Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturin...Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturing was employed to fabricate pure Zn with a heterogeneous microstructure and exceptional strength-ductility synergy.An optimized processing window of LPBF was established for printing Zn samples with relative densities greater than 99%using a laser power range of 80∼90 W and a scanning speed of 900 mm s−1.The Zn sample printed with a power of 80 W at a speed of 900 mm s−1 exhibited a hierarchical heterogeneous microstructure consisting of millimeter-scale molten pool boundaries,micrometer-scale bimodal grains,and nanometer-scale pre-existing dislocations,due to rapid cooling rates and significant thermal gradients formed in the molten pools.The printed sample exhibited the highest ductility of∼12.1%among all reported LPBF-printed pure Zn to date with appreciable ultimate tensile strength(∼128.7 MPa).Such superior strength-ductility synergy can be attributed to the presence of multiple deformation mechanisms that are primarily governed by heterogeneous deformation-induced hardening resulting from the alternative arrangement of bimodal Zn grains with pre-existing dislocations.Additionally,continuous strain hardening was facilitated through the interactions between deformation twins,grains and dislocations as strain accumulated,further contributing to the superior strength-ductility synergy.These findings provide valuable insights into the deformation behavior and mechanisms underlying exceptional mechanical properties of LPBF-printed Zn and its alloys for implant applications.展开更多
In recent years, with the large increase in the number of motor vehicles in colleges and universities and the lag in campus planning, the relative shortage of parking spaces on campus has become increasingly serious. ...In recent years, with the large increase in the number of motor vehicles in colleges and universities and the lag in campus planning, the relative shortage of parking spaces on campus has become increasingly serious. Taking Baoding College as an example, this article analyzes the current situation of static traffic on campus and finds out the problem of parking on campus through questionnaire surveys and field surveys. Analyze the growth trend of the number of motor vehicles based on the data, use the GM (1, 1) model and the linear fitting model to predict the number of motor vehicles in the future, and determine the size and layout of the parking lot based on the campus size, functional zoning, and road layout. The big campus-based parking system planning method based on big data can effectively solve the problems of small sample data, low accuracy, and poor timeliness of traditional methods, which improves the practicability and scientificity of planning results.展开更多
With wide application of electric vehicles and large-scale in energy storage systems, the requirement ofsecondary batteries with higher power density and better safety gets urgent. Owing to the merits of hightheoretic...With wide application of electric vehicles and large-scale in energy storage systems, the requirement ofsecondary batteries with higher power density and better safety gets urgent. Owing to the merits of hightheoretical capacity, relatively low cost and suitable discharge voltage, much attention has been paid tothe transition metal sulfides. Recently, a large amount of research papers have reported about the appli-cation of transition metal sulfides in lithium ion batteries. However, the practical application of transitionmetal sulfides is still impeded by their fast capacity fading and poor rate performance. More well-focusedresearches should be operated towards the commercialization of transition metal sulfides in lithium ionbatteries. In this review, recent development of using transition metal sulfides such as copper sulfides,molybdenum sulfides, cobalt sulfides, and iron sulfides as electrode materials for lithium ion batteriesis presented. In addition, the electrochemical reaction mechanisms and synthetic strategy of transitionmetal sulfides are briefly summarized. The critical issues, challenges, and perspectives providing a fur-ther understanding of the associated electrochemical processes are also discussed.展开更多
Photoanodes based on In_2S_3/ZnO heterojunction nanosheet arrays(NSAs) have been fabricated by atomic layer deposition of ZnO over In_2S_3 NSAs, which were in situ grown on fluorine-doped tin oxide glasses via a facil...Photoanodes based on In_2S_3/ZnO heterojunction nanosheet arrays(NSAs) have been fabricated by atomic layer deposition of ZnO over In_2S_3 NSAs, which were in situ grown on fluorine-doped tin oxide glasses via a facile solvothermal process. The as-prepared photoanodes show dramatically enhanced performance for photoelectrochemical(PEC) water splitting, compared to single semiconductor counterparts. The optical and PEC properties of In_2S_3/ZnO NSAs have been optimized by modulating the thickness of the Zn O overlayer. After pairing with ZnO, the NSAs exhibit a broadened absorption range and an increased light absorptance over a wide wavelength region of 250–850 nm. The optimized sample of In_2S_3/ZnO-50 NSAs shows a photocurrent density of 1.642 m A cm^(-2)(1.5 V vs. RHE) and an incident photonto-current efficiency of 27.64% at 380 nm(1.23 V vs.RHE), which are 70 and 116 times higher than those of the pristine In_2S_3 NSAs, respectively. A detailed energy band edge analysis reveals the type-II band alignment of the In_2S_3/ZnO heterojunction, which enables efficient separation and collection of photogenerated carriers,especially with the assistance of positive bias potential, and then results in the significantly increased PEC activity.展开更多
A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-br...A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU+/NG2+cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury.展开更多
Objective:To examine the effects of accumulated heat in GI tract (AHGIT) on lung tissue protein expression in pneumonic mice.Methods:Nebulized lipopolysaccharides (LPS) were administered to induce a pneumonic mouse mo...Objective:To examine the effects of accumulated heat in GI tract (AHGIT) on lung tissue protein expression in pneumonic mice.Methods:Nebulized lipopolysaccharides (LPS) were administered to induce a pneumonic mouse model (M1),and a high-calorie/protein diet combined with nebulized LPS was used to induce AHGIT pneumonia (M2).Isobaric tag for relative and absolute quantitation (iTRAQ)proteomics was applied to study lung protein expression,followed by bioinformatics analysis.Results:M1 mice developed alveolar damage with prominent septum thickening,vascular dilation,hyperaemia and infiltration of large amounts of inflammatory cells.M2 mice developed more severe pathological responses.A total of 2626 proteins were reliably identified in the lung tissue.Compared with normal mice,the M1 mice had 344 differentially expressed proteins in their lungs,which are involved in the following biological processes:response to organic substance,response to cytokine,response to external stimulus,defense response and immune system process.They are also involved in the following Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways:ECM-receptor interaction,leukocyte transendothelial migration,Fc gamma R-mediated phagocytosis,complement and coagulation cascades,and antigen processing and presentation.Compared with the M1 group,the M2 mice had 164 differentially expressed proteins in their lungs,including 14 upregulated and 150 downregulated proteins.These proteins are involved in the following biological processes:small molecule metabolism,ribose phosphate metabolic process,cell adhesion and biological adhesion.The relevant KEGG pathways included oxidative phosphorylation,Citrate cycle (TCA cycle),complement and coagulation cascades,and vascular smooth muscle contraction.Conclusions:AHGIT aggravated the lung inflammatory damage in the mice with LPS-induced pneumonia.It may affect the mouse substance/energy metabolism,and therefore the immune function,to aggravate the LPS-induced inflammatory damage.展开更多
Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the ave...Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the average binding energy is 1.54 eV,which is much larger than the cohesive energy of 1.13 eV for bulk Na.A maximum of four H2 molecules can be adsorbed around each Na with average adsorption energies of 0.25–0.32 eV/H2.Also,H2 storage gravimetric of 8.85 wt%is obtained,and this meets the U.S.Department of Energy(DOE)ultimate target.These results are instrumental in seeking a promising hydrogen energy carrier.展开更多
With the expansion of the scale of our hospital robot laboratory, equipment use, reserves are increasing, manual management equipment information has been unable to adapt to daily management, such as data record error...With the expansion of the scale of our hospital robot laboratory, equipment use, reserves are increasing, manual management equipment information has been unable to adapt to daily management, such as data record error rate increased, the number of experiments increased, equipment loss and maintenance is not clearly defined. In order to ensure the safety and accuracy of the equipment, a system of equipment management systems was developed as a result of the conversion to the use of management systems for the recording and storage of information. The design of this system is a perfect robot laboratory equipment management system based on the development of web framework technology for equipment management functions. The back end of this system uses the Java language, the SSM framework as the main body, the database is built by MySQL relational database, the front-end page uses JSP, Bootstrap, jQuery and other technologies, and uses Eclipse project construction tools for system development. After a period of trial operation, the level of laboratory equipment management has been significantly improved.展开更多
Linear algebra has a very important application in physics and technical disciplines. This article conducted a questionnaire survey on the factors that affect the effect of linear algebra learning;the questionnaire co...Linear algebra has a very important application in physics and technical disciplines. This article conducted a questionnaire survey on the factors that affect the effect of linear algebra learning;the questionnaire contains several aspects of learning attitude, learning interest, learning methods, teaching methods, etc.;based on recycling data, cross chi-square test and multiple logistic regression analysis </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">are </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">us</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ed</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> to obtain the factors that affect the effect of linear algebra learning. The research results show that: learning methods, learning attitudes, teaching methods and elementary algebra basics are the main factors that affect the learning effect of linear algebra;among them, there are positive correlations between teaching methods, learning methods, learning attitudes and learning effects;teaching methods, learning methods 3. The three principal components of learning attitude are positively correlated. Based on the research and analysis, the following conclusions are drawn: finding a suitable learning method for the college students and maintaining a positive learning attitude are effective means to improve the linear algebra learning effect of the college students;in teaching, it is recommended to advance with the times, the teaching content and teaching methods innovate to stimulate students’ interest in learning</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> thus improv</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ing</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> the learning effect of college students’ linear algebra courses.展开更多
In order to find geomagnetic anomalies associated with Ms ≥ 6.0 strong earthquakes in Yunnan area, geomagnetic harmonic wave amplitude ratios with Z, H and D components in TCH, THJ, CHX and YOS stations were analyzed...In order to find geomagnetic anomalies associated with Ms ≥ 6.0 strong earthquakes in Yunnan area, geomagnetic harmonic wave amplitude ratios with Z, H and D components in TCH, THJ, CHX and YOS stations were analyzed. It was found that geomagnetic amplitude ratio of Yzhx experienced a trend of decrease and increase before most of strong earthquakes. Moreover, these variations in different periods were inconsistent and no similar changes appeared for Yzhy, which may relate to fault-zone conductivity variation and seismogenic structure.展开更多
INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) as d...INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes. The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.展开更多
基金National Natural Science Foundation of China (52305358)the Fundamental Research Funds for the Central Universities (2023ZYGXZR061)+3 种基金Guangdong Basic and Applied Basic Research Foundation (2022A1515010304)Science and Technology Program of Guangzhou (202201010362)Young Elite Scientists Sponsorship Program by CAST . (2023QNRC001)Young Talent Support Project of Guangzhou (QT-2023-001)
文摘Zinc(Zn)is considered a promising biodegradable metal for implant applications due to its appropriate degradability and favorable osteogenesis properties.In this work,laser powder bed fusion(LPBF)additive manufacturing was employed to fabricate pure Zn with a heterogeneous microstructure and exceptional strength-ductility synergy.An optimized processing window of LPBF was established for printing Zn samples with relative densities greater than 99%using a laser power range of 80∼90 W and a scanning speed of 900 mm s−1.The Zn sample printed with a power of 80 W at a speed of 900 mm s−1 exhibited a hierarchical heterogeneous microstructure consisting of millimeter-scale molten pool boundaries,micrometer-scale bimodal grains,and nanometer-scale pre-existing dislocations,due to rapid cooling rates and significant thermal gradients formed in the molten pools.The printed sample exhibited the highest ductility of∼12.1%among all reported LPBF-printed pure Zn to date with appreciable ultimate tensile strength(∼128.7 MPa).Such superior strength-ductility synergy can be attributed to the presence of multiple deformation mechanisms that are primarily governed by heterogeneous deformation-induced hardening resulting from the alternative arrangement of bimodal Zn grains with pre-existing dislocations.Additionally,continuous strain hardening was facilitated through the interactions between deformation twins,grains and dislocations as strain accumulated,further contributing to the superior strength-ductility synergy.These findings provide valuable insights into the deformation behavior and mechanisms underlying exceptional mechanical properties of LPBF-printed Zn and its alloys for implant applications.
文摘In recent years, with the large increase in the number of motor vehicles in colleges and universities and the lag in campus planning, the relative shortage of parking spaces on campus has become increasingly serious. Taking Baoding College as an example, this article analyzes the current situation of static traffic on campus and finds out the problem of parking on campus through questionnaire surveys and field surveys. Analyze the growth trend of the number of motor vehicles based on the data, use the GM (1, 1) model and the linear fitting model to predict the number of motor vehicles in the future, and determine the size and layout of the parking lot based on the campus size, functional zoning, and road layout. The big campus-based parking system planning method based on big data can effectively solve the problems of small sample data, low accuracy, and poor timeliness of traditional methods, which improves the practicability and scientificity of planning results.
基金the financial support of the National Natural Science Foundation of China (21273185 and 21621091)the National Found for Fostering Talents of Basic Science (J1310024)
文摘With wide application of electric vehicles and large-scale in energy storage systems, the requirement ofsecondary batteries with higher power density and better safety gets urgent. Owing to the merits of hightheoretical capacity, relatively low cost and suitable discharge voltage, much attention has been paid tothe transition metal sulfides. Recently, a large amount of research papers have reported about the appli-cation of transition metal sulfides in lithium ion batteries. However, the practical application of transitionmetal sulfides is still impeded by their fast capacity fading and poor rate performance. More well-focusedresearches should be operated towards the commercialization of transition metal sulfides in lithium ionbatteries. In this review, recent development of using transition metal sulfides such as copper sulfides,molybdenum sulfides, cobalt sulfides, and iron sulfides as electrode materials for lithium ion batteriesis presented. In addition, the electrochemical reaction mechanisms and synthetic strategy of transitionmetal sulfides are briefly summarized. The critical issues, challenges, and perspectives providing a fur-ther understanding of the associated electrochemical processes are also discussed.
基金sponsored by the National Natural Science Foundation of China (Nos. 51402190, 61574091)Shanghai Sailing Program (18YF1427800)the special funds for theoretical physics of the National Natural Science Foundation of China (No. 11747029)
文摘Photoanodes based on In_2S_3/ZnO heterojunction nanosheet arrays(NSAs) have been fabricated by atomic layer deposition of ZnO over In_2S_3 NSAs, which were in situ grown on fluorine-doped tin oxide glasses via a facile solvothermal process. The as-prepared photoanodes show dramatically enhanced performance for photoelectrochemical(PEC) water splitting, compared to single semiconductor counterparts. The optical and PEC properties of In_2S_3/ZnO NSAs have been optimized by modulating the thickness of the Zn O overlayer. After pairing with ZnO, the NSAs exhibit a broadened absorption range and an increased light absorptance over a wide wavelength region of 250–850 nm. The optimized sample of In_2S_3/ZnO-50 NSAs shows a photocurrent density of 1.642 m A cm^(-2)(1.5 V vs. RHE) and an incident photonto-current efficiency of 27.64% at 380 nm(1.23 V vs.RHE), which are 70 and 116 times higher than those of the pristine In_2S_3 NSAs, respectively. A detailed energy band edge analysis reveals the type-II band alignment of the In_2S_3/ZnO heterojunction, which enables efficient separation and collection of photogenerated carriers,especially with the assistance of positive bias potential, and then results in the significantly increased PEC activity.
基金supported by the Study Science Foundation of the Department of Education, Yunnan Province, China, No. 2011Y184the National Natural Science Foundation of China, No. 10S090202+1 种基金Doctoral Innovation Foundation of Kunming Medical University, No. 2011D01the Natural Science Foundation of Kunming University, No. XJ11L016
文摘A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU+/NG2+cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury.
基金The present study was supported by the National Natural Science Foundation(81373769 and 81403328)by the Collaborative Projects of Beijing Department of Education(1000062520115).
文摘Objective:To examine the effects of accumulated heat in GI tract (AHGIT) on lung tissue protein expression in pneumonic mice.Methods:Nebulized lipopolysaccharides (LPS) were administered to induce a pneumonic mouse model (M1),and a high-calorie/protein diet combined with nebulized LPS was used to induce AHGIT pneumonia (M2).Isobaric tag for relative and absolute quantitation (iTRAQ)proteomics was applied to study lung protein expression,followed by bioinformatics analysis.Results:M1 mice developed alveolar damage with prominent septum thickening,vascular dilation,hyperaemia and infiltration of large amounts of inflammatory cells.M2 mice developed more severe pathological responses.A total of 2626 proteins were reliably identified in the lung tissue.Compared with normal mice,the M1 mice had 344 differentially expressed proteins in their lungs,which are involved in the following biological processes:response to organic substance,response to cytokine,response to external stimulus,defense response and immune system process.They are also involved in the following Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways:ECM-receptor interaction,leukocyte transendothelial migration,Fc gamma R-mediated phagocytosis,complement and coagulation cascades,and antigen processing and presentation.Compared with the M1 group,the M2 mice had 164 differentially expressed proteins in their lungs,including 14 upregulated and 150 downregulated proteins.These proteins are involved in the following biological processes:small molecule metabolism,ribose phosphate metabolic process,cell adhesion and biological adhesion.The relevant KEGG pathways included oxidative phosphorylation,Citrate cycle (TCA cycle),complement and coagulation cascades,and vascular smooth muscle contraction.Conclusions:AHGIT aggravated the lung inflammatory damage in the mice with LPS-induced pneumonia.It may affect the mouse substance/energy metabolism,and therefore the immune function,to aggravate the LPS-induced inflammatory damage.
基金Project supported by the National Natural Science Foundation of China(Grant No.11804169)the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20180741)
文摘Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the average binding energy is 1.54 eV,which is much larger than the cohesive energy of 1.13 eV for bulk Na.A maximum of four H2 molecules can be adsorbed around each Na with average adsorption energies of 0.25–0.32 eV/H2.Also,H2 storage gravimetric of 8.85 wt%is obtained,and this meets the U.S.Department of Energy(DOE)ultimate target.These results are instrumental in seeking a promising hydrogen energy carrier.
文摘With the expansion of the scale of our hospital robot laboratory, equipment use, reserves are increasing, manual management equipment information has been unable to adapt to daily management, such as data record error rate increased, the number of experiments increased, equipment loss and maintenance is not clearly defined. In order to ensure the safety and accuracy of the equipment, a system of equipment management systems was developed as a result of the conversion to the use of management systems for the recording and storage of information. The design of this system is a perfect robot laboratory equipment management system based on the development of web framework technology for equipment management functions. The back end of this system uses the Java language, the SSM framework as the main body, the database is built by MySQL relational database, the front-end page uses JSP, Bootstrap, jQuery and other technologies, and uses Eclipse project construction tools for system development. After a period of trial operation, the level of laboratory equipment management has been significantly improved.
文摘Linear algebra has a very important application in physics and technical disciplines. This article conducted a questionnaire survey on the factors that affect the effect of linear algebra learning;the questionnaire contains several aspects of learning attitude, learning interest, learning methods, teaching methods, etc.;based on recycling data, cross chi-square test and multiple logistic regression analysis </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">are </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">us</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ed</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> to obtain the factors that affect the effect of linear algebra learning. The research results show that: learning methods, learning attitudes, teaching methods and elementary algebra basics are the main factors that affect the learning effect of linear algebra;among them, there are positive correlations between teaching methods, learning methods, learning attitudes and learning effects;teaching methods, learning methods 3. The three principal components of learning attitude are positively correlated. Based on the research and analysis, the following conclusions are drawn: finding a suitable learning method for the college students and maintaining a positive learning attitude are effective means to improve the linear algebra learning effect of the college students;in teaching, it is recommended to advance with the times, the teaching content and teaching methods innovate to stimulate students’ interest in learning</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> thus improv</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ing</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> the learning effect of college students’ linear algebra courses.
文摘In order to find geomagnetic anomalies associated with Ms ≥ 6.0 strong earthquakes in Yunnan area, geomagnetic harmonic wave amplitude ratios with Z, H and D components in TCH, THJ, CHX and YOS stations were analyzed. It was found that geomagnetic amplitude ratio of Yzhx experienced a trend of decrease and increase before most of strong earthquakes. Moreover, these variations in different periods were inconsistent and no similar changes appeared for Yzhy, which may relate to fault-zone conductivity variation and seismogenic structure.
文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as "hyperglycemia first recognized during pregnancy" and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes. The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.