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Mechanism of Huanglian Detoxification Soup Relieving Postherpetic Neuralgia by Enhancing IL-2 Levels in Rats
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作者 Min YE Fengqin ZHANG +1 位作者 Quiping YUAN yong xiang 《Medicinal Plant》 2024年第3期39-40,共2页
[Objectives]To explore the mechanism of Huanglian detoxification soup improving pain behavior by affecting serum IL-2 levels in postherpetic neuralgia(post herpes neuralgia,PHN)model rats.[Methods]20 PHN rats were ran... [Objectives]To explore the mechanism of Huanglian detoxification soup improving pain behavior by affecting serum IL-2 levels in postherpetic neuralgia(post herpes neuralgia,PHN)model rats.[Methods]20 PHN rats were randomly divided into model group(PHN group)and detoxification decoction group(n=10).In the group,10%Huanglian detoxification soup(0.4 mL/0.1 kg)was given once in the morning and evening for 14 d.The PHN group was filled with an equal volume of 0.9%sodium chloride solution.Tail vein serum inflammatory factor interleukin-2(IL-2),IL-βand IL-6 levels were measured using ELISA kits at 7 and 21 d.[Results]IL-2 increased at 14 and 21 d in IL group,while IL-βand IL-6 decreased compared with the PHN group(P<0.05).[Conclusions]Huanglian detoxification soup may raise IL-2 levels after VZV infection to promote the differentiation of cells of the immune system,so as to relieve the pain caused by IL-βand IL-6 inflammatory factors. 展开更多
关键词 Huanglian DETOXIFICATION SOUP Postherpetic NEURALGIA SERUM INFLAMMATORY factor
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PUMA、IQGAP1在胰腺癌中的表达及与临床病理、预后生存的相关性 被引量:3
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作者 胡怀远 夏燕 +2 位作者 雍翔 邹萍 刘岩 《分子诊断与治疗杂志》 2021年第9期1515-1519,共5页
目的探讨PUMA、IQGAP1蛋白在胰腺癌中的表达及与临床病理、预后生存的相关性。方法选取2016年10月至2018年10月本院收治的胰腺癌患者胰腺癌组织标本、远离胰腺肿瘤3 cm的癌旁组织标本各74份,比较两组织中PUMA、IQGAP1蛋白的表达情况,并... 目的探讨PUMA、IQGAP1蛋白在胰腺癌中的表达及与临床病理、预后生存的相关性。方法选取2016年10月至2018年10月本院收治的胰腺癌患者胰腺癌组织标本、远离胰腺肿瘤3 cm的癌旁组织标本各74份,比较两组织中PUMA、IQGAP1蛋白的表达情况,并探讨其与病理特征的关系。随访2年,了解74例患者生存率,采用ROC曲线分析不同PUMA、IQGAP1表达的胰腺癌患者预后2年生存情况,采用Logistic回归模型分析影响胰腺癌患者2年预后的独立危险因素。结果胰腺癌组织中的PUMA阳性率显著低于癌旁组织,IQGAPl阳性率显著高于癌旁组织,差异均有统计学意义(P<0.05)。TNM分期为Ⅲ~Ⅵ期、有淋巴结转移、分化程度为中-低分化的胰腺癌患者PUMA阴性率、IQGAPl阳性率更高(P<0.05)。74例胰腺癌患者2年生存率为16.22%。PUMA阴性表达、IQGAPl阳性表达的胰腺癌患者死亡率高于PUMA阳性表达、IQGAPl阴性表达的患者,差异有统计学意义(P<0.05)。生存分析显示PUMA(表达阳性)、IQGAPl(表达阴性)者生存期较长,Keplan-meier生存曲线明显不同(P<0.05)。TNM(Ⅲ~Ⅵ期)、淋巴结转移(有)、分化程度(中-低分化)、PUMA(表达阴性)、IQGAPl(表达阳性)为影响胰腺癌患者预后生存的独立危险因素(P<0.05)。结论 PUMA阴性、IQGAPl阳性为影响胰腺癌患者预后生存的危险因素,临床可通过加强监测二者表达情况,以评估胰腺癌患者病情进展情况及预后。 展开更多
关键词 PUMA蛋白 IQGAP1蛋白 胰腺癌 临床病理特征
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胃癌组织的LINC01105水平及临床意义
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作者 胡怀远 汤衡 +2 位作者 雍翔 邹萍 刘岩 《临床肿瘤学杂志》 CAS 2021年第4期347-351,共5页
目的探讨胃癌组织的长基因间非蛋白编码RNA 1105(LINC01105)水平及临床意义。方法利用GEPIA在线工具分析LINC01105在癌症基因组图谱(TCGA)中胃腺癌患者癌组织和基因型组织表达数据库(GTEx)正常组织中的水平,采用实时定量PCR(qPCR)检测本... 目的探讨胃癌组织的长基因间非蛋白编码RNA 1105(LINC01105)水平及临床意义。方法利用GEPIA在线工具分析LINC01105在癌症基因组图谱(TCGA)中胃腺癌患者癌组织和基因型组织表达数据库(GTEx)正常组织中的水平,采用实时定量PCR(qPCR)检测本院2016年1月至2019年12月手术切除的95例胃癌组织和87例癌旁组织的LINC01105水平,比较胃癌不同临床病理特征的LINC01105水平,Kaplan-Meier Plotter在线数据库分析胃癌组织的LINC01105水平与总生存期(OS)、疾病进展后生存期(PPS)和首次进展后生存期(FP)的关系。结果TCGA数据库中408例胃癌组织的LINC01105中位数水平为0.02,低于211例正常组织的2.45(P<0.05);qPCR结果显示,95例胃癌组织的LINC01105水平为0.636±0.226,低于87例癌旁组织的1.175±0.453(t=10.305,P<0.01)。LINC01105水平与胃癌患者的性别、年龄和分化程度无关(P>0.05),而与肿瘤直径、TNM分期、淋巴结转移和浸润深度有关(P<0.05),其中肿瘤直径较大、TNM分期较晚、淋巴结转移和深浸润组织的LINC01105水平较低。Kaplan-Meier Plotter数据库分析显示LINC01105水平与FP无关(P>0.05),而与OS和PPS有关(P<0.05),其中LINC01105高水平者的中位OS和PPS为93.2和16.7个月,优于低水平者的40.0和10.6个月(P<0.05)。结论胃癌组织中低表达的LINC01105发挥类似抑癌基因的作用,参与了胃癌的恶性进展且与不良预后有关,有作为胃癌诊治靶点的潜能。 展开更多
关键词 胃癌 长基因间非蛋白编码RNA 1105 临床意义 预后
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食管鳞状细胞癌中SOX2和Slug的表达及与肿瘤出芽之间的关系 被引量:6
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作者 雍翔 宋瑞 +3 位作者 胡怀远 武世伍 秦燕子 吴琼 《中国组织化学与细胞化学杂志》 CAS CSCD 2019年第3期236-241,共6页
目的探讨食管鳞状细胞癌中SOX2、Slug的表达与临床病理参数的关系及两者表达与肿瘤出芽的关系。方法应用免疫组织化学染色方法检测89例食管鳞状细胞癌及癌旁组织中SOX2、Slug的表达及计算食管鳞状细胞癌病例HE切片中肿瘤出芽的数量。分... 目的探讨食管鳞状细胞癌中SOX2、Slug的表达与临床病理参数的关系及两者表达与肿瘤出芽的关系。方法应用免疫组织化学染色方法检测89例食管鳞状细胞癌及癌旁组织中SOX2、Slug的表达及计算食管鳞状细胞癌病例HE切片中肿瘤出芽的数量。分析SOX2、Slug的表达在ESCC侵袭和转移中的临床病理学意义。结果食管鳞状细胞癌中SOX2、Slug的表达率分别为53.93%和68.53%,明显高于癌旁组织SOX2和Slug表达率(31.46%和31.46%);癌组织中肿瘤出芽率为39.32%。SOX2高表达与食管鳞状细胞癌的浸润深度、淋巴结转移及高临床分期有关,Slug高表达与食管鳞状细胞癌的分化程度、浸润深度、淋巴结转移及高临床分期有关。肿瘤出芽发生率与食管鳞状细胞癌的分化程度、浸润深度、淋巴结转移及高临床分期有关。Spearman相关性分析表明,食管鳞状细胞癌组织中SOX2表达与Slug表达呈显著正相关,Slug表达与肿瘤出芽明显呈正相关。结论SOX2的高表达可能通过上调Slug的表达从而促进肿瘤的出芽,在食管鳞状细胞癌的侵袭及转移过程中发挥重要作用。 展开更多
关键词 食管鳞状细胞癌 SOX2 SLUG 肿瘤出芽
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肺鳞癌组织中IGF1和CCL20的表达与患者临床病理特征及预后的关系 被引量:5
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作者 孙宇 雍翔 +2 位作者 孙祝 尹群 赵玉魁 《安徽医学》 2018年第5期533-536,共4页
目的探讨肺鳞癌组织中胰岛素样生长因子1(IGF-1)和趋化因子20(CCL20)的表达与患者临床病理特征及预后的相关性。方法选取2014年2月至2015年2月皖北煤电集团总医院收治的肺鳞癌患者30例,采用免疫组织化学染色法检测患者肺鳞癌组织中IGF-1... 目的探讨肺鳞癌组织中胰岛素样生长因子1(IGF-1)和趋化因子20(CCL20)的表达与患者临床病理特征及预后的相关性。方法选取2014年2月至2015年2月皖北煤电集团总医院收治的肺鳞癌患者30例,采用免疫组织化学染色法检测患者肺鳞癌组织中IGF-1和CCL20蛋白的表达,通过单因素分析IGF-1和CCL20蛋白与患者临床病理特征的相关性;采用单因素和多因素Cox比例风险模型分析其对患者预后的关系。结果 30例肺鳞癌患者中,18例(60.00%)患者IGF-1蛋白呈阳性表达,且与患者TNM分期及淋巴结转移有关(P<0.05);23例(76.67%)患者CCL20呈阳性表达,且与患者淋巴结转移、浸润深度、TNM分期有关(P<0.05)。经单因素和多因素Cox比例风险模型分析,浸润深度、淋巴结转移、TNM分期、IGF-1、CCL20阳性表达是影响肺鳞癌患者3年生存期的独立危险因素(P<0.05)。结论 IGF-1及CCL20高表达与肺鳞癌的侵袭转移密切相关,可作为判定肺鳞癌患者预后的指标之一。 展开更多
关键词 肺鳞癌组织 胰岛素样生长因子1 趋化因子20 预后
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Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility 被引量:18
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作者 Wanguo Zheng Xiaofeng Wei +21 位作者 Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang yong xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng 《Matter and Radiation at Extremes》 SCIE EI CAS 2017年第5期243-255,共13页
The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the req... The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. 展开更多
关键词 Inertial confinement fusion Laser driver SG-III Power balance Beam smoothing
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一种电力电缆的随机电热退化模型(英文) 被引量:6
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作者 Swati Sachan Rui Wen +2 位作者 yong xiang Leiming Yao Chengke Zhou 《高电压技术》 EI CAS CSCD 北大核心 2015年第4期1178-1187,共10页
In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degrada... In this paper a methodology is proposed to model the stochastic electro-thermal degradation accumulation in cables.The cable life and the reliability are predicted by estimating the accumulated electro-thermal degradation during seasonal load cycles.The degradation is considered,in a novel approach,as stochastic in nature due to variations in the manufacturing process of insulation raw material and in operational and environmental conditions.The methodology is based on estimation of life by using combined electro-thermal life model,simulation of degradation accumulation process under electro-thermal stress in each season of the year based on Miner’s cumulative damage theory and reliability prediction from a probabilistic point of view.A case study is demonstrated on 10 k V XLPE cables which are directly buried in the UK and China.Results show that,the electro-thermal life of the cable is 56 and 69 years in China and the UK,respectively at 50%failure probability,or the life of the cable in the UK would be 13 years longer than in China,when other stresses such as mechanical and environmental are also considered and assumed to be the same. 展开更多
关键词 电力电缆 退化模型 随机 可靠性预测 电热 使用寿命 积累过程 季节性负荷
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Determination and correlation solubility of m-phenylenediamine in (methanol, ethanol, acetonitrile and water) and their binary solvents from 278.15 K to 313.15 K 被引量:5
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作者 Pengbao Lian Huipeng Zhao +3 位作者 Jianlong Wang Lizhen Chen yong xiang Qinghua Ren 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2019年第5期1149-1158,共10页
In this study, the solubility of m-phenylenediamine in four pure solvents(methanol, ethanol, acetonitrile and water) and three binary solvent(methanol + water),(ethanol + water) and(acetonitrile + water) systems were ... In this study, the solubility of m-phenylenediamine in four pure solvents(methanol, ethanol, acetonitrile and water) and three binary solvent(methanol + water),(ethanol + water) and(acetonitrile + water) systems were determined in the temperature ranging from 278.15 K to 313.15 K by using the gravimetric method under atmospheric pressure. In the temperature range of 278.15 K to 313.15 K, the mole fraction solubility values of m-phenylenediamine in water, methanol, ethanol, and acetonitrile are 0.0093–0.1533, 0.1668–0.5589,0.1072–0.5356, and 0.1717–0.6438, respectively. At constant temperature and solvent composition, the mole fraction solubility of o-phenylenediamine in four pure solvents was increased as the following order:water b ethanol b methanol b acetonitrile;and in the three binary solvent mixtures could be ranked as follows:(ethanol + water) b(methanol + water) b(acetonitrile + water). The relationship between the experimental temperature and the solubility of m-phenylenediamine was revealed as follows: the solubility of mphenylenediamine in pure and binary solvents could be increased with the increase of temperature. The experimental values were correlated with the Jouyban–Acree model, van’t Hoff–Jouyban–Acree model, modified Apelblat–Jouyban–Acree model, Sun model and Ma model. The standard dissolution enthalpy, standard dissolution entropy and the Gibbs energy were calculated based on the experimental solubility data. In the binary solvent mixtures, the dissolution of m-phenylenediamine could be an endothermic process. The solubility data,correlation equations and thermodynamic property obtained from this study would be invoked as basic data and models regarding the purification and crystallization process of m-phenylenediamine. 展开更多
关键词 M-PHENYLENEDIAMINE SOLUBILITY SOLID-LIQUID equilibrium Jouyban-Acree model THERMODYNAMIC property
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Individualized Pixel Synthesis and Characterization of Combinatorial Materials Chips 被引量:7
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作者 Xiao-Dong xiang Gang Wang +2 位作者 Xiaokun Zhang yong xiang Hong Wang 《Engineering》 SCIE EI 2015年第2期225-233,共9页
Conventionally, an experimentally determined phase diagram requires studies of phase formation at a range of temperatures for each composition, which takes years of effort from multiple research groups. Combinatorial ... Conventionally, an experimentally determined phase diagram requires studies of phase formation at a range of temperatures for each composition, which takes years of effort from multiple research groups. Combinatorial materials chip technology, featuring high-throughput synthesis and characterization, is able to determine the phase diagram of an entire composition spread of a binary or ternary system at a single temperature on one materials library, which, though significantly increasing efficiency, still requires many libraries processed at a series of temperatures in order to complete a phase diagram. In this paper, we propose a "one-chip method" to construct a complete phase diagram by individually synthesizing each pixel step by step with a progressive pulse of energy to heat at different temperatures while monitoring the phase evolution on the pixel in situ in real time. Repeating this process pixel by pixel throughout the whole chip allows the entire binary or ternary phase diagram to be mapped on one chip in a single experiment. The feasibility of this methodology is demonstrated in a study of a Ge-Sb-Te ternary alloy system, on which the amorphouscrystalline phase boundary is determined. 展开更多
关键词 combinatorial materials chip phase diagram pixel synthesis in-situ characterization phase-boundary determination
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Regulating the d band in WS_(2)@NC hierarchical nanospheres for efficient lithium polysulfide conversion in lithium-sulfur batteries 被引量:3
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作者 Jintao Liu Shuhao Xiaoa +5 位作者 Le Chang Long Lai Rui Wu yong xiang Xingquan Liu Jun Song Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第5期343-352,共10页
The performance of lithium-sulfur batteries is deteriorated by the inferior conductivity of sulfur,the shuttle effect of lithium polysulfides(LiPSs),sluggish redox kinetics of polysulfide intermediates and serious vol... The performance of lithium-sulfur batteries is deteriorated by the inferior conductivity of sulfur,the shuttle effect of lithium polysulfides(LiPSs),sluggish redox kinetics of polysulfide intermediates and serious volumetric expansion of sulfur.To overcome these challenges,we report a versatile route to prepare multi-functional nanocomposites with tuable hierarchical structure via ammonium hydroxide(NH_(3)·H_(2) O)induced self-assembly.The versatility of the system has been demonstrated that the organization of the hierarchical structure can be regulated by adding different amounts of NH_(3)·H_(2) O,and WS_(2) and Co_(9)S_(8) with nitrogen-doped carbon coating(denoted as WS_(2)@NC and Co_(9)S_(8)@NC)can be prepared by adding different precursor salts.When the as-prepared materials are applied for Li-S batteries,the WS_(2)@NC composite exhibits a reversible capacity of 1107.4 mAh g^(-1) at 0.1 C after 500 cycles and even 728.9 mAh g^(-1) at2 C for 1000 cycles,which is significantly better than the Co_(9)S_(8) counterpart and other reported WS_(2) sulfur hosts.Experimentally,the advantageous performance of WS_(2) could be attributed to its higher surface area and total pore volume,giving rise to the easier access to electrolyte and better ability to buffer the volume change during the charge/discharge process.Theoretically,the density function theory(DFT)calculation reveals that the as-prepared WS_(2) has a higher binding energy towards LiPSs as well as a lower energy barrier for Li^(+)diffusion on the surface than Co_(9)S_(8).More significantly,the density of states(DOS)analysis further confirms that the superior performance is mainly ascribed to the more prominent shifting and the more charge compensation from d band of W than Co,which increase electronic concentration and give more hybridization of d-p orbitals in the Fermi level of the adsorbed Li2 S4 to accelerate the lithium polysulfide interfacial redox and conversion dynamics in WS_(2).By proposing this mechanism,this work sheds new light on the understanding of catalytic conversion of lithium polysulfides at the atomic level and the strategy to develop advanced cathode materials for high-performance lithium-sulfur batteries. 展开更多
关键词 Dband regulation Density of states DFT theoretical calculations Metal sulfides Lithium-sulfur batteries
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Vacancy defect modulation in hot-casted NiOx film for efficient inverted planar perovskite solar cells 被引量:2
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作者 Aili Wang Zhiyuan Cao +9 位作者 Jianwei Wang Shurong Wang Chengbo Li Nuo Li Lisha Xie yong xiang Tingshuai Li Xiaobin Niu Liming Ding Feng Hao 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第9期426-434,I0012,共10页
Nickel oxide(NiOx)has exhibited great potential as an inorganic hole transport layer(HTL)in perovskite solar cells(PSCs)due to its wide optical bandgap and superior stability.In this study,we have modulated the Ni26 v... Nickel oxide(NiOx)has exhibited great potential as an inorganic hole transport layer(HTL)in perovskite solar cells(PSCs)due to its wide optical bandgap and superior stability.In this study,we have modulated the Ni26 vacancies in NiOx film by controlling deposition temperature in a hot-casting process,resulting the change of coordination structure and charge state of NiOx.Moreover,the change of the HOMO level of NiOx makes it more compatible with perovskite to decrease energy losses and enhance hole carrier injection efficiency.Besides,the defect modulation in the electronic structure of NiOx is beneficial for increasing the electrical conductivity and mobility,which are considered to achieve the balance of charge carrier transport and avoid charge accumulation at the interface between perovskite and HTL effectively.Both experimental analyses and theoretical calculations reveal the increase of nickel vacancy defects change the electronic structure of NiOx by increasing the ratio of Ni3^+/Ni2^+-and improving the p-type characteristics.Accordingly,an optimal deposition temperature at 120℃enabled a 36.24%improvement in the power conversion efficiency compared to that deposited at room temperature(25℃).Therefore,this work provides a facile method to manipulate the electronic structure of NiOx to improve the charge carrier transport and photovoltaic performance of related PSCs. 展开更多
关键词 VACANCY Energy level CONDUCTIVITY Mobility Electronic structure Hole transport layer
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调强放疗对比三维适形放疗治疗非小细胞肺癌的疗效及对血清CEA、CYFRA21-1的影响 被引量:21
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作者 孙祝 雍翔 +2 位作者 孙宇 张武 赵玉魁 《实用癌症杂志》 2020年第5期774-777,共4页
目的探讨对非小细胞肺癌进行调强放疗(IMRT)与三维适形放疗(3D-CRT)的临床效果,并观察血清CEA、CYFRA21-1的变化。方法将77例非小细胞肺癌患者按随机数字法分为2组,38例行IMRT,设为甲组;39组行3D-CRT设为乙组。观察2组临床疗效及并发症... 目的探讨对非小细胞肺癌进行调强放疗(IMRT)与三维适形放疗(3D-CRT)的临床效果,并观察血清CEA、CYFRA21-1的变化。方法将77例非小细胞肺癌患者按随机数字法分为2组,38例行IMRT,设为甲组;39组行3D-CRT设为乙组。观察2组临床疗效及并发症情况;并对比治疗前后2组血清癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)水平变化。结果2组患者临床有效率无明显差异(P>0.05),但甲组放疗后并发症发生率相比乙组明显更低(P<0.05),且血清CEA、CYFRA21-1水平明显低于乙组(P<0.05)。结论IMRT、3D-CRT在非小细胞肺癌治疗中均有良好疗效,且IMRT可有效降低非小细胞肺癌患者放疗后并发症发生率、降低血清CEA及CYFRA21-1水平,值得推广。 展开更多
关键词 三维适形放疗 非小细胞肺癌 调强放疗 细胞角蛋白19片段抗原21-1 癌胚抗原
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Study on the ignition process of a segmented plasma torch 被引量:2
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作者 Xiuquan CAO Deping YU +3 位作者 yong xiang Chao LI Hui JIANG Jin YAO 《Plasma Science and Technology》 SCIE EI CAS CSCD 2017年第7期63-70,共8页
Direct current plasma torches have been applied to generate unique sources of thermal energy in many industrial applications. Nevertheless, the successful ignition of a plasma torch is the key process to generate the ... Direct current plasma torches have been applied to generate unique sources of thermal energy in many industrial applications. Nevertheless, the successful ignition of a plasma torch is the key process to generate the unique source (plasma jet). However, there has been tittle study on the underlying mechanism of this key process. A thorough understanding of the ignition process of a plasma torch will be helpful for optimizing the design of the plasma torch structure and selection of the ignition parameters to prolong the service life of the ignition module. Thus, in this paper, the ignition process of a segmented plasma torch (SPT) is theoretically and experimentally modeled and analyzed. Corresponding electrical models of different stages of the ignition process axe set up and used to derive the electrical parameters, e.g. the variations of the arc voltage and arc current between the cathode and anode. In addition, the experiments with different ignition parameters on a home-made SPT have been conducted. At the same time, the variations of the arc voltage and arc current have been measured, and used to verify the ones derived in theory and to determine the optimal ignition parameters for a particular SPT. 展开更多
关键词 ignition process segmented plasma torch ignition parameters
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Large aperture and non-critical phase-matched fourth harmonic generation of Nd:Glass lasers 被引量:2
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作者 Fang Wang Fuquan Li +8 位作者 Wei Han Wei Wang Ping Li Lidan Zhou yong xiang Bin Feng Xuewei Deng Jingqin Su Qihua Zhu 《Matter and Radiation at Extremes》 SCIE CAS 2019年第4期9-14,共6页
A fourth harmonic generation(FHG)scheme in focusing beams is proposed and demonstrated for large aperture Nd:glass laser facilities.By placing the focusing lens before the FHG crystal,the problem of ultraviolet damage... A fourth harmonic generation(FHG)scheme in focusing beams is proposed and demonstrated for large aperture Nd:glass laser facilities.By placing the focusing lens before the FHG crystal,the problem of ultraviolet damage can be overcome,largely without affecting FHG conversion efficiency owing to the large angular acceptance of the non-critical phase matching technique.A numerical simulation of the FHG process indicates that angular acceptance can be appropriately increased by lowering the working temperature and jointing the two adjacent compensating angles,so that FHG in focusing beams with relatively small F numbers becomes feasible.With a 170mm3170mm37mmand 65%deuterated potassium dihydrogen phosphate crystal mounted in a high-precision,temperature-controlled system,high-efficiency FHG has been demonstrated in the focusing beam with a full beam convergence angle of 36 mrad.When driven with a 223 J,second harmonic radiation(2ω),1 ns flat-top pulse with a beam area of 130 cm2,corresponding to 1.7 GW/cm22ωinput intensity,182 J of fourth harmonic radiation(4ω)were generated. 展开更多
关键词 HARMONIC CRITICAL BEAM
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4D printing of soft orthoses for tremor suppression 被引量:1
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作者 Moslem Mohammadi Ali Zolfagharian +2 位作者 Mahdi Bodaghi yong xiang Abbas Z.Kouzani 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2022年第4期786-807,共22页
Tremor is an involuntary and oscillatory movement disorder that makes daily activities difficult for affected patients. Hand tremor-suppression orthoses are noninvasive, wearable devices designed to mitigate tremors. ... Tremor is an involuntary and oscillatory movement disorder that makes daily activities difficult for affected patients. Hand tremor-suppression orthoses are noninvasive, wearable devices designed to mitigate tremors. Various studies have shown that these devices are effective, economical, and safe;however, they have drawbacks such as large weight, awkward shape, and rigid parts. This study investigates different types of tremor-suppression orthoses and discusses their efficiency, mechanism,benefits, and disadvantages. First, various orthoses(with passive, semi-active, and active mechanisms) are described in detail.Next, we look at how additive manufacturing(AM) has progressed recently in making sensors and actuators for application in tremor orthoses. Then, the materials used in AM are further analyzed. It is found that traditional manufacturing problems can be solved with the help of AM techniques, like making orthoses that are affordable, lighter, and more customizable. Another concept being discussed is using smart materials and AM methods, such as four-dimensional(4D) printing, to make orthoses that are more comfortable and efficient. 展开更多
关键词 Tremor suppression Parkinson’s disease Essential tremor Additive manufacturing 4D printing
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射频通信对超声波计量模组的干扰浅析
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作者 蒋韦 苗晓楠 +1 位作者 项勇 张伟 《城市燃气》 2022年第6期14-19,共6页
为提高计量计价的准确性并为客户提供更优质的服务,国家开始大力推广超声波计量技术;超声波燃气表打破了传统机械表的计量和计费模式,实现了高精度的微小流量计量,并可进行计量体积的温度修正,使计价计费更为公平合理.但是,超声波流体... 为提高计量计价的准确性并为客户提供更优质的服务,国家开始大力推广超声波计量技术;超声波燃气表打破了传统机械表的计量和计费模式,实现了高精度的微小流量计量,并可进行计量体积的温度修正,使计价计费更为公平合理.但是,超声波流体计量技术,较之传统机械计量方式,具有可靠性不高和易受干扰等问题;同时,现阶段通信技术的发展,无线射频通信信号无处不在的条件下,成为了超声波流体计量需要克服的主要问题,本文将对此展开论述,以供参阅. 展开更多
关键词 射频信号 传导 辐射 屏蔽 防护器件 接地
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Streamlined whole-genome genotyping through NGS-enhanced thermal asymmetric interlaced(TAIL)-PCR
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作者 Sheng Zhao Yue Wang +8 位作者 Zhenghang Zhu Peng Chen Wuge Liu Chongrong Wang Hong Lu yong xiang Yuwen Liu Qian Qian Yuxiao Chang 《Plant Communications》 SCIE CSCD 2024年第9期25-37,共13页
Whole-genome genotyping(WGG)stands as a pivotal element in genomic-assisted plant breeding.Nevertheless,sequencing-based approaches for WGG continue to be costly,primarily owing to the high expenses associated with li... Whole-genome genotyping(WGG)stands as a pivotal element in genomic-assisted plant breeding.Nevertheless,sequencing-based approaches for WGG continue to be costly,primarily owing to the high expenses associated with library preparation and the laborious protocol.During prior development of foreground and background integrated genotyping by sequencing(FBI-seq),we discovered that any sequence-specific primer(SP)inherently possesses the capability to amplify a massive array of stable and reproducible non-specific PCR products across the genome.Here,we further improved FBI-seq by replacing the adapter ligated by Tn5 transposase with an arbitrary degenerate(AD)primer.The protocol for the enhanced FBI-seq unexpectedly mirrors a simplified thermal asymmetric interlaced(TAIL)-PCR,a technique that is widely used for isolation of flanking sequences.However,the improved TAIL-PCR maximizes the primer-template mismatched annealing capabilities of both SP and AD primers.In addition,leveraging of next-generation sequencing enhances the ability of this technique to assay tens of thousands of genome-wide loci for any species.This cost-effective,user-friendly,and powerful WGG tool,which we have named TAIL-PCR by sequencing(TAIL-peq),holds great potential for widespread application in breeding programs,thereby facilitating genome-assisted crop improvement. 展开更多
关键词 whole-genome genotyping primer-template mismatched annealing specific primer arbitrary degenerate primer molecular breeding
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大口径反射镜低应力夹持优化设计 被引量:2
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作者 马文静 徐振源 +4 位作者 曹庭分 张军伟 向勇 陈良明 郑胜亨 《中国激光》 EI CAS CSCD 北大核心 2020年第11期180-185,共6页
为了同时满足激光装置对大口径反射镜面形精度和结构稳定性的控制要求,提出了一种反射镜多自由度解耦的多点夹持方式,通过限位实现对反射镜多自由度的控制,以此避免由夹持带来的附加面形。采用有限元法分析了所提方式的有效性,并通过实... 为了同时满足激光装置对大口径反射镜面形精度和结构稳定性的控制要求,提出了一种反射镜多自由度解耦的多点夹持方式,通过限位实现对反射镜多自由度的控制,以此避免由夹持带来的附加面形。采用有限元法分析了所提方式的有效性,并通过实验验证了分析方法及该夹持方式的可行性,结果表明采用该反射镜夹持方式带来的附加面形较小,满足反射镜低应力附加夹持面形的要求。在此基础上,对45°倾斜放置的反射镜的面形进行了模拟,探究了不同夹持点位置分布对反射镜面形精度的影响规律,模拟结果表明:为了保证反射镜的面形精度,至少要有一个夹持点位于反射镜的长边。该研究成果对大口径反射镜夹持设计具有重要的指导意义。 展开更多
关键词 光学设计 大口径反射镜 低应力夹持 面形精度 有限元模拟
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Sdr4 dominates pre-harvest sprouting and facilitates adaptation to local climatic condition in Asian cultivated rice 被引量:7
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作者 Bo Zhao Hui Zhang +6 位作者 Tianxiao Chen Ling Ding Liying Zhang Xiali Ding Jun Zhang Qian Qian yong xiang 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2022年第6期1246-1263,共18页
Pre-harvest sprouting(PHS),which reduces grain yield and quality,is controlled by seed dormancy genes.Because few dormancy-related genes have been cloned,the genetic basis of seed dormancy in rice(Oryza sativa L.)rema... Pre-harvest sprouting(PHS),which reduces grain yield and quality,is controlled by seed dormancy genes.Because few dormancy-related genes have been cloned,the genetic basis of seed dormancy in rice(Oryza sativa L.)remains unclear.Here,we performed a genome-wide association study and linkage mapping to dissect the genetic basis of seed dormancy in rice.Our findings suggest that Seed Dormancy4(Sdr4),a central modulator of seed dormancy,integrates the abscisic acid and gibberellic acid signaling pathways at the transcriptional level.Haplotype analysis revealed that three Sdr4 alleles in rice cultivars already existed in ancestral Oryza rufipogon accessions.Furthermore,like the semi-dwarf 1(SD1)and Rc loci,Sdr4 underwent selection during the domestication and improvement of Asian cultivated rice.The distribution frequency of the Sdr4-n allele in different locations in Asia is negatively associated with local annual temperature and precipitation.Finally,we developed functional molecular markers for Sdr4,SD1,and Rc for use in molecular breeding.Our results provide clues about the molecular basis of Sdr4-regulated seed dormancy.Moreover,these findings provide guidance for utilizing the favorable alleles of Sdr4 and Rc to synergistically boost PHS resistance,yield,and quality in modern rice varieties. 展开更多
关键词 climatic adaptation pre-harvest sprouting Rc RICE SD1 Sdr4 seed dormancy
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Laser performance of the SG-Ⅲ laser facility 被引量:16
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作者 Wanguo Zheng Xiaofeng Wei +21 位作者 Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang yong xiang Xuewei Deng 《High Power Laser Science and Engineering》 SCIE CAS CSCD 2016年第3期5-12,共8页
SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power bala... SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. 展开更多
关键词 inertial confinement fusion laser driver SG-Ⅲ
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