Construction of competency evaluation system for infection control personnel in traditional Chinese medicine hospitals

Background:This study uses a literature review and the Delphi expert consultation method to construct a competency evaluation model for infection control personnel in traditional Chinese medicine(TCM)hospitals.The aim is to strengthen infection control management in TCM hospitals,assess the competency of infection control personnel in their positions,and assist them in identifying the competencies that need improvement.Methods:Based on the literature research method and the Delphi expert consultation method,a competency model for the position was constructed through two rounds of expert consultations,analyzing the relationships between various factors and establishing a hierarchical structure model.Pairwise comparisons were made among the elements at the same level to construct a judgment matrix.Through the analytic hierarchy process,the weight coefficients of the indicators at each level in the competency model were obtained.Results:This study conducted a comprehensive assessment of various capabilities and practices related to hospital infection control.The survey results indicate that participants excelled in multiple areas,with a high overall satisfaction rate.95.28%of participants were able to develop hospital infection monitoring plans based on national infection control policies,demonstrating a good understanding and execution of these policies.94.09%of participants were familiar with high-risk populations and key departments in the hospital.91.73%of participants were able to establish monitoring scopes based on the trends of multidrug-resistant bacteria and conduct information monitoring,reflecting strong response capabilities.92.91%of participants were able to collaborate with relevant departments to conduct bacterial resistance monitoring,showing a good team spirit.94.49%of participants were able to perform targeted monitoring,including surgical site infections,indicating that they have effective monitoring strategies.91.34%of participants were able to collect and organize monitoring data and establish a systematic database,demonstrating good data management skills.90.16%of participants were able to interpret laws and regulations related to hospital infection management,indicating a high level of legal knowledge.89.37%of participants generally possessed good communication skills.92.52%of participants were able to guide medical staff on occupational safety and protective knowledge,showing an emphasis on occupational health.Participants demonstrated a strong desire to learn and innovate,with 87.01%actively participating in continuing education and research activities,reflecting a pursuit of professional development.Conclusion:Based on the results of the two rounds of expert consultations,a competency evaluation model for infection control personnel in TCM hospitals was formed.Through the analytic hierarchy process,the weight coefficients of various indicators at different levels in the model were obtained,and the research results have good scientific validity and reliability.

Correlation between the Xba Ⅰ polymorphism of apoB gene and serum lipid profiles in Li ethnic group

Objective:To study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.Methods:Total 1S1 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control;blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.Results:There were lower serum total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)levels in serum of Li people;while,high density lipoprotein cholesterol(HDL-C),X^-/X^-genotype and X^+allele frequencies exhibited higher levels than Han people.Interestingly,HDL-C level was reduced,while LDL-C level was enhanced in subjects carrying heterozygous(X^-/X^-)genotype compared to homozygous(X^-/X^-)genotype.Additionally,there were no difference in serum level of triglyceride,TC,apoprotein A(apo A)and apoprotein B(apo B)between Li and Han people,the same results were showed between X^-/X^+and X^-/X^-genotype carriers.Conclusions:XbaⅠpolymorphism of apoB gene is correlated to the profiles of serum lipid level,X^-/X^+genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.

The protective effect and underlying mechanism of Hainan papaya water extract against neuronal apoptosis induced by A β 40

Objective:To investigate whether Hainan papayas has protective effects in an Aimary neuron injury model and elucidate the underlying molecular mecha β 40-induced prnism.Methods:Cultured primary neurons from the dorsal root ganglia(DRG) of Sprague-Dawley(SD) rats were treated with 20 μM A culture medium β 40 peptide,100 μg/L Hainan papaya water extract,peptide plus extract,or for 24 h.Cell viability was measured by MTT assay,and neuronal apoptosis was evaluated by DAPI staining.ERK signaling pathway-associated molecule activation and changes in Bax expression were analyzed by Western blotting and immunofluorescence.Results:A cell viability rate of(44.11±6.59)% in the Ading different concentrations of the extract β 40 group was rescued to(79.13±6.64)% by ad.DAPI showed pyknotic nuclei in 39.5% of A β 40-treated cells;the fraction dropped to 17.4% in the 100 μg/L extract group.ERK phosphorylation was observed in the Aent with 100 μg/L extract.Hainan papaya water ex β 40 group but was ameliorated by pretreatmtract also prevented Ation of MEK,RSK1 and CREB associated with ERK signaling and d β 40-induced phosphorylaownregulated Bax expression in the neurons.Conclusion:The resultss suggest that Hainan papaya water extract has protective effects on neurons;the mechanism may be related to suppression of ERK signaling activation.