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Tuning the product selectivity of dimethyl oxalate hydrogenation over WO_(x) modified Cu/SiO_(2) catalysts
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作者 Zheng Li Zhuo Ma +9 位作者 Yihui Li Ziang Zhao yuan tan Ziyin Liu Xingkun Chen Nian Lei Huigang Wang Wei Lu Hejun Zhu Yunjie Ding 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第10期128-138,I0004,共12页
Product selectivity and reaction pathway are highly dependent on surface structure of heterogeneous catalysts.For vapor-phase hydrogenation of dimethyl oxalate(DMO),"EG route"(DMO→methyl glycolate(MG)ethyle... Product selectivity and reaction pathway are highly dependent on surface structure of heterogeneous catalysts.For vapor-phase hydrogenation of dimethyl oxalate(DMO),"EG route"(DMO→methyl glycolate(MG)ethylene glycol(EG)→ethanol(ET))and"MA route"(DMO→MG→methyl acetate(MA))were proposed over traditional Cu based catalysts and Mo-based or Fe-based catalysts,respectively.Herein,tunable yield of ET(93.7%)and MA(72.1%)were obtained through different reaction routes over WO_(x) modified Cu/SiO_(2) catalysts,and the corresponding reaction route was further proved by kinetic study and in-situ DRIFTS technology.Mechanistic studies demonstrated that H_(2) activation ability,acid density and Cu-WO_(x) interaction on the catalysts were tuned by regulating the surface W density,which resulted in the different reaction pathway and product selectivity.What's more,high yield of MA produced from DMO hydrogenation was firstly reported with the H_(2) pressure as low as 0.5 MPa. 展开更多
关键词 ETHANOL Dimethyl oxalate Selective hydrogenation Methyl acetate WCu/SiO_(2)catalyst
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Recent advances in protein conformation sampling by combining machine learning with molecular simulation
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作者 唐一鸣 杨中元 +7 位作者 姚逸飞 周运 谈圆 王子超 潘瞳 熊瑞 孙俊力 韦广红 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期80-87,共8页
The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with... The rapid advancement and broad application of machine learning(ML)have driven a groundbreaking revolution in computational biology.One of the most cutting-edge and important applications of ML is its integration with molecular simulations to improve the sampling efficiency of the vast conformational space of large biomolecules.This review focuses on recent studies that utilize ML-based techniques in the exploration of protein conformational landscape.We first highlight the recent development of ML-aided enhanced sampling methods,including heuristic algorithms and neural networks that are designed to refine the selection of reaction coordinates for the construction of bias potential,or facilitate the exploration of the unsampled region of the energy landscape.Further,we review the development of autoencoder based methods that combine molecular simulations and deep learning to expand the search for protein conformations.Lastly,we discuss the cutting-edge methodologies for the one-shot generation of protein conformations with precise Boltzmann weights.Collectively,this review demonstrates the promising potential of machine learning in revolutionizing our insight into the complex conformational ensembles of proteins. 展开更多
关键词 machine learning molecular simulation protein conformational space enhanced sampling
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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes
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作者 yuan tan Ying-Shi Zou +8 位作者 Ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin Duo-Ru Lin Yi-Zhi Liu Hao-Tian Lin Zhen-Zhen Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第3期473-479,共7页
●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patient... ●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were recruited.Data on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was performed.The main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular features.Cluster 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior cataracts.Cluster 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual outcomes.This innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts. 展开更多
关键词 CLASSIFICATION congenital cataract PHENOTYPE visual acuity cluster analysis
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基于多模式持续性健康管理的强化饮食干预在^(131)I治疗甲状腺功能亢进症合并糖尿病患者中的应用效果
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作者 袁坦 张媛媛 +1 位作者 王艺梦 叶红丽 《内科》 2023年第1期33-36,51,共5页
目的 观察基于多模式持续性健康管理的强化饮食干预在^(131)I治疗甲状腺功能亢进症合并糖尿病患者中的应用效果。方法 选取113例^(131)I治疗甲状腺功能亢进症合并糖尿病患者作为研究对象,将其随机分为对照组(56例)和观察组(57例)。对照... 目的 观察基于多模式持续性健康管理的强化饮食干预在^(131)I治疗甲状腺功能亢进症合并糖尿病患者中的应用效果。方法 选取113例^(131)I治疗甲状腺功能亢进症合并糖尿病患者作为研究对象,将其随机分为对照组(56例)和观察组(57例)。对照组采用多模式持续性健康管理,观察组在对照组的基础上联合强化饮食干预,两组均干预2个月。比较两组患者血糖水平、甲状腺功能指标水平、能量消耗情况和并发症发生情况。结果 干预前,两组患者的空腹血糖、餐后2h血糖水平差异均无统计学意义(均P>0.05)。干预2个月后,观察组的空腹血糖、餐后2h血糖水平均低于对照组(均P<0.05)。干预前,两组患者血清游离四碘甲状腺原氨酸(FT_(4))、游离三碘甲状腺原氨酸(FT_(3))、促甲状腺激素(TSH)水平差异均无统计学意义(均P>0.05)。干预2个月后,观察组的血清FT_(4)、FT_(3)、TSH水平均低于对照组(均P<0.05)。干预前,两组患者静息代谢率、静息代谢率/体质量比值差异均无统计学意义(均P>0.05)。干预2个月后,观察组的静息代谢率、静息代谢率/体质量比值低于对照组(均P<0.05)。干预期间,观察组患者低血糖昏迷的发生率低于对照组(P<0.05)。结论 基于多模式持续性健康管理的强化饮食干预在^(131)I治疗甲状腺功能亢进症合并糖尿病患者的治疗中效果确切,能有效地控制血糖水平,改善甲状腺功能和能量消耗情况,减少低血糖昏迷的发生。 展开更多
关键词 甲状腺功能亢进症 糖尿病 ^(131)I 强化饮食干预 多模式持续性健康管理 甲状腺功能 血糖 能量代谢
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无创正压通气与同步间歇指令通气治疗早产儿呼吸窘迫综合征的疗效比较 被引量:16
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作者 廖勇杰 张华 +3 位作者 全裕凤 谭媛 杨欢 岳嗣凤 《中国现代医学杂志》 CAS 2019年第23期83-86,共4页
目的比较无创正压通气(NIPPV)与同步间歇指令通气(SIMV)治疗早产儿呼吸窘迫综合征(NRDS)的疗效。方法选取2017年1月-2018年6月桂林医学院附属医院NRDS早产儿80例,采用随机数字表法将患儿分为对照组和观察组,每组40例。对照组患儿给予SIM... 目的比较无创正压通气(NIPPV)与同步间歇指令通气(SIMV)治疗早产儿呼吸窘迫综合征(NRDS)的疗效。方法选取2017年1月-2018年6月桂林医学院附属医院NRDS早产儿80例,采用随机数字表法将患儿分为对照组和观察组,每组40例。对照组患儿给予SIMV模式治疗,观察组患儿给予NIPPV模式治疗。比较两组血气分析指标、呼吸机参数、治疗时间及并发症发生率。结果治疗0、24和48 h时,观察组各指标与对照组比较,差异有统计学意义(P<0.05),观察组在24和48 h血氧分压(PaO2)、动脉血氧饱和度(SaO2)、氧指数(OI)水平高于对照组,动脉血二氧化碳分压(PaCO2)、吸入氧浓度(FiO2)低于对照组。观察组氧疗时间、呼吸机使用时间及住院时间与对照组比较,差异有统计学意义(P <0.05),观察组短于对照组。治疗期间两组患者均出现呼吸机相关性肺炎、颅脑出血、肺出血等并发症,且两组并发症发生率差异无统计学意义(P>0.05)。结论相对SIMV有创通气模式,NIPPV通气疗法对ARDS患儿通气、氧合状态的改善程度及治疗时间优势更为明显,且安全可靠。 展开更多
关键词 呼吸窘迫综合征 新生儿 无创正压通气 步间歇指令通气 疗效
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老年冠心病患者经皮冠状动脉介入术术后应用低剂量替格瑞洛的可行性及安全性研究 被引量:14
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作者 渊潭 李今朝 《陕西医学杂志》 CAS 2021年第1期86-88,92,共4页
目的:观察经皮冠状动脉介入术(PCI)术后辅助应用替格瑞洛在治疗老年冠心病的可行性及安全性。方法:选取老年冠心病患者120例,将入组病人随机分为对照组和低剂量组,每组60例。两组病人PCI术后均口服阿司匹林;对照组给予替格瑞洛180 mg/d,... 目的:观察经皮冠状动脉介入术(PCI)术后辅助应用替格瑞洛在治疗老年冠心病的可行性及安全性。方法:选取老年冠心病患者120例,将入组病人随机分为对照组和低剂量组,每组60例。两组病人PCI术后均口服阿司匹林;对照组给予替格瑞洛180 mg/d,分2次口服;低剂量组给予替格瑞洛90 mg/d,分2次口服。比较两组病人治疗前后二磷酸腺苷(ADP)诱导的血小板聚集率、凝血功能状态、主要心血管不良事件(MACE)发生率及出血事件发生率。结果:两组治疗后ADP诱导血小板聚集率均明显低于治疗前(P<0.05);低剂量组治疗后ADP诱导血小板聚集率与对照组比较,差异无统计学意义(P>0.05)。两组患者在治疗前和治疗后凝血酶原时间(PT)、纤维蛋白原(FIB)、血小板最大聚集率(MPAR)水平间比较均无统计学差异(P>0.05);治疗后,两组患者凝血酶原时间、纤维蛋白原均较治疗前显著提高,血小板最大聚集率与治疗前相比显著降低,差异具有统计学意义(P<0.05)。两组患者MACE发生率比较,差异无统计学意义(P>0.05);低剂量组病人发生出血事件率显著低于对照组,比较差异具有统计学意义(P<0.05)。结论:PCI术后90 mg/d替格瑞洛口服辅助治疗老年冠心病患者可有效预防出血事件发生,且未增加MACE风险,是安全可行的。 展开更多
关键词 冠心病 老年人 经皮冠状动脉介入术 替格瑞洛 可行性 安全性
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胸腔镜下肺部手术后发生广泛皮下气肿的临床分析 被引量:7
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作者 梁鲁彪 谭媛 宋永祥 《中国内镜杂志》 2021年第7期43-46,共4页
目的探讨胸腔镜下肺部手术后发生广泛皮下气肿的影响因素。方法回顾性分析2015年10月-2020年10月3314例行胸腔镜下肺部手术后发生广泛皮下气肿患者的临床资料,寻找发生广泛皮下气肿的相关因素,分析皮下气肿的治疗效果。结果术后广泛皮... 目的探讨胸腔镜下肺部手术后发生广泛皮下气肿的影响因素。方法回顾性分析2015年10月-2020年10月3314例行胸腔镜下肺部手术后发生广泛皮下气肿患者的临床资料,寻找发生广泛皮下气肿的相关因素,分析皮下气肿的治疗效果。结果术后广泛皮下气肿发生率为1.90%(63/3314)。其中,肺减容、胸腔粘连、合并肺气肿和术后持续漏气的患者术后广泛皮下气肿发生率高(P<0.05)。结论胸腔镜下肺部手术后广泛皮下气肿的发生与肺减容手术方式、胸腔粘连、合并肺气肿和术后持续漏气有关。 展开更多
关键词 胸腔镜 皮下气肿 并发症 临床分析
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Effective removal of the protective ligands from Au nanoclusters by ambient pressure nonthermal plasma treatment for CO oxidation 被引量:2
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作者 yuan tan Hua Liu +3 位作者 Xiao Yan Liu Aiqin Wang Changjun Liu Tao Zhang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2018年第5期929-936,共8页
We used a dielectric barrier discharge(DBD)plasma technique to eliminate the protective ligand of ZnAl-hydrotalcite-supported gold nanoclusters.We used X-ray powder diffraction,ultraviolet-visible spectrophotometry,th... We used a dielectric barrier discharge(DBD)plasma technique to eliminate the protective ligand of ZnAl-hydrotalcite-supported gold nanoclusters.We used X-ray powder diffraction,ultraviolet-visible spectrophotometry,thermogravimetric analysis,and high angle annular dark-field-scanning transmission electron microscopy characterization to show that the samples pretreated with/without DBD-plasma displayed different performances in CO oxidation.The enhanced activity was obtained on the plasma-treated samples,implying that the protective ligand was effectively removed via the plasma technique.The crystal structure of the plasma-treated samples changed markedly,suggesting that the plasma treatment could not only break the chemical bond between the gold and the protective agent but could also decompose the interlayer ions over the hydrotalcite support.The particle sizes of the gold after DBD-plasma treatment implied that it was a good way to control the size of the gold nanoparticles under mild conditions. 展开更多
关键词 Gold cluster PLASMA Supported gold catalyst Protective ligand Carbon monoxide oxidation
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Producing of cinnamyl alcohol from cinnamaldehyde over supported gold nanocatalyst 被引量:1
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作者 yuan tan Xiaoyan Liu +3 位作者 Leilei Zhang Fei Liu Aiqin Wang Tao Zhang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2021年第3期470-481,共12页
Chemoselective hydrogenation of unsaturated aldehyde to unsaturated alcohol has attracted growing interests in recent years due to its widespread applications in fine chemicals.However,the hydrogenation of the C=O bon... Chemoselective hydrogenation of unsaturated aldehyde to unsaturated alcohol has attracted growing interests in recent years due to its widespread applications in fine chemicals.However,the hydrogenation of the C=O bond was thermodynamically and kinetically unfavorable over the hydrogenation of the C=C bond.Thus,to obtain the unsaturated alcohol from the unsaturated aldehyde is very difficult in most of the catalytic systems.In this work,ZnAl-hydrotalcite-supported cysteine-capped Au25 nanoclusters were used as the precatalysts for chemoselective hydrogenation of cinnamaldehyde to cinnamyl alcohol.The catalyst showed stable high selectivity(~95%)at prolonged reaction time and complete conversion of the substrate.According to the results of the control experiments,the in-situ DRIFTS of the substrate under high pressure of hydrogen and the 27Al MAS-NMR spectroscopy,we proposed that the difference of the preferential adsorption of the C=O bond to that of the C=C bond was derived from the nature of the support of the gold catalysts. 展开更多
关键词 Gold nanocluster Support effect Cinnamyl alcohol Selective hydrogenation CINNAMALDEHYDE
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Design of high-performance ion-doped CoP systems for hydrogen evolution:From multi-level screening calculations to experiment 被引量:1
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作者 Xiaofei Cao Siqian Xing +6 位作者 Duo Ma yuan tan Yucheng Zhu Jun Hu Yao Wang Xi Chen Zhong Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第7期307-316,I0007,共11页
Rational design of high-performance electrocatalysts for hydrogen evolution reaction(HER)is vital for future renewable energy systems.The incorporation of foreign metal ions into catalysts can be an effective approach... Rational design of high-performance electrocatalysts for hydrogen evolution reaction(HER)is vital for future renewable energy systems.The incorporation of foreign metal ions into catalysts can be an effective approach to optimize its performance.However,there is a lack of systematic theoretical studies to reveal the quantitative relationships at the electronic level.Here,we develop a multi-level screening methodology to search for highly stable and active dopants for CoP catalysts.The density functional theory(DFT)calculations and symbolic regression(SR)were performed to investigate the relationship between the adsorption free energy(ΔG_(H^(*)))and 10 electronic parameters.The mathematic formulas derived from SR indicate that the difference of work function(ΔΦ)between doped metal and the acceptor plays the most important role in regulatingΔG_(H^(*)),followed by the d-band center(d-BC)of doped system.The descriptor of HER can be expressed asΔG_(H^(*))=1.59×√|0.188ΔΦ+d BC+0.120|1/2-0.166 with a high determination coefficient(R^(2)=0.807).Consistent with the theoretical prediction,experimental results show that the Al-CoP delivers superior electrocatalytic HER activity with a low overpotential of75 m V to drive a current density of 10 mA cm^(-2),while the overpotentials for undoped CoP,Mo-CoP,and V-CoP are 206,134,and 83 m V,respectively.The current work proves that theΔΦis the most significant regulatory parameter ofΔG_(H^(*))for ion-doped electrocatalysts.This finding can drive the discovery of high-performance ion-doped electrocatalysts,which is crucial for electrocatalytic water splitting. 展开更多
关键词 Design of ion-doped catalyst Symbolic regression Density functional theory calculation Hydrogen evolution reaction
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PHOTOTHERAPY FOR MILD TO MODERATE ACNE VULGARIS WITH PORTABLE BLUE AND RED LED
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作者 GUANGDA LIU CHANGE PAN +2 位作者 KAI LI yuan tan XUNBIN WEI 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2011年第1期45-52,共8页
In this paper,we studied portable blue and red light-emitting-diode(LED)light sources in phototherapy for mild to moderate acne vulgaris to evaluate the efficacy and tolerance of patients.Patients,randomly divided int... In this paper,we studied portable blue and red light-emitting-diode(LED)light sources in phototherapy for mild to moderate acne vulgaris to evaluate the efficacy and tolerance of patients.Patients,randomly divided into blue and red groups,received either blue or red LED phototherapy twice a week for four weeks.After complete treatment,the number of lesions reduced by 71.4% in the blue group,in contrast to 19.5% in the red group.No obvious side effects were observed during and one month after the treatment,except for some mild dryness mentioned by several patients. 展开更多
关键词 Acne vulgaris light emitting diode PHOTOTHERAPY portable light sources
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Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022:a scientometric analysis
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作者 yuan tan Wei Jiang +6 位作者 Le-Yi Hu Yan-Yu Shen Hui Chen Ying-Shi Zou Li-Xia Luo Guang-Ming Jin Zhen-Zhen Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第10期1682-1691,共10页
AIM:To explore the hotspots and frontiers of genetic research on pediatric cataracts.METHODS:Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Co... AIM:To explore the hotspots and frontiers of genetic research on pediatric cataracts.METHODS:Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection,and were analyzed in terms of the publication counts,countries,journals,authors,keywords,cited references,subject categories,and the underlying hotspots and frontiers.RESULTS:Totally 699 publications were included in the final analysis.The predominant actors were identified,with China(n=240)and PLoS One(n=33)being the most productive country and journal respectively.The research hotspots extracted from keywords were crystallin gene mutations,pathogenicity evaluation,phenotypes of ocular and neurodevelopmental abnormalities,genes encoding membrane proteins,and diagnosis of multisystemic disorders.The co-cited articles formed 10 clusters of research topics,including FYCO1(56 items),mutation screening(43 items),gap junction(29 items),the Warburg Micro syndrome(29 items),ephrin-A5(28 items),novel mutation(24 items),eye development and function(22 items),cholestanol(7 items),OCRL(6 items),and pathogenicity prediction(3 items).The research frontiers were FYCO1,ephrin-A5,and cholestanol.Cell biology showed the strongest bridging effects among different disciplines in the field(betweenness centrality=0.44).CONCLUSION:With the progress in next-generation sequencing and multidisciplinary collaboration,genetic research on pediatric cataracts broadens the knowledge scope of the crystalline lens,as well as other organs and systems,shedding light on the molecular mechanisms of systemic diseases.Cell biology may integrate multidisciplinary content to address cutting-edge issues in the field. 展开更多
关键词 GENE pediatric cataract next generation sequencing genotype phenotype association
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Theoretical Simulation of the Temporal Behavior of Bragg Diffraction Derived from Lattice Deformation
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作者 Cong Guo Shuai-Shuai Sun +5 位作者 Lin-Lin Wei Huan-Fang Tian Huai-Xin Yang Shu Gao yuan tan Jian-Qi Li 《Chinese Physics Letters》 SCIE CAS CSCD 2020年第7期71-74,共4页
A theoretical study on the structural dynamics of the temporal behavior of Bragg diffraction is presented and compared with experimental results obtained via ultrafast electron crystallography.In order to describe the... A theoretical study on the structural dynamics of the temporal behavior of Bragg diffraction is presented and compared with experimental results obtained via ultrafast electron crystallography.In order to describe the time-dependent lattices and calculate the Bragg diffraction intensity,we introduce the basic vector offset matrix,which can be used to quantify the shortening,lengthening and rotation of the three lattice vectors(i.e.,lattice deformation).Extensive simulations are performed to evaluate the four-dimensional electron crystallography model.The results elucidate the connection between structural deformations and changes in diffraction peaks,and sheds light on the quantitative analysis and comprehensive understanding of the structural dynamics. 展开更多
关键词 dynamics. STRUCTURAL LATTICE
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Transcriptional factorⅢA promotes colorectal cancer progression by upregulating cystatin A
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作者 Jing Wang yuan tan +1 位作者 Qun-Ying Jia Fa-Qin tang 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第10期1918-1932,共15页
BACKGROUND Advanced colorectal cancer(CRC) generally has poor outcomes and high mortality rates. Clarifying the molecular mechanisms underlying CRC progression is necessary to develop new diagnostic and therapeutic st... BACKGROUND Advanced colorectal cancer(CRC) generally has poor outcomes and high mortality rates. Clarifying the molecular mechanisms underlying CRC progression is necessary to develop new diagnostic and therapeutic strategies to improve CRC outcome and decrease mortality. Transcriptional factor Ⅲ A(GTF3A), an RNA polymerase Ⅲ transcriptional factor, is a critical driver of tumorgenesis and aggravates CRC cell growth.AIM To confirm whether GTF3A promotes CRC progression by regulating the expression of cystatin A(Csta) gene and investigate whether GTF3A can serve as a prognostic biomarker and therapeutic target for patients with CRC.METHODS Human tissue microarrays containing 90 pairs of CRC tissues and adjacent nontumor tissues, and human tissue microarrays containing 20 pairs of CRC tissues,adjacent non-tumor tissues, and metastatic tissues were examined for GTF3A expression using immunohistochemistry. The survival rates of patients were analyzed. Short hairpin GTF3As and CSTAs were designed and packaged into the virus to block the expression of Gtf3a and Csta genes, respectively. In vivo tumor growth assays were performed to confirm whether GTF3A promotes CRC cell proliferation in vivo. Electrophoretic mobility shift assay and fluorescence in situ hybridization assay were used to detect the interaction of GTF3A with Csta,whereas luciferase activity assay was used to evaluate the expression of the Gtf3a and Csta genes. RNA-Sequencing(RNA-Seq) and data analyses were used to screen for target genes of GTF3A.RESULTS The expression of GTF3A was higher in CRC tissues and lymph node metastatic tissues than in the adjacent normal tissues. GTF3A was associated with CRC prognosis, and knockdown of the Gtf3a gene impaired CRC cell proliferation, invasion, and motility in vitro and in vivo. Moreover, RNASeq analysis revealed that GTF3A might upregulate the expression of Csta, whereas the luciferase activity assay showed that GTF3A bound to the promoter of Csta gene and increased Csta transcription. Furthermore, CSTA regulated the expression of epithelial-mesenchymal transition(EMT) markers.CONCLUSION GTF3A increases CSTA expression by binding to the Csta promoter, and increased CSTA level promotes CRC progression by regulating the EMT. Inhibition of GTF3A prevents CRC progression. Therefore, GTF3A is a potential novel therapeutic target and biomarker for CRC. 展开更多
关键词 Transcription factor IIIA Cystatin A Colorectal cancer Epithelial-mesenchymal transition
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Factors associated with the spread of Chinese Tallow in East Texas forestlands
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作者 Zhaofei Fan yuan tan Michael K. Crosby 《Open Journal of Ecology》 2012年第3期121-130,共10页
Chinese tallow tree (Triadica sebifera (L.) Small, Sapium sebiferum (L.) Roxb) is an invasive species that is replacing native ecosystems in areas of eastern Texas. It is imperative that the spatial pattern of the spr... Chinese tallow tree (Triadica sebifera (L.) Small, Sapium sebiferum (L.) Roxb) is an invasive species that is replacing native ecosystems in areas of eastern Texas. It is imperative that the spatial pattern of the spread of this species be identified, as well as causal mechanisms. To that end, we seek to determine factors that contribute to the spread of Chinese tallow using classification and regression tree (CART) and logistic regression. We also attempt to identify current locations and spread rates across eastern Texas using Forest Inventory Analysis (FIA) data within major forest types. Distance to formerly infested plots and roads, slope, and disturbances (natural and anthropogenic) were identified as major (either facilitating or impeding) factors for the spread of Chinese tallow across the landscape. The highest probability of occurrence and spread rate of Chinese tallow were found in the oak/ gum/cypress forest type. Continued disturbance, from harvest events or natural disasters will allow the species to continue to spread throughout the region and could threaten overall forest productivity. We also discuss some implications of the continued spread of Chinese tallow on forest management. Forest managers could benefit from this analysis and use it as a guide for monitoring forest types with the highest risk of invasion. 展开更多
关键词 CHINESE TALLOW Rate of SPREAD CART LOGISTIC Regression FIA
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Evolution and trends of high myopia research from 2002 to 2021: a scientometric analysis
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作者 yuan tan Weining Zhu +7 位作者 Yingshi Zou Bowen Zhang Yinglin Yu Wei Li Chaoqun Xu Leyi Hu Guangming Jin Zhenzhen Liu 《Annals of Eye Science》 2023年第4期22-35,共14页
Background:Research on high myopia has gradually formed a complex network of knowledge,but a panorama of evolutionary trends is lacking.By conducting a scientometric analysis,we can gain a deeper understanding of the ... Background:Research on high myopia has gradually formed a complex network of knowledge,but a panorama of evolutionary trends is lacking.By conducting a scientometric analysis,we can gain a deeper understanding of the development and evolution of this field.Methods:The global literature on high myopia published from 2002 to 2021 was extracted from the Science Citation Index Expanded in the Web of Science Core Collection.Microsoft Excel,VOSviewer,and CiteSpace were used to analyse and visualize the bibliometric data.Publication-related information,including countries,journals,authors,citations,subject categories,and its’time trends,was analysed.Results:A total of 4,226 included publications showed an annually increasing trend during the past 20 years.The high myopia research hotspots were refractive error correction,epidemiology,ocular biometry,drug and laser treatment of myopic fundus lesions,and surgical treatment of myopic fundus lesions.Cocitation analysis showed that high myopia genetics and myopic fundus lesion research were the research frontiers.A total of 116 disciplines were involved in high myopia research.Ophthalmology(n=3,338)was the most dominant subject category.Engineering(betweenness centrality=0.65)was the discipline with the most obvious bridge role.Science&technology—other topics(burst years:2015–2021;strength=14.88)had the greatest strength as of 2021,which was the hottest subject category.Conclusions:High myopia genetics and myopic fundus lesion research showed a potential for breakthroughs.Medical-engineering cross-innovation is a cutting-edge technology trend. 展开更多
关键词 High myopia theme change EVOLUTION research hotspot
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A comparative study on design standards of screw conveyors in China,Germany,and the USA-Part Ⅱ:Discrete element method
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作者 yuan tan Michael Rackl +3 位作者 Weijie Yang Johannes Fottner Wenjun Meng Stephan Kessler 《Particuology》 SCIE EI CAS CSCD 2024年第9期113-125,共13页
This part of the study aims to evaluate the advantages and disadvantages of technical standards of screw conveyors in China,Germany,and the USA for industrial applications.The source or determination method of empiric... This part of the study aims to evaluate the advantages and disadvantages of technical standards of screw conveyors in China,Germany,and the USA for industrial applications.The source or determination method of empirical coefficients as well as the theoretical foundation of dimensioning-relevant diagrams in these standards is not explicitly documented in the literature.Therefore,instead of less efficient on-site tests,the numerical simulation by discrete element method is conducted.Based on the geometrical and operational designs determined in three standards for horizontal,slightly inclined,and vertical conveyance of three representative bulk solids(barley,lignite,and sand),the potential influencing factors are discussed.With constant particle and contact parameters,the potential deviations caused by particle models are eliminated.Furthermore,the accuracy of power consumption calculation of each standard and the divergence between accessible and required mass flows is comprehensively assessed based on the analysis of simulated outcomes.Two main conclusions are drawn:(1)Particle fall back is barely considered by all three standards and leads to overestimated mass throughput;(2)The decrease in mass throughput caused by an increasing degree of filling can be compensated by slowing down the rotational speed. 展开更多
关键词 Discrete element method Design standard Screw conveyor Screw auger Bulk solid
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A comparative study on design standards of screw conveyors in China,Germany and the USA-PartⅠ:Theoretical calculation and quantitative analysis 被引量:1
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作者 yuan tan Michael Rackl +3 位作者 Weijie Yang Johannes Fottner Wenjun Meng Stephan Kessler 《Particuology》 SCIE EI CAS CSCD 2022年第10期61-76,共16页
Screw conveyors,widely used devices for transporting bulk materials,play an irreplaceable role in the modern industrial system.Despite of their traditional advantages,designers of screw conveyors still heavily rely on... Screw conveyors,widely used devices for transporting bulk materials,play an irreplaceable role in the modern industrial system.Despite of their traditional advantages,designers of screw conveyors still heavily rely on their own country's experiments and standards,which are closely related to empirical data.Therefore,the same conveying task often results in different designs.This work aims to compare the design standards of screw conveyors in China,Germany and the USA.Based on related standards acquired from renowned associations in the three countries,the similarities and particularities of these design guidances are compared.With preforming the geometrical and operational designs for horizon-tal,slightly inclined and vertical conveyance of three representative bulk solids(barley,lignite,sand),the advantages and disadvantages of these semi-empirical designs are comprehensively presented.Fur-thermore,the potential influence of empirical coefficients,which are not explicitly documented,are extensively discussed.By analysing all outcomes,the compatibility and applicability of each standard are qualitatively assessed. 展开更多
关键词 Design standard Screw conveyor Screw feeder Screw auger Bulk solids
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Detection of parathion methyl using a surface plasmon resonance sensor combined with molecularly imprinted films 被引量:6
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作者 yuan tan Israr Ahmad Tian-Xin Wei 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第6期797-800,共4页
An ultra-sensitive and highly selective parathion methyl (PM) detection method by surface plasmon resonance (SPR) combined with molecularly imprinted films (MIF) was developed. The PM-imprinted film was prepared... An ultra-sensitive and highly selective parathion methyl (PM) detection method by surface plasmon resonance (SPR) combined with molecularly imprinted films (MIF) was developed. The PM-imprinted film was prepared by thermo initiated polymerization on the bare Au surface of an SPR sensor chip, Template PM molecules were quickly removed by an organic solution of acetonitrilelacetic acid (9:1, v/v), causing a shift of 0.5° in SPR angle. In the concentrations range of 10^-13-10^-10 mol/L, the refractive index showed a gradual increase with higher concentrations of template PM and the changes of SPR angles were linear with the negative logarithm of PM concentrations. In the experiment, the minimum detectable concentration was 10^-13 mol/L. The selectivity of the thin PM-imprinted film against diuron, tetrachlorvinphose and fenitrothion was examined, but no observable binding was detected. The results in the experiment suggested that the MIF had the advantages of high sensitivity and selectivity. 展开更多
关键词 PM detection Surface plasmon resonance Molecularly imprinted films
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Curative effect and possible mechanism of taurine on early corneal alkali burns
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作者 yuan tan Min Zhang +1 位作者 Yingzhe Pan Lixia Xie 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第6期744-746,共3页
To the Editor:Corneal alkali burns(CABs)have been a difficult problem in clinical treatment for a long time.In severe cases,blindness occurs;hence,research on the repair mechanism underlying corneal injury is particul... To the Editor:Corneal alkali burns(CABs)have been a difficult problem in clinical treatment for a long time.In severe cases,blindness occurs;hence,research on the repair mechanism underlying corneal injury is particularly important to identify potential therapeutic targets.Alkali-induced corneal injuries often trigger aggressive aseptic inflammatory responses,which are key to autoimmune responses.[1]However,Nod-like receptor protein 3(NLRP3)inflammasomes play an important role in aseptic inflammation.[2]Under stimuli,such as infection or stress,the activated NLRP3 inflammasome not only processes procaspase-1 into mature caspase-1 but also further promotes the maturation and release of interleukin(IL)-1βand IL-18.[3]Taurine(Tau)is widely distributed in ocular structures and is an immune regulator.Tau can maintain the stability of the corneal epithelium and improve the survival rate of corneal epithelial cells through antioxidant effects.[4]The purpose of this study was to investigate the effect of Tau eye drops on CAB and elucidate the mechanism underlying corneal inflammatory responses. 展开更多
关键词 CORNEAL BURNS INJURIES
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