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Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator 被引量:1
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作者 Yang Zhang Sheng-Quan Yan +36 位作者 Ming He Qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning Li Xiao-Fei Wang Jian-Cheng Liu Zhao-Hua Peng Zhuo Liang Ai-Ling Li Jian Zheng Qi-Wen Fan Yun-Ju Li You-Bao Wang Zhi-Hong Li Yang-Ping Shen Ding Nan Wei Nan Yu-Qiang Zhang Jia-Ying-Hao Li Jun-Wen Tian jiang-Lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao Zhu Yu-Wen Chen yu-chen jiang Tao Tian Jin-Long Ma Yi-Hui Liu Jing-Yu Dong Run-Long Liu Mei-Yue-Nan Ma Yong-Shou Chen Wei-Ping Liu Bing Guo 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第4期136-143,共8页
The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae.Lunar samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides... The Moon provides a unique environment for investigating nearby astrophysical events such as supernovae.Lunar samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)Fe.In this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy degrader.For particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the spectrograph.Finally,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS system.These results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)Ni.The sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated. 展开更多
关键词 Accelerator mass spectrometry Wien filter Isobar separation SUPERNOVAE Chang'e-5 lunar samples
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New strategies against drug resistance to herpes simplex virus 被引量:16
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作者 yu-chen jiang Hui Feng +1 位作者 Yu-Chun Lin Xiu-Rong Guo 《International Journal of Oral Science》 SCIE CAS CSCD 2016年第1期1-6,共6页
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleos... Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV. 展开更多
关键词 new strategies drug resistance herpes simplex virus Janus-type nucleoside analogues lethal mutagenesis
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Recent progress in nuclear astrophysics research and its astrophysical implications at the China Institute of Atomic Energy
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作者 Wei-Ping Liu Bing Guo +28 位作者 Zhu An Bao-Qun Cui Xiao Fang Chang-Bo Fu Bin-Shui Gao Jian-Jun He yu-chen jiang Chong Lv Er-Tao Li Ge-Xing Li Yun-Ju Li Zhi-Hong Li Gang Lian Wei-Ping Lin Yi-Hui Liu Wei Nan Wei-Ke Nan Yang-Ping Shen Na Song Jun Su Liang-Ting Sun Xiao-Dong Tang Luo-Huan Wang Shuo Wang You-Bao Wang Di Wu Xiao-Feng Xi Sheng-Quan Yan Li-Yong Zhang 《Nuclear Science and Techniques》 SCIE EI CAS 2024年第12期376-408,共33页
Nuclear astrophysics is a rapidly developing interdisciplinary feld of research that has received extensive attention from the scientifc community since the midtwentieth century.Broadly,it uses the laws of extremely s... Nuclear astrophysics is a rapidly developing interdisciplinary feld of research that has received extensive attention from the scientifc community since the midtwentieth century.Broadly,it uses the laws of extremely small atomic nuclei to explain the evolution of the universe.Owing to the complexity of nucleosynthesis processes and our limited understanding of nuclear physics in astrophysical environments,several critical astrophysical problems remain unsolved.To achieve a better understanding of astrophysics,it is necessary to measure the cross sections of key nuclear reactions with the precision required by astrophysical models.Direct measurement of nuclear reaction cross sections is an important method of investigating how nuclear reactions infuence stellar evolution.Given the challenges involved in measuring the extremely low crosssections of nuclear reactions in the Gamow peak and preparing radioactive targets,indirect methods,such as the transfer reaction,coulomb dissociation,and surrogate ratio methods,have been developed over the past several decades.These are powerful tools in the investigation of,for example,neutron-capture(n,r)reactions with short-lived radioactive isotopes.However,direct measurement is still preferable,such as in the case of reactions involving light and stable nuclei.As an essential part of stellar evolution,these low-energy stable nuclear reactions have been of particular interest in recent years.To overcome the diffculties in measurements near or deeply within the Gamow window,the combination of an underground laboratory and high-exposure accelerator/detector complex is currently the optimal solution.Therefore,underground experiments have emerged as a new and promising direction of research.In addition,to better simulate the stellar environment in the laboratory,research on nuclear physics under laser-driven plasma conditions has gradually become a frontier hotspot.In recent years,the CIAE team conducted a series of distinctive nuclear astrophysics studies,relying on the Jinping Underground Nuclear Astrophysics platform and accelerators in Earth’s surface laboratories,including the Beijing Radioactive Ion beam Facility,as well as other scientifc platforms at home and abroad.This research covered nuclear theories,numerical models,direct measurements,indirect measurements,and other novel approaches,achieving great interdisciplinary research results,with high-level academic publications and signifcant international impacts.This article reviews the above research and predicts future developments. 展开更多
关键词 Nuclear astrophysics Indirect method Underground laboratory Direct measurement Lowenergy nuclear reaction
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