An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantiosel...An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantioselectivities and diastereoselectivities. Further transformations of product are demonstrated. A diamine mediated catalytic cycle is proposed.展开更多
基金National Natural Science Foundation of China (Nos. 21877005, 21907059, 22001147)Taishan Scholars Project of Shandong Province (No. tsqn202103027)+2 种基金Distinguished Young Scholars of Shandong Province (Overseas) (No. 2022HWYQ-001)Academic Promotion Programme of Shandong First Medical University (No. 2019LJ003)Natural Science Foundation of Shandong Province (No. ZR2021MB102) for financial support。
文摘An enantioselective organo-catalyzed reaction of furanones with α,β-unsaturated ketones has been established herein, which provides an efficient access to chiral bicyclic γ-butyrolactones in good yields, enantioselectivities and diastereoselectivities. Further transformations of product are demonstrated. A diamine mediated catalytic cycle is proposed.
