Vibration Control of a High-Rise Building Structure:Theory and Experiment

In this study,an innovative solution is developed for vibration suppression of the high-rise building.The infinite dimensional system model has been presented for describing high-rise building structures which have a large inertial load with the help of the Hamilton’s principle.On the basis of this system model and with the use of the Lyapunov’s direct method,a boundary controller is proposed and the closed-loop system is uniformly bounded in the time domain.Finally,by using the Smart Structure laboratory platform which is produced by Quancer,we conduct a set of experiments and find that the designed method is resultful.

Expression of proto-oncogene Fra-1 in human neoplastic breast tissues

Objective： Invasion and metastasis are the most significant and intrinsic biological characteristics of cancers, also which are main factors of malignant tumor causing treatment failure and death. Recent studies have found that Fra-1 plays an important role on cell migration, invasion, and maintaining malignant phenotype of transformed cells. But there are few stud- ies about the expression and location of Fra-1 in breast tissues and cells being reported .This study just aims to discuss the expression and location of transcription factor Fra-1 in benign and malignant human breast tissues. Methods： The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prog- nosis （ER, PR and ErbB2 receptors） were analyzed. Results： All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-l-recognizing antibody. In 85% of benign tumors （17/20）, the immunoreactive for Fra-l-recognizing antibody as exclusively restricted to the nuclei. In three cases （3/20, 15%）, focal unequivocal cytoplas- mic staining was also exhibited. Strong positive nuclear staining for Fra-1 was easily seen in all types of breast carcinomas. However the nucleaflcytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in 90.2% （37/41） of breast carcinomas. No inverse relationship between Fra-1 and ER and PR protein levels was noticed in malignant tumors. The relative expression level of Fra-1 was not correlated with the expression of ErbB2. Conclusion： The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis.

Modeling and control design of a bronchoscope robotics system

For the pulmonary nodule biopsy problem,this paper investigates an intervention robotics system based on the bronchoscope.To achieve precise control of the system,the mathematical model is established at first.The system mainly consists of an inserting tube and a tube tip,which are modeled based on a moving flexible beam and a soft robot,respectively.In order to reduce the harm to the patient during the operation,the robot system should suppress the vibration of the inserting tube during the process of tracking the desired trajectory in the bronchus.Therefore,we use the boundary control algorithm to design a controller capable of suppressing vibration for the inserting tube.Meanwhile,in order for the robot system to accurately select the bronchus corresponding to the branch,we designed a soft robot controller that can bend or deflect the soft robot to a specified posture.Finally,we used theoretical proof and numerical simulation to verify the conclusion.

Efficacy and clinical outcome of chemotherapy and endocrine therapy as first-line treatment in patients with hormone receptor-positive HER2-negative metastatic breast cancer

Background:Endocrine therapy(ET)and ET-based regimens are the preferred first-line treatment options for hormone receptor(HR)-positive and human epidermal growth factor receptor 2(HER2)-negative metastatic breast cancer(HR+/HER2-MBC),while chemotherapy(CT)is commonly used in clinical practice.The aim of this study was to investigate the efficacy and clinical outcome of ET and CT as first-line treatment in Chinese patients with HR+/HER2-MBC.Methods:Patients diagnosed with HR+/HER2-MBC between January 1st,1996 and September 30th,2018 were screened from the Chinese Society of Clinical Oncology Breast Cancer database.The initial and maintenance first-line treatment,progression-free survival(PFS),and overall survival(OS)were analyzed.Results:Among the 1877 included patients,1215(64.7%)received CT and 662(35.3%)received ET as initial first-line treatment.There were no statistically significant differences in PFS and OS between patients receiving ET and CT as initial first-line treatment in the total population(PFS:12.0 vs.11.0 months,P=0.22;OS:54.0 vs.49.0 months,P=0.09)and propensity score matched population.For patients without disease progression after at least 3 months of initial therapy,maintenance ET following initial CT(CT-ET cohort,n=449)and continuous schedule of ET(ET cohort,n=527)had longer PFS than continuous schedule of CT(CT cohort,n=406)in the total population(CT-ET cohort vs.CT cohort:17.0 vs.8.5 months;P<0.01;ET cohort vs.CT cohort:14.0 vs.8.5 months;P<0.01)and propensity score matched population.OS in the three cohorts yielded the same results as PFS.Conclusions:ET was associated with similar clinical outcome to CT as initial first-line treatment.For patients without disease progression after initial CT,switching to maintenance ET showed superiority in clinical outcome over continuous schedule of CT.