Construction of Dynamic Alloy Interfaces for Uniform Li Deposition in Li-Metal Batteries

It is well accepted that a lithiophilic interface can effectively regulate Li deposition behaviors,but the influence of the lithiophilic interface is gradually diminished upon continuous Li deposition that completely isolates Li from the lithiophilic metals.Herein,we perform in-depth studies on the creation of dynamic alloy interfaces upon Li deposition,arising from the exceptionally high diffusion coefficient of Hg in the amalgam solid solution.As a comparison,other metals such as Au,Ag,and Zn have typical diffusion coefficients of 10-20 orders of magnitude lower than that of Hg in the similar solid solution phases.This difference induces compact Li deposition pattern with an amalgam substrate even with a high areal capacity of 55 mAh cm^(-2).This finding provides new insight into the rational design of Li anode substrate for the stable cycling of Li metal batteries.

Active control of flow past an elliptic cylinder using an artificial neural network trained by deep reinforcement learning

The active control of flow past an elliptical cylinder using the deep reinforcement learning(DRL)method is conducted.The axis ratio of the elliptical cylinderΓvaries from 1.2 to 2.0,and four angles of attackα=0°,15°,30°,and 45°are taken into consideration for a fixed Reynolds number Re=100.The mass flow rates of two synthetic jets imposed on different positions of the cylinderθ1andθ2are trained to control the flow.The optimal jet placement that achieves the highest drag reduction is determined for each case.For a low axis ratio ellipse,i.e.,Γ=1.2,the controlled results atα=0°are similar to those for a circular cylinder with control jets applied atθ1=90°andθ2=270°.It is found that either applying the jets asymmetrically or increasing the angle of attack can achieve a higher drag reduction rate,which,however,is accompanied by increased fluctuation.The control jets elongate the vortex shedding,and reduce the pressure drop.Meanwhile,the flow topology is modified at a high angle of attack.For an ellipse with a relatively higher axis ratio,i.e.,Γ1.6,the drag reduction is achieved for all the angles of attack studied.The larger the angle of attack is,the higher the drag reduction ratio is.The increased fluctuation in the drag coefficient under control is encountered,regardless of the position of the control jets.The control jets modify the flow topology by inducing an external vortex near the wall,causing the drag reduction.The results suggest that the DRL can learn an active control strategy for the present configuration.

Asymptotic solutions of the flow of a Johnson-Segalman fluid through a slowly varying pipe using double perturbation strategy

A double perturbation strategy is presented to solve the asymptotic solutions of a Johnson-Segalman （J-S） fluid through a slowly varying pipe. First, a small parameter of the slowly varying angle is taken as the small perturbation parameter, and then the second-order asymptotic solution of the flow of a Newtonian fluid through a slowly varying pipe is obtained in the first perturbation strategy. Second, the viscoelastic parameter is selected as the small perturbation parameter in the second perturbation strategy to solve the asymptotic solution of the flow of a J-S fluid through a slowly varying pipe. Finally, the parameter effects, including the axial distance, the slowly varying angle, and the Reynolds number, on the velocity distributions are analyzed. The results show that the increases in both the axial distance and the slowly varying angle make the axial velocity slow down. However, the radial velocity increases with the slowly varying angle, and decreases with the axial distance. There are two special positions in the distribution curves of the axial velocity and the radial velocity with different Reynolds numbers, and there are different trends on both sides of the special positions. The double perturbation strategy is applicable to such problems with the flow of a non-Newtonian fluid through a slowly varying pipe.

Evaluation of the metabolism of PEP06,an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp(RGDRGD)30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus.The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect.However,little is known about the kinetics and degradation products of PEP06 in vitro or in vivo.In this study,we investigated the in vitro metabolic stability of PEP06 after it was incubated with living cells obtained from animals of different species;we further identified the degradation characteristics of its cleavage products.PEP06 underwent rapid enzymatic degradation in multiple types of living cells,and the liver,kidney,and blood play important roles in the metabolism and clearance of the peptides resulting from the molecular degradation of PEP06.We identified metabolites of PEP06 using full-scan mass spectrometry(MS)and tandem MS(MS2),wherein 43 metabolites were characterized and identified as the degradation metabolites from the parent peptide,formed by successive losses of amino acids.The metabolites were C and N terminal truncated products of PEP06.The structures of 11 metabolites(M6,M7,M16,M17,M21,M25,M33,M34,M39,M40,and M42)were further confirmed by comparing the retention times of similar full MS spectrum and MS2 spectrum information with reference standards for the synthesized metabolites.We have demonstrated the metabolic stability of PEP06 in vitro and identified a series of potentially bioactive downstream metabolites of PEP06,which can support further drug research.

Scale properties of turbulent transport and coherent structure in stably stratified flows

The empirical mode decomposition （EMD） is used to study the scale properties of turbulent transport and coherent structures based on velocity and temperature time series in stably stratified turbulence. The analysis is focused on the scale properties of intermittency and coherent structures in different modes and the contributions of energy-contained coherent structures to turbulent scalar counter-gradient transport （CGT）. It is inferred that the velocity intermittency is scattered to more modes with the development of the stratified flow, and the intermittency is enhanced by the vertical stratification, especially in small scales. The anisotropy of the field is presented due to different time scales of coherent structures of streamwise and vertical velocities. There is global counter-gradient heat transport close to the turbulence-generated grid, and there is local counter-gradient heat transport at certain modes in different positions. Coherent structures play a principal role in the turbulent vertical transport of temperature.

Efficient reduction of hexavalent chromium with microscale Fe/Cu bimetals:Efficiency and the role of Cu

Microscale zero valent iron(mFe^(0))is one of the most potential water pollution remediation materials,but the effective utilization ability of electrons released by mFe^(0)in the reduction of hexavalent chromium(Cr(VI))is not satisfactory.Here,we find the microscale iron-copper(m Fe/Cu)bimetals coated with copper on the surface of mFe^(0)can significantly improve the effective utilization of electrons released by mFe^(0).Electrochemical analysis displays that copper plating on the surface of m Fe/Cu can promote the release the electrons from mFe^(0)and reduce the impedance of mFe^(0).Spin-polarized density functional theory(DFT)calculation reveals that Cu on the surface of m Fe/Cu bimetals promotes the release of electrons from mFe^(0)and reduces the adsorption energy of Fe to Cr.As the electron transporter,moreover,Cu can always attract Cr to the hollow position near itself of the Fe surface,which could promote the effective utilization of electrons released by Fe.Effective utilization ability of electrons in m Fe/Cu system is 12.5 times higher than that in mFe^(0)system.Our findings provide another basis for the efficient reduction of Cr(VI)by m Fe/Cu bimetals,which could promote the application and popularization of m Fe/Cu bimetals.

Therapeutic potential of bright light therapy for the non-motor symptoms in Parkinson's disease

To the Editor:Alterations of circadian rhythms seem to be the casual contribution to sleep disturbances,depression,and other non-motor symptoms in Parkinson's disease(PD).[1,2]By restoring the circadian rhythm,bright light therapy(BLT)might be a potentially new treatment option for PD.However,no studies have conclusively demonstrated the effects of BLT on the non-motor symptoms in PD.