Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focus...Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.展开更多
The jamming resource allocation problem of the aircraft formation cooperatively jamming netted radar system is investigated.An adaptive allocation strategy based on dynamic adaptive discrete cuckoo search algorithm(DA...The jamming resource allocation problem of the aircraft formation cooperatively jamming netted radar system is investigated.An adaptive allocation strategy based on dynamic adaptive discrete cuckoo search algorithm(DADCS)is proposed,whose core is to adjust allocation scheme of limited jamming resource of aircraft formation in real time to maintain the best jamming effectiveness against netted radar system.Firstly,considering the information fusion rules and different working modes of the netted radar system,a two-factor jamming effectiveness evaluation function is constructed,detection probability and aiming probability are adopted to characterize jamming effectiveness against netted radar system in searching and tracking mode,respectively.Then a nonconvex optimization model for cooperatively jamming netted radar system is established.Finally,a dynamic adaptive discrete cuckoo search algorithm(DADCS)is constructed by improving path update strategies and introducing a global learning mechanism,and a three-step solution method is proposed subsequently.Simulation results are provided to demonstrate the advantages of the proposed optimization strategy and the effectiveness of the improved algorithm.展开更多
To deal with the radio frequency threat posed by modern complex radar networks to aircraft,we researched the unmanned aerial vehicle(UAV)formations radar countermeasures,aiming at the solution of radar jamming resourc...To deal with the radio frequency threat posed by modern complex radar networks to aircraft,we researched the unmanned aerial vehicle(UAV)formations radar countermeasures,aiming at the solution of radar jamming resource allocation under system countermeasures.A jamming resource allocation method based on an improved firefly algorithm(FA)is proposed.Firstly,the comprehensive factors affecting the level of threat and interference efficiency of radiation source are quantified by a fuzzy comprehensive evaluation.Besides,the interference efficiency matrix and the objective function of the allocation model are determined to establish the interference resource allocation model.Finally,A mutation operator and an adaptive heuristic are integtated into the FA algorithm,which searches an interference resource allocation scheme.The simulation results show that the improved FA algorithm can compensate for the deficiencies of the FA algorithm.The improved FA algorithm provides a more scientific and reasonable decision-making plan for aircraft mission allocation and can effectively deal with the battlefield threats of the enemy radar network.Moreover,in terms of convergence accuracy and speed as well as algorithm stability,the improved FA algorithm is superior to the simulated annealing algorithm(SA),the niche genetic algorithm(NGA),the improved discrete cuckoo algorithm(IDCS),the mutant firefly algorithm(MFA),the cuckoo search and fireflies algorithm(CSFA),and the best neighbor firefly algorithm(BNFA).展开更多
To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and...To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and its corresponding characteristics, derives the probability density functions of the LFM signal and Gaussian white noise within WHT based on entropy (WHTE), dimension under different assumptions and puts forward a WHT algorithm based on entropy of slice to improve the capacity of detecting the LFM signal. Entropy of the WHT domain slice is adopted to assess the information size of polar radius or angle slice, which is converted into the weight factor to weight every slice. Double-deck weight is used to weaken the influences of noise and disturbance terms and WHTE treatment and signal detection procedure are also summarized. The rationality of the algorithm is demonstrated through theoretical analysis and formula derivation, the efficiency of the algorithm is verified by simulation comparison between WHT, fractional Fourier transform and periodic WHT, and it is highlighted that the WHTE algorithm has better detection accuracy and range of application against strong noise background.展开更多
Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopon...Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin(OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures,and analyze the relationship between the expressiones of them.Results:OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group, the result showed statistical significance(P【0.05).There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P【0.05).Conclusions:The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.展开更多
AIM: To explore the efficacy of conbercept after switching from bevacizumab/ranibizumab in eyes of central retinal vein occlusion(CRVO) through optical coherence tomography angiography(OCTA). METHODS: Patients with pr...AIM: To explore the efficacy of conbercept after switching from bevacizumab/ranibizumab in eyes of central retinal vein occlusion(CRVO) through optical coherence tomography angiography(OCTA). METHODS: Patients with prior treatment of a minimum of three consecutive intravitreal injections of either bevacizumab or ranibizumab, followed by injection of conbercept, were recruited. The minimal follow-up period after switching was 12 mo. Central retinal thickness(CRT), best-corrected visual acuity(BCVA), the interval of injections was reviewed. Perfusion density(PD) and vascular length density(VLD) of superficial and deep capillary plexus were acquired from OCTA images before and after switching. RESULTS: Twenty-four eyes were included. CRT significantly decreased from 460.71±153.23 μm(before switching) to 283.92±38.27 μm at the end of follow-up(P<0.001). However, BCVA gained to some extent(from 0.98±0.33 to 0.76±0.42 log MAR) but the difference was not significant(P=0.070). After switching to conbercept the injection interval extended from 5.2±2.3 wk to 8.3±3.9 wk(P=0.012). At the end of follow-up, PD of deep retinal layer decreased significantly compared with before switching(from 34.62%±5.27% to 33.26%±5.82%, P=0.016), similar result was found in VLD of deep retinal layer but not in PD or VLD in superficial layer.CONCLUSION: In cases of refractory macular edema secondary to CRVO, switching to conbercept improves macular thickness and extends interval of injection. Retinal microvasculature cannot improve with treatment of conbercept.展开更多
The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bioni...The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated chemotherapy.Briefly,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and internalization.Once internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient EDT.Simultaneously,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional chemotherapy.Consequently,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor inhibition.This intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.展开更多
Aiming at the yaw problem caused by inertial navigation system errors accumulation during the navigation of an intelligent aircraft,a three-dimensional trajectory planning method based on the particle swarm optimizati...Aiming at the yaw problem caused by inertial navigation system errors accumulation during the navigation of an intelligent aircraft,a three-dimensional trajectory planning method based on the particle swarm optimization-A star(PSO-A*)algorithm is designed.Firstly,an environment model for aircraft error correction is established,and the trajectory is discretized to calculate the positioning error.Next,the positioning error is corrected at many preset trajectory points.The shortest trajectory and the fewest correction times are regarded as optimization goals to improve the heuristic function of A star(A*)algorithm.Finally,the index weights are continuously optimized by the particle swarm optimization algorithm.The optimal trajectory is found by the A*algorithm under the current evaluation index,so the ideal trajectory is planned.The experimental results show that the PSO-A*algorithm can quickly search for ideal trajectories in different environment models,indicating that the algorithm has certain feasibility and adaptability,and verifies the rationality of the proposed trajectory planning model.The PSO-A*algorithm has better convergence accuracy than the A*algorithm,and the search efficiency is significantly better than the grid search A star(GS-A*)algorithm.The PSO-A*algorithm proposed in this paper has certain engineering application value.The researchers will study the real-time and systematic nature of the algorithm.展开更多
基金supported by National Key Research and Development Program of China(contract No.2019YFA0904800)National Nature Science Foundation of China(32030065,31722033,92049304 to Y.Z.)+5 种基金Shanghai Sailing Program(contract No.21YF1410300)Science and Technology Commission of Shanghai Municipality(contract No.10DZ2220500)The Shanghai Committee of Science and Technology(grant No.11DZ2260600)Shanghai Frontiers Science Center of Optogenetic Techniques for CellMetabolism(Y.Z.)Research Unit of New Techniques for Live-cell Metabolic Imaging(Chinese Academy of Medical Sciences,2019-I2M-5-013 to Y.Z.)the State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities.
文摘Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter.These studies have mainly focused on the production and pharmacological side effects caused by H_(2)S.Therefore,effective strategies to remove H_(2)S has become a key research topic.Furthermore,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)S.This paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and conditions.Second,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were summarized.Not only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this review.Furthermore,this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail.Finally,potential challenges of HRNs were proposed.This study demonstrates the excellent potential of HRNs for biomedical applications.
文摘The jamming resource allocation problem of the aircraft formation cooperatively jamming netted radar system is investigated.An adaptive allocation strategy based on dynamic adaptive discrete cuckoo search algorithm(DADCS)is proposed,whose core is to adjust allocation scheme of limited jamming resource of aircraft formation in real time to maintain the best jamming effectiveness against netted radar system.Firstly,considering the information fusion rules and different working modes of the netted radar system,a two-factor jamming effectiveness evaluation function is constructed,detection probability and aiming probability are adopted to characterize jamming effectiveness against netted radar system in searching and tracking mode,respectively.Then a nonconvex optimization model for cooperatively jamming netted radar system is established.Finally,a dynamic adaptive discrete cuckoo search algorithm(DADCS)is constructed by improving path update strategies and introducing a global learning mechanism,and a three-step solution method is proposed subsequently.Simulation results are provided to demonstrate the advantages of the proposed optimization strategy and the effectiveness of the improved algorithm.
文摘To deal with the radio frequency threat posed by modern complex radar networks to aircraft,we researched the unmanned aerial vehicle(UAV)formations radar countermeasures,aiming at the solution of radar jamming resource allocation under system countermeasures.A jamming resource allocation method based on an improved firefly algorithm(FA)is proposed.Firstly,the comprehensive factors affecting the level of threat and interference efficiency of radiation source are quantified by a fuzzy comprehensive evaluation.Besides,the interference efficiency matrix and the objective function of the allocation model are determined to establish the interference resource allocation model.Finally,A mutation operator and an adaptive heuristic are integtated into the FA algorithm,which searches an interference resource allocation scheme.The simulation results show that the improved FA algorithm can compensate for the deficiencies of the FA algorithm.The improved FA algorithm provides a more scientific and reasonable decision-making plan for aircraft mission allocation and can effectively deal with the battlefield threats of the enemy radar network.Moreover,in terms of convergence accuracy and speed as well as algorithm stability,the improved FA algorithm is superior to the simulated annealing algorithm(SA),the niche genetic algorithm(NGA),the improved discrete cuckoo algorithm(IDCS),the mutant firefly algorithm(MFA),the cuckoo search and fireflies algorithm(CSFA),and the best neighbor firefly algorithm(BNFA).
基金supported by the Aeronautical Science Fund of China(201455960252015209619)
文摘To enhance the capacity of the radar-reconnaissance interception receiver recognizing linear frequency modulated (LFM) at a low signal-noise ratio, this paper presents WignerHough transform (WHT) of the LFM signal and its corresponding characteristics, derives the probability density functions of the LFM signal and Gaussian white noise within WHT based on entropy (WHTE), dimension under different assumptions and puts forward a WHT algorithm based on entropy of slice to improve the capacity of detecting the LFM signal. Entropy of the WHT domain slice is adopted to assess the information size of polar radius or angle slice, which is converted into the weight factor to weight every slice. Double-deck weight is used to weaken the influences of noise and disturbance terms and WHTE treatment and signal detection procedure are also summarized. The rationality of the algorithm is demonstrated through theoretical analysis and formula derivation, the efficiency of the algorithm is verified by simulation comparison between WHT, fractional Fourier transform and periodic WHT, and it is highlighted that the WHTE algorithm has better detection accuracy and range of application against strong noise background.
文摘Objective:To explore the significance of osteopontin and nuclear factorκB(NF-κB) expression in patients with knee osteoarthritis.Methods:RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin(OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures,and analyze the relationship between the expressiones of them.Results:OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group, the result showed statistical significance(P【0.05).There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P【0.05).Conclusions:The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
文摘AIM: To explore the efficacy of conbercept after switching from bevacizumab/ranibizumab in eyes of central retinal vein occlusion(CRVO) through optical coherence tomography angiography(OCTA). METHODS: Patients with prior treatment of a minimum of three consecutive intravitreal injections of either bevacizumab or ranibizumab, followed by injection of conbercept, were recruited. The minimal follow-up period after switching was 12 mo. Central retinal thickness(CRT), best-corrected visual acuity(BCVA), the interval of injections was reviewed. Perfusion density(PD) and vascular length density(VLD) of superficial and deep capillary plexus were acquired from OCTA images before and after switching. RESULTS: Twenty-four eyes were included. CRT significantly decreased from 460.71±153.23 μm(before switching) to 283.92±38.27 μm at the end of follow-up(P<0.001). However, BCVA gained to some extent(from 0.98±0.33 to 0.76±0.42 log MAR) but the difference was not significant(P=0.070). After switching to conbercept the injection interval extended from 5.2±2.3 wk to 8.3±3.9 wk(P=0.012). At the end of follow-up, PD of deep retinal layer decreased significantly compared with before switching(from 34.62%±5.27% to 33.26%±5.82%, P=0.016), similar result was found in VLD of deep retinal layer but not in PD or VLD in superficial layer.CONCLUSION: In cases of refractory macular edema secondary to CRVO, switching to conbercept improves macular thickness and extends interval of injection. Retinal microvasculature cannot improve with treatment of conbercept.
基金This work was supported by the National Natural Science Foundation of China(51773231)Shenzhen Science and Technology Project(JCYJ20190807160801664)the Project of Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province(2011A060901013).
文摘The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated chemotherapy.Briefly,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and internalization.Once internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient EDT.Simultaneously,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional chemotherapy.Consequently,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor inhibition.This intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.
文摘Aiming at the yaw problem caused by inertial navigation system errors accumulation during the navigation of an intelligent aircraft,a three-dimensional trajectory planning method based on the particle swarm optimization-A star(PSO-A*)algorithm is designed.Firstly,an environment model for aircraft error correction is established,and the trajectory is discretized to calculate the positioning error.Next,the positioning error is corrected at many preset trajectory points.The shortest trajectory and the fewest correction times are regarded as optimization goals to improve the heuristic function of A star(A*)algorithm.Finally,the index weights are continuously optimized by the particle swarm optimization algorithm.The optimal trajectory is found by the A*algorithm under the current evaluation index,so the ideal trajectory is planned.The experimental results show that the PSO-A*algorithm can quickly search for ideal trajectories in different environment models,indicating that the algorithm has certain feasibility and adaptability,and verifies the rationality of the proposed trajectory planning model.The PSO-A*algorithm has better convergence accuracy than the A*algorithm,and the search efficiency is significantly better than the grid search A star(GS-A*)algorithm.The PSO-A*algorithm proposed in this paper has certain engineering application value.The researchers will study the real-time and systematic nature of the algorithm.
