目的探讨肠通膏穴位贴敷对慢性肾脏病患者消化道并发症的效果。方法选择2021年1月~2021年10月在我院肾病内科进行住院治疗的95例第3~5期慢性肾脏病伴消化道并发症患者作为研究对象,用随机排列的方法分为对照组(n=47)和观察组(n=48),其...目的探讨肠通膏穴位贴敷对慢性肾脏病患者消化道并发症的效果。方法选择2021年1月~2021年10月在我院肾病内科进行住院治疗的95例第3~5期慢性肾脏病伴消化道并发症患者作为研究对象,用随机排列的方法分为对照组(n=47)和观察组(n=48),其中对照组应用常规的治疗方法,观察组在此基础上增加肠通膏贴敷治疗,治疗2周后对两组患者的胃肠道症状、胃肠激素、肾脏功能、满意度等多维度进行对比分析。结果治疗前,两组患者胃肠道症状量表(GSRS)评分比较、血清生长抑素(SS)和血管活性肠肽(VIP)、胃动素(MOT)、肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白(24 h UTP)比较,差异无统计学意义(P>0.05)。干预2周后,观察组患者的胃肠道症状量表(GSRS)评分、胃动素(MOT)含量水平、胃肠功能恢复正常时间、Scr、24 h UTP水平均低于对照组(P<0.05);观察组患者满意度高于对照组(P<0.05);两组患者治疗前后BUN、生长抑素(SS)和血管活性多肽(VIP)含量无明显改变,差异无统计学意义(P>0.05)。结论肠通膏穴位贴敷治疗3~5期慢性肾脏病伴有消化道并发症的患者,可有效减轻其胃肠反应症状,降低患者的胃肠激素水平,提升患者满意度,临床未产生明显不良反应,可供临床借鉴。展开更多
Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent d...Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.展开更多
Objective To improve the efficiency of patent clustering related to COVID-19 through the topic extraction algorithm and BERT model,and to help researchers understand the patent applications for novel corona virus.Meth...Objective To improve the efficiency of patent clustering related to COVID-19 through the topic extraction algorithm and BERT model,and to help researchers understand the patent applications for novel corona virus.Methods The weights of topic vector and BERT model vector were adjusted by cross-entropy loss algorithm to obtain joint vector.Then,k-means++algorithm was used for patent clustering after dimension reduction.Results and Conclusion The model was applied to patents for corona virus drugs,and five clustering topics were generated.Through comparison,it is proved that the clustering results of this model are more centralized and the differentiation between clusters is significant.The five clusters generated are visually analyzed to reveal the development status of patents for corona virus drugs.展开更多
Objective To provide new ideas for the effective treatment of many serious diseases and to solve many major medical problems faced by mankind.Methods In this paper,the invention patents in the field of stem cells in C...Objective To provide new ideas for the effective treatment of many serious diseases and to solve many major medical problems faced by mankind.Methods In this paper,the invention patents in the field of stem cells in China from 2010 to 2020 were taken as the research object,and the technology status quo in the field of stem cells was analyzed to predict the future development direction through quantitative analysis method.Results and Conclusion The development of stem cell technology in China is in a period of growth with great potential.Therefore,it is necessary to strengthen the ability of Chinese universities to combine production,education and research.Nowadays,the hotspots in stem cell technology are using culture medium to improve cell proliferation ability,production efficiency,and to induce differentiated cells.Meanwhile,the production efficiency of embryonic stem cells should be improved,and the immunomodulatory effect of embryonic stem cells can be exerted to screen drugs.Besides,the function of hematopoietic stem cells should be enhanced and apply mesenchymal cells in therapy.Since the potential technological gaps are the improvement of therapy,induced differentiation and efficiency of pluripotent stem cells,the improvement of progenitor cell proliferation and the control of cost,we should strengthen R&D investment in culture medium,embryonic stem cells and other technical fields,and achieve the purpose of reducing R&D costs and improving R&D efficiency.展开更多
文摘目的探讨肠通膏穴位贴敷对慢性肾脏病患者消化道并发症的效果。方法选择2021年1月~2021年10月在我院肾病内科进行住院治疗的95例第3~5期慢性肾脏病伴消化道并发症患者作为研究对象,用随机排列的方法分为对照组(n=47)和观察组(n=48),其中对照组应用常规的治疗方法,观察组在此基础上增加肠通膏贴敷治疗,治疗2周后对两组患者的胃肠道症状、胃肠激素、肾脏功能、满意度等多维度进行对比分析。结果治疗前,两组患者胃肠道症状量表(GSRS)评分比较、血清生长抑素(SS)和血管活性肠肽(VIP)、胃动素(MOT)、肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白(24 h UTP)比较,差异无统计学意义(P>0.05)。干预2周后,观察组患者的胃肠道症状量表(GSRS)评分、胃动素(MOT)含量水平、胃肠功能恢复正常时间、Scr、24 h UTP水平均低于对照组(P<0.05);观察组患者满意度高于对照组(P<0.05);两组患者治疗前后BUN、生长抑素(SS)和血管活性多肽(VIP)含量无明显改变,差异无统计学意义(P>0.05)。结论肠通膏穴位贴敷治疗3~5期慢性肾脏病伴有消化道并发症的患者,可有效减轻其胃肠反应症状,降低患者的胃肠激素水平,提升患者满意度,临床未产生明显不良反应,可供临床借鉴。
文摘Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.
文摘Objective To improve the efficiency of patent clustering related to COVID-19 through the topic extraction algorithm and BERT model,and to help researchers understand the patent applications for novel corona virus.Methods The weights of topic vector and BERT model vector were adjusted by cross-entropy loss algorithm to obtain joint vector.Then,k-means++algorithm was used for patent clustering after dimension reduction.Results and Conclusion The model was applied to patents for corona virus drugs,and five clustering topics were generated.Through comparison,it is proved that the clustering results of this model are more centralized and the differentiation between clusters is significant.The five clusters generated are visually analyzed to reveal the development status of patents for corona virus drugs.
文摘Objective To provide new ideas for the effective treatment of many serious diseases and to solve many major medical problems faced by mankind.Methods In this paper,the invention patents in the field of stem cells in China from 2010 to 2020 were taken as the research object,and the technology status quo in the field of stem cells was analyzed to predict the future development direction through quantitative analysis method.Results and Conclusion The development of stem cell technology in China is in a period of growth with great potential.Therefore,it is necessary to strengthen the ability of Chinese universities to combine production,education and research.Nowadays,the hotspots in stem cell technology are using culture medium to improve cell proliferation ability,production efficiency,and to induce differentiated cells.Meanwhile,the production efficiency of embryonic stem cells should be improved,and the immunomodulatory effect of embryonic stem cells can be exerted to screen drugs.Besides,the function of hematopoietic stem cells should be enhanced and apply mesenchymal cells in therapy.Since the potential technological gaps are the improvement of therapy,induced differentiation and efficiency of pluripotent stem cells,the improvement of progenitor cell proliferation and the control of cost,we should strengthen R&D investment in culture medium,embryonic stem cells and other technical fields,and achieve the purpose of reducing R&D costs and improving R&D efficiency.
