Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet

Trimethylamine N-oxide(TMAO)is a risk factor of various chronic diseases,which was produced by metabolism from precursors to trimethylamine(TMA)in gut and the oxidation from TMA in liver.The TMA generation was influenced by diet,mainly due to the rich TMAO precursors in diet.However,it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO.Here,the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA,respectively,in mice fed with carbohydrates,proteins and fats in different proportion and sources.The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA,and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver.The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO,the risk factor for atherosclerosis,which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis.

Effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in healthy mice

Sea cucumber saponins have attracted more attention in recent years due to biological activities.It is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in China.However,knowledge of the effect of alcohol on the absorption and metabolism of sea cucumber saponins is limited.The effects of alcohol on digestion,absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous injection.The results showed that the content of saponins in serum and liver was significantly higher under the influence of alcohol than that in the control group after oral administration.Alcohol promoted the absorption of sea cucumber saponins prototype as well as inhibited the process of saponins being transformed into deglycositic metabolites in the small intestine.Moreover,sea cucumber saponins remained in circulation for a long time and alcohol slowed down the clearance of sea cucumber saponins under the influence of alcohol after intravenous injection.This confirmed the feasibility of marinating sea cucumber in Baijiu to improve the efficacy of saponins and provides an important theoretical basis for the utilization of sea cucumber and the development of sea cucumber liquor.

The Mars orbiter magnetometer of Tianwen-1:in-flight performance and first science results

The Mars Orbiter MAGnetometer(MOMAG)is a scientific instrument onboard the orbiter of China’s first mission for Mars—Tianwen-1.Since November 13,2021,it has been recording magnetic field data from the solar wind to the magnetic pile-up region surrounding Mars.Here we present its in-flight performance and first science results,based on its first one and one-half months’data.Comparing these early MOMAG observations to the magnetic field data in the solar wind from NASA’s Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we report that the MOMAG magnetic field data are at the same level in magnitude,and describe the same magnetic structures with similar variations in three components.We recognize 158 clear bow shock(BS)crossings in these MOMAG data;their locations match well statistically with the modeled average BS.We also identify and compare five pairs of datasets collected when Tianwen-1’s orbiter and the MAVEN probe made simultaneous BS crossings.These BS crossings confirm the global shape of modeled BS,as well as the south-north asymmetry of the Martian BS.Two cases presented in this paper suggest that the BS is probably more dynamic at flank than near the nose.So far,MOMAG performs well,and provides accurate magnetic field vectors.MOMAG is continuously scanning the magnetic field surrounding Mars.Data from MOMAG’s measurements complement data from MAVEN and will undoubt edly advance our understanding of the plasma environment of Mars.

Advances in low-protein diets for swine

Recent years have witnessed the great advantages of reducing dietary crude protein(CP) with free amino acids(AA)supplementation for sustainable swine industry, including saving protein ingredients, reducing nitrogen excretion, feed costs and the risk of gut disorders without impairing growth performance compared to traditional diets. However, a tendency toward increased fatness is a matter of concern when pigs are fed low-protein(LP) diets. In response, the use of the net energy system and balanced AA for formulation of LP diets has been proposed as a solution. Moreover, the extent to which dietary CP can be reduced is complicated. Meanwhile, the requirements for the first five limiting AA(lysine, threonine, sulfur-containing AA, tryptophan, and valine) that growing-finishing pigs fed LP diets were higher than pigs fed traditional diets, because the need for nitrogen for endogenous synthesis of non-essential AA to support protein synthesis may be increased when dietary CP is lowered. Overall, to address these concerns and give a better understanding of this nutritional strategy, this paper reviews recent advances in the study of LP diets for swine and provides some insights into future research directions.

“天问一号”火星磁强计伸杆机构

3 m多长的伸杆机构是天问一号火星磁强计的一个重要组成部分,用于将磁通门磁强计探头伸离卫星本体以减小卫星对磁场测量的影响。火星磁强计伸杆机构是一种多关节、铰链转轴驱动的一次性展开机构。在设计时充分考虑到了其功能性、可靠性和系统约束要求等因素。力学分析和地面验证试验表明火星磁强计伸杆机构足以承受最坏情况下的在轨环境。在经历了漫长的地火转移旅程后,火星磁强计伸杆机构于2021年5月25日成功展开。展开过程耗时约4.6 s,两个探头被送至远离环绕器本体位置,其中外侧探头距离环绕器3.19 m,内侧探头距离环绕器2.29 m。展开到位后,外侧探头处所测得的磁场大小由1250 nT减弱至不到6 nT。火星磁强计伸杆机构为后续探测任务中需在低温环境下长期贮存的空间展开机构的研制提供了宝贵的工程经验。

Mars Orbiter magnetometer of China’s First Mars Mission Tianwen-1

As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction with the solar wind.The instrument consists of two identical triaxial fluxgate magnetometer sensors,mounted on a 3.19 meter-long boom with a seperation of about 90 cm.The dual-magnetometers configuration will help eliminate the magnetic field interference generated by the spacecraft platform and payloads.The sensors are controlled by an electric box mounted inside the orbiter.Each magnetometer measures the ambient vector magnetic field over a wide dynamic range(to 10,000 nT per axis)with a resolution of 1.19 pT.Both magnetometers sample the ambient magnetic field at an intrinsic frequency of 128 Hz,but will operate in a model with alternating frequency between 1 and 32 Hz to meet telemetry allocations.

Horizontal transfer of vanA between probiotic Enterococcus faecium and Enterococcus faecalis in fermented soybean meal and in digestive tract of growing pigs

Background: The aim of this study was to investigate the intergeneric transfer of vancomycin resistance gene vanA between probiotic enterococci in the fermentation progress of soybean meal and in the digestive tract of growing pigs.One vanA genotype vancomycin resistant E.faecium strain,Efm4,and one chloramphenicol-resistant E.faecalis strain,Efs2,were isolated from twenty-nine probiotic basis feed material/additive samples.For in vitro conjugation,Efm4 and Efs2 were used as starter to ferment soybean meal.For in vivo conjugation,thirty growing pigs were randomly assigned to five groups(n = 6),treated with a basic diet,or supplemented with 10% fermented soybean meal,1% Efm4,5% Efs2 or a combination of 1% Efm4 + 5% Efs2 for 7 d,respectively.Fecal samples of pigs in each group were collected daily for the isolation and dynamic analysis of Efm4,Efs2 and transconjugants.The sequence types(STs) of Efm4,Efs2 and transconjugants were analyzed by multilocus sequence typing(MLST).The vanA harboring plasmid in Efm4 and transconjugants was analyzed by S1-pulsed field gel electrophoresis(PFGE)and further verified by multiple alignments.Results: The results showed that,in FSBM,transconjugants were detected 1 h after the fermentation,with a conjugation frequency of ~ 10^-3 transconjugants/recipient.Transconjugants proliferated with Efm4 and Efs2 in the first 8 h and maintained steadily for 10 d till the end of the experiment.Additionally,in vivo experiment showed that transcojugants were recovered in one of six pigs in both FSBM and Efm4 + Efs2 groups,with conjugation frequency of ~ 10^-5 and ~ 10^-4,respectively.MLST revealed the ST of Efm4,Efs2 and transconjugants was ST1014,ST69 and ST69,respectively.S1-PFGE confirmed the existence of the vanA-harboring,142,988-bp plasmid,which was also a multi-drug resistant plasmid containing Tn1546-like transposon.Conclusions: The findings revealed the potential safety hazard existing in the commercial probiotic enterococci in China,because the horizontal transfer from farm to fork could potentially pose a safety risk to the public.

The absorption kinetics of Antarctic krill oil phospholipid liposome in blood and the digestive tract of healthy mice by single gavage

Antarctic krill(Euphausia superba)oil has been gaining increasing attention due to its nutritional and functional potentials.Krill oil usually contains a high concentration(about 50%)of phospholipids(AKOP)rich in DHA and EPA accompanied with 30%–40%triacylglycerols.Phospholipids can be made into liposomes without emulsifiers due to its amphiphilic characteristics.However,the absorption kinetics of AKOP liposome in vivo is not clear,which restrict the molecular mechanism analysis related to its distinct bioactivities.The lipid analysis in serum,small intestinal content and wall was carried out after oral administration of AKOP liposome to illustrate its absorption kinetics in blood and the digestive tract of healthy mice by single gavage.The major type of the obtained AKOP was phosphatidylcholine,and the total contents of the DHA and EPA were 29.31%.AKOP liposome was almost completely digested in the small intestine in 1 h and the hydrolysis products could be quickly absorbed by intestinal enterocytes.The DHA in serum peaked at 2 h after administration of AKOP liposome.AKOP liposome could be quickly digested and absorbed in vivo.The obtained results might provide a scientific basis for the molecular mechanism analysis related to distinct bioactivities of Antarctic krill oil phospholipid.

Empirical correction of kinetic model for polymer thermal reaction process based on first order reaction kinetics

Based on the theory of first-order reaction kinetics,a thermal reaction kinetic model in integral form has been derive.To make the model more applicable,the effects of time and the conversion degree on the reaction rate parameters were considered.Two types of undetermined functions were used to compensate for the intrinsic variation of the reaction rate,and two types of correction methods are provided.The model was explained and verified using published experimental data of different polymer thermal reaction systems,and its effectiveness and wide adaptability were confirmed.For the given kinetic model,only one parameter needs to be determined.The proposed empirical model is expected to be used in the numerical simulation of polymer thermal reaction process.

Exohiss wave enhancement following substorm electron injection in the dayside magnetosphere

Exohiss is a low-frequency structureless whistler-mode emission potentially contributing to the precipitation loss of radiation belt electrons outside the plasmasphere. Exohiss is usually considered the plasmaspheric hiss leaked out of the dayside plasmapause.However, the evolution of exohiss after the leakage has not been fully understood. Here we report the prompt enhancements of exohiss waves following substorm injections observed by Van Allen Probes. Within several minutes, the energetic electron fluxes around 100 keV were enhanced by up to 5 times, accompanied by an up to 10-time increase of the exohiss wave power. These substorm-injected electrons are shown to produce a new peak of linear growth rate in the exohiss band(< 0.1 f_(ce)). The corresponding path-integrated growth rate of wave power within 10° latitude of the magnetic equatorial plane can reach 13.4, approximately explaining the observed enhancement of exohiss waves. These observations and simulations suggest that the substorm-injected energetic electrons could amplify the preexisting exohiss waves.

Locating the source field lines of Jovian decametric radio emissions

Decametric(DAM) radio emissions are one of the main windows through which one can reveal and understand the Jovian magnetospheric dynamics and its interaction with the moons. DAMs are generated by energetic electrons through cyclotron-maser instability. For Io(the most active moon) related DAMs, the energetic electrons are sourced from Io volcanic activities, and quickly trapped by neighboring Jovian magnetic field. To properly interpret the physical processes behind DAMs, it is important to precisely locate the source field lines from which DAMs are emitted. Following the work by Hess et al.(2008, 2010), we develop a method to locate the source region as well as the associated field lines for any given DAM emission recorded in a radio dynamic spectrum by, e.g.,Wind/WAVES or STEREO/WAVES. The field lines are calculated by the state-of-art analytical model, called JRM09(Connerney et al., 2018).By using this method, we may also derive the emission cone angle and the energy of associated electrons. If multiple radio instruments at different perspectives observe the same DAM event, the evolution of its source region and associated field lines is able to be revealed. We apply the method to an Io-DAM event, and find that the method is valid and reliable. Some physical processes behind the DAM event are also discussed.

Recent investigations of the near-Mars space environment by the planetary aeronomy and space physics community in China

The present issue of Earth and Planetary Physics is dedicated to the near-space neutral and plasma environments of Mars.The issue includes nine papers that present new results on the properties of the Martian exosphere,ionosphere,and magnetosphere,from both observational and modeling points of view.Due to the similarity between the two objects,the issue also includes two additional papers on the near-Venus plasma environment.

A new model describing Forbush Decreases at Mars: combining the heliospheric modulation and the atmospheric influence

Forbush decreases are depressions in the galactic cosmic rays (GCRs) that are caused primarily by modulations of interplanetary coronal mass ejections (ICMEs) but also occasionally by stream/corotating interaction regions (SIRs/CIRs). Forbush decreases have been studied extensively using neutron monitors at Earth;recently, for the first time, they have been measured on the surface of another planet, Mars, by the Radiation Assessment Detector (RAD) on board the Mars Science Laboratory’s (MSL) rover Curiosity. The modulation of GCR particles by heliospheric transients in space is energy-dependent;afterwards, these particles interact with the Martian atmosphere, the interaction process depending on particle type and energy. In order to use ground-measured Forbush decreases to study the space weather environment near Mars, it is important to understand and quantify the energy-dependent modulation of the GCR particles by not only the pass-by heliospheric disturbances but also by the Martian atmosphere. Accordingly, this study presents a model that quantifies both at the Martian surface and in the interplanetary space near Mars the amplitudes of Forbush decreases at Mars during the pass-by of an ICME/SIR by combining the heliospheric modulation of GCRs with the atmospheric modification of such modulated GCR spectra. The modeled results are in good agreement with measurements of Forbush decreases caused by ICMEs/SIRs based on data collected by MSL on the surface of Mars and by the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft in orbit. Our model and these findings support the validity of both the Forbush decrease description and Martian atmospheric transport models.

Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice

It is unclear how docosahexaenoic acid(DHA)improves insulin resistance via modulating gut microbiome in obese individuals.We used diet-induced obesity(DIO)mice as a model to study the effects of DHA-rich fish oil(DHA-FO)on host metabolic disorders and colonic microbiome.DHA-FO reduced fat deposition,regulated lipid profiles and alleviated insulin resistance in DIO mice.Probably because DHA-FO prevented the permeation of lipopolysaccharide across intestinal epithelial barrier,and promoted peptide YY(PYY)secretion via the mediation of short chain fatty acids receptor(FFAR2)in colon.Furthermore,DHA-FO might regulate PYY expression by reversing microbial dysbiosis,including increasing the abundance ofAkkermansia muciniphila and Lactobacillus,and suppressing the growth of Helicobacter.DHA-FO also altered gut microbial function(e.g."linoleic acid metabolism")associated with PYY expression(r>0.80,P<0.05).Herein,DHA-FO enhanced insulin action on glucose metabolism by altering gut microbiome and facilitating colonic PYY expression in DIO mice.

A statistical study of the likelihood of a super geomagnetic storm occurring in a mild solar cycle

The activities of geomagnetic storms are generally controlled by solar activities. The current solar cycle(SC) 24 is found to be mild; compared to SCs 19–23, the storm occurrence and size derived by averaging the occurrence number and D_(st) around the solar maximum are reduced by about 50–82% and 36–61%, respectively. We estimate separately, for SC 19 to 24, the repeat intervals between geomagnetic storms of specific D_(st), based on fits of power-law and log-normal distributions to the storm data for each SC. Repeat intervals between super geomagnetic storms with D_(st)≤–250 nT are found to be 0.36–2.95 year(s) for SCs 19–23, but about 20 years based on the data for SC 24. We also estimate the repeat intervals between coronal mass ejections(CMEs) of specific speed(V_(CME)) since CMEs are known to be the main drivers of intense storms and the related statistics may provide information about the potential occurrence of super geomagnetic storms from the location of the Sun. Our analysis finds that a CME with V_(CME)≥1860 km/s may occur once per 3 and 5 months in SC 23 and 24, respectively. Based on a V_(CME)-D_(st) relationship, such a fast CME may cause a storm with D_(st)=–250 nT if arriving at the Earth. By comparing the observed geomagnetic storms to storms expected to be caused by CMEs, we derive the probability of CME caused storms, which is dependent on V_(CME). For a CME faster than 1860 km/s, the probability of a CME caused storm with D_(st)≤–250 nT is about 1/5 for SC 23 or 1/25 for SC 24. All of the above results suggest that the likelihood of the occurrence of super geomagnetic storms is significantly reduced in a mild SC.

Reply to Comment by Lamy et al. on “Locating the source field lines of Jovian decametric radio emissions”

Locating the source of decametric(DAM)radio emissions is a key step in the use of remote radio observations to understand the Jovian magnetospheric dynamics and their interaction with the planet’s moons.Wang YM et al.(2020)presented a method by which recorded arc-shaped DAM emissions in the radio dynamic spectra can be used to locate the source of a DAM.An Io-related DAM event on March 14,2014 was used to demonstrate the method.A key parameter in the method is whether the DAM is emitted in the northern or the southern hemisphere;the hemisphere of origin can be determined definitively from the polarization of the emission.Unfortunately,polarization information for the emission on March 14,2014 event was not recorded.Our analysis assumed the source to be in the northern hemisphere.Lamy et al.(2022)argue convincingly that the source was probably in the southern hemisphere.We appreciate the helpful contribution of Lamy et al.(2022)to this discussion and have updated our analysis,this time assuming that the DAM source was in the southern hemisphere.We also explore the sensitivity of our method to another parameter-the height at which the value of fce,max,which is the maximal electron cyclotron frequency reached along the active magnetic flux tube,is adopted.Finally,we introduce our recent statistical study of 68 DAM events,which lays a more solid basis for testing the reliability of our method,which we continue to suggest is a promising tool by which remote radio observations can be used to locate the emission source of Jovian DAMs.

Post-polio syndrome: a literature review

Post-polio syndrome(PPS)is a neurologic disorder characterized by an accumulation of symptoms,most often muscle weakness,fatigue,and pain,decades after the initial polio.Diagnosis of PPS is based on the presence of a lower motor neuron disorder which is supported by neuro-physiological findings,as well as exclusion of other disorders as causes of new symptoms.The pathogenesis of PPS is still disputed.Rehabilitation for patients with PPS should take a comprehensive approach.Evaluation of the need for orthoses is often required.

Application of Modern Communication Technology in Water Conservancy Work

The role of communication is very important in the process of flood prevention work.Modern communication technology can transmit information effectively and implement the communication target of dispatching instructions.Today,the communication technology covers various types such as mobile communication,satellite communication,short-wave communication,optical fiber communication and digital microwave communication.These modern communication technologies are widely used in transmission of information during the process of domestic flood prevention and water conditions.This article focuses on the research of using modern communication technology as the main objective and its specific application in water conservancy work.

Product Promotion Prediction Model Based on Evaluation Information

This paper mainly studies the impact of evaluation information on e-commerce platform on the future of products.Through natural language processing and rating,an evaluation model based on user rating and evaluation is defined to measure product quality.Among them,evaluations are differentiated:review sentiment coefficient(R)and review length(L).The evaluation model is:.In order to predict the future reputation of products,based on the above evaluation model,time series is used to rank the products studied.Each customer purchases the product through Markov chain model,so as to predict the probability of future word-of-mouth spread of the product.Use TOPSIS method to select monthly sales,stars and comment sentiment coefficient as indicators.The comprehensive measurement method based on text and score is determined to predict whether the product is successfully promoted.

用有限元模拟分析优化宽基轮胎的成型工艺和设计

宽基轮胎是近年来应用和发展较快的一种新型轮胎。在载重汽车用宽基轮胎替代并装双胎的普通轮胎,具有改善车辆与地面的附着性和耐磨性等多项性能的潜在优势。但是,宽基轮胎在成型制造过程中,很容易出现胎面变形和应力分布不均匀的现象。本文研究的目的是应用数值分析技术仿真模拟宽基载重汽车充气轮胎的成型制造过程,进而指导优化轮胎的施工设计。首先,应用有限元分析技术模拟385/55R22.5规格轮胎的成型制造过程,包括四个阶段:分别是成型主鼓部件贴合、辅助成型鼓部件贴合、半成品胎坯成型和最后的胶囊硫化机硫化定型过程。其次,为了解决435/50R19.5规格轮胎生产中存在的实际轮胎结构与理论设计的轮胎结构在材料分布方面的差别,根据轮胎施工设计仿真模型的分析结果,提出曲面鼓成型半成品胎坯的方法,并且确定了曲面鼓的设计参数。在本文中,我们给出了收集轮胎材料的方法、测试过程、分析方法、试验结果和相关数据的统计。最后,通过试验检测结果对仿真模拟模型的准确性进行了验证。