Review of the genus Brachytarsophrys(Anura:Megophryidae),with revalidation of Brachytarsophrys platyparietus and description of a new species from China

The genus-level recognition of monophyletic short-legged toads(Brachytarsophrys)has been recently implicated in the taxonomic debate of Megophrys sensu lato.In the present study,Brachytarsophrys is reasonably regarded as a distinct genus based on significant morphological differentiations and recent molecular analyses.Furthermore,a comprehensive review of this genus is performed,with two species groups proposed based on morphological differences and phylogenetic relationships.Particularly,Brachytarsophrys platyparietus is removed as a synonym of Brachytarsophrys carinense and considered a valid species due to significant genetic divergence and distinct morphological differences.In addition,a new species,Brachytarsophrys orientalis sp.nov.,is described based on a series of specimens collected from southeastern China.This work takes the member species of the genus Brachytarsophrys to seven,suggesting that the diversity of Brachytarsophrys is underestimated.In addition,the genus levels of other monophyletic groups within the subfamily Megophryinae are discussed.

On the behaviour characterization of metallic cellular materials under impact loading

This paper reviews the common mechanical features of the metallic cellular material under impact loading as well as the characterization methods of such behaviours. The main focus is on the innovations of various testing methods at impact loading rates.Following aspects were discussed in details.（1） The use of soft nylon Hopkinson/Kolsky bar for an enhanced measuring accuracy in order to assess if there is a strength enhancement or not for this class of cellular materials under moderate impact loading;（2） The use of digital image correlations to determine the strain fields during the tests to confirm the existence of a pseudo-shock wave propagation inside the cellular material under high speed impact： （3） The use of new combined shear compression device to determine the loading envelop of cellular materials under impact multiaxial loadings.

Author Correction:Review of the genus Brachytarsophrys(Anura:Megophryidae),with revalidation of Brachytarsophrys platyparietus and description of a new species from China

Following the publication of our paper(Li et al.,2020),it has come to our attention that,due to our oversight,the contributions of some colleagues were not reflected in the"ACKNOWLEDGEMENTS"section.Hereby,we wish to add the following to the"ACKNOWLEDGEMENTS"section as a correction:"We especially thank Dr.Chatmongkon Suwannapoom and Dr.Jing Che for providing the tissue collections in Thailand.Their specimen collection protocols were approved by the Institutional Ethical Committee of Animal Experimentation,University of Phayao(certificate number UP-AE59-01-04-0022).

Application of split Hopkinson tension bar technique to the study of dynamic fracture properties of materials

A novel approach is proposed in determining dy- namic fracture toughness （DFT） of high strength steel, using the split Hopkinson tension bar （SHTB） apparatus, com- bined with a hybrid experimental-numerical method. The center-cracked tension specimen is connected between the bars with a specially designed fixture device. The fracture initiation time is measured by the strain gage method, and dynamic stress intensity factors （DSIF） are obtained with the aid of 3D finite element analysis （FEA）. In this approach, the dimensions of the specimen are not restricted by the connec- tion strength or the stress-state equilibrium conditions, and hence plane strain state can be attained conveniently at the crack tip. Through comparison between the obtained results and those in open publication, it is concluded that the ex- perimental data are valid, and the method proposed here is reliable. The validity of the obtained DFT is checked with the ASTM criteria, and fracture surfaces are examined at the end of paper.

Demonstration of a Shock-Timing Experiment in a CH Layer at the Shen Guang Ⅲ Laser Facility

Shock-timing experiments are indispensable to inertial confinement fusion mainly because the timing of multiple shock waves is crucial to understanding the processes of laser irradiation of targets. Investigations into shock waves driven by a two-step radiation pulse in polystyrene（CH） capsule targets are experimentally conducted at the Shen Guang Ⅱ laser facility. Differing from the traditional shock-timing implementation in which one shock wave could catch up with another one in solid CH, in this experiment, the second shock front in a rarefaction CH layer is observed through velocity interferometry. This second shock could also be made to converge with rarefaction waves within only a few micrometers of the CH capsule by designing the two-shock coalescence time. A shock-timing diagnostic technique to tune the multi-shock convergence in the CH capsule can thereby be achieved.The experimental results in the CH layer are quasi-quantitatively interpreted using streamlines simulated with the Multi-1 D program. The experimental results are expected to offer important information for target structure and laser pulse design, both of which are important for realizing inertial confinement fusion.

Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various tumors.However,a systematic pan-cancer analysis of TNFAIP6 is lacking.Here we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon cancer.Methods:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor types.GEPIA2 was used to evaluate the effect of TNFAIP6 on clinical cancer prognosis.cBioportal was used to assess TNFAIP6 mutations.The correlation between TNFAIP6 and cancer immune infiltrates was explored using TIMER2.0.The CancerSEA database was used to perform functional analysis of TNFAIP6.Metascape was used to identify TNFAIP6-related gene enrichment pathways.Immunohistochemistry was performed to detect TNFAIP6 protein expression in the colon cancer.In addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with TNFAIP6.Results:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer prognosis.TNFAIP6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial cells.TNFAIP6 and similar genes may also be involved in the PID_VEGF_VEGFR_pathway.Immunohistochemistry revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer tissues.Several known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics Database.These results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.Conclusions:TNFAIP6 may function as an oncogene in certain cancers.Furthermore,this study provides evidence that TNFAIP6 is an important factor in colon cancer progression.

Research progress on desulfurization technology of high-sulfur bauxite

Bauxite is the main raw material of the alumina industry.However,high-sulfur bauxite constitutes a relatively large proportion of bauxite resource in China.Excessive sulfur impurities in bauxite have significant impact on the Bayer process,such as corrosion of equipment and pipelines,increased consumption of alkali,and difficulties in sedimentation of red mud particles after digestion.As the mainstreams of bauxite desulfurization technologies,the bauxite pre-desulfurization(roasting,electrochemistry,biology,flotation,etc)and Bayer process desulfurization(oxidation and precipitation)need to be fully understood for the further improvement of desulfurization performance.Here,an in-depth review on their mechanisms and advantages/disadvantages is presented.

Formation of adiabatic shearing band for high-strength Ti-5553 alloy:A dramatic thermoplastic microstructural evolution

By using split Hopkinson pressure bar, optical microscopy and electronic microscopy, we investigate the influence of initial microstructures on the adiabatic shear behavior of high-strength Ti-5Al-5V-5Mo-3Cr(Ti-5553) alloy with lamellar microstructure and bimodal microstructure. Lamellar alloy tends to form adiabatic shearing band(ASB) at low compression strain, while bimodal alloy is considerably ASBresistant. Comparing with the initial microstructure of Ti-5553 alloy, we find that the microstructure of the ASB changes dramatically. Adiabatic shear of lamellar Ti-5553 alloy not only results in the formation of recrystallized β nano-grains within the ASB, but also leads to the chemical redistribution of the alloying elements such as Al, V, Cr and Mo. As a result, the alloying elements distribute evenly in the ASB.In contrast, the dramatic adiabatic shear of bimodal alloy might give rise to the complete lamination of the globular primary a grain and the equiaxial prior β grain, which is accompanied by the dynamic recrystallization of a lamellae and β lamellae. As a result, ASB of bimodal alloy is composed of a/β nanomultilayers. Chemical redistribution does not occur in ASB of bimodal alloy. Bimodal Ti-5553 alloy should be a promising candidate for high performance armors with high mass efficiency due to the processes high dynamic flow stress and excellent ASB-resistance.

Dynamic fracture toughness of high strength metals under impact loading:increase or decrease

An elusive phenomenon is observed in previous investigations on dynamic fracture that the dynamic fracture toughness （DFT） of high strength metals always increases with the loading rate on the order of TPa.m1/2.s-1. For the purpose of verification, variation of DFT with the loading rate for two high strength steels commonly used in the aviation industry, 30CrMnSiA and 40Cr, is studied in this work. Results of the experiments are compared, which were conducted on the modified split Hopkinson pressure bar （SHPB） apparatus, with striker velocities ranging from 9.2 to 24.1 m/s and a constant value of 16.3 m/s for 30CrMnSiA and 40Cr, respectively. It is observed that for 30CrMnSiA, the crack tip loading rate increases with the increase of the striker velocity, while the fracture initiation time and the DFT simultaneously decrease. However, in the tests of 40Cr, there is also an increasing tendency of DFT, similar to other reports. Through an in-depth investigation on the relationship between the dynamic stress intensity factor （DSIF） and the loading rate, it is concluded that the generally increasing tendency in previous studies could be false, which is induced from a limited striker velocity domain and the errors existing in the experimental and numerical processes. To disclose the real dependency of DFT on the loading rate, experimentsneed to be performed in a comparatively large striker velocity range.

Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes.Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances(such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.

Comparative Study on Solid-State and Metastable Liquid-State Aging for SAC305/Cu Joints

In order to study the in?uence of the physical state of solder on the interfacial reaction of dip-soldered Sn-3.0 Ag-0.5 Cu/Cu system, two kinds of experiments were designed, including:(1) solid-state aging between the solder and Cu substrate;(2)liquid-state aging between the metastable supercooled liquid-state solder and Cu substrate. The aging times were 30, 60,120 and 180 min, respectively, and the aging temperature was 8 ℃ lower than the melting point of the Sn-3.0 Ag-0.5 Cu(SAC305) alloy(217 ℃). The experimental data revealed that the physical state of the solder obviously affected the formation of the intermetallic compound(IMC), and resulted in the difference in the diffusion of atoms on the interface between the SAC305 solder and Cu substrate. The IMC interface after aging for 30 min presents unique characteristics compared with that of the sample after dip soldering. The IMC interface of solid-state aged SAC305/Cu couple is relatively planar, while the IMC interface under metastable supercooled liquid-state aging conditions presents scallop-like shape.

CRISPR-mediated BnaIDAediting prevents silique shattering, floral organ abscission, and spreading of Sclerotinia sclerotiorum in Brassica napus

Dear Editor,Rapeseed(Brassica napus)oil is a major source of vegetable oil around the world.Stem rot disease caused by the necrotrophic fungus Sclerotinia sclerotiorum and silique shattering during harvest are two major contributors to yield loss in B.napus(Zhang et al.,2021).Infection by S.sclerotiorum occurs when ascospores land on detached petals where they germinate and form mycelia that ultimately infects the leaves(Ding et al.,2021).Consistent with this mode of infection,reduced damage from stem rot has been achieved by generating apetalous rapeseed that are resistant to petal-mediated infection(Yu et al.,2016).We propose that preventing petal shedding should also reduce leaf infections.Moreover,attached floral organs will promote rapeseed flower tourism and provide an additional economic benefit.

Functional decoration on a regenerable bifunctional porous covalent organic framework probe for rapid detection and adsorption of copper ions

Developing fluorescence porous probe for detecting and eliminating Cu^(2+) contamination in water or biosystem is an essential research project that has attracted considerable attention.However,improving the fluorescence detecting efficiency while enhancing the adsorption capacity of the porous probe is of great challenge.Herein,a bifunctional two-dimensional imine-based porous covalent organic framework(TTP-COF)probe was designed and synthesized from 1,3,5-tris(4-aminophenyl)benzene(TAPB)and 2,4,6-Triformylphloroglucinol(TP)ligand.TTP-COF displayed rapid detection of Cu^(2+)(limit of detection(LOD)=10 nmol·L^(−1) while achieving a high adsorption capacity of 214 mg·g^(−1)(pH=6)at room temperature with high reusability(>5 cycles).The key roles and contributions of highπ-conjugate and delocalized electrons in TABP and functional–OH groups in TP were proved.More importantly,the fluorescence quenching mechanism of TTP-COF was studied by density functional theory theoretical calculations,revealing the crucial role of intramolecular hydrogen bonds among C=N and–OH groups and the blocking of the excited state intramolecular proton transfer process in detecting process of Cu^(2+).

Hierarchical Homochiral Assembly of Polyhedral Cage-Type Nanoclusters

Hierarchical chiral self-assembly is of profound significance for biomolecules for their biological functions.Atom-precise metal nanoclusters(NCs)offer better opportunities to construct hierarchical superlattices.Nevertheless,achieving hierarchical homochiral assembly of nanocrystals protected by achiral ligands has proven to be a formidable task,with existing examples primarily limited to heterochiral assembly.Here we put forward a hierarchical assembly strategy towards precisely fabricating highly ordered homochiral superstructures.First,clusterin-nanocage type copper-hydride NCs act as synthons,of which entity is featured with a hexagonal close-packed Cu_(9)kernel embedded in a C_(3)-symmetric trigonal-prismatic metallacage,leading to a chiral core-shell primary structure with either P or M conformation.Then four homochiral NCs combined with guests through synergistic noncovalent interactions spontaneously organize into a supramolecular tetrahedral secondary structure within a unit cell.Finally,these nanoscopic supramolecular motifs pack into tertiary hierarchical superlattice of chiral cubic crystalline phase.Additionally,the crystalline material shows excellent robustness,and fascinating blueexcitable near-infrared thermally activated delayed fluorescence behavior.This work not only exhibits that nanocage-type NCs can be smart as proteins to translate chiral primary structure into tertiary chiral hierarchical complexity,but also provides new insights into structure-to-superstructure,enabling bottom-up creation of higher-level hierarchical homochiral superlattice structures.

Three-dimensional Printed Scaffolds with Gelatin and Platelets Enhance In vitro Preosteoblast Growth Behavior and the Sustained-release Effect of Growth Factors

Background：Three-dimensional （3D） printing technology holds great promise for treating diseases or injuries that affect human bones with enhanced performance over traditional techniques.Different patterns of design can lead to various mechanical properties and biocompatibility to various degrees.However,there is still a long way to go before we can fully take advantage of 3D printing technologies.Methods：This study tailored 3D printed scaffolds with gelatin and platelets to maximize bone regeneration.The scaffolds were designed with special internal porous structures that can allow bone tissue and large molecules to infiltrate better into the scaffolds.They were then treated with gelatin and platelets via thermo-crosslinking and freeze-drying,respectively.Vascular endothelial growth factor （VEGF） and transforming growth factor （TGF）-β1 were measured at different time points after the scaffolds had been made.Cell proliferation and cytotoxicity were determined via cell counting kit-8 （CCK-8） assay.Results：There was a massive boost in the level of VEGF and TGF-β1 released by the scaffolds with gelatin and platelets compared to that of scaffolds with only gelatin.After 21 days of culture,the CCK-8 cell counts of the control group and treated group were significantly higher than that of the blank group （P 〈 0.05）.The cytotoxicity test also indicated the safety of the scaffolds.Conclusions：Our experiments confirmed that the 3D printed scaffolds we had designed could provide a sustained-release effect for growth factors and improve the proliferation of preosteoblasts with little cytotoxicity in vitro.They may hold promise as bone graft substitute materials in the future.

Distance-Based Detection of Ag^(+) with Gold Nanoparticles-Coated Microfluidic Paper

In this study,we developed a microfluidic paper analysis device(μPAD)for distance-based detection of Ag^(+)in water.TheμPAD was manufactured by wax printing method on filter paper.Then,a layer of gold nanoparticles(AuNPs)was deposited and ascorbic acid was printed on the channel.In the detection,Ag^(+)was reduced by ascorbic acid and coated on the surface of the AuNPs on the channel,forming Au@Ag core/shell nanoparticles.Based on the capillary flow principle,diff erent concentrations of Ag^(+)formed diff erent distances of color ribbons.Thus,quantitative detection of Ag^(+)can be achieved by measuring the distance of the color ribbon.The detection limit of this method was as low as 1 mg·L^(-1)within 15 min and the interference of common metal ions in water can be eliminated.In conclusion,this method had successfully realized the leap from colorimetry to direct reading,realizing fast read and easy manipulation with low-cost.

Angiosarcoma around Hip Joint Prosthesis

Angiosarcoma,a rare and malignant tumor,is known to be associated with prosthesis and trauma.Up to now,only a few cases related to knee prosthesis and fewer cases related to hip prosthesis have been reported.

Compressive behavior and deformation kinetics of ultrafine grained aluminum processed by equal channel angular pressing

In the present work,the uniaxial compressive mechanical proper\ties of ultrafine grained(UFG)aluminum produced by equal channel angular pressing method were investigated experimentally over a wide temperatures ranging from 77 to 473 K under both quasi-static and dynamic loading conditions.Based on the experimental results,the strain rate,temperature sensitivity,and the apparent activation volume were estimated.The coupling effects of both experimental temperature and applied strain rate on thermal-activated plastic deformation behavior were also investigated.Based on the thermal activation theory,the rate-controlling mechanisms for the UFG aluminum under both quasi-static and dynamic loading conditions were discussed.