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Effect of fermented Rosa roxburghii Tratt fruit juice on gut microbiota in a dextran sulfate sodium-induced colitis mouse model
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作者 Yunyang Zuo Haoxiang Xu +6 位作者 Dandan Feng yuanyuan shi Jiuchang Li Maoyang Wei Ling Wang Yulong Zhang Ping Hu 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期2234-2243,共10页
This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced u... This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in mice.Compared to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of S.sciuri,Desulfovibrio C21_c20,R.gnavus and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of B.acidifaciens in mice.LAB-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC mice.Besides,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ treatment.Compared with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis mice.Correlation analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis mice.Taken together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition. 展开更多
关键词 Rosa roxburghii Tratt Lacticaseibacillus paracasei Ulcerative colitis Fermentation characteristics
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Evaluation of Soil Fertility Quality and Environmental Driving Factors in Different Soil Types of Artificial Forests
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作者 Songyu YU Zhenhui LIAO +3 位作者 Mingwu YANG Ronghui HU yuanyuan shi Junyu ZHAO 《Meteorological and Environmental Research》 2024年第2期64-70,共7页
The aim was to clarify the environmental driving factors of soil fertility indicators in artificial forests of Guangxi and comprehensively evaluate the soil fertility level.By collecting data on the current status of ... The aim was to clarify the environmental driving factors of soil fertility indicators in artificial forests of Guangxi and comprehensively evaluate the soil fertility level.By collecting data on the current status of soil in artificial forests,the spatial distribution of major soil fertility indicators was analyzed,and the distribution map of the fertility index of artificial forests in the entire region and the comprehensive fertility index of artificial forests of different soil types were obtained.Canonical correspondence analysis method was used to analyze soil fertility indicators and environmental factors,and the environmental driving factors of soil fertility indicators for artificial forests of the main soil types in Guangxi were obtained.The results showed that over 90%of the soil fertility index of artificial forests in the entire region was between 0.20 and 0.50.The order of soil fertility index of different soil types of artificial forests from high to low was yellow brown soil>yellow red soil>yellow soil>red soil>limestone soil>latosolic red soil>laterite.In artificial forests of latosolic red soil,the correlation between soil alkaline nitrogen and organic matter,annual average temperature was high,while the correlation between soil available phosphorus and organic matter,pH was high,and the correlation between soil available potassium and environmental factors such as slope,altitude,rainfall,accumulated temperature,and slope aspect was high.In artificial forests of red soil,the correlation between soil alkaline nitrogen and slope,altitude was high,while the correlation between soil available phosphorus and accumulated temperature,rainfall was high,and the correlation between soil available potassium and pH was high.In artificial forests of limestone soil,there was a high correlation between soil alkaline nitrogen and slope,organic matter,a high correlation between soil available phosphorus and accumulated temperature,rainfall,and a high correlation between soil available potassium and pH. 展开更多
关键词 Soil fertility index GIS Forest soil Canonical correspondence analysis
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Progress on the mechanisms of Ru-based electrocatalysts for the oxygen evolution reaction in acidic media 被引量:2
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作者 yuanyuan shi Han Wu +2 位作者 Jiangwei Chang Zhiyong Tang Siyu Lu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第10期220-238,I0008,共20页
Water electrolysis using proton-exchange membranes is one of the most promising technologies for carbon-neutral and sustainable energy production.Generally,the overall efficiency of water splitting is limited by the o... Water electrolysis using proton-exchange membranes is one of the most promising technologies for carbon-neutral and sustainable energy production.Generally,the overall efficiency of water splitting is limited by the oxygen evolution reaction(OER).Nevertheless,a trade-off between activity and stability exists for most electrocatalytic materials in strong acids and oxidizing media,and the development of efficient and stable catalytic materials has been an important focus of research.In this view,gaining in-depth insights into the OER system,particularly the interactions between reaction intermediates and active sites,is significantly important.To this end,this review introduces the fundamentals of the OER over Ru-based materials,including the conventional adsorbate evolution mechanism,lattice oxygen oxidation mechanism,and oxide path mechanism.Moreover,the up-to-date progress of representative modifications for improving OER performance is further discussed with reference to specific mechanisms,such as tuning of geometric,electronic structures,incorporation of proton acceptors,and optimization of metal-oxygen covalency.Finally,some valuable insights into the challenges and opportunities for OER electrocatalysts are provided with the aim to promote the development of next-generation catalysts with high activity and excellent stability. 展开更多
关键词 Oxygen evolution reaction Ru-based electrocatalysts Acidic solutions Mechanism Proton-exchange membranes
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页岩油组分对油水界面性质的影响
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作者 史园园 何凯 吴文中 《日用化学工业(中英文)》 CAS 北大核心 2023年第10期1140-1146,共7页
探讨了页岩油组分对油水界面性质的影响,油水界面性质对非常规储层中碳氢化合物的回收和运移起着至关重要的作用。研究考察了页岩油的组分含量变化对油水界面性质的影响,包括饱和分、芳香分、胶质、沥青质和蜡的变化。系统评价了不同组... 探讨了页岩油组分对油水界面性质的影响,油水界面性质对非常规储层中碳氢化合物的回收和运移起着至关重要的作用。研究考察了页岩油的组分含量变化对油水界面性质的影响,包括饱和分、芳香分、胶质、沥青质和蜡的变化。系统评价了不同组分质量分数下油水界面张力和界面模量,建立了页岩油组成与界面性质之间的相关性。结果表明,沥青质和胶质的存在显著影响油水界面性质,导致界面张力降低,质量分数为1%的沥青质和胶质组分分别可将平衡界面张力降低至22.48 mN/m和19.42 mN/m;沥青质对界面膜的稳定起到主要作用,不同胶质/沥青质(R/A)含量下对界面张力和界面模量大小改善程度不相同;蜡组分没有降低界面张力的能力,但与胶质-沥青质存在协同作用,可提高界面膜的稳定性,降低高胶质/沥青质(R/A)比例下的竞争吸附,当R/A为10时,胶质/沥青质-蜡的平衡界面张力为17.06 mN/m、黏性模量为6.42 mN/m、弹性模量为36.98 mN/m、扩张模量为37.61 mN/m。这些发现为页岩油组成与油水界面性质之间的复杂关系提供了有价值的见解,有助于开发更有效的提高采收率(EOR)技术和更好地理解非常规储层中的多相流动行为。 展开更多
关键词 页岩油 界面张力 界面模量 油水界面性质 提高采收率
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Ceramide is involved in alcohol-induced neural proliferation 被引量:1
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作者 Zhixin Wang Tongxing Deng +6 位作者 Jiexin Deng Jinbo Deng Xiaoqun Gao yuanyuan shi Bin Liu Zhanyou Ma Haixiao Jin 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第23期2178-2189,共12页
Prenatal alcohol exposure, especially during early pregnancy, can lead to fetal alcohol syndrome. The pharmacological and toxicological mechanisms of ethanol are related to the effects of ceramide In this study, we es... Prenatal alcohol exposure, especially during early pregnancy, can lead to fetal alcohol syndrome. The pharmacological and toxicological mechanisms of ethanol are related to the effects of ceramide In this study, we established an alcohol exposure model in wild-type mice and in knockout mice for the key enzyme involved in ceramide metabolism, sphingomyelin synthase 2. This model received daily intragastric administration of 25% ethanol, and pups were used at postnatal days 0, 7, 14, 30 for experiments. Serology and immunofluorescence staining found that ethanol exposure dose-dependently reduced blood sphingomyelin levels in two genotypes of pups, and increased neural cell proliferation and the number of new neurons in the hippocampal dentate gyrus. Western blot analysis showed that the relative expression level of protein kinase C e increased in two genotypes of pups after ethanol exposure. Compared with witd-type pups, the expression level of the important activator protein of the ceramide/ceramide-l-phosphate pathway, protein kinase C a, was reduced in the hippocampus of sphingomyelin synthase 2 knockouts. Our findings illustrate that ceramide is involved in alcohol-induced neural proliferation in the hippocampal dentate gyrus of pups after prenatal ethanol exposure, and the mechanism may be associated with increased ex- pression of protein kinase C a activating the ceramide/ceramide-l-phosphate pathway. 展开更多
关键词 neural regeneration brain injury CERAMIDE neural cells PROLIFERATION prenatal alcohol exposure sphingomyelin synthase 2 knockout mice SPHINGOMYELIN sphingomyelin synthase cera-mide-l-phosphate fetal alcohol syndrome grants-supported paper NEUROREGENERATION
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Organ donation in China:the major progress and the continuing problem 被引量:4
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作者 Ni An yuanyuan shi +1 位作者 Yabo Jiang Linlin Zhao 《The Journal of Biomedical Research》 CAS CSCD 2016年第2期81-82,共2页
China has banned harvesting organs from executed prisoners since January 1st, 2015, making voluntary donation the only legitimate venue for organ transplant. It is a critical move to settle all the controversies about... China has banned harvesting organs from executed prisoners since January 1st, 2015, making voluntary donation the only legitimate venue for organ transplant. It is a critical move to settle all the controversies about China's organ transplant process by making a loud and strong statement worldwide that the Chinese government respects human rights and is streamlining its organ transplant process to conform with internationally accepted standards on organ transplantation. This regulation removes one major obstacle of organ transplant in China; however, China still faces the other maior obstacle of critical organ shortage. 展开更多
关键词 transplant continuing voluntary venue conform settle executed statement organs donor
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A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years 被引量:2
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作者 Mingqing Wei Xuekai Zhang +11 位作者 Jing shi Jingnian Ni Ting Li Tao Lu yuanyuan shi Liping Zhang Pengwen Wang Shenghua Kang Fuyun Ma Yumeng Li Chenmeng Li Jinzhou Tian 《World Journal of Neuroscience》 2017年第2期209-215,共7页
Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChE... Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia. 展开更多
关键词 Alzheimer’s Disease Sequential Therapy CHOLINESTERASE INHIBITORS HERBAL Medicine
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Pharmacological evaluation and mechanistic study of compound Xishu Granule in hepatocellular carcinoma 被引量:1
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作者 Pin Li yuanyuan shi +8 位作者 Baosheng Zhao Wenhui Xu Ziying Xu Jingxuan Zhang Zhaojuan Guo Yucong Bi Tieshan Wang Yu Qin Ting Wang 《Journal of Traditional Chinese Medical Sciences》 2020年第3期255-264,共10页
Objective:In this study,we used HepG2 human hepatocellular carcinoma cells to study the effects of Compound Xishu Granule(CXG)on cell proliferation,apoptosis,and the cell cycle in vitro.We also used a xenograft tumor ... Objective:In this study,we used HepG2 human hepatocellular carcinoma cells to study the effects of Compound Xishu Granule(CXG)on cell proliferation,apoptosis,and the cell cycle in vitro.We also used a xenograft tumor model to study the anti-tumor effects of CXG and related mechanisms in vivo.Methods:The effect of CXG on cell viability was measured using Cell Counting Kit-8 and a colony formation assay.The effect of CXG on apoptosis and the cell cycle was analyzed using flow cytometry.The in vivo anti-tumor effect of CXG was assessed by measuring the volume change in xenograft tumors after drug administration.The CXG anti-tumor mechanism was studied using western blotting assay to detect cell cycle and apoptotic associated proteins.Results:CXG suppressed HepG2 cell proliferation in a time-and dose-dependent manner in vitro.Colony formation experiments showed that CXG administration for 24 h significantly reduced HepG2 cell formations(P<.01).Flow cytometric analysis showed that CXG treatment for 48 h promoted apoptosis and blocked HepG2 cells in the G2/M phase.Western blotting results showed that Bax was significantly upregulated and Bcl-2 was down-regulated in graft tumor tissues and HepG2 cells after CXG administration,which increased the Bax/Bcl-2 ratio.PLK1,CDC25 C,CDK1,and Cyclin B1 expression were upregulated.CXG had a good inhibitory effect on graft tumor growth in vivo.Conclusion:CXG has good anti-tumor effects in vitro and in vivo.In vitro,CXG promoted HepG2 cell apoptosis and induced G2/M phase arrest.In vivo,CXG significantly inhibited graft tumor growth.The CXG mechanism in treating hepatocellular carcinoma may be that CXG can induce abnormal apoptotic and cell cycle associated protein expression,leading to mitotic catastrophe and apoptosis. 展开更多
关键词 Compound Xishu Granule Hepatocellular carcinoma Cell cycle CDK1 Cyclin B1 PLK1 Mitotic catastrophe
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Network pharmacology used to decode potential active ingredients in Ferula assafoetida and mechanisms for the application to Alzheimer’s disease 被引量:1
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作者 Meng Xu Lili Zhang +2 位作者 Pin Li Chunguo Wang yuanyuan shi 《Journal of Traditional Chinese Medical Sciences》 2020年第2期199-209,共11页
Background:Alzheimer’s disease(AD)is a neurodegenerative disease that primarily manifests as progressive memory loss and cognitive impairment.Traditional herbal medicines may be helpful in the discovery of new anti-A... Background:Alzheimer’s disease(AD)is a neurodegenerative disease that primarily manifests as progressive memory loss and cognitive impairment.Traditional herbal medicines may be helpful in the discovery of new anti-AD drugs.Studies have shown that Ferula assafoetida has neuroprotective and memory-enhancing effects,which may be beneficial for the treatment of AD.However,the combination of active ingredients and their mechanisms remain unclear.Therefore,we aimed to identify potential active ingredients in F.assafoetida and their mechanisms of action against AD by using network pharmacology.Methods:In our study,an integrated network pharmacological approach,that included adsorption,distribution,metabolism and excretion screening,target identification,network construction,topological analysis,gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis,and molecular docking,was used to predict the pharmacological material basis and potential mechanisms through which these ingredients may treat and prevent AD.Results:The results indicated that 12 key active ingredients,obtained by topological analysis(including farnesiferol a,conferol,farnesiferol b,ferulic acid,etc.),may be the primary pharmacological components that may ameliorate AD.The 2 key significant pathways identified are the cholinergic synapse signaling pathway(critical targets include ACHE,CHRM1,CHRM2,MAPK1,PIK3CA,PIK3CB,PIK3CD,and PIK3CG)and the AD signaling pathway(critical targets include APP,BACE1,GSK3B,MAPK1,NCSTN,NOS1,PSEN1).These critical targets are closely related to the regulation of three typical pathological features of AD[central nervous system(CNS)cholinergic hypofunction,amyloid-β(Aβ)plaques,and hyperphosphorylated tau proteins].Finally,14 critical targets in the 2 key significant pathways were validated by molecular docking analysis.Conclusion:F.assafoetida may be effective for alleviating AD symptoms,through multi-component,multi-target,and multi-pathway synergistic effects,associated with the multiple pathogenesis hypotheses of AD.Our study may provide certain clues for the further development and utilization of this natural herbal medicine. 展开更多
关键词 Ferula assafoetida Alzheimer’s disease Network pharmacology Molecular docking Pharmacological mechanism
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Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network 被引量:1
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作者 Qihong Ma shi Dong +1 位作者 yuanyuan shi Tiangong Lu 《TMR Modern Herbal Medicine》 CAS 2021年第4期78-89,共12页
Objective:Ovarian cancer(OC)is the most lethal gynecological malignancy.Frequent peritoneal dissemination is the main cause of low survival rate.Guizhi-Fuling formula(GZFL)is a classical traditional Chinese herbal for... Objective:Ovarian cancer(OC)is the most lethal gynecological malignancy.Frequent peritoneal dissemination is the main cause of low survival rate.Guizhi-Fuling formula(GZFL)is a classical traditional Chinese herbal formula,and has been clinically used for treating ovarian cancer with good outcome.However,its therapeutic mechanism for treating OC has not been clearly elucidated.Methods:Network pharmacology analysis was used to predict potential molecular mechanisms of GZFL in treating OC.In vitro and in vivo analysis,including STAT3 KO/WT cells proliferation assay,scratch assay and antitumor efficacy study were performed to assess the biological activity of GZFL on targeting STAT3 in OC cells.Results:We generated a“GZFL target-OC-STAT3”gene interaction network,and predicted that GZFL is tightly associated with IL6/JAK/STAT3 signal pathway and cancer metastasis.Our preliminary data showed that GZFL inhibited OC cell proliferation in a STAT3 dependent manner.It suppressed cell migration and downregulated p-STAT3 expression.In a tumor bearing mouse model,GZFL displayed a safety profile.Conclusion:GZFL inhibits OC progression by targeting STAT3 signaling network.Our newly proposed pharmacological mechanisms of Guizhi-Fuling formula will provide a new insight for its clinical use in treating OC. 展开更多
关键词 Guizhi-Fuling formula Ovarian cancer STAT3 TCM Cancer metastasis
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Review of dynamic gesture recognition 被引量:2
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作者 yuanyuan shi Yunan LI +2 位作者 Xiaolong FU Kaibin MIAO Qiguang MIAO 《Virtual Reality & Intelligent Hardware》 2021年第3期183-206,共24页
In recent years,gesture recognition has been widely used in the fields of intelligent driving,virtual reality,and human-computer interaction.With the development of artificial intelligence,deep learning has achieved r... In recent years,gesture recognition has been widely used in the fields of intelligent driving,virtual reality,and human-computer interaction.With the development of artificial intelligence,deep learning has achieved remarkable success in computer vision.To help researchers better understanding the development status of gesture recognition in video,this article provides a detailed survey of the latest developments in gesture recognition technology for videos based on deep learning.The reviewed methods are broadly categorized into three groups based on the type of neural networks used for recognition:two stream convolutional neural networks,3D convolutional neural networks,and Long-short Term Memory(LSTM)networks.In this review,we discuss the advantages and limitations of existing technologies,focusing on the feature extraction method of the spatiotemporal structure information in a video sequence,and consider future research directions. 展开更多
关键词 Video-based gesture recognition Deep learning Convolutional neural networks Human computer interaction
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Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E
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作者 Hongmin Sun Xingxing Li +14 位作者 Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu yuanyuan shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si 《Engineering》 SCIE EI CAS 2022年第9期176-186,共11页
Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from s... Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until now.We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics analysis.Through bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral compounds.Bioactivity-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural analogues.Finally,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation broth.Among them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new compounds.Omicsynins B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to 300.Omicsynins B1–B4 also showed significant antiviral activity against human coronavirus HCoV-229E.By integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals. 展开更多
关键词 Multi-omics Anti-influenza A virus Anti-coronavirus Streptomyces sp.1647 Pseudo-tetrapeptides
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Antioxidant mechanism of modified Qiongyu paste against aging based on network pharmacology and experimental validation
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作者 Tianshu Xie Qi Ding +2 位作者 Siwen Feng Zimin Liu yuanyuan shi 《Journal of Traditional Chinese Medical Sciences》 CAS 2022年第4期420-431,共12页
Objective:To provide a possible basis for the anti-aging effect of modified Qiongyu paste(MQP).Methods:Ultra-high-performance liquid chromatography-Q-Orbitrap mass spectrometry was applied to confirm the effective com... Objective:To provide a possible basis for the anti-aging effect of modified Qiongyu paste(MQP).Methods:Ultra-high-performance liquid chromatography-Q-Orbitrap mass spectrometry was applied to confirm the effective components of MQP that we had identified from databases and research literature.Then,network pharmacology was employed to predict the possible underlying mechanism of MQP against aging.According to the overlap with age-related gene targets,we obtained key targets of MQP against aging using protein-protein interaction analyses.Superoxide dismutase(SOD)tests were performed in vitro and in vivo.Western blotting of P62 and LC3B and quantitative polymerase chain reaction of the expression of the P62,LC3B,HO-1,Keap1,and Nrf2 genes were conducted on H_(2)O_(2) -induced PC12 cells.Enzyme-linked immunosorbent assays of tumor necrosis factor-a and interleukin-6 were conducted on a D-galactose-induced aging mice model.Results:A total of 44 compounds in MQP were finally identified,and 48 gene targets were considered related to anti-aging.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses linked the principal anti-aging mechanisms of MQP to oxidative resistance,genomic stabilization,and growth hormone regulation.In vitro,H_(2)O_(2)-induced PC12 cells showed that MQP was able to activate SOD,prolong telomeres,and enhance the expression levels of P62,LC3B,HO-1,Keap1,and Nrf2.The quantitative polymerase chain reaction results were affirmed with the reactive oxygen species inhibitor N-acetylcysteine and the reactive oxygen species agonist diallyl-tetrasulfide.In vivo,the D-gal-induced aging mice showed that MQP increased SOD in the brain and reduced tumor necrosis factor-α and interleukin-6 in the serum.Thus,our results suggest that the mechanism of the anti-aging effect of MQP primarily involves antagonizing oxidative stress.Conclusion:From the analyses and experimental validation,we may conclude that oxidative stress resistance may be a potential mechanism of the MQP anti-aging effect. 展开更多
关键词 AGING Modified Qiongyu paste Network pharmacology Oxidative stress Reactive oxygen species N-ACETYLCYSTEINE Diallyl-tetrasulfide
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Progress of Mid Infrared Spectroscopy in Soil Environment Research
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作者 Zehong ZHAO Jian TANG +3 位作者 Junyu ZHAO Zuoyu QIN Huili WANG yuanyuan shi 《Meteorological and Environmental Research》 CAS 2021年第3期1-5,10,共6页
Soil is the basis of agricultural and forestry production,and it is of great significance to obtain soil information efficiently and comprehensively for soil management.Due to the complexity of soil organic components... Soil is the basis of agricultural and forestry production,and it is of great significance to obtain soil information efficiently and comprehensively for soil management.Due to the complexity of soil organic components,it is difficult to obtain the information of soil organic components comprehensively by traditional chemical analysis method.As a non-destructive,real-time and high-throughput analysis method,mid infrared spectroscopy(MIR)has the ability to obtain soil organic environmental information efficiently and accurately.It can provide a large number of basic data for soil environmental monitoring,digital mapping,agricultural and forestry production,and help to realize the real-time monitoring of soil environment and the informatization of agriculture and forestry.In this paper,the detection process of MIR obtaining soil environmental spectral information and processing methods of spectral data were briefly introduced,and the research progress on extraction and influencing factors of mid infrared spectrum characteristics of soil in recent years was reviewed.Moreover,the significance and future development direction of soil science for the technology were discussed. 展开更多
关键词 Organic matter Soil environment Spectroscopy analysis Portable spectrometer ALLELOPATHY Agricultural informatization Research progress
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Analysis of Soil Fertility Evolution Characteristics in Main Eucalyptus Producing Areas of Guangxi from 1993 to 2018
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作者 Chongfu XIAO Jian TANG +4 位作者 Junyu ZHAO Zuoyu QIN Huili WANG yuanyuan shi Zehong ZHAO 《Meteorological and Environmental Research》 CAS 2021年第5期55-59,64,共6页
The research aimed to explore the impact of long-term continuous planting management mode on soil fertility evolution of eucalyptus plantation in Guangxi and evolution characteristics of each soil fertility index,and ... The research aimed to explore the impact of long-term continuous planting management mode on soil fertility evolution of eucalyptus plantation in Guangxi and evolution characteristics of each soil fertility index,and establish a reasonable management method of eucalyptus plantation in Guangxi.Main production area of eucalyptus in Guangxi was taken as the research object,and the soil fertility quality of eucalyptus plantation in Guangxi from 1993 to 2018 was evaluated by means of fuzzy mathematics by selecting soil chemical properties such as p H,organic matter,total nitrogen,total phosphorus,total potassium,alkali-hydrolyzed nitrogen,available phosphorus and available potassium.The results showed that the soil p H value of eucalyptus plantation in Guangxi decreased from 4.83 to 4.63,a decrease of 4.14%.The contents of soil organic matter,total phosphorus,available nitrogen and available potassium all showed a significant decreasing trend.The soil fertility quality index( IFI) was between 0.475 and 0.613,and the overall fertility index was low.The soil of eucalyptus plantation in Guangxi showed a trend of acidification under continuous management during 1993-2018.In the actual production,it should pay more attention to soil improvement,advocate soil testing and reasonable fertilization,reduce the use of acid fertilizer,increase the application of organic fertilizer and slow release fertilizer,and ensure the ecological health and sustainable development of eucalyptus plantation. 展开更多
关键词 EUCALYPTUS Long-term continuous cropping High strength PLANTATION Soil fertility evaluation
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The Three Levels of Education in Site Design Course of Architecture
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作者 yuanyuan shi 《Journal of World Architecture》 2021年第3期18-23,共6页
“Professional Guiding Standards for Advanced Education Architecture in University Undergraduate Students”(2013 edition)indicates that the education system of architecture should include a section on“environment and... “Professional Guiding Standards for Advanced Education Architecture in University Undergraduate Students”(2013 edition)indicates that the education system of architecture should include a section on“environment and site.”It should involve six learning components which are concepts of site and environment,site terrain classifications,environment of two tendencies,elements involved in the sites,elements of environmental impact,and site design.[1]As site design(drawing)has become a significant topic in the examination of registered architects,many domestic architecture colleges have set up site design courses as independent ones.After more than ten years of exploration and research in developing the education system of site design courses,teaching experiences and achievements have been acquired.Site design courses have been gradually integrated with general plan design,registered architect examination,and architectural programming.Teachers have specified relevant learning goals in the regular daily curriculum in addition to the basic and vocational education of architecture.In this way,the site design course would be more in line with the educational goals of architecture.This paper aims to analyze the education of site design courses in hope of developing the future architectural education. 展开更多
关键词 Site design General plan Architect registration examination Architectural programming
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Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese popula- tion: a cross-section study 被引量:1
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作者 Jie Zheng Yuzhen Gao +9 位作者 Yuejuan Jing Xiaoshuang Zhou yuanyuan shi Yanhong Li Lihua Wang Ruiying Wang Maolian Li Chuanshi Xiao Yafeng Li Rongshan Li 《Frontiers of Medicine》 SCIE CAS CSCD 2014年第4期477-483,共7页
The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for hi... The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects (1027 men, and 2433 women, aged 35-75 years old) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376 ± 0.018; middle tertiles, 5.324± 0.018; highest tertiles, 5.276±0.018mmol/L; P = 0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75; 95% CI: 1.20-2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio. 展开更多
关键词 DYSLIPIDEMIA plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes
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Electrocatalytic water splitting:Mechanism and electrocatalyst design 被引量:18
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作者 Han Wu Qiaoxian Huang +2 位作者 yuanyuan shi Jiangwei Chang Siyu Lu 《Nano Research》 SCIE EI CSCD 2023年第7期9142-9157,共16页
Hydrogen energy,a new type of clean and efficient energy,has assumed precedence in decarbonizing and building a sustainable carbon-neutral economy.Recently,hydrogen production from water splitting has seen considerabl... Hydrogen energy,a new type of clean and efficient energy,has assumed precedence in decarbonizing and building a sustainable carbon-neutral economy.Recently,hydrogen production from water splitting has seen considerable advancements owing to its advantages such as zero carbon emissions,safety,and high product purity.To overcome the large energy barrier and high cost of water splitting,numerous efficient electrocatalysts have been designed and reported.However,various difficulties in promoting the industrialization of electrocatalytic water splitting remain.Further,as high-performance electrocatalysts that satisfy industrial requirements are urgently needed,a better understanding of water-splitting systems is required.In this paper,the latest progress in water electrolysis is reviewed,and experimental evidence from in situ/operando spectroscopic surveys and computational analyses is summarized to present a mechanistic understanding of hydrogen and oxygen evolution reactions.Furthermore,some promising strategies,including alloying,morphological engineering,interface construction,defect engineering,and strain engineering for designing and synthesizing electrocatalysts are highlighted.We believe that this review will provide a knowledge-guided design in fundamental science and further inspire technical engineering developments for constructing efficient electrocatalysts for water splitting. 展开更多
关键词 water splitting MECHANISM operando spectroscopy design strategy
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Biosynthesis of antibiotic chuangxinmycin from Actinoplanes tsinanensis 被引量:2
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作者 yuanyuan shi Zhibo Jiang +6 位作者 Xingxing Li Lijie Zuo Xuan Lei Liyan Yu Linzhuan Wu Jiandong Jiang Bin Hong 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第2期283-294,共12页
Chuangxinmycin is an antibiotic isolated from Actinoplanes tsinanensis CPCC 200056 in the1970 s with a novel indole-dihydrothiopyran heterocyclic skeleton. Chuangxinmycin showed in vitro antibacterial activity and in ... Chuangxinmycin is an antibiotic isolated from Actinoplanes tsinanensis CPCC 200056 in the1970 s with a novel indole-dihydrothiopyran heterocyclic skeleton. Chuangxinmycin showed in vitro antibacterial activity and in vivo efficacy in mouse infection models as well as preliminary clinical trials.But the biosynthetic pathway of chuangxinmycin has been obscure since its discovery. Herein, we report the identification of a stretch of DNA from the genome of A. tsinanensis CPCC 200056 that encodes genes for biosynthesis of chuangxinmycin by bioinformatics analysis. The designated cxn cluster was then confirmed to be responsible for chuangxinmycin biosynthesis by direct cloning and heterologous expressing in Streptomyces coelicolor M1146. The cytochrome P450 CxnD was verified to be involved in the dihydrothiopyran ring closure reaction by the identification of seco-chuangxinmycin in S. coelicolor M1146 harboring the cxn gene cluster with an inactivated cxn D. Based on these results, a plausible biosynthetic pathway for chuangxinmycin biosynthesis was proposed, by hijacking the primary sulfur transfer system for sulfur incorporation. The identification of the biosynthetic gene cluster of chuangxinmycin paves the way for elucidating the detail biochemical machinery for chuangxinmycin biosynthesis, and provides the basis for the generation of novel chuangxinmycin derivatives by means of combinatorial biosynthesis and synthetic biology. 展开更多
关键词 Chuangxinmycin Actinoplanes tsinanensis Biosynthesis gene cluster Heterologous expression Cytochrome P450 Seco-chuangxinmycin C–S bond formation Sulfur incorporation
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High-resolution characterization of hexagonal boron nitride coatings exposed to aqueous and air oxidative environments 被引量:2
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作者 Lanlan Jiang Na Xiao +12 位作者 Bingru Wang Enric Grustan-Gutierrez Xu Jing Petr Babor Miroslav Kogbal Guangyuan Lu Tianru Wu Haomin Wang Fei Hui yuanyuan shi Bo Song Xiaoming Xie Mario Lanza 《Nano Research》 SCIE EI CAS CSCD 2017年第6期2046-2055,共10页
Hexagonal boron nitride (h-BN) is believed to offer better passivation to metallic surfaces than graphene owing to its insulating nature, which facilitates blocking the flow of electrons, thereby preventing the occu... Hexagonal boron nitride (h-BN) is believed to offer better passivation to metallic surfaces than graphene owing to its insulating nature, which facilitates blocking the flow of electrons, thereby preventing the occurrence of galvanic reactions. Nevertheless, this may not be the case when an h-BN-protected material is exposed to aqueous environments. In this work, we analyzed the stability of mono and multilayer h-BN stacks exposed to H202 and atmospheric conditions. Our experiments revealed that monolayer h-BN is as inefficient as graphene as a protective coating when exposed to H202. Multilayer h-BN offered a good degree of protection. Monolayer h-BN was found to be ineffective in an air atmosphere as well. Even a 10-15 layers-thick h-BN stack could not completely protect the surface of the metal under consideration. By combining Auger electron spectroscopy and secondary ion mass spectrometry techniques, we observed that oxygen could diffuse through the grain boundaries of the h-BN stack to reach the metallic substrate. Fortunately, because of the diffusive nature of the process, the oxidized area did not increase with time once a saturated state was reached. This makes multflayer (not monolayer) h-BN a suitable long-term oxidation barrier. Oxygen infiltration could not be observed by X-ray photoelectron spectroscopy. This technique cannot assess the chemical composition of the deeper layers of a material. Hence, the previous reports, which relied on XPS to analyze the passivating properties of h-BN and graphene, may have ignored some important subsurface phenomena. The results obtained in this study provide new insights into the passivating properties of mono and multilayer h-BN in aqueous media and the degradation kinetics of h-BN-coated metals exposed to an air environment. 展开更多
关键词 hexagonal boron nitride protective coating local oxidation NANOSCALE two-dimensional (2D)materials
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