Quality-adjusted time without symptoms or toxicity analysis of haploidentical-related donor vs.identical sibling donor hematopoietic stem cell transplantation in acute myeloid leukemia

Objective:We aimed to compare the quality-adjusted time without symptoms or toxicity(Q-TWiST)in acute myeloid leukemia(AML)patients who received haploidentical-related donor(HID)and identical sibling donor(ISD)hematopoietic stem cell transplantation(HSCT).Methods:Five clinical health states were defined:toxicity(TOX),acute graft-versus-host disease(GVHD),chronic GVHD(cGVHD),time without symptoms and toxicity(TWiST)and relapse(REL).The equation used in this study was as follows:Q-TWiST=UTOX×TOX+UTWiST×TWiST+UREL×REL+UaGVHD×aGVHD+UcGVHD×cGVHD.Results:A total of 239 AML patients were enrolled.We established a mathematical model,i.e.,Q-TWiST HID HSCT>Q-TWiST ISD HSCT,to explore the range of utility coefficients satisfying the inequality.Based on the raw data,the utility coefficient is equivalent to the following inequality:10.57067UTOX-46.27733UREL+105.9374+3.388078UaGVHD-210.8198UcGVHD>0.The model showed that when UTOX,UREL,and UaGVHD were within the range of 0-1,as well as when UcGVHD was within the range of 0-0.569,the inequality Q-TWiST HID HSCT>Q-TWiST ISD HSCT was valid.According to the results of the ChiCTR1800016972 study,the median coefficients of TOX,acute GVHD(aGVHD),and cGVHD were 0.56(0.41-0.76),0.56(0.47-0.72),and 0.54(0.37-0.79),respectively.We selected a series of specific examples of the coefficients,i.e.,UTOX=0.5,UREL=0.05,UaGVHD-0.5,and UcGVHD-0.5.The Q-TWiST values of ISD and HID HSCT were 896 and 900 d,respectively(P=0.470).Conclusions:We first observed that Q-TWiST was comparable between AML patients receiving HID HSCT and those receiving ISD HSCT.

A Study on the Integration of Traditional Chinese Culture into College English Education Under the Context of Course-Based Ideological and Political Education

The construction of course-based ideological and political education is currently in its full swing.With both instrumentality and humanity,college English is the ideal carrier of ideological and political education.College English education should keep pace with the era,integrate with ideological and political education based on traditional Chinese culture,and construct a teaching system with Chinese characteristics.It is necessary to strengthen ideological and political orientation,reasonably integrate the teaching content,comprehensively enhance the quality of teachers,and actively innovate the teaching method,so as to further improve the effect of course-based ideological and political practice as well as realize the fundamental task of cultivating students through moral cultivation in higher education.

Fuel economy of multiple conditions self-adaptive tractors with hydro-mechanical CVT

Fuel economy is one of the most important properties of wheeled tractors.To improve the fuel economy,it is necessary to improve the engine fuel economy and the tractive efficiency of the driving mechanism.By analyzing the fuel economy evaluation index of wheeled tractors,the correlation among the tractor specific fuel consumption,the engine effective specific fuel consumption and the tractive efficiency of the driving mechanism were clarified in this paper.A tractor with a new type of hydro-mechanical continuously variable transmission(HMCVT)was designed and its whole model was established too.On the basis of each module’s simulation model,the binary speed ratio matching simulation model of the gearbox-engine system was obtained by the control system reconstruction,and the fuel economy simulation analysis of the wheeled tractor with HMCVT was carried out under the two typical working conditions of plowing and sowing.Compared with the current national standard,the fuel economy of the newly designed wheeled tractors with the power of 130 kW was 380 g/(kW·h),specific fuel consumption was reduced by 21.1%.The results showed that the new tractor fuel economy was greatly improved.Further,automatic navigation technology can be combined with the self-adaptive tractors to adapt to different working conditions and achieve the optimal fuel economy,which can be applied in precision agriculture.

语块理论应用于商务英语写作的实证研究

二语习得研究发现,语块能力是二语综合能力的一个重要指标。语言的流利程度和选词的地道性取决于语块存储的多少。近些年来,语言学界对于基于语块理论的语块教学法愈加重视。尽管语块理论的重要性已经被多方讨论,但对于语块教学法的实证研究仍显匮乏。因此,本文首先介绍了语块理论的起源及其定义,商务英语写作的特点以及语块在商务英语写作中的重要性。进而以80名商务英语写作学生为研究对象,根据Lewis对语块的定义将语块理论应用于商务英语写作教学进行了实证研究。实验通过调查研究分析和运用SPSS21.0对研究结果进行了数据分析,探讨了语块在商务英语写作教学中的作用,印证了语块教学法可以提高商务英语写作准确性和流利性。