As the scale of urban rail transit(URT)networks expands,the study of URT resilience is essential for safe and efficient operations.This paper presents a comprehensive review of URT resilience and highlights potential ...As the scale of urban rail transit(URT)networks expands,the study of URT resilience is essential for safe and efficient operations.This paper presents a comprehensive review of URT resilience and highlights potential trends and directions for future research.First,URT resilience is defined by three primary abilities:absorption,resistance,and recovery,and four properties:robustness,vulnerability,rapidity,and redundancy.Then,the metrics and assessment approaches for URT resilience were summarized.The metrics are divided into three categories:topology-based,characteristic-based,and performance-based,and the assessment methods are divided into four categories:topological,simulation,optimization,and datadriven.Comparisons of various metrics and assessment approaches revealed that the current research trend in URT resilience is increasingly favoring the integration of traditional methods,such as conventional complex network analysis and operations optimization theory,with new techniques like big data and intelligent computing technology,to accurately assess URT resilience.Finally,five potential trends and directions for future research were identified:analyzing resilience based on multisource data,optimizing train diagram in multiple scenarios,accurate response to passenger demand through new technologies,coupling and optimizing passenger and traffic flows,and optimal line design.展开更多
This work applies non-stationary random processes to resilience of power distribution under severe weather. Power distribution, the edge of the energy infrastructure, is susceptible to external hazards from severe wea...This work applies non-stationary random processes to resilience of power distribution under severe weather. Power distribution, the edge of the energy infrastructure, is susceptible to external hazards from severe weather. Large-scale power failures often occur, resulting in millions of people without electricity for days. However, the problem of large-scale power failure, recovery and resilience has not been formulated rigorously nor studied systematically. This work studies the resilience of power distribution from three aspects. First, we derive non-stationary random processes to model large-scale failures and recoveries. Transient Little’s Law then provides a simple approximation of the entire life cycle of failure and recovery through a queue at the network-level. Second, we define time-varying resilience based on the non-stationary model. The resilience metric characterizes the ability of power distribution to remain operational and recover rapidly upon failures. Third, we apply the non-stationary model and the resilience metric to large-scale power failures caused by Hurricane Ike. We use the real data from the electric grid to learn time-varying model parameters and the resilience metric. Our results show non-stationary evolution of failure rates and recovery times, and how the network resilience deviates from that of normal operation during the hurricane.展开更多
In 2020,the COVID-19 pandemic spreads rapidly around the world.To accurately predict the number of daily new cases in each country,Lanzhou University has established the Global Prediction System of the COVID-19 Pandem...In 2020,the COVID-19 pandemic spreads rapidly around the world.To accurately predict the number of daily new cases in each country,Lanzhou University has established the Global Prediction System of the COVID-19 Pandemic(GPCP).In this article,the authors use the ensemble empirical mode decomposition(EEMD)model and autoregressive moving average(ARMA)model to improve the prediction results of GPCP.In addition,the authors also conduct direct predictions for those countries with a small number of confirmed cases or are in the early stage of the disease,whose development trends of the pandemic do not fully comply with the law of infectious diseases and cannot be predicted by the GPCP model.Judging from the results,the absolute values of the relative errors of predictions in countries such as Cuba have been reduced significantly and their prediction trends are closer to the real situations through the method mentioned above to revise the prediction results out of GPCP.For countries such as El Salvador with a small number of cases,the absolute values of the relative errors of prediction become smaller.Therefore,this article concludes that this method is more effective for improving prediction results and direct prediction.展开更多
Excessive reactive oxygen species(ROS)can cause oxidative damage and lead to various metabolic disease.Tartary buckwheat(Fagopyrum tataricum(L.)Gaertn)is a new kind of protein-rich functional food,the protein in which...Excessive reactive oxygen species(ROS)can cause oxidative damage and lead to various metabolic disease.Tartary buckwheat(Fagopyrum tataricum(L.)Gaertn)is a new kind of protein-rich functional food,the protein in which has been proved to have good antioxidant capacity.In this study,in order to further explore the antioxidant mechanism of Tartary buckwheat protein,4 peptides(CR-8,LR-8,GK-10 and SR-12)were isolated and identified from it.H2 O2 was used to induce oxidative damage to Caco-2 cells to evaluate antioxidant capacity of these peptides.The results of superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and mitochondrial membrane potential etc.showed that these peptides have superior antioxidant capacity.CR-8 has the best antioxidant capacity.In order to further clarify the antioxidant mechanism of CR-8,metabolomics was used to analyze related metabolites and metabolic pathways.The results showed that after CR-8 intervention,the content of metabolites such as L-acetyl carnitine has increased.This indicated that CR-8 can improve the antioxidant capacity of damaged cells by intervening in multiple metabolic pathways.This also revealed the anti-oxidant mechanism of tartary buckwheat protein.In conclusion,it provided a theoretical basis for further studying the activity of tartary buckwheat portein and utilizing buckwheat resources.展开更多
At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by gover...At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by governments and the World Health Organization.To capture and understand the characteristics of the epidemic trend,parameter optimization algorithms are needed to obtain model parameters.In this study,the authors propose using the Levenberg–Marquardt algorithm(LMA)to identify epidemic models.This algorithm combines the advantage of the Gauss–Newton method and gradient descent method and has improved the stability of parameters.The authors selected four countries with relatively high numbers of confirmed cases to verify the advantages of the Levenberg–Marquardt algorithm over the traditional epidemiological model method.The results show that the Statistical-SIR(Statistical-Susceptible–Infected–Recovered)model using LMA can fit the actual curve of the epidemic well,while the epidemic simulation of the traditional model evolves too fast and the peak value is too high to reflect the real situation.展开更多
Functional polymer composites(FPCs)have attracted increasing attention in recent decades due to their great potential in delivering a wide range of functionalities.These functionalities are largely determined by funct...Functional polymer composites(FPCs)have attracted increasing attention in recent decades due to their great potential in delivering a wide range of functionalities.These functionalities are largely determined by functional fillers and their network morphology in polymer matrix.In recent years,a large number of studies on morphology control and interfacial modification have been reported,where numerous preparation methods and exciting performance of FPCs have been reported.Despite the fact that these FPCs have many similarities because they are all consisting of functional inorganic fillers and polymer matrices,review on the overall progress of FPCs is still missing,and especially the overall processing strategy for these composites is urgently needed.Herein,a"Toolbox"for the processing of FPCs is proposed to summarize and analyze the overall processing strategies and corresponding morphology evolution for FPCs.From this perspective,the morphological control methods already utilized for various FPCs are systematically reviewed,so that guidelines or even predictions on the processing strategies of various FPCs as well as multi-functional polymer composites could be given.This review should be able to provide interesting insights for the field of FPCs and boost future intelligent design of various FPCs.展开更多
Components with strong adsorption capacity for cholates from buckwheat proteins were screened, separated and purified by several methods, and the effects of ultra-high-pressure(UHP) on the structure and function of bu...Components with strong adsorption capacity for cholates from buckwheat proteins were screened, separated and purified by several methods, and the effects of ultra-high-pressure(UHP) on the structure and function of buckwheat 13S globulin(BW13SG) were studied. Samples were treated by UHP at different p H(3.0 and 7.0) value(s) and at 100–500 MPa for 10–30 min. The results showed that the tertiary structure of BW13SG was partially denatured and aggregated. The decrease in the unordered structure indicated that UHP resulted in a looser secondary structure of BW13SG. UHP treatment also increased solubility, emulsion activity and stability, foaming capacity and stability. The samples treated at 500 MPa, p H 3.0 for 30 min had the most enhanced functionality. Moreover, under this condition, the sodium cholate and sodium deoxycholate adsorption capacities of BW13SG were both higher than 98% and the adsorption capacity of sodium taurocholate, which can be difficult to adsorb, was higher than 60%.展开更多
Language is a mirror of a particular society. In the field of foreign language teaching, researchers and scholars focus on the importance of cultural awareness of target language. Still English learners have some diff...Language is a mirror of a particular society. In the field of foreign language teaching, researchers and scholars focus on the importance of cultural awareness of target language. Still English learners have some difficulties that they feel hard to overcome even if they have a good command of the target language and its culture. This paper attempts to give a new direction to English teaching in China through a discussion of integrating Chinese culture in TEFL.展开更多
Apple(Malus domestica)fruit generally undergoes a climacteric.During its ripening process,there is a peak in ethylene release and its firmness simultaneously decreases.Although more in-depth research into the mechanis...Apple(Malus domestica)fruit generally undergoes a climacteric.During its ripening process,there is a peak in ethylene release and its firmness simultaneously decreases.Although more in-depth research into the mechanism of climacteric-type fruit ripening is being carried out,some aspects remain unclear.In this study,we compared the transcriptomes of 0-Pre and 15-Post(pre-and post-climacteric fruit),and 15-Post and 15-MCP[fruit treated with 1-MCP(1-methylcyclopropene)].Various transcription factors,such as MADS-box,ERF,NAC,Dof and SHF were identified among the DEGs(differential gene expressions).Furthermore,these transcription factors were selected for further validation analysis by qRT-PCR.Moreover,yeast one hybrid(Y1H),β-glucuronidase(GUS)transactivation assay and dual-luciferase reporter assay showed that MdAGL30,MdAGL104,MdERF008,MdNAC71,MdDof1.2,MdHSFB2a and MdHSFB3 bound to MdACS1 promoter and directly regulated its transcription,thereby regulating ethylene biosynthesis in apple fruit.Our results provide useful information and new insights for research on apple fruit ripening.展开更多
Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular prot...Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular protection, anti-inflammatory, antiviral, chemopreventive effect, neuroprotective effect, immunomodulation and so on. However, owing to its poor oral bioavailability, the application of resveratrol is greatly restricted. Because of that, a large amount of efforts had been made by researchers on designing its derivatives to obtain compounds with improved efficiency and low toxicity for developing more active drugs for clinical application. In this report, we review the current development of studying on resveratrol derivatives including their properties and activities. Additionally, this article also presents the synthetic routes of correlative resveratrol derivatives.展开更多
基金supported by the National Natural Science Foundation of China(72288101,72331001,and 72071015)the Research Grants Council of the Hong Kong Special Administrative Region(PolyU 15222221)+1 种基金the 111 Center(B20071)an XPLORER PRIZE.
文摘As the scale of urban rail transit(URT)networks expands,the study of URT resilience is essential for safe and efficient operations.This paper presents a comprehensive review of URT resilience and highlights potential trends and directions for future research.First,URT resilience is defined by three primary abilities:absorption,resistance,and recovery,and four properties:robustness,vulnerability,rapidity,and redundancy.Then,the metrics and assessment approaches for URT resilience were summarized.The metrics are divided into three categories:topology-based,characteristic-based,and performance-based,and the assessment methods are divided into four categories:topological,simulation,optimization,and datadriven.Comparisons of various metrics and assessment approaches revealed that the current research trend in URT resilience is increasingly favoring the integration of traditional methods,such as conventional complex network analysis and operations optimization theory,with new techniques like big data and intelligent computing technology,to accurately assess URT resilience.Finally,five potential trends and directions for future research were identified:analyzing resilience based on multisource data,optimizing train diagram in multiple scenarios,accurate response to passenger demand through new technologies,coupling and optimizing passenger and traffic flows,and optimal line design.
文摘This work applies non-stationary random processes to resilience of power distribution under severe weather. Power distribution, the edge of the energy infrastructure, is susceptible to external hazards from severe weather. Large-scale power failures often occur, resulting in millions of people without electricity for days. However, the problem of large-scale power failure, recovery and resilience has not been formulated rigorously nor studied systematically. This work studies the resilience of power distribution from three aspects. First, we derive non-stationary random processes to model large-scale failures and recoveries. Transient Little’s Law then provides a simple approximation of the entire life cycle of failure and recovery through a queue at the network-level. Second, we define time-varying resilience based on the non-stationary model. The resilience metric characterizes the ability of power distribution to remain operational and recover rapidly upon failures. Third, we apply the non-stationary model and the resilience metric to large-scale power failures caused by Hurricane Ike. We use the real data from the electric grid to learn time-varying model parameters and the resilience metric. Our results show non-stationary evolution of failure rates and recovery times, and how the network resilience deviates from that of normal operation during the hurricane.
基金This work was jointly supported by the National Natural Science Foundation of China[grant numbers 41521004 and 41875083]the Gansu Provincial Special Fund Project for Guiding Scientific and Technological Innovation and Development[grant number 2019ZX-06].
文摘In 2020,the COVID-19 pandemic spreads rapidly around the world.To accurately predict the number of daily new cases in each country,Lanzhou University has established the Global Prediction System of the COVID-19 Pandemic(GPCP).In this article,the authors use the ensemble empirical mode decomposition(EEMD)model and autoregressive moving average(ARMA)model to improve the prediction results of GPCP.In addition,the authors also conduct direct predictions for those countries with a small number of confirmed cases or are in the early stage of the disease,whose development trends of the pandemic do not fully comply with the law of infectious diseases and cannot be predicted by the GPCP model.Judging from the results,the absolute values of the relative errors of predictions in countries such as Cuba have been reduced significantly and their prediction trends are closer to the real situations through the method mentioned above to revise the prediction results out of GPCP.For countries such as El Salvador with a small number of cases,the absolute values of the relative errors of prediction become smaller.Therefore,this article concludes that this method is more effective for improving prediction results and direct prediction.
基金Shanghai Natural Science Foundation(20ZR1455800)the National Science Foundation of China(31871805)+1 种基金China Agriculture Research System(CARS-08-D2)Shanghai Municipal Education Commission(Plateau Discipline Construction Program)。
文摘Excessive reactive oxygen species(ROS)can cause oxidative damage and lead to various metabolic disease.Tartary buckwheat(Fagopyrum tataricum(L.)Gaertn)is a new kind of protein-rich functional food,the protein in which has been proved to have good antioxidant capacity.In this study,in order to further explore the antioxidant mechanism of Tartary buckwheat protein,4 peptides(CR-8,LR-8,GK-10 and SR-12)were isolated and identified from it.H2 O2 was used to induce oxidative damage to Caco-2 cells to evaluate antioxidant capacity of these peptides.The results of superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and mitochondrial membrane potential etc.showed that these peptides have superior antioxidant capacity.CR-8 has the best antioxidant capacity.In order to further clarify the antioxidant mechanism of CR-8,metabolomics was used to analyze related metabolites and metabolic pathways.The results showed that after CR-8 intervention,the content of metabolites such as L-acetyl carnitine has increased.This indicated that CR-8 can improve the antioxidant capacity of damaged cells by intervening in multiple metabolic pathways.This also revealed the anti-oxidant mechanism of tartary buckwheat protein.In conclusion,it provided a theoretical basis for further studying the activity of tartary buckwheat portein and utilizing buckwheat resources.
基金This work was jointly supported by the National Natural Science Foundation of China[grant number 41521004]the Gansu Provincial Special Fund Project for Guiding Scientific and Technological Innovation and Development[grant number 2019ZX-06].
文摘At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by governments and the World Health Organization.To capture and understand the characteristics of the epidemic trend,parameter optimization algorithms are needed to obtain model parameters.In this study,the authors propose using the Levenberg–Marquardt algorithm(LMA)to identify epidemic models.This algorithm combines the advantage of the Gauss–Newton method and gradient descent method and has improved the stability of parameters.The authors selected four countries with relatively high numbers of confirmed cases to verify the advantages of the Levenberg–Marquardt algorithm over the traditional epidemiological model method.The results show that the Statistical-SIR(Statistical-Susceptible–Infected–Recovered)model using LMA can fit the actual curve of the epidemic well,while the epidemic simulation of the traditional model evolves too fast and the peak value is too high to reflect the real situation.
基金National Natural Science Foundation of China(51922071,51773139).
文摘Functional polymer composites(FPCs)have attracted increasing attention in recent decades due to their great potential in delivering a wide range of functionalities.These functionalities are largely determined by functional fillers and their network morphology in polymer matrix.In recent years,a large number of studies on morphology control and interfacial modification have been reported,where numerous preparation methods and exciting performance of FPCs have been reported.Despite the fact that these FPCs have many similarities because they are all consisting of functional inorganic fillers and polymer matrices,review on the overall progress of FPCs is still missing,and especially the overall processing strategy for these composites is urgently needed.Herein,a"Toolbox"for the processing of FPCs is proposed to summarize and analyze the overall processing strategies and corresponding morphology evolution for FPCs.From this perspective,the morphological control methods already utilized for various FPCs are systematically reviewed,so that guidelines or even predictions on the processing strategies of various FPCs as well as multi-functional polymer composites could be given.This review should be able to provide interesting insights for the field of FPCs and boost future intelligent design of various FPCs.
基金the financial support by the Open Project Program of State Key Laboratory of Dairy Biotechnology (No. SKLDB2018-002)National Natural Science Foundation of China (No. 31871805 & No. 31501437)+1 种基金Shanghai Municipal Education Commission (Plateau Discipline Construction Program)China Agriculture Research System (CARS-08-D2)。
文摘Components with strong adsorption capacity for cholates from buckwheat proteins were screened, separated and purified by several methods, and the effects of ultra-high-pressure(UHP) on the structure and function of buckwheat 13S globulin(BW13SG) were studied. Samples were treated by UHP at different p H(3.0 and 7.0) value(s) and at 100–500 MPa for 10–30 min. The results showed that the tertiary structure of BW13SG was partially denatured and aggregated. The decrease in the unordered structure indicated that UHP resulted in a looser secondary structure of BW13SG. UHP treatment also increased solubility, emulsion activity and stability, foaming capacity and stability. The samples treated at 500 MPa, p H 3.0 for 30 min had the most enhanced functionality. Moreover, under this condition, the sodium cholate and sodium deoxycholate adsorption capacities of BW13SG were both higher than 98% and the adsorption capacity of sodium taurocholate, which can be difficult to adsorb, was higher than 60%.
文摘Language is a mirror of a particular society. In the field of foreign language teaching, researchers and scholars focus on the importance of cultural awareness of target language. Still English learners have some difficulties that they feel hard to overcome even if they have a good command of the target language and its culture. This paper attempts to give a new direction to English teaching in China through a discussion of integrating Chinese culture in TEFL.
基金supported by grants from the National Natural Science Foundation of China(Grant No.32002006)China Postdoctoral Science Foundation(Grant No.2020M680984).
文摘Apple(Malus domestica)fruit generally undergoes a climacteric.During its ripening process,there is a peak in ethylene release and its firmness simultaneously decreases.Although more in-depth research into the mechanism of climacteric-type fruit ripening is being carried out,some aspects remain unclear.In this study,we compared the transcriptomes of 0-Pre and 15-Post(pre-and post-climacteric fruit),and 15-Post and 15-MCP[fruit treated with 1-MCP(1-methylcyclopropene)].Various transcription factors,such as MADS-box,ERF,NAC,Dof and SHF were identified among the DEGs(differential gene expressions).Furthermore,these transcription factors were selected for further validation analysis by qRT-PCR.Moreover,yeast one hybrid(Y1H),β-glucuronidase(GUS)transactivation assay and dual-luciferase reporter assay showed that MdAGL30,MdAGL104,MdERF008,MdNAC71,MdDof1.2,MdHSFB2a and MdHSFB3 bound to MdACS1 promoter and directly regulated its transcription,thereby regulating ethylene biosynthesis in apple fruit.Our results provide useful information and new insights for research on apple fruit ripening.
文摘Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular protection, anti-inflammatory, antiviral, chemopreventive effect, neuroprotective effect, immunomodulation and so on. However, owing to its poor oral bioavailability, the application of resveratrol is greatly restricted. Because of that, a large amount of efforts had been made by researchers on designing its derivatives to obtain compounds with improved efficiency and low toxicity for developing more active drugs for clinical application. In this report, we review the current development of studying on resveratrol derivatives including their properties and activities. Additionally, this article also presents the synthetic routes of correlative resveratrol derivatives.
