Li intercalation in an MoSe_(2) electrocatalyst:In situ observation and modulation of its precisely controllable phase engineering for a high-performance flexible Li-S battery

Sophisticated efficient electrocatalysts are essential to rectifying the shuttle effect and realizing the high performance of flexible lithium-sulfur batteries(LSBs).Phase transformation of MoSe_(2) from the 2H phase to the 1T phase has been proven to be a significant method to improve the catalytic activity.However,precisely controllable phase engineering of MoSe_(2) has rarely been reported.Herein,by in situ Li ions intercalation in MoSe_(2),a precisely controllable phase evolution from 2H-MoSe_(2) to 1T-MoSe_(2) was realized.More importantly,the definite functional relationship between cut-off voltage and phase structure was first identified for phase engineering through in situ observation and modulation methods.The sulfur host(CNFs/1T-MoSe_(2))presents high charge density,strong polysulfides adsorption,and catalytic kinetics.Moreover,Li-S cells based on it display capacity retention of 875.3mAh g^(-1) after 500 cycles at 1 C and an areal capacity of 8.71mAh cm^(-2) even at a high sulfur loading of 8.47mg cm^(-2).Furthermore,the flexible pouch cell exhibiting decent performance will endow a promising potential in the wearable energy storage field.This study proposes an effective strategy to precisely control the phase structure of MoSe_(2),which may provide the reference to fabricate the highly efficient electrocatalysts for LSBs and other energy systems.

Influence of synergistic effect of LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)@Cr_(2)O_(5)composite on the electrochemical properties

LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)@Cr_(2)O_(5)composite electrode combines the high rate-capability characteristics of NCA with the stability of Cr_(2)O_(5),playing a synergistic role in improving the cyclic stability,initial discharge capacity and the security of low cut-off voltage(2.0 V).When the mass ratio of Cr_(2)O_(5)in NCA is 45%(mass),the capacity retention rate increases from 58.5% without Cr_(2)O_(5)to 69.3% in the range of 2.0-4.3 V.The initial discharge capacity of NCA@Cr_(2)O_(5)composite material is 211.4 mA·h·g^(-1),its first coulombic efficiency is 94.2%,and the charging capacity remains approximately constant when mixed with 15%(mass)Cr_(2)O_(5).The reason for the improvement of the initial charge-discharge efficiency(ICDE)was explained.Impedance and cyclic voltammetry analysis reveal more detailed reasons of the observed improvements.Compared with NCA cathode material,the NCA@Cr_(2)O_(5)composite material can provide not only additional stable sites and channels for Li^(+)insertion/extraction to make up for the loss of active Li^(+)sites and prevent the accumulation of Li+in the circulation process,but also protect the NCA electrode from the corrosion of the electrolyte decomposition by the Cr_(2)O_(5)nanoparticles adhering to NCA interface.

Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer:neoSCORE trial

Dear Editor,Lung cancer is the predominant cause of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)accounting for 85%of all cases.1 The five-year overall survival(OS)after surgery remains poor because of the high rate of postoperative recurrence and metastasis.Recently,immune checkpoint inhibitors(ICIs)have shown promising efficacy in resectable NSCLC.

Spatial TIME landscape and its prognostic value in the lung and brain tumor:location matters

In two recently published papers in Nature,^(1,2)Logan Walsh and colleagues utilized imaging mass cytometry(IMC)to create comprehensive single-cell spatial landscapes of the tumor immune microenvironment(TIME)in lung tumors from 416 lung adenocarcinoma(LUAD)patients,as well as brain tumors from 139 high-grade glioma and 46 brain metastasis(BrM)patients.By conducting a thorough analysis to characterize cellular spatial interactions and neighborhood patterns,and correlating these spatial features with clinical outcomes(Fig.1),the researchers gained novel insights into the complexities of tumoral architecture.Ultimately,they identified two sets of clinically relevant predictive immune markers that could be used to assist in guiding clinical decisions.

Unexpected Breg-NK crosstalk in STING agonist therapy

In a recent paper published in Nature,Li et al.identified that resistance to stimulator of interferon genes(STING)monotherapy in solid tumors is attributable to the unexpected surge of IL-35-producing regulatory B(Breg)cells that impair NK-cell cytotoxicity[1].They depict STING-induced Breg-NK-cell crosstalk and propose that combining the STING agonist 2'3'cyclic GMP-AMP(cGAMP)with anti-IL-35 blockade is a promising strategy to overcome tumor immunosuppression,especially in pancreatic cancers[1].