The failure propagation of weakly stable sediment:A reason for the formation of high-velocity turbidity currents in submarine canyons

The long-distance movement of turbidity currents in submarine canyons can transport large amounts of sediment to deep-sea plains.Previous studies show obvious differences in the turbidity current velocities derived from the multiple cables damage events ranging from 5.9 to 28.0 m/s and those of field observations between 0.15 and 7.2 m/s.Therefore,questions remain regarding whether a turbid fluid in an undersea environment can flow through a submarine canyon for a long distance at a high speed.A new model based on weakly stable sediment is proposed(proposed failure propagation model for weakly stable sediments,WS S-PFP model for short)to explain the high-speed and long-range motion of turbidity currents in submarine canyons through the combination of laboratory tests and numerical analogs.The model is based on two mechanisms:1)the original turbidity current triggers the destabilization of the weakly stable sediment bed and promotes the destabilization and transport of the soft sediment in the downstream direction and 2)the excitation wave that forms when the original turbidity current moves into the canyon leads to the destabilization and transport of the weakly stable sediment in the downstream direction.The proposed model will provide dynamic process interpretation for the study of deep-sea deposition,pollutant transport,and optical cable damage.

Effect of particle composition and consolidation degree on the wave-induced liquefaction of soil beds

The wave-induced liquefaction of seabed is responsible for causing damage to marine structures.Particle composition and consolidation degree are the key factors affecting the pore water pressure response and liquefaction behavior of the seabed under wave action.The present study conducted wave flume experiments on silt and silty fine sand beds with varying particle compositions.Furthermore,a comprehensive analysis of the differences and underlying reasons for liquefaction behavior in two different types of soil was conducted from both macroscopic and microscopic perspectives.The experimental results indicate that the silt bed necessitates a lower wave load intensity to attain the liquefaction state in comparison to the silty fine sand bed.Additionally,the duration and development depth of liquefaction are greater in the silt bed.The dissimilarity in liquefaction behavior between the two types of soil can be attributed to the variation in their permeability and plastic deformation capacity.The permeability coefficient and compression modulus of silt are lower than those of silty fine sand.Consequently,silt is more prone to the accumulation of pore pressure and subsequent liquefaction under external loading.Prior research has demonstrated that silt beds with varying consolidation degrees exhibit distinct initial failure modes.Specifically,a dense bed undergoes shear failure,whereas a loose bed experiences initial liquefaction failure.This study utilized discrete element simulation to examine the microscopic mechanisms that underlie this phenomenon.

Efficacy and safety of low-dose cyclophosphamide combined with lenvatinib, pembrolizumab and TACE for unresectable hepatocellular carcinoma:A single-center, prospective,single-arm clinical trial

Objective: Unresectable hepatocellular carcinoma(uHCC) continues to pose effective treatment options. The objective of this study was to assess the efficacy and safety of combining low-dose cyclophosphamide with lenvatinib, pembrolizumab and transarterial chemoembolization(TACE) for the treatment of uHCC.Methods: From February 2022 to November 2023, a total of 40 patients diagnosed with uHCC were enrolled in this small-dose, single-center, single-arm, prospective study. They received a combined treatment of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE. Study endpoints included progression-free survival(PFS), objective response rate(ORR), and safety assessment. Tumor response was assessed using the modified Response Evaluation Criteria in Solid Tumors(mRECIST), while survival analysis was conducted through KaplanMeier curve analysis for overall survival(OS) and PFS. Adverse events(AEs) were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 5.0).Results: A total of 34 patients were included in the study. The median follow-up duration was 11.2 [95% confidence interval(95% CI), 5.3-14.6] months, and the median PFS(mPFS) was 15.5(95% CI, 5.4-NA) months.Median OS(mOS) was not attained during the study period. The ORR was 55.9%, and the disease control rate(DCR) was 70.6%. AEs were reported in 27(79.4%) patients. The most frequently reported AEs(with an incidence rate >10%) included abnormal liver function(52.9%), abdominal pain(44.1%), abdominal distension and constipation(29.4%), hypertension(20.6%), leukopenia(17.6%), constipation(17.6%), ascites(14.7%), and insomnia(14.7%). Abnormal liver function(14.7%) had the most common grade 3 or higher AEs.Conclusions: A combination of low-dose cyclophosphamide with lenvatinib, pembrolizumab, and TACE is safe and effective for u HCC, showcasing a promising therapeutic strategy for managing uHCC.

热处理在冷喷涂增材制造中的应用

作为一种固态沉积技术,冷喷涂增材制造(CS-AM)存在的主要问题是喷涂制备材料的塑性较差,而后续热处理可以有效改善这一问题,相关研究涉及冷喷涂Cu、Zn、Al、铝合金、Ti、Ti6Al4V、低碳不锈钢等金属涂层(材料)。本文概述了热处理对冷喷涂增材制造上述金属涂层(材料)电阻率、耐腐蚀性能以及力学性能的影响,为热处理在冷喷涂增材制造中的应用提供参考。

Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity:A comprehensive review

Primary liver cancer is a significant health problem worldwide.Hepatocellular carcinoma(HCC)is the main pathological type of primary liver cancer,accounting for 75%-85%of cases.In recent years,radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC.However,radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors.How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration.This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy,including epigenetics,transportation and metabolism,regulated cell death pathways,the microenvironment,and redox status,as well as the effect of nanoparticles on the radiosensitivity of liver cancer.It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy.

HIGH ORDER FINITE DIFFERENCE HERMITE WENO FAST SWEEPING METHODS FOR STATIC HAMILTON-JACOBI EQUATIONS

In this paper,we propose a novel Hermite weighted essentially non-oscillatory(HWENO)fast sweeping method to solve the static Hamilton-Jacobi equations efficiently.During the HWENO reconstruction procedure,the proposed method is built upon a new finite difference fifth order HWENO scheme involving one big stencil and two small stencils.However,one major novelty and difference from the traditional HWENO framework lies in the fact that,we do not need to introduce and solve any additional equations to update the derivatives of the unknown functionϕ.Instead,we use the currentϕand the old spatial derivative ofϕto update them.The traditional HWENO fast sweeping method is also introduced in this paper for comparison,where additional equations governing the spatial derivatives ofϕare introduced.The novel HWENO fast sweeping methods are shown to yield great savings in computational time,which improves the computational efficiency of the traditional HWENO scheme.In addition,a hybrid strategy is also introduced to further reduce computational costs.Extensive numerical experiments are provided to validate the accuracy and efficiency of the proposed approaches.

High Order Finite Difference Hermite WENO Fixed-Point Fast Sweeping Method for Static Hamilton-Jacobi Equations

In this paper, we combine the nonlinear HWENO reconstruction in [43] andthe fixed-point iteration with Gauss-Seidel fast sweeping strategy, to solve the staticHamilton-Jacobi equations in a novel HWENO framework recently developed in [22].The proposed HWENO frameworks enjoys several advantages. First, compared withthe traditional HWENO framework, the proposed methods do not need to introduceadditional auxiliary equations to update the derivatives of the unknown function φ.They are now computed from the current value of φ and the previous spatial derivatives of φ. This approach saves the computational storage and CPU time, which greatlyimproves the computational efficiency of the traditional HWENO scheme. In addition,compared with the traditional WENO method, reconstruction stencil of the HWENOmethods becomes more compact, their boundary treatment is simpler, and the numerical errors are smaller on the same mesh. Second, the fixed-point fast sweeping methodis used to update the numerical approximation. It is an explicit method and doesnot involve the inverse operation of nonlinear Hamiltonian, therefore any HamiltonJacobi equations with complex Hamiltonian can be solved easily. It also resolves someknown issues, including that the iterative number is very sensitive to the parameterε used in the nonlinear weights, as observed in previous studies. Finally, to furtherreduce the computational cost, a hybrid strategy is also presented. Extensive numerical experiments are performed on two-dimensional problems, which demonstrate thegood performance of the proposed fixed-point fast sweeping HWENO methods.

Microstructure and Mechanical Properties of Ti–Ta Composites Prepared Through Cold Spray Additive Manufacturing

In this study, an innovative approach was used to fabricate Ti–Ta composite biomaterials through cold spray additive manufacturing followed by a diff usion treatment. The microstructure and mechanical properties of the composites were investigated in detail using field emission scanning electron microscopy, electron backscatter diff raction, 3D X-ray computed tomography, tensile test, nanohardness test and resonance vibration test. The obtained results indicated that the prepared composites have inhomogeneity in their microstructure and composition. A unique microstructure, composed of Ti-rich, Ta-rich and diff usion regions, was evolved in the composites due to incomplete diff usion between Ti and Ta splats. Further, Kirkendall pores were formed in the composites due to uneven diff usion of the two phases(of Ti and Ta) during high-temperature heat treatment. The prepared composites simultaneously showed low elastic modulus and high tensile strength which is required for a good biomaterial. Low elastic modulus was associated with the residual pores and the alloying eff ect of Ta in Ti, while high tensile strength was related to the solid solution strengthening eff ects. The obtained results indicated that the prepared Ti–Ta composites have a great potential to become a new candidate for biomedical applications.