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Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess:a prospective study 被引量:8
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作者 Chun Yuan Xiaoqiang Liu +3 位作者 yundong mao Feiyang Diao Yugui Cui Jiayin Liu 《The Journal of Biomedical Research》 CAS CSCD 2016年第3期197-202,共6页
Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. ... Biochemical or clinical changes of hyperandrogenism are important elements of polycystic ovary syndrome (PCOS). There is currently no consensus on the definition and diagnostic criteria of hyperandrogenism in PCOS. The aim of this study was to investigate the complex symptoms of hyperandrogenic disorders and the correlations between metabolism and hyperandrogenism in patients with PCOS from an outpatient reproductive medicine clinic in China. We conducted a case control study of 125 PCOS patients and 130 controls to evaluate differences in body mass index (BMI), total testosterone (TT), modified Ferriman-Gallwey hirsutism score, sex hormone binding globulin (SHBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR) and free androgen index (FAI) between PCOS patients and controls and subgroups of PCOS. The prevalence of acne and hirsutism did not differ significantly between the hyperandrogenic and non-hyperandrogenic subgroup. Patients with signs of hyper- androgenism had significantly higher BMI (P 〈 0.05), but differences in TT, SHBG, FAI and waist/hip ratio were insignificant. The odds ratio of overweight was calculated for all PCOS patients. Our results suggest that PCOS patients with high BMI tend to have functional disorders of androgen excess; therefore, BMI may be a strong pre-dictor of hyperandrogenism in PCOS. 展开更多
关键词 polycystic ovary syndrome diagnostic criteria OBESITY reproductive health long-term weight
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The remedial effect of soluble interleukin-1 receptor type Ⅱ on endometriosis in the nude mouse model 被引量:1
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作者 Liying Gao Liang Sun +6 位作者 Yugui Cui Zhen Hou Li Gao Jing Zhou yundong mao Suping Han Jiayin Liu 《The Journal of Biomedical Research》 CAS 2010年第1期43-50,共8页
Objective: Recent studies have shown that the local expression of soluble interleukin (IL) -1 receptor type Ⅱ (slL-1 R Ⅱ ) in endometrial tissue of women with endometriosis is decreased, and the depression of I... Objective: Recent studies have shown that the local expression of soluble interleukin (IL) -1 receptor type Ⅱ (slL-1 R Ⅱ ) in endometrial tissue of women with endometriosis is decreased, and the depression of IL-1 R Ⅱ was more significant in infertile women than that in fertile women with endometriosis. In this research, we investigated the remedial effect of slL-1-R Ⅱ administration on endometriosis in the nude mouse model. Methods: Nineteen nude model mice with endometriosis were randomly divided into three groups: group A was treated by intraperitoneal administration with only slL-1 R Ⅱ for two weeks, group B was similarly treated with only IL- 1, and group C (control) was administered saline. After 2 weeks, the size of the ectopic endometrial lesions was calculated, and the expression of vascular endothelial growth factor (VEGF) and B-cell lymphoma leukemia-2 (Bcl- 2) were detected by immunohistochemistry. The IL-8 and VEGF levels in the peritoneal fluid (PF) and serum were also measured by enzyme-linked immunosorbent assay (ELISA). Results: The mean size of ectopic endometrial lesion did not differ between the three groups (P 〉 0.05). Compared with the control, the expression of VEGF and Bcl-2 was significantly lower in group A, and higher in group B. In the three groups, the levels of IL-8 in the PF and serum were highest in group A, and lowest in group B. Conclusion: slL-1 R Ⅱ may suppresse hyperplasia of ectopic endometriosis, perhaps by reducing the expression of certain cytokines, such as VEGF, IL-8, and Bcl-2, which could provide a new clinical strategy for the treatment of endometriosis. 展开更多
关键词 INTERLEUKIN-1 solubleinterleukin-1 receptor type ENDOMETRIOSIS nude mouse model
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妇产科手术后盆腹腔粘连预防中国指南(2023年版) 被引量:6
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作者 朱兰 郎景和 +26 位作者 任常 张越伦 陈敦金 陈龙 陈亦乐 崔满华 狄文 段华 郝敏 黄向华 李佩玲 冒韵东 漆洪波 史惠蓉 宋磊 王沂峰 徐开红 许学先 薛翔 杨慧霞 姚书忠 张国楠 章汉旺 张淑兰 周慧梅 周应芳 朱卫国 《中华妇产科杂志》 CAS CSCD 北大核心 2023年第3期161-169,共9页
粘连是最常见的手术并发症,术后粘连在妇产科手术后也较为常见,术后粘连可能引起病理性的并发症,严重者甚至可危及生命。为了在临床上更好地预防粘连,在2015年的《预防妇产科手术后盆腹腔粘连的中国专家共识》基础上,根据新的研究结果,... 粘连是最常见的手术并发症,术后粘连在妇产科手术后也较为常见,术后粘连可能引起病理性的并发症,严重者甚至可危及生命。为了在临床上更好地预防粘连,在2015年的《预防妇产科手术后盆腹腔粘连的中国专家共识》基础上,根据新的研究结果,专家组遴选了与临床密切相关的12项问题进行了文献检索,并根据国际通用的标准进行了严谨评级和严格推荐。在兼顾严肃性、严谨性、严格性、实用性、科学性、权威性、政策性和安全性的前提下,最终制定了本指南,以规范临床工作,指导选择防粘连材料,加强防粘连意识,最终使患者获益。 展开更多
关键词 盆腹腔粘连 预防粘连 妇产科手术后 术后粘连 文献检索 中国专家共识 病理性 严谨性
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