Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model ...Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.展开更多
Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the ave...Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the average binding energy is 1.54 eV,which is much larger than the cohesive energy of 1.13 eV for bulk Na.A maximum of four H2 molecules can be adsorbed around each Na with average adsorption energies of 0.25–0.32 eV/H2.Also,H2 storage gravimetric of 8.85 wt%is obtained,and this meets the U.S.Department of Energy(DOE)ultimate target.These results are instrumental in seeking a promising hydrogen energy carrier.展开更多
基金supported by China Rehabilitation Research Center,No.2021zx-03the Special Fund for Joint Training of Doctoral Students between the University of Health and Rehabilitation Sciences and China Rehabilitation Research Center,No.2020 kfdx-008(both to TZ)。
文摘Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.
基金Project supported by the National Natural Science Foundation of China(Grant No.11804169)the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20180741)
文摘Using first-principles calculations based on density functional theory(DFT),we investigate the potential hydrogen storage capacity of the Na-decorated net-Y single layer nanosheet.For double-side Na decoration,the average binding energy is 1.54 eV,which is much larger than the cohesive energy of 1.13 eV for bulk Na.A maximum of four H2 molecules can be adsorbed around each Na with average adsorption energies of 0.25–0.32 eV/H2.Also,H2 storage gravimetric of 8.85 wt%is obtained,and this meets the U.S.Department of Energy(DOE)ultimate target.These results are instrumental in seeking a promising hydrogen energy carrier.
