatic ductal adenocarcinoma(PDAC)and pancreatic inflammatory masses(PIM).METHODS:Electronic databases(updated to ... AIM:To evaluate the accuracy of endoscopic ultrasound(EUS)elastography for differentiating between pancreatic ductal adenocarcinoma(PDAC)and pancreatic inflammatory masses(PIM).METHODS:Electronic databases(updated to December 2012)and manual bibliographical searches were carried out.A meta-analysis of all diagnostic clinical trials evaluating the accuracy of EUS elastography in differentiating PDAC from PIM was conducted.Heterogeneity was assessed among the studies.The metaanalysis was performed to evaluate the accuracy of EUS elastography in differentiating PDAC from PIM in homogeneous studies.RESULTS:Ten studies involving 781 patients were included in the analysis.Significant heterogeneity in sensitivity was observed among the studies(Cochran Q test=24.16,df=9,P=0.0041,I2=62.8%),while heterogeneity in specificity was not observed(Cochran Q test=5.93,df=9,P=0.7473,I2=0.0%).The area under the curve under the Sports Rights Owners Coalition was 0.8227.Evaluation of heterogeneity suggested that the different diagnostic standards used in the included studies were the source of heterogeneity.In studies using the color pattern as the diagnostic standard,the pooled sensitivity,specificity,positive likelihood ratio(LR),negative LR and diagnostic OR were0.99(0.97-1.00),0.76(0.67-0.83),3.36(2.39-4.72),0.03(0.01-0.07)and 129.96(47.02-359.16),respectively.In studies using the hue histogram as the diagnostic standard,the pooled sensitivity,specificity,positive LR,negative LR and diagnostic OR were 0.92(0.89-0.95),0.68(0.57-0.78),2.84(2.05-3.93),0.12(0.08-0.19)and 24.69(12.81-47.59),respectively.CONCLUSION:EUS elastography is a valuable method for the differential diagnosis between PDAC and PIM.And a preferable diagnostic standard should be explored and improvements in specificity are required. 展开更多
关键词 ENDOSCOPIC ultrasound ELASTOGRAPHY PANCREATIC ADENOCARCINOMA META-ANALYSIS
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Replanting of broadleaved trees alters internal nutrient cycles of native and exotic pines in subtropical plantations of China 被引量:2
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作者 yong lin Chengkang Xia +4 位作者 Gaoyang Wu Fangchao Wang Shengnan Wang Yuanqiu Liu Fusheng Chen 《Forest Ecosystems》 SCIE CSCD 2022年第5期701-709,共9页
Background:The replanting of broadleaved trees in pure coniferous plantations is widely implemented,as mixed plantations are generally more stable and functional.However,the effect of interspecific interactions betwee... Background:The replanting of broadleaved trees in pure coniferous plantations is widely implemented,as mixed plantations are generally more stable and functional.However,the effect of interspecific interactions between broadleaved and coniferous trees on internal nutrient cycles of conifers remains unclear.Methods:We selected pure coniferous plantations of a native(Pinus massoniana)and an exotic(P.elliottii)pine species and their corresponding mixed plantations with broadleaved trees(Schima superba)in subtropical China,and measured the nitrogen(N)and phosphorus(P)contents in the rhizosphere soils,fine roots,twigs,needles and needle litter of pines.We calculated the root capture,needle resorption and translocation of N and P by pines to determine the mobility of nutrients in trees.Results:Although the N and P in the rhizosphere soils increased due to the replanting of broadleaved trees,the N and P contents in the aboveground tissues of the two pine species did not increase in mixed plantations.Mixed planting had a negative effect on the N and P capture of native pine and a positive effect on that of exotic pine.The N and P resorption efficiencies increased in native pine but were unchanged in exotic pine after the replanting of S.superba.Native pine preferentially employed an aboveground nutrient resorption strategy,whereas exotic pine tended to adopt a belowground nutrient capture strategy after replanting.Translocation of N and P in trees was detected,which reflected the trade-offs between root nutrient capture and needle nutrient resorption.Conclusions:The effect of mixed planting varied between the species of native and exotic pines,and the internal nutrient cycles of both pine species might be dominated by interspecific interaction effects on nutrients rather than soil nutrients.Our study highlights the importance of selecting suitable broadleaved species for replanting in coniferous plantations. 展开更多
关键词 Interspecific interaction Mixture effect Needle resorption N and P translocation Root capture
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Study on Extraction Process of Sipunculus nudus Polysaccharide and Its Antioxidant Activity 被引量:1
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作者 Wen CHEN Xiangjun WANG +5 位作者 Dongxu SHAO Lirong LI Yuzhi HUANG Hongyuan SUN lingyan LI yong lin 《Agricultural Biotechnology》 CAS 2018年第2期112-118,123,共8页
[Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a ... [Objectives] This study was conducted to optimize the extraction process of Sipunculus nudus polysaccharide. [Methods]S. nudus polysaccharide was extracted by ultrasonic water extraction,with the marine S. nudus as a raw material from Sanya City,Hainan Province,by single factor variable method,to find the optimal extraction conditions including ultrasonic power,solid-liquid ratio,ultrasonic extraction temperature,ultrasonic extraction time,ultrasonic extraction times and lye concentration. The absorbance of the polysaccharide was determined by an ultraviolet spectrophotometer,and polysaccharide yield were calculated. The antioxidant activity of scavenging hydroxyl and DPPH radicals was measured at different concentrations. [Results]The optimal extraction conditions for S. nudus polysaccharide were as follows: solid-liquid ratio at 1∶11 mg/ml,extraction temperature at 60 ℃,three times of ultrasonic extraction,ultrasonic power of 960 W,extraction time of 1. 5 h,and lye concentration of 5%,under which the polysaccharide yield was 3. 21%. The scavenging rates of hydroxyl radical and DPPH radical were 12. 58% at the concentration of 0. 20 mg/ml. Moreover,the scavenging rates increased significantly with the increase of concentration. [Conclusions] This method is a new trial with satisfactory results. 展开更多
关键词 Sipunculus nudus Ultrasound Lye concentration Polysaccharide Antioxidant activityHome
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Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19
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作者 Wei Song Jie Wei +42 位作者 Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han yong lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2021年第6期241-253,共13页
Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide re... Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. 展开更多
关键词 SARS-CoV-2 COVID-19 Cardiac arrest CPR Nosocomial infection Personal protective equipment
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HARNACK AND MEAN VALUE INEQUALITIES ON GRAPHS
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作者 yong lin Hongye SONG 《Acta Mathematica Scientia》 SCIE CSCD 2018年第6期1751-1758,共8页
We prove a Harnack inequality for positive harmonic functions on graphs whichis similar to a classical result of Yau on Riemannian manifolds. Also, we prove a mean valueinequality of nonnegative subharmonic functions ... We prove a Harnack inequality for positive harmonic functions on graphs whichis similar to a classical result of Yau on Riemannian manifolds. Also, we prove a mean valueinequality of nonnegative subharmonic functions on graphs. 展开更多
关键词 harmonic function subharmonic function Harnack inequality mean valueinequality GRAPH
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Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release
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作者 Jia Li yong lin +1 位作者 Xueyu Wang Mengji Lu 《Virologica Sinica》 SCIE CAS CSCD 2024年第1期24-30,共7页
Hepatitis B virus(HBV)produces and releases various particle types,including complete virions,subviral particles with envelope proteins,and naked capsids.Recent studies demonstrate that HBV exploits distinct intracell... Hepatitis B virus(HBV)produces and releases various particle types,including complete virions,subviral particles with envelope proteins,and naked capsids.Recent studies demonstrate that HBV exploits distinct intracellular membrane trafficking pathways,including the endosomal vesicle trafficking and autophagy pathway,to assemble and release viral and subviral particles.Herein,we summarize the findings about the distinct roles of autophagy and endosomal membrane trafficking and the interaction of both pathways in HBV replication,assembly,and release. 展开更多
关键词 Amphisome AUTOPHAGY Endosomal vesicle Hepatitis B virus(HBV)
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信迪利单抗联合瑞戈非尼治疗晚期结直肠癌的疗效与安全性分析
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作者 梁文龙 曹杰 +5 位作者 黄庆 林泳 黄红丽 杨平 李冠炜 胡鹤 《中华消化病与影像杂志(电子版)》 2023年第6期409-413,共5页
目的探究免疫检查点抑制剂信迪利单抗联合瑞戈非尼治疗晚期结直肠癌(CRC)患者疗效与安全性的影响。方法前瞻性选取2020年1月至2022年1月在广州市第一人民医院接受治疗的晚期CRC患者90例,按照随机数字表法分为观察组和对照组各45例。对... 目的探究免疫检查点抑制剂信迪利单抗联合瑞戈非尼治疗晚期结直肠癌(CRC)患者疗效与安全性的影响。方法前瞻性选取2020年1月至2022年1月在广州市第一人民医院接受治疗的晚期CRC患者90例,按照随机数字表法分为观察组和对照组各45例。对照组口服瑞戈非尼,观察组在对照组基础上加用信迪利单抗注射液。比较两组临床疗效、肿瘤标志物及免疫功能水平、生存时间及不良反应发生情况。结果治疗后,观察组CRC患者的客观缓解率为53.33%、疾病控制率为80.00%,对照组分别为20.00%、60.00%(P<0.05);两组糖类抗原(CA199)、细胞角蛋白19片段抗原21-1(CYFRA21-1)、癌胚抗原(CEA)均下降,且观察组比对照组更低(P<0.05);两组细胞毒性T细胞(CD8^(+))占比均下降,两组辅助性T细胞(CD4^(+))占比、CD4^(+)/CD8^(+)比值均上升,而且观察组CD4^(+)占比、CD4^(+)/CD8^(+)比值比对照组更高(P<0.05),CD8^(+)占比比对照组更低(P>0.05)。观察组总生存期(P=0.040)和无进展生存期(P=0.046)均比对照组长;观察组比对照组出现不良反应概率更低(64.44%比62.22%,P>0.05)。结论免疫检查点抑制剂信迪利单抗联合瑞戈非尼在晚期CRC的治疗中有较好的应用效果和安全性,延长了生存时间,减轻肿瘤给患者带来的痛苦。 展开更多
关键词 结直肠癌 免疫检查点抑制剂 临床疗效 生存分析 安全性
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