Mechanism of Gegen Qinlian Decoction in Treating Type 2 Diabetes Mellitus Complicated with NAFLD Based on Network Pharmacology

[Objectives]To explore the mechanism of Gegen Qinlian Decoction in treating type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD)by analyzing the effective components of Gegen Qinlian Decoction.[Methods]TCMSP database was used to analyze the active components of Gegen Qinlian Decoction,and pubchem and Swiss ADME databases were also used to predict drug targets,extract T2DM complicated with NAFLD targets from OMIM and Genecards databases.Venny plot was drawn to obtain intersection targets,and finally Cytoscape was used to make core target maps and drug-target-disease network maps.Using DAVID and Metascape database to analyze the intersection targets,the gene ontology information of Go and KEGG was obtained.Microbial informatics technology was used to visualize GO,and Cytoscape was used to make drug-target-disease network map-enrichment pathway map.[Results]The network pharmacological analysis showed that Gegen Qinlian Decoction acted on the key targets of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease,such as ALB and ALT1,through many components,and achieved the purpose of treating this disease.The chemical constituents of the drug include formononetin,5-hydroxyisomucronulatol-2,5-2-O-glucoside,cholesteryl laurate,isoliquiritigenin,etc.[Conclusions]This study provides a new idea and theoretical support for future drug research and clinical practice.

A Multi-slack Bus Model for Bi-directional Energy Flow Analysis of Integrated Power-gas Systems

The bi-directional energy conversion components such as gas-fired generators(GfG)and power-to-gas(P2G)have enhanced the interactions between power and gas systems.This paper focuses on the steady-state energy flow analysis of an integrated power-gas system(IPGS)with bi-directional energy conversion components.Considering the shortcomings of adjusting active power balance only by single GfG unit and the capacity limitation of slack bus,a multi-slack bus(MSB)model is proposed for integrated power-gas systems,by combining the advantages of bi-directional energy conversion components in adjusting active power.The components are modeled as participating units through iterative participation factors solved by the power sensitivity method,which embeds the effect of system conditions.On this basis,the impact of the mixed problem of multi-type gas supply sources(such as hydrogen and methane generated by P2G)on integrated system is considered,and the gas characteristics-specific gravity(SG)and gross calorific value(GCV)are modeled as state variables to obtain a more accurate operational results.Finally,a bi-directional energy flow solver with iterative SG,GCV and participation factors is developed to assess the steady-state equilibrium point of IPGS based on Newton-Raphson method.The applicability of proposed methodology is demonstrated by analyzing an integrated IEEE 14-bus power system and a Belgian 20-node gas system.

From 4P to 4C:Strategies for College Students to Break Through in Job Hunting Competitiveness

This article analyzes the 4C(Customer,Cost,Convenience,Communication)strategy from the perspective of marketing,and explores its application in the job hunting process of college students,aiming to provide effective strategies for college students to break through in job hunting competitiveness.By regarding themselves as"products",college students can enhance their competitiveness as"product"attributes in the job market by starting from meeting the needs of employers,reasonably positioning their own value,expanding job search channels,and effectively promoting themselves.

维生素D与女性生殖系统健康关系的研究进展

维生素D是固醇类衍生物,除了调节钙磷代谢维持骨质平衡的经典作用外,还具有调节免疫反应、调节细胞增殖和分化等非经典作用。近年来大量研究显示维生素D缺乏与女性生殖系统疾病的发生发展有密切关系,补充维生素D对女性生殖健康有重要意义。本文就维生素D与女性卵巢、子宫以及妊娠期相关疾病的关系及机制做简要综述。

Controllable fabrication and multifunctional applications of graphene/ceramic composites

Graphene with excellent comprehensive properties has been considered as a promising filler to reinforce ceramics.While numerous studies have been devoted to the improvement of mechanical and electrical properties,incorporating graphene to ceramics also offers new opportunities for endowing ceramics with versatility.In this review,the recent development of graphene/ceramic bulk composites is summarized with the focus on the construction of well-designed architecture and the realization of multifunctional applications.The processing technologies of the composites are systematically summarized towards homogeneous dispersion and even ordered orientation of graphene sheets in the ceramic matrix.The improvement of composites in mechanical,electrical,electromagnetic,and thermal performances is discussed.The novel multifunctional applications brought by smart integration of graphene in ceramics are also addressed,including microwave absorption,electromagnetic interference shielding,ballistic armors,self-monitor damage sensors,and energy storage and conversion.

Motility-based label-free detection of parasites in bodily fluids using holographic speckle analysis and deep learning

Parasitic infections constitute a major global public health issue.Existing screening methods that are based on manual microscopic examination often struggle to provide sufficient volumetric throughput and sensitivity to facilitate early diagnosis.Here,we demonstrate a motility-based label-free computational imaging platform to rapidly detect motile parasites in optically dense bodily fluids by utilizing the locomotion of the parasites as a specific biomarker and endogenous contrast mechanism.Based on this principle,a cost-effective and mobile instrument,which rapidly screens~3.2 mL of fluid sample in three dimensions,was built to automatically detect and count motile microorganisms using their holographic time-lapse speckle patterns.We demonstrate the capabilities of our platform by detecting trypanosomes,which are motile protozoan parasites,with various species that cause deadly diseases affecting millions of people worldwide.Using a holographic speckle analysis algorithm combined with deep learningbased classification,we demonstrate sensitive and label-free detection of trypanosomes within spiked whole blood and artificial cerebrospinal fluid(CSF)samples,achieving a limit of detection of ten trypanosomes per mL of whole blood(~five-fold better than the current state-of-the-art parasitological method)and three trypanosomes per mL of CSF.We further demonstrate that this platform can be applied to detect other motile parasites by imaging Trichomonas vaginalis,the causative agent of trichomoniasis,which affects 275 million people worldwide.With its costeffective,portable design and rapid screening time,this unique platform has the potential to be applied for sensitive and timely diagnosis of neglected tropical diseases caused by motile parasites and other parasitic infections in resource-limited regions.

核壳结构LaOCl/LaFeO_(3)纳米纤维的阻抗匹配设计及其电磁吸波性能研究

电磁波在无线通信等领域的广泛应用导致了严重的电磁污染,迫切需要研发高性能电磁波吸收材料.本文针对吸波材料阻抗不匹配等关键问题,设计并成功制备了新型核壳LaOCl/LaFeO_(3)纳米纤维电磁波吸收剂.这种独特的一维多级结构由导电LaFeO_(3)磁性壳层和离子化合物LaOCl核层组成.基于介电-磁损耗耦合和阻抗匹配的协同作用,LaOCl/LaFeO_(3)纳米纤维在超低负载条件下(4 w t%),表现出-40.1 d B(2.0 mm)的反射损耗和6.4 GHz(2.4 mm)的有效吸收带宽.该工作提出了一种新型LaOCl/LaFeO_(3)纳米纤维吸波材料,并为阻抗匹配调控和电磁吸波性能优化开辟了新策略.

Therapeutic applications of genetic code expansion

In nature,a limited,conservative set of amino acids are utilized to synthesize proteins.Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids(ncAAs)through orthogonal aminoacyltRNA synthetase(aaRS)/tRNA pairs.The past decade has witnessed the rapid growth in diversity and scope for therapeutic applications of this technology.Here,we provided an update on the recent progress using genetic code expansion in the following areas:antibody-drug conjugates(ADCs),bispecific antibodies(BsAb),immunotherapies,long-lasting protein therapeutics,biosynthesized peptides,engineered viruses and cells,as well as other therapeutic related applications,where the technique was used to elucidate the mechanisms of biotherapeutics and drug targets.

Effective interventions on health effects of Chinese rural elderly under heat exposure

Due to climate change,the heatwave has become a more serious public health threat with aging as an aggravating factor in recent years.There is a pressing need to detect the most effective prevention and response measures.However,the specific health effects of interventions have not been characterized on an individual scale.In this study,an intervention experiment was designed to explore the health effects of heat exposure at the individual level and assess the effects of different interventions based on a comprehensive health sensitivity index(CHSI)in Xinyi,China.Forty-one subjects were recruited randomly,and divided into one control group and three intervention groups.Interventions included education(Educate by lecturing,offering relative materials,and communication),subsidy support(offer subsidy to offset the cost of running air conditioning),and cooling-spray(install a piece of cooling-spray equipment in the yard).Results showed that systolic blood pressure(SBP)and deep sleep duration(DSD)were significantly affected by short-term heat exposure,and the effects could be alleviated by three types of interventions.The estimated CHSI indicated that the effective days of the education group were longer than other groups,while the lower CHSI of the subsidy group showed lower sensitivity than the control group.These findings provide feasible implementation strategies to optimize Heat-health action plans and evaluate the intervention performance.

Self-assembled Ag_(4)V_(2)O_(7)/Ag_(3)VO_(4) Z-scheme heterojunction by pH adjustment with efficient photocatalytic performance

Semiconductor heterojunction plays a pivotal role in photocatalysis.However,the construction of a heterojunction with a fine microstructure usually requires complex synthetic procedures.Herein,a pH-adjusted one-step method was employed to controllably synthesize Ag_(4)V_(2)O_(7)/Ag_(3)VO_(4) heterojunction with a well-tuned 0D/1D hierarchical structure for the first time.It is noteworthy that the ordered stacking of vanadium oxide tetrahedron(VO_(3)-)guided by the pH value wisely realizes the in-situ growth of Ag_(4)V_(2)O_(7) nanoparticles on the surface of Ag_(3)VO_(4) nanorods.Furthermore,comprehensive characterization and calculation decipher the electronic structures of Ag_(4)V_(2)O_(7) and Ag_(3)VO_(4) and the formation of Z-scheme heterojunction,benefiting the visible light harvesting and carrier utilization.Such a new Ag_(4)V_(2)O_(7)/Ag_(3)VO_(4) heterojunction exhibits remarkable photocatalytic activity and excellent stability.Complete degradation of Rhodamine B(RhB)can be achieved in 10 min by the Ag_(4)V_(2)O_(7)/Ag_(3)VO_(4) heterojunction under visible light irradiation,demonstrating an outstanding reaction rate of 0.35 min^(−1) that is up to 84-fold higher than those of other silver vanadates.More importantly,this integration of synthesis technology and heterojunction design,based on the intrinsic crystal and electronic structures,could be inspiring for developing novel heterostructured materials with advanced performance.

Step further towards targeted senolytic therapy:therapeutic potential of uPAR-CAR T cells for senescence-related diseases

A very recent study published in Nature by Amor et al.1 identifies the urokinase-type plasminogen activator receptor(uPAR)as a broadly induced specific cell-surface marker during cell senescence,which could be used as a target for chimeric antigen receptor(CAR)T cell to specifically ablate senescent cells in vitro and in vivo.The authors intriguingly show that uPAR-specific CAR T-cell therapy improves the treatment outcome of lung adenocarcinomas and efficiently reduces liver fibrosis in mouse models,thus offering a promising novel therapeutic strategy for senescence-associated diseases(Fig.1).

Can differences in the background characteristics of the chairperson-CEO vertical dyad reduce management agency costs?——A perspective Based on the internal configuration of the top management team

We test whether differences in the background characteristics of firms’chairperson and CEO can reduce management agency costs.We find that when the chairperson is older,has a higher level of education,and has more overseas experience than the CEO,the management agency costs will be lower.A series of robustness tests do not change our conclusions.In further analysis,we find that the negative relationship between the two is more significant for SOEs or firms experiencing fierce market competition.Finally,we also find that the chairman-CEO’s vertical dyad background characteristics differences can help to improve firm performance.Our study provides theoretical and practical implications for companies on how to best configure their top management team.