Research on Leading Edge Erosion and Aerodynamic Characteristics of Wind Turbine Blade Airfoil

The effects of the erosion present on the leading edge of a wind turbine airfoil(DU 96-W-180)on its aerodynamic performances have been investigated numerically in the framework of a SST k–ωturbulence model based on the Reynolds Averaged Navier-Stokes equations(RANS).The results indicate that when sand-induced holes and small pits are involved as leading edge wear features,they have a minimal influence on the lift and drag coefficients of the airfoil.However,if delamination occurs in the same airfoil region,it significantly impacts the lift and resistance characteristics of the airfoil.Specifically,as the angle of attack grows,there is a significant decrease in the lift coefficient accompanied by a sharp increase in the drag coefficient.As wear intensifies,these effects gradually increase.Moreover,the leading edge wear can exacerbate flow separation near the trailing edge suction surface of the airfoil and cause forward displacement of the separation point.

Influence of Surface Ice Roughness on the Aerodynamic Performance of Wind Turbines

The focus of this research was on the equivalent particle roughness height correction required to account for the presence of ice when determining the performances of wind turbines.In particular,two icing processes(frost ice and clear ice)were examined by combining the FENSAP-ICE and FLUENT analysis tools.The ice type on the blade surfaces was predicted by using a multi-time step method.Accordingly,the influence of variations in icing shape and ice surface roughness on the aerodynamic performance of blades during frost ice formation or clear ice formation was investigated.The results indicate that differences in blade surface roughness and heat flux lead to disparities in both ice formation rate and shape between frost ice and clear ice.Clear ice has a greater impact on aerodynamics compared to frost ice,while frost ice is significantly influenced by the roughness of its icy surface.

强化制造业产业链现代化的财税政策

“十四五”规划明确提出,推进产业基础高级化、产业链现代化。近年来,关于产业链现代化的研究逐渐增多,但专家很少从财税政策视角进行分析。本文从产业生态系统和外部要求两方面厘清产业链现代化的内涵,认为产业链现代化既需要提升研发、生产制造、销售服务各生产环节,也应满足安全可控、绿色环保、规模保证、新型基建等外部要求。此外,结合我国产业链现代化现状,梳理出产业链附加值较低、关键技术受制约等亟需弥补的短板,进一步整理财税政策助力产业链现代化的思路,从创新政策工具、产业自主可控、智能化转型、绿色制造、成本控制等维度,提出助力产业链现代化的财税政策建议。

Intranasal delivery of rapid-onset antidepressants:a new trend of treating major depressive disorder

Existing antidepressants seem to have an onset time of several weeks.However,newly found depression-related receptors and pathways may enlighten us to find more rapid-onset antidepressants,in which ketamine is one of the most potential antidepressants.By intranasal administration,drugs can be directly delivered to the brain via olfactory nerve route,which is proved to be suitable for some antidepressants.Well-designed rapid-onset antidepressants are the urgent requirements of the patients with depression.Intranasal administration,as a potential strategy to deliver antidepressants to brain,can improve drug efficacy and largely shorten the onset time.In this article,we sorted out some new formulation approaches in treating depression with different mechanisms and pathways compared with traditional treating strategies,along with new findings in clinical studies,proving that the combination of rapid-onset antidepressants with intranasal delivery will lead a new trend in treating depression.

Activatable and Self-Monitoring Hydrogen Sulfide-Based Molecular Senomorphics for Visualized Regulation of Cellular Senescence

Specific regulation of the senescence-associated secretory phenotype(SASP)is vital to block senescence-induced detrimental cellular plasticity.Recently,some chemical compounds called senomorphics have demonstrated such potential,but it remains challenging to achieve site-specific activation and real-time monitoring of the action of senomorphics,posing great obstacles for transformable applications.Here,we report a tailor-made hydrogen sulfide(H_(2)S)donor(Lyso-FH_(2)S-Gal)as a new class of molecule senomorphics for spatially controlled delivery of H_(2)S for visualization of regulation of cellular senescence.It comprises four functional moieties in a single molecular structure,including a lysosome-targeting group for cell recognition,a lysosomal enzyme-cleaved scaffold for site-specific activation,thiocarbamate as the H_(2)S precursor,and a switchable fluorophore for concurrent selfreporting of H_(2)S release and senescence imaging.Lyso-FH_(2)S-Gal exhibited remarkable response selectivity,sustained H_(2)S release,and 141-fold fluorescence enhancement.In cellular models,Lyso-FH_(2) S-Gal preferentially enriched in senescent cells over nonsenescent cells,and alleviated the levels of SASP and reactive oxygen species(ROS)in senescent cells,while remaining inert in nonsenescent cells.More impressively,it efficiently inhibited the SASPmediated crosstalk between senescent cells and surrounding nonsenescent cells,thereby preventing senescence propagation.This work offers a useful molecular tool with the hope for controlled intervention of senescence-related important biological processes.