How does the motor relearning program improve neurological function of brain ischemia monkeys?

The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.

Acellular ostrich corneal stroma used as scaffold for construction of tissue-engineered cornea

AIM： To assess acellular ostrich corneal matrix used as a scaffold to reconstruct a damaged cornea. METHODS： A hypertonic saline solution combined with a digestion method was used to decellularize the ostrich cornea. The microstructure of the acellular corneal matrix was observed by transmission electron microscopy （TEM） and hematoxylin and eosin （H＆E） staining. The mechanical properties were detected by a rheometer and a tension machine. The acellular corneal matrix was also transplanted into a rabbit cornea and cytokeratin 3 was used to check the immune phenotype, RESULTS： The microstructure and mechanical properties of the ostrich cornea were well preserved after the decellularization process, in vitro, the methyl thiazolyl tetrazoUum results revealed that extracts of the acellular ostrich corneas （AOCs） had no inhibitory effects on the proliferation of the corneal epithelial or endothelial cells or on the keratocytes, The rabbit lamellar keratoplasty showed that the transplanted AOCs were transparent and completely incorporated into the host cornea while corneal turbidity and graft dissolution occurred in the acellular porcine cornea （APC） transplantation, The phenotype of the reconstructed cornea was similar to a normal rabbit cornea with a high expression of cytokeratin 3 in the superficial epithelial cell layer, CONCLUSION： We first used AOCs as scaffolds to reconstruct damaged corneas. Compared with porcine corneas, the anatomical structures of ostrich corneas are closer to those of human corneas. In accordance with the principle that structure determines function, a xenograft lamellar keratoplasty also confirmed that the AOC transplantation generated a superior outcome compared to that of the APC graft.

Expression of visual system homeobox 1 in human keratoconus

AIM: To investigate the expression of visual system homeobox 1(VSX1) and myofibroblast marker alpha smooth muscle actin(α-SMA) in keratoconus(KC). METHODS: Thirty corneal tissue were collected from KC patients after corneal transplantation and 15 normal donor corneas were obtained. All corneal tissues divided into 4 parts for different detections. Scanning electron microscopy was used to observe the ultrastructure of the specimens. VSX1 and α-SMA localization in cornea tissues was detected using immunofluorescence histochemistry. Reverse transcription-quantitative polymerase chain reaction(RT-qPCR) and Western blot were performed to analyze the expression level of VSX1 and α-SMA. RESULTS: Compared to normal cornea tissue, the collagen fibers in KC stroma were distortional and attenuated and keratocytes were abnormally changed. VSX1 and α-SMA located in the corneal stroma. The mRNA and protein expression level of VSX1 in KC were about 3 times as high as that of normal tissue(P<0.001). α-SMA was hardly expressed in the normal corneas, however, its expression in the KC was about 1.5 times higher than that of the normal corneas(P<0.0001). CONCLUSION: Compared with normal corneal the expression of VSX1 and α-SMA in KC both increased. VSX1 is related to the activation of keratocytes and involved in the pathogenesis of keratoconus.

Mathematical Model of Small Water-plane Area Twin-hull and Application in Marine Simulator

Small water-plane area twin-hull（SWATH） has drawn the attention of many researchers due to its good sea-keeping ability.In this paper,MMG＇s idea of separation was used to perform SWATH movement modeling and simulation;respectively the forces and moment of SWATH were divided into bare hull,propeller,rudder at the fluid hydrodynamics,etc.Wake coefficient at the propellers which reduces thrust coefficient,and rudder mutual interference forces among the hull and propeller,for the calculation of SWATH,were all considered.The fourth-order Runge-Kutta method of integration was used by solving differential equations,in order to get SWATH＇s movement states.As an example,a turning test at full speed and full starboard rudder of ‘Seagull＇ craft is shown.The simulation results show the SWATH＇s regular pattern and trend of motion.It verifies the correctness of the mathematical model of the turning movement.The SWATH＇s mathematical model is applied to marine simulator in order to train the pilots or seamen,or safety assessment for ocean engineering project.Lastly,the full mission navigation simulating system（FMNSS） was determined to be a successful virtual reality technology application sample in the field of navigation simulation.

Sedimentary characteristics and processes of the Paleogene Dainan Formation in the Gaoyou Depression, North Jiangsu Basin, eastern China

In this paper,the type,vertical evolution,and distribution pattern of sedimentary facies of the Paleogene Dainan Formation in the Gaoyou Depression of the North Jiangsu Basin are studied in detail.Results show that fan delta,delta,nearshore subaqueous fan,and lacustrine facies developed during the Dainan Formation period and their distribution pattern was mainly controlled by tectonics and paleogeography.The fan delta and nearshore subaqueous fan facies predominantly occur in the southern steep slope region where fault-induced subsidence is thought to have created substantial accommodation,whereas the delta facies are distributed on the northern gentle slope which is thought to have experienced less subsidence.Finally,the lacustrine facies is shown to have developed in the center of the depression,as well as on the flanks of the fan delta,delta,and nearshore subaqueous fan facies.Vertically,the Dainan Formation represents an integrated transgressiveregressive cycle,with the E2d1being the transgressive sequence and the E2d2being the regressive sequence.This distribution model of sedimentary facies plays an important role in predicting favorable reservoir belts for the Dainan Formation in the Gaoyou Depression and similar areas.In the Gaoyou Depression,sandstones of the subaqueous distributary channels in the fan delta and the subaqueous branch channels in the delta are characterized by physical properties favorable for reservoir formation.

Ka波段高效率扩展互作用振荡器的电路设计（英文）

设计并讨论了一种高效率的基于梯形结构的扩展互作用振荡器(EIO)。优化了提升器件效率的关键因素包括间隙数目、频率分隔度、间隙长度、特性阻抗R/Q和品质因数Qe,从而实现有效电子束调制并避免模式竞争。本文初步设计了适用于高互作用效率的EIO电路。

Rate-dependent inhomogeneous creep behavior in metallic glasses

Creep deformation can be classified as homogeneous flow and inhomogeneous flow in bulk metallic glass(BMG).In order to understand the conversion conditions of the two types of creep deformation,the effect of loading rate on the creep behavior of a Ti_(40)Zr_(10)Cu_(47)Sn_(3)(at.%)BMG at ambient temperature was investigated using nanoindentation and molecular dynamic simulation.Results indicate that at low loading rates,many serrations appear in loading stage,leading to inhomogeneous serrated flow in the creep stage.When the loading rate is high enough,the creep deformation tends to be homogeneous.The related mechanism responsible for the rate-dependent creep behavior is attributed to the number of pre-existing major shear bands which is influenced significantly by the loading rate.

Plasma simulation to analyze velocity distribution characteristics of pseudospark-sourced electron beam

Pseudospark-sourced electron beam is a promising candidate for driving vacuum electronic devices to generate millimeter wave and terahertz wave radiation as it has a very high combined beam current density. However, the inherent velocity spread of the beam, which is difficult to measure in experiment, has a great influence on the operating frequency and efficiency of the vacuum electronic device. In this paper, the velocity distribution characteristics of the electron beam produced by a single-gap hollow cathode electron gun are numerically studied and a three-dimensional kinetic plasma simulation model of a single-gap hollow cathode electron gun is built by using particle in cell and Monte Carlo collision methods in Vorpal. Based on the simulation model, the time-dependent evolution of the plasma formation inside the hollow cathode and electron beam generation process are observed. It is demonstrated that the pseudospark-sourced electron beam has a relatively large velocity spread. The time-dependent velocity distribution of the beam is analyzed, and the dependence of the beam velocity distribution under various operating conditions such as anode–cathode potential difference, gas pressure, and cathode aperture size are also studied.

Manufacturing enterprise collaboration network:An empirical research and evolutionary model

With the increasingly fierce market competition,manufacturing enterprises have to continuously improve their competitiveness through their collaboration and labor division with each other,i.e.forming manufacturing enterprise collaborative network(MECN)through their collaboration and labor division is an effective guarantee for obtaining competitive advantages.To explore the topology and evolutionary process of MECN,in this paper we investigate an empirical MECN from the viewpoint of complex network theory,and construct an evolutionary model to reproduce the topological properties found in the empirical network.Firstly,large-size empirical data related to the automotive industry are collected to construct an MECN.Topological analysis indicates that the MECN is not a scale-free network,but a small-world network with disassortativity.Small-world property indicates that the enterprises can respond quickly to the market,but disassortativity shows the risk spreading is fast and the coordinated operation is difficult.Then,an evolutionary model based on fitness preferential attachment and entropy-TOPSIS is proposed to capture the features of MECN.Besides,the evolutionary model is compared with a degree-based model in which only node degree is taken into consideration.The simulation results show the proposed evolutionary model can reproduce a number of critical topological properties of empirical MECN,while the degree-based model does not,which validates the effectiveness of the proposed evolutionary model.

Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility

This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility.A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine(with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain,pain reduction with heat application,and cold extremities)were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only.Treatment continued for six menstrual cycles.The pregnancy rate of the treatment group was significantly increased with the control group(50.0%vs.23.3%,P=0.021).Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group(3.87±2.03 vs.5.70±1.01,P=0.002 and 7.33±4.11 vs.10.52±2.33,P=0.006,respectively),and there was also significant between-group differences in serum cancer antigen 125(55.45±14.65 vs.63.34±11.41,P=0.031).However,the average uterus diameters in the treatment and control groups were not significantly different(67.13±7.59 vs.69.89±5.30,P=0.137).Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.

Survey of Stereotactic Body Radiation Oncology for Early Staged Non-Small Cell Lung Cancer in China

Purpose: To evaluate the current status of stereotactic body radiotherapy (SBRT) for early staged non-small cell lung cancer (NSCLC) at main cancer hospitals in China. Methods and Materials: The questionnaire was sent by mail and email to 21 hospitals, which include the patient enrollment, treatment technique, dose and fractionation, quality control, disease control and side effects. Results: Nineteen hospitals responded. It was found that SBRT has been used for early staged NSCLC in most of the hospitals participating in the survey. The patient characteristics and techniques were relatively consistent, but there were many controversies regarding dose fractionation and quality control. Conclusions: SBRT for early staged NSCLC has been applied at main cancer hospitals in China. However, considerable variation exists. The establishment of clinical guidelines and standardized quality control are crucial for further improvement.

Discrimination between Chinese Jing Wine and Counterfeit Using Different Signal Features of an Electronic Nose

Because sensory analysis and chromatographic analysis were not well suitable for the discrimination between Chinese Jing wines and counterfeits, an electronic nose (in short, eNose) was employed to carry out the task. In the investigation three kinds of features of eNose signals were extracted and as input data of principal component analysis (PCA). These features are named as mean-differential coefficient value (MDCV), energy value of wavelet packet decomposition (WE) and relative steady-state response value (RSV), respectively. The results demonstrated that the discrimination based on these features data could all be performed by PCA, and the RSV was the best. At the same time, an evaluation method was proposed to evaluate the discrimination capability of these features quantitatively, and the evaluation results are basically in accord with PCA discrimination results. This showed the evaluation method was appropriate for evaluating the discrimination capability of different features. In conclusion, the investigation indicated that the eNose coupled with PCA was absolutely competent for the discrimination tasks, and especially the feature RSV was simple and reliable.

Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

Mycoplasma pneumoniae(M.pneumoniae),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and adolescents.The infection occurs endemically with an epidemic peak every few years.The worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation

Ferroptosis is a newly discovered prototype of programmed cell death (PCD) driven by iron-dependent phospholipid peroxidation accumulation, and it has been linked to numerous organ injuries and degenerative pathologies. Although studies have shown that a variety of cell death processes contribute to JEV-induced neuroinflammation and neuronal injury, there is currently limited research on the specific involvement of ferroptosis. In this study, we explored the neuronal ferroptosis induced by JEV infection in vitro and in vivo. Our results indicated that JEV infection induces neuronal ferroptosis through inhibiting the function of the antioxidant system mediated by glutathione (GSH)/glutathione peroxidase 4 (GPX4), as well as by promoting lipid peroxidation mediated by yes-associated protein 1 (YAP1)/long-chain acyl-CoA synthetase 4 (ACSL4). Further analyses revealed that JEV E and prM proteins function as agonists, inducing ferroptosis. Moreover, we found that treatment with a ferroptosis inhibitor in JEV-infected mice reduces the viral titers and inflammation in the mouse brains, ultimately improving the survival rate of infected mice. In conclusion, our study unveils a critical role of ferroptosis in the pathogenesis of JEV, providing new ideas for the prevention and treatment of viral encephalitis.

Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

Background Mycoplasma pneumoniae(M.pneumoniae)is a significant contributor to community-acquired pneumonia among children.Since 1968,when a strain of M.pneumoniae resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant M.pneumoniae(MRMP)has been documented in many countries worldwide,with varying incidence rates.MRMP infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line antibiotics.Since 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of M.pneumoniae infections in children and attracted widespread attention from pediatricians.However,there is still no global consensus on the diagnosis and treatment of MRMP in children.Methods We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence collection.The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane Library.We used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“M.pneumoniae”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are highlighted.Early and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory specimens.Although the resistance rate to macrolide remains high,it is fortunate that M.pneumoniae still maintains good in vitro sensitivity to second-line antibiotics such as tetracyclines and quinolones,making them an effective treatment option for patients with initial treatment failure caused by macrolide antibiotics.Conclusions This consensus,based on international and national scientific evidence,provides scientific guidance for the diagnosis and treatment of MRMP in children.Further studies on tetracycline and quinolone drugs in children are urgently needed to evaluate their effects on the growth and development.Additionally,developing an antibiotic rotation treatment strategy is necessary to reduce the prevalence of MRMP strains.

A nested partitioning-based solution method for seru scheduling problem with resource allocation

This paper investigates the production scheduling problems of allocating resources and sequencing jobs in the seru production system(SPS).As a new-type manufacturing mode arising from Japanese production practices,seru production can achieve efficiency,flexibility,and responsiveness simultaneously.The production environment in which a set of jobs must be scheduled over a set of serus according to due date and different execution modes is considered,and a combination optimization model is provided.Motivated by the problem complexity and the characteristics of the proposed seru scheduling model,a nested partitioning method(NPM)is designed as the solution approach.Finally,computational studies are conducted,and the practicability of the proposed seru scheduling model is proven.Moreover,the efficiency of the nested partitioning solution method is demonstrated by the computational results obtained from different scenarios,and the good scalability of the proposed approach is proven via comparative analysis.

Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection:a randomized controlled trial

Background Saline nasal irrigation is an effective therapy for relieving common cold symptoms.This study aimed to investigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with Omicron.Methods This randomized controlled trial was conducted in Shanghai,China,and 403 children with mild and asymptomatic infection with Omicron were included.These children were allocated into the PSNI group and the control group.The primary outcome was the duration of viral shedding(DVS),and the secondary outcome was the change in clinical symptoms.Results The median age of all participants was 5.59(6.26)years old.The DVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter DVS compared with patients in the control group[hazard ratio(HR),1.27;95%confidence interval(CI),1.04–1.55;P=0.017].Subgroup analysis suggested that the DVS of patients without full vaccination was significantly reduced in the PSNI group.The proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control group.Conclusion PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.

Development and validation of radiomics model built by incorporating machine learning for identifying liver fibrosis and early-stage cirrhosis

Background:Liver fibrosis(LF)continues to develop and eventually progresses to cirrhosis.However,LF and early-stage cirrhosis(ESC)can be reversed in some cases,while advanced cirrhosis is almost impossible to cure.Advances in quantitative imaging techniques have made it possible to replace the gold standard biopsy method with non-invasive imaging,such as radiomics.Therefore,the purpose of this study is to develop a radiomics model to identify LF and ESC.Methods:Patients with LF(n=108)and ESC(n=116)were enrolled in this study.As a control,patients with healthy livers were involved in the study(n=145).Diffusion-weighted imaging(DWI)data sets with three b-values(0,400,and 800 s/mm2)of enrolled cases were collected in this study.Then,radiomics features were extracted from manually delineated volumes of interest.Two modeling strategies were performed after univariate analysis and feature selection.Finally,an optimal model was determined by the receiver operating characteristic area under the curve(AUC).Results:The optimal models were built in plan 1.For model 1 in plan 1,the AUCs of the training and validation cohorts were 0.973(95%confidence interval[CI]0.946-1.000)and 0.948(95%CI 0.903-0.993),respectively.For model 2 in plan 1,the AUCs of the training and validation cohorts were 0.944,95%CI 0.905 to 0.983,and 0.968,95%CI 0.940 to 0.996,respectively.Conclusions:Radiomics analysis of DWI images allows for accurate identification of LF and ESC,and the non-invasive biomarkers extracted from the functional DWI images can serve as a better alternative to biopsy.

Exploring atmospheric environmental drivers of asthma among children in Shanghai, China: Evidence-informed policies are required

It is important to identify atmospheric environmental drivers of childhood asthma because asthma is the most common chronic disease in children globally.We provided an overview of the impacts of exposure to atmospheric environmental factors(e.g.,meteorological factors and air pollutants)on childhood asthma,based on a series of studies with the cutting-edge environmental epidemiological methodology in Shanghai,China.Overall,we found that the prevalence of asthma among the children aged 3–7 years had increased by approximately 7 fold,from 2.1%in 1990 to 14.6%in 2019.Most meteorological factors(i.e.daily mean temperature,temperature difference,air pressure,air pressure difference,precipitation,relative humidity,sunshine and wind speed)and air pollutants(PM10,PM2.5,NO2,SO2 and O3)were significantly associated with childhood asthma(p<0.05),but meteorological factors appeared to play more important roles than air pollutants in the occurrence of asthma exacerbations.We also found that temperature variability was significantly associated with the elevated relative risk of daily outpatient visits for childhood asthma(p<0.05).Furthermore,we conducted a systematic review on climate change adaptation measures and childhood asthma and found that there were a number of adaptation measures proposed for childhood asthma in response to climate change,including vulnerability assessment,improving ventilation and heating,enhancing community education,developing forecast models,and early warning systems.However,the effectiveness of most adaptation measures,except for improving ventilation and heating in winter,have not been explored and quantified.Since asthma is sensitive to the variation of atmospheric environmental conditions,it is critical to develop and implement appropriate climate change mitigation and adaptation strategies as global heating becomes apparent.

Predicting late radiation-induced xerostomia in nasopharyngeal carcinoma based on radiomics features extracted from T2WI images of parotids

Objective:To explore the value of radiomics features extracted from the T2-weighted imaging(T2WI)images of parotids in predicting late radiation-induced xerostomia in nasopharyngeal carcinoma(NPC)patients after radiotherapy(RT).Methods:A retrospective analysis was conducted for 123 NPC patients who received RT at the Affiliated Tumour Hospital of Xinjiang Medical University from January 2019 to March 2021.All the patients underwent MRI pre-RT and post-RT.They were randomly divided into a training set and a testing set at a ratio of 4:1 using a random number table,with the former and the latter comprising 98 and 25 cases,respectively.The ipsilateral parotid gland(iPG)and the contralateral parotid gland(cPG)were delineated on T2WI images pre-RT and post-RT as regions of interest(ROIs).A total of 851 radiomics features were extracted from each ROI.Spearman analysis was used to remove redundant features,and the recursive feature elimination(RFE)method was then used to determine useful features.Using radiomics features extracted from images pre-treatment,images post-treatment,and differences between images pre-and post-treatment,this study constructed three radiomic models,namely the pre-treatment radiomics model(preRT),the post-treatment radiomics model(postRT),and the deltaradiomics model(DeltaRT).Then,this study plotted the receiver operating characteristic(ROC)curves based on the late radiation-induced xerostomia grades of patients post-RT.Furthermore,the models’effectiveness and performance in predicting late radiation-induced xerostomia and advanced radioactive xerostomia was evaluated.In addition,the area under the curve(AUC),sensitivity,specificity,accuracy,precision,and negative predictive value(NPV)were calculated.Results:Among the features extracted from bilateral parotid glands(PGs),20 were determined pre-RT(six from iPG and 14 from cPG),19 were determined post-RT(six from iPG and 13 from cPG),and 20 were derived from the DeltaRT(20 from cPG).The PGs pre-RT and post-RT in the training set had AUCs of 0.902(95%CI:0.895-0.909)and 0.761(95%CI:0.744-0.778),respectively,while those in the testing set had AUCs of 0.740(95%CI:0.504-0.983)and 0.701(95%CI:0.478-0.924),respectively.In contrast,the AUC of the cPG derived from the DeltaRT was 0.867(95%CI:0.856-0.878)in the training set and 0.851(95%CI:0.697-0.999)in the testing set.Conclusions:There are significant correlations between radiomics features extracted from MRI T2WI images of parotids and late radiation-induced xerostomia in NPC patients.Among the radiomics features,the changes in cPG features pre-RT and post-RT have higher accuracy in predicting late radiation-induced xerostomia.