Both sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)are considered as promising candidates in grid-level energy storage devices.Unfortunately,the larger ionic radii of K+and Na+induce poor diffusion kineti...Both sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)are considered as promising candidates in grid-level energy storage devices.Unfortunately,the larger ionic radii of K+and Na+induce poor diffusion kinetics and cycling stability of carbon anode materials.Pore structure regulation is an ideal strategy to promote the diffusion kinetics and cyclic stability of carbon materials by facilitating electrolyte infiltration,increasing the transport channels,and alleviating the volume change.However,traditional pore-forming agent-assisted methods considerably increase the difficulty of synthesis and limit practical applications of porous carbon materials.Herein,porous carbon materials(Ca-PC/Na-PC/K-PC)with different pore structures have been prepared with gluconates as the precursors,and the amorphous structure,abundant micropores,and oxygen-doping active sites endow the Ca-PC anode with excellent potassium and sodium storage performance.For PIBs,the capacitive contribution ratio of Ca-PC is 82%at 5.0 mV s^(-1) due to the introduction of micropores and high oxygen-doping content,while a high reversible capacity of 121.4 mAh g^(-1) can be reached at 5 A g^(-1) after 2000 cycles.For SIBs,stable sodium storage capacity of 101.4 mAh g^(-1) can be achieved at 2 A g^(-1) after 8000 cycles with a very low decay rate of 0.65%for per cycle.This work may provide an avenue for the application of porous carbon materials in the energy storage field.展开更多
Flocculation flotation is the most efficient method for recovering fine-grained minerals,and its essence lies in flotation and recovery of flocs.Fundamental physical characteristics of flocs are mainly determined by t...Flocculation flotation is the most efficient method for recovering fine-grained minerals,and its essence lies in flotation and recovery of flocs.Fundamental physical characteristics of flocs are mainly determined by their apparent particle size and structure(density and morphology).Substantial researches have been conducted regarding the effect of floc characteristics on particle settling and water treatment.However,the influence of floc characteristics on flotation has not been widely studied.Based on the floc formation and flocculation flotation,this study reviews the fundamental physical characteristics of flocs from the perspectives of floc particle size and structure,summarizing the interaction between floc particle size and structure.Moreover,it thoroughly discusses the effect of floc particle size and structure on floc floatability,further revealing the influence of floc characteristics on bubble collision and adhesion and elucidating the mechanisms of interaction between flocs and bubbles.Thus,it is observed that floc particle size is not the only factor influencing flocculation flotation.Within the appropriate apparent particle size range,flocs with a compact structure exhibit higher efficiency in bubble collision and adhesion during flotation,thereby resulting in enhanced flotation performance.This study aims to provide a reference for flocculation flotation,targeting the development of more efficient and refined flocculation flotation processes in the future.展开更多
An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed yet.Here,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation mechanism.The abundant s...An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed yet.Here,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation mechanism.The abundant surface nickel and cobalt components as active sites led to strong Ni-Co interaction with charge transfer from nickel to cobalt.Notably,electron-enriched Coδ-species participated in efficient chemisorption and activation of CO_(2)to generate monodentate carbonate.Simultaneously,plentiful available Ni0sites facilitated H2dissociation,thus CO_(2)and H2were smoothly activated at zones of Coδ-species and Ni0,respectively.Detailed in situ DRIFTS,quasi situ XPS,TPSR,and DFT calculations substantiated a new formate evolution mechanism via monodentate carbonate instead of traditional bidentate carbonate based on synergistic catalysis of Coδ-species and Ni0.The zonal activation of CO_(2)and H2by tuning electron behaviors of double-center catalysts can boost heterogeneous catalytic hydrogenation performance.展开更多
A dandelion algorithm(DA) is a recently developed intelligent optimization algorithm for function optimization problems. Many of its parameters need to be set by experience in DA,which might not be appropriate for all...A dandelion algorithm(DA) is a recently developed intelligent optimization algorithm for function optimization problems. Many of its parameters need to be set by experience in DA,which might not be appropriate for all optimization problems. A self-adapting and efficient dandelion algorithm is proposed in this work to lower the number of DA's parameters and simplify DA's structure. Only the normal sowing operator is retained;while the other operators are discarded. An adaptive seeding radius strategy is designed for the core dandelion. The results show that the proposed algorithm achieves better performance on the standard test functions with less time consumption than its competitive peers. In addition, the proposed algorithm is applied to feature selection for credit card fraud detection(CCFD), and the results indicate that it can obtain higher classification and detection performance than the-state-of-the-art methods.展开更多
Glass is the precious material evidence of the trade of the early Silk Road. The ancient glass was easily affected by the environmental impact and weathering, and the change of composition ratios affected the correct ...Glass is the precious material evidence of the trade of the early Silk Road. The ancient glass was easily affected by the environmental impact and weathering, and the change of composition ratios affected the correct judgment of its category. In this paper, mathematical models and methods such as Chi-square test, weighted average method, principal component analysis, cluster analysis, binary classification model and grey correlation analysis were used comprehensively to analyze the data of sample glass products combined with their categories. The results showed that the weathered high-potassium glass could be divided into 12, 9, 10 and 27, 7, 22 and so on.展开更多
Friction plays a critical role in dexterous robotic manipulation.However,realizing friction sensing remains a challenge due to the difficulty in designing sensing structures to decouple multi-axial forces.Inspired by ...Friction plays a critical role in dexterous robotic manipulation.However,realizing friction sensing remains a challenge due to the difficulty in designing sensing structures to decouple multi-axial forces.Inspired by the topological mechanics of knots,we construct optical fiber knot(OFN)sensors for slip detection and friction measurement.By introducing localized self-contacts along the fiber,the knot structure enables anisotropic responses to normal and frictional forces.By employing OFNs and a change point detection algorithm,we demonstrate adaptive robotic grasping of slipping cups.We further develop a robotic finger that can measure tri-axial forces via a centrosymmetric architecture composed of five OFNs.Such a tactile finger allows a robotic hand to manipulate human tools dexterously.This work could provide a straightforward and cost-effective strategy for promoting adaptive grasping,dexterous manipulation,and human-robot interaction with tactile sensing.展开更多
BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions...BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated.Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment.Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n=110)were retrospectively analyzed.These patients were divided into three groups:Basic treatment+oral glucosamine(group A,n=37),oral celecoxib+basic treatment+oral glucosamine(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores and patient satisfaction before and after treatment.The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5±2.7 mo.The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment.Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment.VAS and HSS scores were significantly improved in each group compared with before(P<0.001).There were significant differences among the three groups in VAS and HSS scores(P<0.001).The clinical efficacy of group C was superior to that of groups A and B(P<0.001),while group B outperformed group A in this respect(P<0.001).The patient satisfaction was the highest in group C(P<0.001).After treatment,the levels of tumor necrosis factorα(TNF-α)and interleukin(IL)-6 in the synovial fluid decreased in each group compared with before(P<0.001),while the levels of IL-10 increased(P<0.001).The three groups differed significantly in the levels of TNF-a,IL-6 and IL-10 in the synovial fluid after treatment(P<0.001).CONCLUSION For patients with early knee osteoarthritis,intra-articular injection of parecoxib could effectively improve clinical symptoms.This method may be a reliable alternative for early knee osteoarthritis.展开更多
Guided bone regeneration(GBR)is an effective and simple method for bone augmentation,which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant area.Titanium mesh has expanded the...Guided bone regeneration(GBR)is an effective and simple method for bone augmentation,which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant area.Titanium mesh has expanded the indications of GBR technology due to its excellent mechanical properties and biocompatibility,so that the GBR technology can be used to repair alveolar ridges with larger bone defects,and can obtain excellent and stable bone augmentation results.Currently,GBR with titanium mesh has various clinical applications,including different clinical procedures.Bone graft materials,titanium mesh covering methods,and titanium mesh fixing methods are also optional.Moreover,the research of GBR with titanium mesh has led to multifarious progresses in digitalization and material modification.This article reviews the properties of titanium mesh and the difference of titanium mesh with other barrier membranes;the current clinical application of titanium mesh in bone augmentation;common complications and management and prevention methods in the application of titanium mesh;and research progress of titanium mesh in digitization and material modification.Hoping to provide a reference for further improvement of titanium mesh in clinical application and related research of titanium mesh.展开更多
Guided bone regeneration(GBR)uses resorbable and non-resorbable membranes as biological barriers.This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and ...Guided bone regeneration(GBR)uses resorbable and non-resorbable membranes as biological barriers.This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement.A total of 40 patients(65 implant sites)were enrolled and divided into two groups:resorbable membrane and digital titanium mesh groups.The alveolar bone was analyzed at two-and three-dimensional levels using conebeam computed tomography and by reconstructing and superimposing the hard tissues at four time points:preoperatively,postoperatively,before second-stage surgery,and 1 year after loading.The use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after loading.Regarding volumetric stability,the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%.However,it was only 23.4%with titanium mesh.Although postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh,after substantial bone resorption within 1 year of loading,the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium mesh.Furthermore,digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation,and the exposure rate was only 10%.Therefore,although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect,digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.展开更多
Functional materials with high viscosity and solid materials have received more and more attentions in flexible pressure sensors,which are inadequate in the most used molding method.Herein,laser direct writing(LDW)met...Functional materials with high viscosity and solid materials have received more and more attentions in flexible pressure sensors,which are inadequate in the most used molding method.Herein,laser direct writing(LDW)method is proposed to fabricate flexible piezoresistive sensors with microstructures on PDMS/MWCNTs composites with an 8%MWCNTs mass fraction.By controlling laser energy,microstructures with different geometries can be obtained,which significantly impacts the performances of the sensors.Subsequently,curved microcones with excellent performance are fabricated under parameters of f=40 kHz and v=150 mm·s^(-1).The sensor exhibits continuous multi-linear sensitivity,ultrahigh original sensitivity of 21.80%kPa^(-1),wide detection range of over 20 kPa,response/recovery time of~100 ms and good cycle stability for more than 1000 times.Besides,obvious resistance variation can be observed when tiny pressure(a peanut of 30 Pa)is applied.Finally,the flexible piezoresistive sensor can be applied for LED brightness controlling,pulse detection and voice recognition.展开更多
BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancrea...BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.展开更多
基金supported by the Natural Science Foundation of Hunan Province,China(No.2021JJ30672)the Science and Technology Project of Education Department of Hunan Province,China(No.22A0100)+1 种基金the National Natural Science Foundation of China(No.51627802)Xiangtan University Scientific Research Start-up Fund。
基金The authors are grateful for the financial support provided by the National Natural Science Foundation of China(52362010,52304326,22305055,and 52274297)the Start-up Research Foundation of Hainan University(KYQD(ZR)-23069,20008,23067,and 23073)the specific research fund of the Innovation Platform for Academicians of Hainan Province(YSPTZX202315).
文摘Both sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs)are considered as promising candidates in grid-level energy storage devices.Unfortunately,the larger ionic radii of K+and Na+induce poor diffusion kinetics and cycling stability of carbon anode materials.Pore structure regulation is an ideal strategy to promote the diffusion kinetics and cyclic stability of carbon materials by facilitating electrolyte infiltration,increasing the transport channels,and alleviating the volume change.However,traditional pore-forming agent-assisted methods considerably increase the difficulty of synthesis and limit practical applications of porous carbon materials.Herein,porous carbon materials(Ca-PC/Na-PC/K-PC)with different pore structures have been prepared with gluconates as the precursors,and the amorphous structure,abundant micropores,and oxygen-doping active sites endow the Ca-PC anode with excellent potassium and sodium storage performance.For PIBs,the capacitive contribution ratio of Ca-PC is 82%at 5.0 mV s^(-1) due to the introduction of micropores and high oxygen-doping content,while a high reversible capacity of 121.4 mAh g^(-1) can be reached at 5 A g^(-1) after 2000 cycles.For SIBs,stable sodium storage capacity of 101.4 mAh g^(-1) can be achieved at 2 A g^(-1) after 8000 cycles with a very low decay rate of 0.65%for per cycle.This work may provide an avenue for the application of porous carbon materials in the energy storage field.
基金financially supported by the National Natural Science Foundation of China(Nos.52174239 and 52204284)。
文摘Flocculation flotation is the most efficient method for recovering fine-grained minerals,and its essence lies in flotation and recovery of flocs.Fundamental physical characteristics of flocs are mainly determined by their apparent particle size and structure(density and morphology).Substantial researches have been conducted regarding the effect of floc characteristics on particle settling and water treatment.However,the influence of floc characteristics on flotation has not been widely studied.Based on the floc formation and flocculation flotation,this study reviews the fundamental physical characteristics of flocs from the perspectives of floc particle size and structure,summarizing the interaction between floc particle size and structure.Moreover,it thoroughly discusses the effect of floc particle size and structure on floc floatability,further revealing the influence of floc characteristics on bubble collision and adhesion and elucidating the mechanisms of interaction between flocs and bubbles.Thus,it is observed that floc particle size is not the only factor influencing flocculation flotation.Within the appropriate apparent particle size range,flocs with a compact structure exhibit higher efficiency in bubble collision and adhesion during flotation,thereby resulting in enhanced flotation performance.This study aims to provide a reference for flocculation flotation,targeting the development of more efficient and refined flocculation flotation processes in the future.
基金funded by the Science and Technology Project of Southwest United Graduate School of Yunnan Province(No.202302AQ370002)the National Natural Science Foundation of China(No.22206066)。
文摘An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed yet.Here,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation mechanism.The abundant surface nickel and cobalt components as active sites led to strong Ni-Co interaction with charge transfer from nickel to cobalt.Notably,electron-enriched Coδ-species participated in efficient chemisorption and activation of CO_(2)to generate monodentate carbonate.Simultaneously,plentiful available Ni0sites facilitated H2dissociation,thus CO_(2)and H2were smoothly activated at zones of Coδ-species and Ni0,respectively.Detailed in situ DRIFTS,quasi situ XPS,TPSR,and DFT calculations substantiated a new formate evolution mechanism via monodentate carbonate instead of traditional bidentate carbonate based on synergistic catalysis of Coδ-species and Ni0.The zonal activation of CO_(2)and H2by tuning electron behaviors of double-center catalysts can boost heterogeneous catalytic hydrogenation performance.
基金supported by the Institutional Fund Projects(IFPIP-1481-611-1443)the Key Projects of Natural Science Research in Anhui Higher Education Institutions(2022AH051909)+1 种基金the Provincial Quality Project of Colleges and Universities in Anhui Province(2022sdxx020,2022xqhz044)Bengbu University 2021 High-Level Scientific Research and Cultivation Project(2021pyxm04)。
文摘A dandelion algorithm(DA) is a recently developed intelligent optimization algorithm for function optimization problems. Many of its parameters need to be set by experience in DA,which might not be appropriate for all optimization problems. A self-adapting and efficient dandelion algorithm is proposed in this work to lower the number of DA's parameters and simplify DA's structure. Only the normal sowing operator is retained;while the other operators are discarded. An adaptive seeding radius strategy is designed for the core dandelion. The results show that the proposed algorithm achieves better performance on the standard test functions with less time consumption than its competitive peers. In addition, the proposed algorithm is applied to feature selection for credit card fraud detection(CCFD), and the results indicate that it can obtain higher classification and detection performance than the-state-of-the-art methods.
文摘Glass is the precious material evidence of the trade of the early Silk Road. The ancient glass was easily affected by the environmental impact and weathering, and the change of composition ratios affected the correct judgment of its category. In this paper, mathematical models and methods such as Chi-square test, weighted average method, principal component analysis, cluster analysis, binary classification model and grey correlation analysis were used comprehensively to analyze the data of sample glass products combined with their categories. The results showed that the weathered high-potassium glass could be divided into 12, 9, 10 and 27, 7, 22 and so on.
基金grateful for financial supports from National Natural Science Foundation of China(61975173)China Postdoctoral Science Foundation(2022M722907,2022M722909)+2 种基金Zhejiang Provincial Natural Science Foundation of China(LQ23F010015)Key Research and Development Project of Zhejiang Province(2021C05003)Major Scientific Research Project of Zhejiang Lab(2019MC0AD01).
文摘Friction plays a critical role in dexterous robotic manipulation.However,realizing friction sensing remains a challenge due to the difficulty in designing sensing structures to decouple multi-axial forces.Inspired by the topological mechanics of knots,we construct optical fiber knot(OFN)sensors for slip detection and friction measurement.By introducing localized self-contacts along the fiber,the knot structure enables anisotropic responses to normal and frictional forces.By employing OFNs and a change point detection algorithm,we demonstrate adaptive robotic grasping of slipping cups.We further develop a robotic finger that can measure tri-axial forces via a centrosymmetric architecture composed of five OFNs.Such a tactile finger allows a robotic hand to manipulate human tools dexterously.This work could provide a straightforward and cost-effective strategy for promoting adaptive grasping,dexterous manipulation,and human-robot interaction with tactile sensing.
基金National Natural Science Foundation of China,NO.81774274Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine,NO.Y19058
文摘BACKGROUND Non-steroid anti-inflammatory drugs(NSAIDs)have played a crucial role in the treatment of osteoarthritis,especially in the early stages.However,the cardiovascular risk and adverse gastrointestinal reactions of oral NSAIDs in elderly people cannot be underestimated.Intra-articular injection of NSAIDs may be a new attempt for early knee osteoarthritis treatment.Parecoxib may be a suitable drug for intra-articular injection.AIM To observe the clinical efficacy of the intra-articular injection of parecoxib for early knee osteoarthritis.METHODS Early knee osteoarthritis patients(n=110)were retrospectively analyzed.These patients were divided into three groups:Basic treatment+oral glucosamine(group A,n=37),oral celecoxib+basic treatment+oral glucosamine(group B,n=37),and intra-articular injection of parecoxib+basic treatment+oral glucosamine(group C,n=36).Intra-articular injection of parecoxib was performed once every 2 wk at a dose of 40 mg each time,for three times total.The three groups were compared in terms of visual analogue scale(VAS)scores,Hospital for Special Surgery(HSS)scores and patient satisfaction before and after treatment.The levels of inflammatory cytokines in the synovial fluid were detected in the three groups before and after treatment.RESULTS All patients were followed up for an average of 15.5±2.7 mo.The clinical efficacy was estimated by VAS and HSS scores at 12 mo after treatment.Inflammatory cytokine levels in the synovial fluid were evaluated at 3 mo after treatment.VAS and HSS scores were significantly improved in each group compared with before(P<0.001).There were significant differences among the three groups in VAS and HSS scores(P<0.001).The clinical efficacy of group C was superior to that of groups A and B(P<0.001),while group B outperformed group A in this respect(P<0.001).The patient satisfaction was the highest in group C(P<0.001).After treatment,the levels of tumor necrosis factorα(TNF-α)and interleukin(IL)-6 in the synovial fluid decreased in each group compared with before(P<0.001),while the levels of IL-10 increased(P<0.001).The three groups differed significantly in the levels of TNF-a,IL-6 and IL-10 in the synovial fluid after treatment(P<0.001).CONCLUSION For patients with early knee osteoarthritis,intra-articular injection of parecoxib could effectively improve clinical symptoms.This method may be a reliable alternative for early knee osteoarthritis.
基金This study was supported by National Natural Science Foundation of China(Grant Nos.81970986,81771125,X.C.and 11872135,12072055 C.W.)。
文摘Guided bone regeneration(GBR)is an effective and simple method for bone augmentation,which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant area.Titanium mesh has expanded the indications of GBR technology due to its excellent mechanical properties and biocompatibility,so that the GBR technology can be used to repair alveolar ridges with larger bone defects,and can obtain excellent and stable bone augmentation results.Currently,GBR with titanium mesh has various clinical applications,including different clinical procedures.Bone graft materials,titanium mesh covering methods,and titanium mesh fixing methods are also optional.Moreover,the research of GBR with titanium mesh has led to multifarious progresses in digitalization and material modification.This article reviews the properties of titanium mesh and the difference of titanium mesh with other barrier membranes;the current clinical application of titanium mesh in bone augmentation;common complications and management and prevention methods in the application of titanium mesh;and research progress of titanium mesh in digitization and material modification.Hoping to provide a reference for further improvement of titanium mesh in clinical application and related research of titanium mesh.
基金This study was supported by National Key R&D Program of China(2019YFA0110600)National Natural Science Foundation of China(81970986,81771125)Exploration and R&D Project of West China Hospital of Stomatology(LCYJ2020-DC-1).
文摘Guided bone regeneration(GBR)uses resorbable and non-resorbable membranes as biological barriers.This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement.A total of 40 patients(65 implant sites)were enrolled and divided into two groups:resorbable membrane and digital titanium mesh groups.The alveolar bone was analyzed at two-and three-dimensional levels using conebeam computed tomography and by reconstructing and superimposing the hard tissues at four time points:preoperatively,postoperatively,before second-stage surgery,and 1 year after loading.The use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after loading.Regarding volumetric stability,the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%.However,it was only 23.4%with titanium mesh.Although postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh,after substantial bone resorption within 1 year of loading,the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium mesh.Furthermore,digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation,and the exposure rate was only 10%.Therefore,although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect,digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.
基金supported by the National Natural Science Foundation of China(No.51922092,No.51705439)Domain Foundation of Equipment Advance Research of 13th Five-year Plan(JZX7Y20190243000801)+1 种基金the Natural Science Foundation of Fujian Province of China(No.2017J06015)Science and Technology Plan Project of Xiamen City(No.3502Z20173024).
文摘Functional materials with high viscosity and solid materials have received more and more attentions in flexible pressure sensors,which are inadequate in the most used molding method.Herein,laser direct writing(LDW)method is proposed to fabricate flexible piezoresistive sensors with microstructures on PDMS/MWCNTs composites with an 8%MWCNTs mass fraction.By controlling laser energy,microstructures with different geometries can be obtained,which significantly impacts the performances of the sensors.Subsequently,curved microcones with excellent performance are fabricated under parameters of f=40 kHz and v=150 mm·s^(-1).The sensor exhibits continuous multi-linear sensitivity,ultrahigh original sensitivity of 21.80%kPa^(-1),wide detection range of over 20 kPa,response/recovery time of~100 ms and good cycle stability for more than 1000 times.Besides,obvious resistance variation can be observed when tiny pressure(a peanut of 30 Pa)is applied.Finally,the flexible piezoresistive sensor can be applied for LED brightness controlling,pulse detection and voice recognition.
基金supported by grants from the National Natural Science Foundation of China(81071775,81272659,81101621,81160311,81172064,81001068,81272425 and 81101870)National“Eleventh Five-Year”Scientific and Technological Support Projects(2006BAI02A13-402)+1 种基金Key Projects of Science Foundation of Hubei Province(2011CDA030)Research Fund of Young Scholars for the Doctoral Program of Higher Education of China(20110142120014)
文摘BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.
