At the Symposium on Ecological Protection and High-quality Development of the Yellow River Basin, General Secretary Xi Jinping pointed out that "it should deeply explore the time value contained in the Yellow Riv...At the Symposium on Ecological Protection and High-quality Development of the Yellow River Basin, General Secretary Xi Jinping pointed out that "it should deeply explore the time value contained in the Yellow River culture, tell the story of the Yellow River well, and protect, inherit and carry forward the Yellow River culture". Water park is an important carrier of the Yellow River culture transmission. In this paper, the basic characteristics and regional distribution of water parks in the Yellow River basin are analyzed. For the problems faced by cultural heritage of water parks in the Yellow River basin, from three aspects of exploring and integrating the connotation, innovating communication methods, and shaping brand IP, cultural heritage of water parks in the Yellow River basin is discussed. It is beneficial to carry forward the Yellow River culture, and better meet the spiritual and cultural needs of the people.展开更多
Planar semiconductor InGaAs/InP single photon avalanche diodes with high responsivity and low dark count rate are preferred single photon detectors in near-infrared communication.However,even with well-designed struct...Planar semiconductor InGaAs/InP single photon avalanche diodes with high responsivity and low dark count rate are preferred single photon detectors in near-infrared communication.However,even with well-designed structures and well-con-trolled operational conditions,the performance of InGaAs/InP SPADs is limited by the inherent characteristics of avalanche pro-cess and the growth quality of InGaAs/InP materials.It is difficult to ensure high detection efficiency while the dark count rate is controlled within a certain range at present.In this paper,we fabricated a device with a thick InGaAs absorption region and an anti-reflection layer.The quantum efficiency of this device reaches 83.2%.We characterized the single-photon performance of the device by a quenching circuit consisting of parallel-balanced InGaAs/InP single photon detectors and single-period sinus-oidal pulse gating.The spike pulse caused by the capacitance effect of the device is eliminated by using the characteristics of parallel balanced common mode signal elimination,and the detection of small avalanche pulse amplitude signal is realized.The maximum detection efficiency is 55.4%with a dark count rate of 43.8 kHz and a noise equivalent power of 6.96×10^(−17 )W/Hz^(1/2) at 247 K.Compared with other reported detectors,this SPAD exhibits higher SPDE and lower noise-equivalent power at a higher cooling temperature.展开更多
Background and Aims:Hepatic ischemia-reperfusion injury(HIRI)is a prevalent complication of liver transplantation,partial hepatectomy,and severe infection,necessitating the development of more effective clinical strat...Background and Aims:Hepatic ischemia-reperfusion injury(HIRI)is a prevalent complication of liver transplantation,partial hepatectomy,and severe infection,necessitating the development of more effective clinical strategies.Receptor activity–modifying protein 1(RAMP1),a member of the G protein–coupled receptor adapter family,has been implicated in numerous physiological and pathological processes.The study aimed to investigate the pathogenesis of RAMP1 in HIRI.Methods:We established a 70%liver ischemia-reperfusion model in RAMP1 knockout(KO)and wild-type mice.Liver and blood samples were collected after 0,6,and 24 h of hypoxia/reperfusion.Liver histological and serological analyses were performed to evaluate liver damage.We also conducted in-vitro and in-vivo experiments to explore the molecular mechanism underlying RAMP1 function.Results:Liver injury was exacerbated in RAMP1-KO mice compared with the sham group,as evidenced by increased cell death and elevated serum transaminase and inflammation levels.HIRI was promoted in RAMP1-KO mice via the induction of hepatocyte apoptosis and inhibition of proliferation.The absence of RAMP1 led to increased activation of the extracellular signal–regulated kinase(ERK)/mitogen-activated protein kinase(MAPK)pathway and yes-associated protein(YAP)phosphorylation,ultimately promoting apoptosis.SCH772984,an ERK/MAPK phosphorylation inhibitor,and PY-60,a YAP phosphorylation inhibitor,reduced apoptosis in in-vitro and in-vivo experiments.Conclusions:Our findings suggest that RAMP1 protects against HIRI by inhibiting ERK and YAP phosphorylation signal transduction,highlighting its potential as a therapeutic target for HIRI and providing a new avenue for intervention.展开更多
In this paper, the MacWilliams type identity for the m-ply Lee weight enumerator for linear codes over F2 ＋uF2 is determined. As an application of this identity, the authors obtain a MacWilliams type identity on Lee ...In this paper, the MacWilliams type identity for the m-ply Lee weight enumerator for linear codes over F2 ＋uF2 is determined. As an application of this identity, the authors obtain a MacWilliams type identity on Lee weight for linear codes over F2m ＋ uF2m. Furthermore, the authors prove a duality for the m-ply Lee weight distributions by taking advantage of the Krawtchouk polynomials.展开更多
文摘At the Symposium on Ecological Protection and High-quality Development of the Yellow River Basin, General Secretary Xi Jinping pointed out that "it should deeply explore the time value contained in the Yellow River culture, tell the story of the Yellow River well, and protect, inherit and carry forward the Yellow River culture". Water park is an important carrier of the Yellow River culture transmission. In this paper, the basic characteristics and regional distribution of water parks in the Yellow River basin are analyzed. For the problems faced by cultural heritage of water parks in the Yellow River basin, from three aspects of exploring and integrating the connotation, innovating communication methods, and shaping brand IP, cultural heritage of water parks in the Yellow River basin is discussed. It is beneficial to carry forward the Yellow River culture, and better meet the spiritual and cultural needs of the people.
基金jointly supported by the National Key Research and Development Program of China (2019YFB22-05202)National Natural Science Foundation of China(61774152)
文摘Planar semiconductor InGaAs/InP single photon avalanche diodes with high responsivity and low dark count rate are preferred single photon detectors in near-infrared communication.However,even with well-designed structures and well-con-trolled operational conditions,the performance of InGaAs/InP SPADs is limited by the inherent characteristics of avalanche pro-cess and the growth quality of InGaAs/InP materials.It is difficult to ensure high detection efficiency while the dark count rate is controlled within a certain range at present.In this paper,we fabricated a device with a thick InGaAs absorption region and an anti-reflection layer.The quantum efficiency of this device reaches 83.2%.We characterized the single-photon performance of the device by a quenching circuit consisting of parallel-balanced InGaAs/InP single photon detectors and single-period sinus-oidal pulse gating.The spike pulse caused by the capacitance effect of the device is eliminated by using the characteristics of parallel balanced common mode signal elimination,and the detection of small avalanche pulse amplitude signal is realized.The maximum detection efficiency is 55.4%with a dark count rate of 43.8 kHz and a noise equivalent power of 6.96×10^(−17 )W/Hz^(1/2) at 247 K.Compared with other reported detectors,this SPAD exhibits higher SPDE and lower noise-equivalent power at a higher cooling temperature.
基金supported by:The National Natural Science Foundation of China(82270688,81402426)The Natural Science Foundation.of Guangdong Province(2021A1515010726,2022A1515012650,2020A1515010302)+1 种基金The Cultivation Project of National Natural Science Foundationof the Third Affliated Hospital of Sun Yat-sen University(No.2020GzRPYMS09)Science and Technology ProjectsinGuangzhou(No.202102010310,202201020427).
文摘Background and Aims:Hepatic ischemia-reperfusion injury(HIRI)is a prevalent complication of liver transplantation,partial hepatectomy,and severe infection,necessitating the development of more effective clinical strategies.Receptor activity–modifying protein 1(RAMP1),a member of the G protein–coupled receptor adapter family,has been implicated in numerous physiological and pathological processes.The study aimed to investigate the pathogenesis of RAMP1 in HIRI.Methods:We established a 70%liver ischemia-reperfusion model in RAMP1 knockout(KO)and wild-type mice.Liver and blood samples were collected after 0,6,and 24 h of hypoxia/reperfusion.Liver histological and serological analyses were performed to evaluate liver damage.We also conducted in-vitro and in-vivo experiments to explore the molecular mechanism underlying RAMP1 function.Results:Liver injury was exacerbated in RAMP1-KO mice compared with the sham group,as evidenced by increased cell death and elevated serum transaminase and inflammation levels.HIRI was promoted in RAMP1-KO mice via the induction of hepatocyte apoptosis and inhibition of proliferation.The absence of RAMP1 led to increased activation of the extracellular signal–regulated kinase(ERK)/mitogen-activated protein kinase(MAPK)pathway and yes-associated protein(YAP)phosphorylation,ultimately promoting apoptosis.SCH772984,an ERK/MAPK phosphorylation inhibitor,and PY-60,a YAP phosphorylation inhibitor,reduced apoptosis in in-vitro and in-vivo experiments.Conclusions:Our findings suggest that RAMP1 protects against HIRI by inhibiting ERK and YAP phosphorylation signal transduction,highlighting its potential as a therapeutic target for HIRI and providing a new avenue for intervention.
基金supported by National Natural Science Funds of China under Grant No.60973125College Doctoral Funds of China under Grant No.20080359003+1 种基金Anhui College Natural Science Research Project under Grant No.KJ2010B171Research Project of Hefei Normal University under Grant No.2012kj10
文摘In this paper, the MacWilliams type identity for the m-ply Lee weight enumerator for linear codes over F2 ＋uF2 is determined. As an application of this identity, the authors obtain a MacWilliams type identity on Lee weight for linear codes over F2m ＋ uF2m. Furthermore, the authors prove a duality for the m-ply Lee weight distributions by taking advantage of the Krawtchouk polynomials.
