哪些因素对农村寄宿生越轨行为的影响更大?——基于随机森林的变量重要性排序

我国农村寄宿生的全面发展情况是值得关注的现实问题,越轨行为作为影响学生全面发展的重要因素之一,需要对其予以关注。基于中国教育追踪调查数据,运用多元回归分析和随机森林回归分析的方法探究了农村寄宿生越轨行为的影响因素和各因素的重要性排序,结果发现:(1)个体因素及人际关系因素均能影响农村寄宿生的越轨行为;(2)教师支持、同伴支持对农村寄宿生越轨行为的影响更为重要;(3)亲子关系对农村寄宿生越轨行为的影响需引起重视。据此,提出构建和谐师生关系、打造良好同伴关系、注重家庭支持、提高农村寄宿生自身情绪控制力和自制力等对策建议,以期帮助农村寄宿生预防或矫正越轨行为。

Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study

Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and practicality.This pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the US for the multiparametric quantitative assessment of human nail.The study involved a small cohort offive healthy volunteers who underwent PAT/US imaging for acquiring the nail unit data.The PAT/US dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail bed.Moreover,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail bed.The quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological conditions.This pilot study highlights the potential of PAT/US dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.

Applications of atmospheric pressure plasma in microbial inactivation and cancer therapy: a brief review

Atmospheric pressure cold plasma, with advantages such as high particle activity, no thermal damage, high efficiency and direct and friendly contact with human tissues, is considered to have great potential in biomedical applications. Therefore, 'plasma medicine' as a new interdiscipline has been developed in the past two decades. This review first briefly describes the development of typical plasma sources suitable for biomedical applications, and those with different discharge forms are simply compared, evaluated and summarized. Subsequently, measurement of the crucial gaseous reactive particles(e.g. OH and O) and their spatio-temporal distributions are introduced. Meanwhile, the generation and variation rules and the related critical macroscopic parameters of the plasma-induced aqueous reactive species are summarized. Finally, related studies in the last ten years on the mechanisms of the plasma-driven microbial inactivation and plasma-induced apoptosis of cancer cells are introduced. Moreover, some scientific problems that need to be urgently solved in the field of plasma medicine are also discussed. This review will provide useful guidance for future related research.

Game and Dynamic Communication Path-Based Pricing Strategies for Microgrids Under Communication Interruption

Nowadays,the microgrid cluster is an important application scenario for energy trading.In trading,one of the most important research directions is the issue of pricing.To determine reasonable pricing for the microgrid cluster,data communication is used to create the cyber-physical system(CPS),which can improve the observability of microgrids.Then,the following works are carried out in the CPS.In the physical layer:1)Regarding trading between microgrids and the load,based on the generalized game theory,an optimal pricing strategy is proposed,which takes into account the interactive relationships among microgrids and transforms the pricing problem into a Nikaido-Isoda function to obtain the optimal prices conveniently;2)Regarding peer-to-peer trading between two microgrids,based on evolutionary game theory and the penalty mechanism,the optimal sale price of the seller is selected with boundary rationality.In the cyber layer,regarding the communication interruption issue existing in pricing(i.e.,the game process),based on the principle of matching the performance of the path with the importance degree of the data,a dynamic regulating method of paths is proposed,i.e.,adopting a new path to re-transmit the interrupted data to the destination.Finally,the effect of the proposed strategies is verified by case studies.

考虑驾驶风格的停车场泊位分配优化方法

针对高峰期间停车场空余泊位数量紧张导致驾驶员难以寻找到符合心理预期的泊位的问题,以同一时段内进场车辆总损失函数值最小为优化目标,构建了考虑驾驶风格的泊位分配模型。分析影响泊位分配的因素,包括时间因素以及受出行目的影响的心理阻抗因素;通过聚类分析将驾驶风格分类,分析得出驾驶风格对分配因素影响的权重,并对权重系数进行灵敏度分析。并通过Vissim进行了仿真验证。算例分析结果显示:考虑驾驶风格的泊位分配方案相比于传统就近寻泊方案,总损失时间减少了22.4%。

A provable-secure and practical two-party distributed signing protocol for SM2 signature algorithm

Mobile devices are widely used for data access,communications and storage.However,storing a private key for signature and other cryptographic usage on a single mobile device can be challenging,due to its computational limitations.Thus,a number of(t,n)threshold secret sharing schemes designed to minimize private key from leakage have been proposed in the literature.However,existing schemes generally suffer from key reconstruction attack.In this paper,we propose an efficient and secure two-party distributed signing protocol for the SM2 signature algorithm.The latter has been mandated by the Chinese government for all electronic commerce applications.The proposed protocol separates the private key to storage on two devices and can generate a valid signature without the need to reconstruct the entire private key.We prove that our protocol is secure under nonstandard assumption.Then,we implement our protocol using MIRACL Cryptographic SDK to demonstrate that the protocol can be deployed in practice to prevent key disclosure.

Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China

Human adenoviruses type 26(HAdV26)and type 35(HAdV35)have increasingly become the choice of adenovirus vectors for vaccine application.However,the population pre-existing immunity to these two adenoviruses in China,which may reduce vaccine efficacy,remains largely unknown.Here,we established micro-neutralizing(MN)assays to investigate the seroprevalence of neutralizing antibodies(nAbs)against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces,China.A total of 1184 serum samples were collected,47.0%and 15.8%of which showed HAdV26 and HAdV35 nAb activity,respectively.HAdV26-seropositive individuals tended to have more moderate nAbs titers(201-1000),while HAdV35-seropositive individuals appeared to have more low nAbs titers(72-200).The seropositive rates of HAdV26 and HAdV35 in individuals younger than 20 years old were very low.The seropositive rates of HAdV26 increased with age before 70 years old and decreased thereafter,while HAdV35 seropositive rates did not show similar characteristics.Notably,the seropositive rates and nAb levels of both HAdV26 and HAdV35 were higher in Guangdong Province than in Shandong Province,but did not exert significant differences between males and females.The seroprevalence between HAdV26 and HAdV35 showed little correlation,and no significant cross-neutralizing activity was detected.These results clarified the characteristics of the herd immunity against HAdV26 and HAdV35,and provided information for the rational development and application of HAdV26 and HAdV35 as vaccine vectors in China.

Transition metal on topological chiral semimetal PdGa with tailored hydrogen adsorption and reduction

The difficulties in designing high-performance hydrogen evolution reaction(HER)catalysts lie in the manipulation of adsorption behaviors of transition metals(TMs).Topological chiral semimetals with super-long Fermi arc surface states provide an ideal platform for engineering the catalytic performance of TMs through the metal-support interaction.We found the adsorption trends of TMs can be modified significantly when deposited at the surface of the PdGa chiral crystal.The electron transfer from the TMs to the surface states of the PdGa reshapes the d band structure of TMs and weakens the hydrogen intermediate bonding.Especially,W/PdGa is expected to be a good HER catalyst with close to zero Gibbs free energy.Experimentally,we found a Pt-like exchange current density and tumover frequency when depositing W atoms at the PdGa nanostructures surface.The findings provide a way to develop high-efficient electrocatalysts by the interplay between topological surface states and metal-support interaction.

Branched-chain amino acid transaminase 1 confers EGFRTKI resistance through epigenetic glycolytic activation

Third-generation EGFR tyrosine kinase inhibitors(TKIs),exemplified by osimertinib,have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer(NSCLC).Our previous work has identified ASK120067 as a novel third-generation EGFR TKI with remarkable antitumor effects that has undergone New Drug Application(NDA)submission in China.Despite substantial progress,acquired resistance to EGFR-TKIs remains a significant challenge,impeding the long-term effectiveness of therapeutic approaches.In this study,we conducted a comprehensive investigation utilizing high-throughput proteomics analysis on established TKI-resistant tumor models,and found a notable upregulation of branched-chain amino acid transaminase 1(BCAT1)expression in both osimertinib-and ASK120067-resistant tumors compared with the parental TKI-sensitive NSCLC tumors.Genetic depletion or pharmacological inhibition of BCAT1 impaired the growth of resistant cells and partially re-sensitized tumor cells to EGFR TKIs.Mechanistically,upregulated BCAT1 in resistant cells reprogrammed branched-chain amino acid(BCAA)metabolism and promoted alpha ketoglutarate(α-KG)-dependent demethylation of lysine 27 on histone H3(H3K27)and subsequent transcriptional derepression of glycolysis-related genes,thereby enhancing glycolysis and promoting tumor progression.Moreover,we identified WQQ-345 as a novel BCAT1 inhibitor exhibiting antitumor activity both in vitro and in vivo against TKI-resistant lung cancer with high BCAT1 expression.In summary,our study highlighted the crucial role of BCAT1 in mediating resistance to third-generation EGFR-TKIs through epigenetic activation of glycolysis in NSCLC,thereby supporting BCAT1 as a promising therapeutic target for the treatment of TKI-resistant NSCLC.