分子水平上的虚拟仿真实验之思政元素的挖掘与提炼——以“高分子的构象、形态及尺寸的模拟与计算”项目为例

高分子的构象、形态及尺寸的模拟与计算,是分子水平上的虚拟仿真实验项目,结合诺贝尔奖获得者de Gennes和P.J.Flory的理论工作、由项目组自身教研成果转化、师生合作研发而成。与小分子化合物相比,高分子的研究方法有很大的不同,特别是需要采用统计方法来描述高分子链的构象、形态,计算高分子链的平均尺寸,这是经典的物理化学方法所不能完成的。本项目从研发到教学实践、再经改进,教学内容的更新优化中,自然融入了诺贝尔奖成果、哲学思想、科学思维、学科发展史、教研成果等多个维度的思政元素。

抗N-甲基-D-天冬氨酸受体脑炎睡眠障碍研究进展

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎患者睡眠障碍表现形式多样,易误诊,机制复杂,需早期鉴别诊断与治疗。本文从抗NMDAR脑炎睡眠障碍的临床表现、电生理学特征、发病机制及治疗原则等方面进行综述,以为临床医师识别和治疗抗NMDAR脑炎睡眠障碍提供帮助。

咬合式柑橘采摘末端执行器优化设计与试验

针对柑橘自动化采摘末端执行器剪切果柄难度大的问题,设计了一种采用球形闭合进行咬合剪切果柄的柑橘采摘末端执行器。对柑橘果柄进行剪切力学特性研究,通过对果柄直径、剪切速度、果柄斜角、树叶阻挡数、刀片间隙5个因素进行剪切试验,基于最小二乘法多项式拟合建立响应面进行影响因素分析;对末端执行器进行几何建模,并以控制刀片间隙为主要约束条件,以增大拢果定位容差为优化目标建立参数优化模型,优化后拢果定位容差由9.2%~48.8%提升到26.0%~71.7%;对关键部件进行了有限元仿真,仿真得到球壳变形对刀片间隙的影响结果。最后设计柑橘采摘末端执行器样机,在柑橘果园进行实地采摘剪切性能测试,直径小于等于4 mm的果柄采摘断柄成功率达95%,满足柑橘采摘要求。

热损伤玉米种子的高光谱无损检测

玉米是世界主要粮食作物之一,使用不符合国家标准的劣质种子将严重影响玉米作物产量,如何快速准确高效鉴别劣质玉米种子亟待解决。采用高光谱图像系统获取900粒“豫安三号”玉米种子的900~1700 nm光谱曲线,其中训练集和测试集比例为3∶2,分别为540粒和360粒。利用电鼓风式烘干箱对种子损伤处理,获得不同损伤程度的玉米种子样本,采集光谱后完成发芽试验,以此判别种子活力。为提高信噪比,截取963.27~1698.75 nm范围内的玉米种子光谱波段作为有效波段;采用标准正态变换(SNV)、多元散射校正(MSC)两种预处理方式对原始光谱数据预处理,并采用连续投影算法(SPA)、竞争性自适应重加权算法(CARS)两种特征波段提取算法对预处理后的光谱数据提取特征波段,波长反射率作为输入矩阵X,预设样本类别作为输出矩阵Y;最后采用支持向量机(SVM)模型建模分析,研究结果表明:MSC-CARS-SVM模型为最佳模型,模型识别成功率为98.33%,其Kappa系数为0.985。在此基础上,采用遗传算法(GA)对SVM中惩罚系数c和核函数参数g寻优,模型准确率提升至100%,可实现对热损伤劣质玉米种子的鉴别。该研究为劣质玉米种子及其他作物种子快速鉴别提供了新思路和方法。

Interaction Mechanisms between Natural Debris Flow and Rigid Barrier Deflectors:A New Perspective for Rational Design and Optimal Arrangement

Rigid barrier deflectors can effectively prevent overspilling landslides,and can satisfy disaster prevention requirements.However,the mechanisms of interaction between natural granular flow and rigid barrier deflectors require further investigation.To date,few studies have investigated the impact of deflectors on controlling viscous debris flows for geological disaster prevention.To investigate the effect of rigid barrier deflectors on impact mechanisms,a numerical model using the smoothed particle hydrodynamics(SPH)method with the Herschel–Bulkley model is proposed to simulate the interaction between natural viscous flow and single/dual barriers with and without deflectors.This model was validated using laboratory flume test data from the literature.Then,the model was used to investigate the influence of the deflector angle and multi-barrier arrangements.The optimal configuration of multi-barriers was analyzed with consideration to the barrier height and distance between the barriers,because these metrics have a significant impact on the viscous flow pile-up,run-up,and overflow mechanisms.The investigation considered the energy dissipation process,retention efficiency,and dead-zone formation.Compared with bare barriers with similar geometric characteristics and spatial distribution,rigid barriers with deflectors exhibit superior effectiveness in preventing the overflow and overspilling of viscous debris flow.Recommendations for the rational design of deflectors and the optimal arrangement of multi-barriers are provided to mitigate geological disasters.

The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

Background:Most bone-related injuries to grassroots troops are caused by training or accidental injuries.To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone regeneration.Methods:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)matrix.The physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were analyzed.Cell and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in vivo.Results:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated electricity.Due to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 cells.The in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury model.The underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 polarization.Conclusion:The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation,angiogenesis,and osteogenesis functions may be used as a substitute in periosteum injuries,thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat efectiveness in grassroots troops.

Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway

Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling pathway.Methods:H9c2 cell viability was determined by CCK-8 and cardiomyocyte apoptosis was detected by TUNEL assay.The protein expressions of SIRT1 and p38 MAPK were measured by Western blot.RT-qPCR was also used to determine SIRT1 mRNA expression.In addition,intracellular reactive oxygen species levels and antioxidant enzyme activities were evaluated.Results:Thrombopoietin treatment reversed doxorubicin-induced decline in H9c2 cell viability.It also increased SIRT1 and decreased p-p38 MAPK protein expressions.In addition,thrombopoietin significantly attenuated doxorubicin-induced apoptosis and oxidative stress,and enhanced antioxidant enzyme activities.However,silencing SIRT1 abrogated the protective effects of thrombopoietin,as evidenced by reduced cell viability and increased oxidative stress and reactive oxygen species levels.Conclusions:Thrombopoietin alleviates doxorubicin-induced cardiomyocyte injury by reducing oxidative stress and apoptosis via the SIRT1/p38 MAPK pathway.However,its protective effects need to be further verified in animal tests.

Chromosome-level genome assembly of the glass catfish(Kryptopterus vitreolus)reveals molecular clues to its transparent phenotype

Glass catfish(Kryptopterus vitreolus)are notable in the aquarium trade for their highly transparent body pattern.This transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body,although certain black and silver pigments remain in the face and head.To date,however,the molecular mechanisms underlying this transparent phenotype remain largely unknown.To explore the genetic basis of this transparency,we constructed a chromosome-level haplotypic genome assembly for the glass catfish,encompassing 32 chromosomes and 23344 protein-coding genes,using PacBio and Hi-C sequencing technologies and standard assembly and annotation pipelines.Analysis revealed a premature stop codon in the putative albinism-related tyrp1b gene,encoding tyrosinase-related protein 1,rendering it a nonfunctional pseudogene.Notably,a synteny comparison with over 30 other fish species identified the loss of the endothelin-3(edn3b)gene in the glass catfish genome.To investigate the role of edn3b,we generated edn3b^(−/−)mutant zebrafish,which exhibited a remarkable reduction in black pigments in body surface stripes compared to wild-type zebrafish.These findings indicate that edn3b loss contributes to the transparent phenotype of the glass catfish.Our high-quality chromosome-scale genome assembly and identification of key genes provide important molecular insights into the transparent phenotype of glass catfish.These findings not only enhance our understanding of the molecular mechanisms underlying transparency in glass catfish,but also offer a valuable genetic resource for further research on pigmentation in various animal species.

Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

Magnetism, heat capacity, magnetocaloric effect, and magneto-transport properties of heavy fermion antiferromagnet CeGaSi

We synthesize high-quality single crystal of CeGaSi by a Ga self-flux method and investigate its physical properties through magnetic susceptibility,specific heat and electrical resistivity measurements as well as high pressure effect.Magnetic measurements reveal that an antiferromagnetic order develops below T_(m)~10.4 K with magnetic moments orientated in the ab plane.The enhanced electronic specific heat coefficient and the negative logarithmic slope in the resistivity of CeGaSi indicate that the title compound belongs to the family of Kondo system with heavy fermion ground states.The max magnetic entropy change-ΔS_(M)^(max)(μ_(0)H⊥c,μ_(0)H=7 T) around T_(m) is found to reach up to 11.85 J·kg^(-1)·K^(-1).Remarkably,both the antiferromagnetic transition temperature and-ln T behavior increase monotonically with pressure applied to 20 kbar(1 bar=10~5 Pa),indicating that much higher pressure will be needed to reach its quantum critical point.

Association of age at diagnosis of diabetes with subsequent risk of age-related ocular diseases and vision acuity

BACKGROUND The importance of age on the development of ocular conditions has been reported by numerous studies.Diabetes may have different associations with different stages of ocular conditions,and the duration of diabetes may affect the development of diabetic eye disease.While there is a dose-response relationship between the age at diagnosis of diabetes and the risk of cardiovascular disease and mortality,whether the age at diagnosis of diabetes is associated with incident ocular conditions remains to be explored.It is unclear which types of diabetes are more predictive of ocular conditions.AIM To examine associations between the age of diabetes diagnosis and the incidence of cataract,glaucoma,age-related macular degeneration(AMD),and vision acuity.METHODS Our analysis was using the UK Biobank.The cohort included 8709 diabetic participants and 17418 controls for ocular condition analysis,and 6689 diabetic participants and 13378 controls for vision analysis.Ocular diseases were identified using inpatient records until January 2021.Vision acuity was assessed using a chart.RESULTS During a median follow-up of 11.0 years,3874,665,and 616 new cases of cataract,glaucoma,and AMD,respectively,were identified.A stronger association between diabetes and incident ocular conditions was observed where diabetes was diagnosed at a younger age.Individuals with type 2 diabetes(T2D)diagnosed at<45 years[HR(95%CI):2.71(1.49-4.93)],45-49 years[2.57(1.17-5.65)],50-54 years[1.85(1.13-3.04)],or 50-59 years of age[1.53(1.00-2.34)]had a higher risk of AMD independent of glycated haemoglobin.T2D diagnosed<45 years[HR(95%CI):2.18(1.71-2.79)],45-49 years[1.54(1.19-2.01)],50-54 years[1.60(1.31-1.96)],or 55-59 years of age[1.21(1.02-1.43)]was associated with an increased cataract risk.T2D diagnosed<45 years of age only was associated with an increased risk of glaucoma[HR(95%CI):1.76(1.00-3.12)].HRs(95%CIs)for AMD,cataract,and glaucoma associated with type 1 diabetes(T1D)were 4.12(1.99-8.53),2.95(2.17-4.02),and 2.40(1.09-5.31),respectively.In multivariable-adjusted analysis,individuals with T2D diagnosed<45 years of age[β95%CI:0.025(0.009,0.040)]had a larger increase in LogMAR.Theβ(95%CI)for LogMAR associated with T1D was 0.044(0.014,0.073).CONCLUSION The younger age at the diagnosis of diabetes is associated with a larger relative risk of incident ocular diseases and greater vision loss.

Diagnostic value of tissue plasminogen activator-inhibitor complex in sepsis-induced liver injury:A single-center retrospective casecontrol study

BACKGROUND Sepsis often causes severe liver injury and leads to poor patient outcomes.Early detection of sepsis-induced liver injury(SILI)and early treatment are key to improving outcomes.AIM To investigate the clinical characteristics of SILI patients and analyze the associated risk factors,to identify potential sensitive biomarkers.METHODS Retrospective analysis of clinical data from 546 patients with sepsis treated in the intensive care unit of the 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force between May 2018 and December 2022.The patients were divided into the sepsis group(n=373)and SILI group(n=173)based on the presence of acute liver injury within 2 hours of admission.We used the random forest algorithm to analyze risk factors and assessed potential diagnostic markers of SILI using the area under the receiver operating characteristic curve,Kaplan-Meier survival curves,subgroup analysis and correlation analysis.RESULTS Compared with the sepsis group,tissue plasminogen activator-inhibitor complex(t-PAIC)levels in serum were significantly higher in the SILI group(P<0.05).Random forest results showed that t-PAIC was an independent risk factor for SILI,with an area under the receiver operating characteristic curve of 0.862(95%confidence interval:0.832-0.892).Based on the optimal cut-off value of 11.9 ng/mL,patients at or above this threshold had significantly higher levels of lactate and Acute Physiology and Chronic Health Evaluation II score.The survival rate of these patients was also significantly worse(hazard ratio=2.2,95%confidence interval:1.584-3.119,P<0.001).Spearman’s correlation coefficients were 0.42 between t-PAIC and lactate,and 0.41 between t-PAIC and aspartate transaminase.Subgroup analysis showed significant differences in t-PAIC levels between patients with different severity of liver dysfunction.CONCLUSION T-PAIC can serve as a diagnostic indicator for SILI,with its elevation correlated with the severity of SILI.

Peritoneal fluid indocyanine green test for diagnosis of gut leakage in anastomotic leakage rats and colorectal surgery patients

BACKGROUND Application of indocyanine green(ICG)fluorescence has led to new developments in gastrointestinal surgery.However,little is known about the use of ICG for the diagnosis of postoperative gut leakage(GL).In addition,there is a lack of rapid and intuitive methods to definitively diagnose postoperative GL.AIM To investigate the effect of ICG in the diagnosis of anastomotic leakage in a surgical rat GL model and evaluate its diagnostic value in colorectal surgery patients.METHODS Sixteen rats were divided into two groups:GL group(n=8)and sham group(n=8).Approximately 0.5 mL of ICG(2.5 mg/mL)was intravenously injected postoperatively.The peritoneal fluid was collected for the fluorescence test at 24 and 48 h.Six patients with rectal cancer who had undergone laparoscopic rectal cancer resection plus enterostomies were injected with 10 mL of ICG(2.5 mg/mL)on postoperative day 1.Their ostomy fluids were collected 24 h after ICG injection to identify the possibility of the ICG excreting from the peripheral veins to the enterostomy stoma.Participants who had undergone colectomy or rectal cancer resection were enrolled in the diagnostic test.The peritoneal fluids from drainage were collected 24 h after ICG injection.The ICG fluorescence test was conducted using OptoMedic endoscopy along with a near-infrared fluorescent imaging system.RESULTS The peritoneal fluids from the GL group showed ICG-dependent green fluorescence in contrast to the sham group.Six samples of ostomy fluids showed green fluorescence,indicating the possibility of ICG excreting from the peripheral veins to the enterostomy stoma in patients.The peritoneal fluid ICG test exhibited a sensitivity of 100%and a specificity of 83.3%for the diagnosis of GL.The positive predictive value was 71.4%,while the negative predictive value was 100%.The likelihood ratios were 6.0 for a positive test result and 0 for a negative result.CONCLUSION The postoperative ICG test in a drainage tube is a valuable and simple technique for the diagnosis of GL.Hence,it should be employed in clinical settings in patients with suspected GL.

Construction of Molecular Biology and Experiment Case Library for Graduate Students

Molecular Biology and Experiment is considered fundamental for graduate students specializing in aquaculture at Guangdong Ocean University.This discipline focuses on the examination of the structure and function of macromolecules,including proteins and nucleic acids.Moreover,it elucidates biological phenomena and principles at the molecular level,making it an essential foundational course for students pursuing various biology majors.As a foundational course for the basic application of aquaculture,Molecular Biology and Experiment requires guidance through numerous examples and cases.However,there are several challenges to address in developing the case library.Consequently,a case library has been established to meet the course requirements of Molecular Biology and Experiment for modern graduate students,with the central goal of reforming the educational model of higher education institutions and enhancing the effectiveness and quality of talent development.This strategy is designed to nurture highly skilled professionals who can address the current needs of the industry.

Research on Sports Public Service Supply in the Chengdu-Chongqing Twin-City Economic Circle under the Background of Regional Economic Development

Using literature,questionnaires,interviews,and mathematical statistics to investigate the current situation of sports public services in the Chengdu-Chongqing Twin-city Economic Circle.The results show that there are some problems in Chengdu-Chongqing sports public services,such as big difference in the development level of supply between urban and rural areas,low supply level,low efficiency,supply mechanism defect,lack of social sports instructors,an outstanding contradiction between the quality of sports public service and residents’demand.To address the problems,government departments should accelerate the transformation of government functions,improve the relevant regulations and systems,increase the investment in sports public services,improve the quality of supply,cultivate the backbone team,integrate resources,and combine the national characteristics with regional characteristics,take into account the personalized needs of the residents,combine the sports public services with intelligence,and build the service system of“Internet+Fitness.”

Discussion on the Application of Technical and Tactical Skills in Mixed Martial Arts Competitions

This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of technical and tactical skills in mixed martial arts competitions,and its primary application strategies.It is hoped that this analysis can provide some guidelines for the appropriate application of mixed martial arts athletes’technical and tactical skills to improve their winning rate in mixed martial arts competitions.

Strategies for Boxing Teaching in Competitive Sports Schools

To improve the quality of boxing teaching in competitive sports schools,it is necessary to first analyze the strengths and weaknesses of boxing teaching in competitive sports schools,and then optimize the teaching strategy.The strategies include innovating the boxing curriculum system and content,building learning communities inside and outside the classroom,personalizing the teaching forms and methods,using multimedia to broaden the teaching path,focusing on the integration of boxing teaching leagues,and diversifying the teaching incentives and evaluations.

Current Research Status of Traditional Chinese Medicine External Treatment for Diarrhea Type Irritable Bowel Syndrome

Irritable bowel syndrome(IBS-D)with diarrhea is a common gastrointestinal functional disease in clinical practice,which seriously affects the quality of life of patients.Cur‐rently,Western medicine has poor therapeutic effects,while traditional Chinese medi‐cine has unique advantages in relieving IBS-D symptoms and preventing recurrence.In recent years,especially with external treatment of traditional Chinese medicine,it has become a new treatment direction in clinical practice and has achieved good therapeutic effects.This article will provide a review of recent research on the treatment of IBS-D using traditional Chinese medicine external treatment methods.

花胶品质改良研究进展

花胶是我国传统海产美食,属“四大海味”之一,近代列入“八珍”,具有很高的营养和药用价值。目前,花胶以传统的家庭或酒店烹饪预制菜为主,其加工产品较少,存在产品深加工程度低、原料综合利用差、废弃物造成环境污染等问题。花胶工业化加工产品形式尚处于初级阶段,影响花胶加工产品深度开发的瓶颈问题尚未有相关研究报道。本文主要介绍了花胶的基本营养成分、花胶制品的主要产品形式、影响花胶品质的主要因素以及相关改良措施。主要包括:花胶产品的脱腥技术、凝胶特性和加工过程中热稳定性。本文从理论和实践技术方面对花胶品质的改良措施进行了深入探讨和概述,比较了各种方法的利弊,提出未来的发展方向,以期为今后开发出品质更加优良的花胶产品提供一定的理论支撑和研究思路。

强脉冲光联合睑板腺按摩治疗MGD相关性干眼疗效的Meta分析

目的:评价强脉冲光(IPL)联合睑板腺按摩(MGX)治疗睑板腺功能障碍(MGD)相关性干眼(DED)的有效性。方法:检索中国期刊全文数据库(CNKI)、万方数据库、维普中文期刊数据库(VIP)、中国生物医学文献数据库(CBM)、ClinicalTrials、PubMed、Embase、Web of Science数据库,纳入2017-01/2022-09试验组采用IPL联合MGX,对照组单纯运用MGX治疗MGD相关性干眼的临床随机对照试验研究(RCTs)。采用Review Manager 5.3和Stata 14软件对临床疗效、眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)评分、泪河高度(TMH)以及睑板腺分泌物性质评分(MGYSS)6个结局指标进行Meta分析。结果:最终纳入15篇RCTs,MGD相关性干眼患者1345例。Meta分析结果表明,与对照组相比,试验组治疗MGD相关性干眼可更好的提高临床疗效(OR=4.95,95%CI:2.76~8.90,Z=5.35,P<0.00001)、BUT(SMD=1.26,95%CI:0.84~1.69,Z=5.78,P<0.00001)、TMH(SMD=0.37,95%CI:0.15~0.59,Z=3.33,P=0.0009),降低OSDI评分(SMD=-0.86,95%CI:-1.44~-0.27,Z=2.85,P=0.004)以及MGYSS(SMD=-2.43,95%CI:-4.31~-0.54,Z=2.52,P=0.01)。但在CFS评分差异无统计学意义(SMD=-0.19,95%CI:-0.46~0.07,Z=1.43,P=0.15)。结论:IPL联合MGX治疗MGD相关性干眼与单纯运用MGX治疗相比,能提高总体有效率,更好地改善MGD相关性干眼患者的症状和体征。