Correlation Analysis between Self-Disclosure and Social Support in Patients with Breast Cancer

Objective: Describe the status quo of self-disclosure and social support in breast cancer patients and analyze the correlation between them. Methods: General data questionnaire, distress disclosure Index scale and Chinese version of medical social support scale were used to investigate the correlation between self-disclosure and social support in breast cancer patients by Pearson correlation analysis. Results: 1) The total self-disclosure score was (38.75 ± 9.18);the total score of social support was (70.57 ± 14.04) scores, including emotional information support dimension (28.39 ± 6.06) scores, practical support dimension (15.62 ± 3.31) scores, elastic support dimension (14.85 ± 3.23) scores, and emotional support dimension (11.70 ± 2.56) scores. 2) Self-disclosure was positively correlated with social support (r = 0.433, p Conclusion: Breast cancer patients had a moderate level of self-disclosure, and the higher the level of self-disclosure, the better the social support. It is suggested that improving the self-disclosure level of breast cancer patients can help them obtain more social support.

The Role of Body Composition Analyzer in the Preoperative Assessment of Breast Cancer Patients

Background: The segmental multi-frequency bioelectrical impedance analysis (SMF-BIA) is a useful method for evaluating physical health and nutritional status in various clinical settings. But less is known about its role in the preoperative assessment of breast cancer patients. Herein, we try to monitor the changes in body composition of preoperative patients by SMF-BIA and figure out its association with clinical features. Methods: The changes in body composition were monitored by SMF-BIA in 563 female patients with breast cancer. Monitor body moisture and collect relevant data on the day before surgery as a prospective study. Retrospective analysis will be conducted based on preoperative data and pathological results after lymph node resection, Spearman’s correlation coefficients were calculated to investigate the correlation among parameters. Results: We found that the body water, extracellular water ratio, and bioelectrical impedance of the affected upper limbs of patients with different tumor stages or different numbers of lymph node metastases were significantly different from those of their healthy upper limbs (P P P P P Conclusion: SMF-BIA can help monitor the changes in body composition of breast cancer patients and provide detailed information for making a personalized treatment plan and individual nursing schedule. However, the value of SMF-BIA in preoperative assessment still needs to be validated in large prospective clinical trials.

Observation of Curative Effect of Surgical Nursing in Patients with Grade III Hand-Foot Syndrome

Objective: To investigate the effect of surgical nursing on grade III Hand-Foot Syndrome (HFS) induced by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery. Method: From January 2019 to December 2019, 10 patients with HFS grade III caused by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery in the Breast Department of Cancer Prevention and Treatment Center of Sun Yat-sen University were selected, and surgical nursing methods were used to intervene and observe the therapeutic effects of the patients. Results: One patient was cured within 7 days, the cure rate was 10% in 7 days, 8 patients were cured within 10 days, the cure rate was 80% in 10 days, 10 patients were cured within 15 days, the cure rate was 100% in 15 days. Conclusion: The surgical nursing method is effective for patients with grade III HFS caused by Doxorubicin hydrochloride liposome chemotherapy after breast cancer surgery, shortening the treatment time of HFS, and is worthy of clinical promotion.

Research Status of Fear of Cancer Recurrence in Breast Cancer Patients

Fear of disease progression is one of the most common psychological problems in the treatment of cancer patients. Early recognition and intervention can effectively control the level of fear of disease progression and improve the quality of life of patients. The present situation and influencing factors of FoP in breast cancer patients were reviewed in this paper, in order to provide reference for clinical research of breast cancer patients.

三级淋巴结构对非小细胞肺癌患者新辅助治疗后病理反应及预后的影响

目的:研究三级淋巴结构(tertiary lymphoid structures,TLS)对接受新辅助治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的病理反应及预后的影响。方法:回顾性收集2019年1月至2023年12月于天津市胸科医院接受新辅助治疗后行手术的NSCLC患者132例,分为新辅助化疗(neoadjuvant chemotherapy,NC)组40例和新辅助化疗联合免疫治疗(neoadjuvant chemotherapy combined with immunotherapy,NCI)组92例。通过H&E染色评估切片中残余肿瘤细胞(residual viable tumor,RVT)百分比和肿瘤浸润淋巴细胞(tumor infiltrating lymphocyte,TIL),采用H&E染色和免疫组织化学染色方法评估TLS数量和成熟度,分析两组中TLS数量和成熟度的差异以及对患者病理反应和预后的影响。结果:NCI组中TIL浸润水平、TLS的总数量、成熟数量以及病理完全缓解(pathologic complete response,pCR)率、主要病理缓解(major pathologic response,MPR)率均明显高于NC组(均P<0.001)。多因素Logistic分析结果显示,成熟TLS数量和TIL浸润是NCI组患者病理反应的影响因素(P<0.05)。多元线性回归分析结果表明,在NC组中TIL低浸润是高RVT的危险因素;同时在NCI组中,成熟TLS数量低、TIL低浸润和治疗前N分期是高RVT的独立危险因素(均P<0.05)。多因素Cox回归分析结果显示成熟TLS数量(P=0.001)和TIL(P=0.009)是NCI组患者无病生存期(disease-free survival,DFS)的独立预测因子,并且生存分析显示NCI组中TLS高成熟和TIL高浸润患者的DFS显著优于低成熟和低浸润者(均P<0.001)。结论:TLS低成熟度和TIL低浸润与NSCLC患者不良的病理反应和较短的DFS有关,TLS成熟度和TIL可以作为接受NCI患者的病理反应和预后的预测指标。

Identification of pathological characteristics in pulmonary tuberculosis using polarization-sensitive optical coherence tomography

The low detection rate of Mycobacterium tuberculosis in clinical practice leads to a high rate of missed diagnosis for pulmonary tuberculosis(PTB).As a noninvasive,high-resolution,real-time imaging technology,polarization-sensitive optical coherence tomography(PS-OCT)may be feasible for the rapid identification of pathological feature.This study aimed to explore the feasibility of using PS-OCT to identify pathological features of PTB.In the experiments,PTB samples containing some surrounding lung tissues were imaged using PS-OCT.It is demonstrated that PS-OCT images showed good consistency with the corresponding pathological images and were able to identify PTB-related characteristic pathological regions.We think PS-OCT can serve as an effective supplement for the diagnosis of PTB,enabling rapid and accurate diagnosis,and aiding in the understanding of the pathological characteristics and pathophysiological processes of PTB.

Riemann面——平面上的空间结构

Riemann面是复变函数课程中的一个很有特色的内容,也是学生学习中的一个难点。本文从代数和几何这两个视度,简单分析了Riemann面的作用。文中的描述,试图简单、直观、易懂,为初学者了解Riemann面,提供点滴直接的帮助。

3D Lamellar-Structured Graphene Aerogels for Thermal Interface Composites with High Through-Plane Thermal Conductivity and Fracture Toughness

Although thermally conductive graphene sheets are efficient in enhancing in-plane thermal conductivities of polymers,the resulting nanocomposites usually exhibit low through-plane thermal conductivities,limiting their application as thermal interface materials.Herein,lamellarstructured polyamic acid salt/graphene oxide(PAAS/GO)hybrid aerogels are constructed by bidirectional freezing of PAAS/GO suspension followed by lyophilization.Subsequently,PAAS monomers are polymerized to polyimide(PI),while GO is converted to thermally reduced graphene oxide(RGO)during thermal annealing at 300℃.Final graphitization at 2800℃ converts PI to graphitized carbon with the inductive effect of RGO,and simultaneously,RGO is thermally reduced and healed to high-quality graphene.Consequently,lamellar-structured graphene aerogels with superior through-plane thermal conduction capacity are fabricated for the first time,and its superior through-plane thermal conduction capacity results from its vertically aligned and closely stacked high-quality graphene lamellae.After vacuum-assisted impregnation with epoxy,the resultant epoxy composite with 2.30 vol% of graphene exhibits an outstanding through-plane thermal conductivity of as high as 20.0 W m^−1 K^−1,100 times of that of epoxy,with a record-high specific thermal conductivity enhancement of 4310%.Furthermore,the lamellar-structured graphene aerogel endows epoxy with a high fracture toughness,~1.71 times of that of epoxy.

Evaluation of Long-term Stability of Vertical Control in Hyperdivergent Patients Treated with Temporary Anchorage Devices

This study aims to evaluate,the long-term stability of vertical control in hyperdivergent patients treated with temporary anchorage devices.The sample included 20 hyperdivergent patients without anterior open bite.The temporary anchorage devices were used to intrude the upper incisor and molars for vertical control.Lateral cephalograms were established prior to treatment,immediately after treatment,and during retention. The upper molars and incisors were intruded by 1.33 mm and 1.41 mm after treatment (P<0.05).U6-PP increased by 0.11 mm and 0.23 mm during the first and second stages of retention (P>0.05).U1-PP was found to possess a significant extrusion of 1.2 mm during the first stage (P<0.05),which increased by 0.68 mm during the second stage (P>0.05). The mandibular plane angle (MP-SN)decreased by 2.58 degrees following treatment, and underwent a relapse of 0.51 degree and 0.42 degree during the first and second stages of retention respectively (P>0.05).No significant soft tissue changes occurred,with the exception of increased upper lip length during the second stage (P<0.05).Maxillary anterior and posterior intrusions,counter clockwise rotation,of the mandibular plane,and improved profiles can be successfully achieved following treatment with vertical control. During the first stage of retention (less than three years),intruded molars and incisors both exhibited some extrusion,and molars had better long-term stability than incisors. During the second stage of retention (three to six years),the therapeutic effects appeared stable,with the exception of some increase in upper lip length.Rotated mandibular plane remained stable during the entire retention period.

A literature review of research exploring the experiences of overseas nurses in the United Kingdom[2002-2017]

Objectives: The goals of this work were to critically explore the challenges faced by overseas nurses during their working careers in the UK, to critically explore the available support for overseas nurses, and to make recommendations on how to minimize the effects of these challenges, as well as how to provide more support for overseas nurses during their working careers in the UK.Methods: A systematic and comprehensive literature review was conducted to explore the said objectives. A search was conducted in the Cumulative Index to Nursing and Allied Health Literature(CINAHL), Scopus, and Academic Search Complete databases for relevant research. Inclusion and exclusion criteria were used to select the included articles. A total of 8 studies including 6 qualitative studies,1 quantitative study, and 1 mixed-method study were selected for literature review. The validity and reliability of these 8 studies were analyzed by using 2 appraisal tools.Results: This review reveals 4 challenges, which overseas nurses experience in the past 15 years, including cultural differences,communication issues, unequal opportunities, and de-skilling. These challenges have a negative impact on overseas nurses' emotions and career development. The formal and informal supports are revealed in this review. Various supports can help overseas nurses to work better.Conclusions: This review reveals 4 challenges faced by overseas nurses, including cultural differences, communication issues,and unequal opportunities and de-skilling. These challenges naturally have a profound negative impact on the emotions and career development of overseas nurses. Additionally, the formal and informal support systems available to these nurses are reviewed. Various support systems can help overseas nurses work more effectively.

Synthesis and Diastereomeric Analysis of Uridine 2’,3’-Cyclic Phosphite

Uridine 2’,3’-cyclic phosphite has been synthesized and the diastereomers were analysed by 2D NMR technique to assign the configuration

SYNTIIESIS OF 2-AMINO-5-THIO-THIADIAZOLINE β-D-RIBOFURANOSIDES

Amino-5-thio-l,3,4-thiadiazoline and 1-O-acety1-2,3,5-triO-benzoylribofuranose were allowed to react by fusion or by the Vorbruggen procedure. Two products were isolated and characterized to be positional isomers 4-(β-D-ribofuranosyl)-2-amino-5-thio-1,3,4-thiadiazoline and 3-(β-D-ribofuranosyl)-2-imino-5-thio-1,2,4-thiadiazoline by 1H,(13)C NMR, mass spectra as well as crystallographic analysis.

MDM2 inhibitors in cancer immunotherapy:Current status and perspective

Murine double minute 2(MDM2)plays an essential role in the cell cycle,apoptosis,DNA repair,and oncogene activation through p53-dependent and p53-independent signaling pathways.Several preclinical studies have shown that MDM2 is involved in tumor immune evasion.Therefore,MDM2-based regulation of tumor cell-intrinsic immunoregulation and the immune microenvironment has attracted increasing research attention.In recent years,im-mune checkpoint inhibitors targeting PD-1/PD-L1 have been widely used in the clinic.Howev-er,the effectiveness of a single agent is only approximately 20%-40%,which may be related to primary and secondary drug resistance caused by the dysregulation of oncoproteins.Here,we reviewed the role of MDM2 in regulating the immune microenvironment,tumor immune evasion,and hyperprogression during immunotherapy.In addition,we summarized preclinical and clinical findings on the use of MDM2 inhibitors in combination with immunotherapy in tu-mors with MDM2 overexpression or amplification.The results reveal that the inhibition of MDM2 could be a promising strategy for enhancing immunotherapy.

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of-the-art treatments still lag behind the continual emergence of new variants.Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural evolution.Here,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)molecules.The core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the molecules.The EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

Association of Renin Binding Protein(RnBP) Gene Polymorphisms with Essential Hypertension in the Hani Minority of Southwestern China

Essential hypertension is one of the most common multi- factorial diseases, affecting 20%--30% of the human popula- tion （Ibrahim and Damasceno, 2012）. Based on the results of twin studies, adoption studies and statistical analyses of blood pressure （BP） across various pedigrees, it has been estimated that 30%--50% of the variability in blood pressure among the general population is genetically determined （Garcia et al., 2003）. Although the genetic mechanisms of essential hyper- tension have not been studied well, investigations for the genes that constitute the renin-angiotensin system （RAS） appear to be particularly promising, since this system plays a central role in the regulation of blood pressure （Ferrario, 2010）.

Synthesis of cycloparaphenylene under spatial nanoconfinement

Suzuki coupling reactions between symmetrical monomers were conducted in various mesoporous silica nanoreactors grafted with palladium catalysts,enabling the selective formation of[12]cycloparaphenylene precursor with separate yield up to 25%in one-pot reactions,much higher than that in homogeneous reaction.The spatial nanoconfinement of the nanoreactors promotes the macrocyclization while limits the concomitant linear oligomer formation,offering more possibilities for the synthesis of macrocycles from symmetrical monomers in one-pot reaction.

Diet drives convergent evolution of gut microbiomes in bamboo-eating species

Gut microbiota plays a critical role in host physiology and health.The coevolution between the host and its gut microbes facilitates animal adaptation to its specific ecological niche.Multiple factors such as host diet and phylogeny modulate the structure and function of gut microbiota.However,the relative contribution of each factor in shaping the structure of gut microbiota remains unclear.The giant(Ailuropoda melanoleuca)and red(Ailurus styani)pandas belong to different families of order Carnivora.They have evolved as obligate bamboo-feeders and can be used as a model system for studying the gut microbiome convergent evolution.Here,we compare the structure and function of gut microbiota of the two pandas with their carnivorous relatives using 16S rRNA and metagenome sequencing.We found that both panda species share more similarities in their gut microbiota structure with each other than each species shares with its carnivorous relatives.This indicates that the specialized herbivorous diet rather than host phylogeny is the dominant driver of gut microbiome convergence within Arctoidea.Metagenomic analysis revealed that the symbiotic gut microbiota of both pandas possesses a high level of starch and sucrose metabolism and vitamin B12 biosynthesis.These findings suggest a diet-driven convergence of gut microbiomes and provide new insight into host-microbiota coevolution of these endangered species.

Improvement of Mechanical Properties of Wood-Plastic Composite Floors Based on the Optimum Structural Design

A study is carried out on the structural design of wood-plastic composite floors. The geometric parameters of the cavities, the structure, and the means to optimize the performance of these light boards are investigated. Various structural parameters of the boards, such as size, shape, and the pattern of cavities are also studied. The optimal structure can be determined by calculation and analysis of the strength, stiffness, weight and cost of the material. A finite element model for the mechanical analysis of wood-plastic composite floors is established; and the results are used to verify the strength criteria under bending deformation, which is the most common loading condition of flooring board.

Crosslinked carboxymethyl cellulose-sodium borate hybrid binder for advanced silicon anodes in lithium-ion batteries

Silicon anodes have drawn ever-increasing attention in lithium-ion batteries(LIBs) owing to their extremely high theoretical capacity and abundance in the earth. Despite promising advantages, the wide use of silicon anodes in LIBs is highly hindered by their fast capacity fading and low Coulombic efficiency arising from their substantial volumetric variation(>300%). Herein, we report a novel aqueous hybrid gel binder for silicon anodes via crosslinking sodium carboxymethyl cellulose(NaCMC) by an inorganic crosslinker-sodium borate. Not only this gel polymer binder can chemically bond to silicon nanoparticle, but also the deformable framework of this crosslinked binder is capable of maintaining electrode integrity, thus buffering dramatic volume change of silicon. Consequently, the silicon anode with this gel binder exhibits good cycle life(1211.5 mAh/g after 600 cycles) and high initial Coulombic efficiency(88.95%).

纸质图书和数字图书增值税税率差异比较

本文通过比较全球35个国家的图书增值税税率,发现图书增值税平均税率远低于增值税标准税率,纸质图书增值税平均税率低于数字图书增值税平均税率。随着信息技术的快速发展,数字图书已成为图书出版的重要组成部分,近年来一些国家相继降低数字图书增值税税率。为了促进知识经济发展,本文建议我国也应进一步降低图书增值税税率,统一纸质图书和数字图书增值税税率,并明确新兴出版物税目。