Strigolactones,a class of plant hormones with multiple functions,mediate plant-plant and plantmicroorganism communications in the rhizosphere.In this study,we developed potent strigolactone antagonists,which covalentl...Strigolactones,a class of plant hormones with multiple functions,mediate plant-plant and plantmicroorganism communications in the rhizosphere.In this study,we developed potent strigolactone antagonists,which covalently bindto the strigolactone receptor D14,by preparing an array of triazole urea compounds.Using yeast two-hybrid and rice-tillering assays,we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors.Liquid chromatography-tandem mass spectrometry analysis and X-ray crystallography revealed that KK094 was hydrolyzed by D14,and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14.Furthermore,we identified two triazole urea compounds KK052 and KK073,whose effects on D14-D53/D14-SLR1 complex formation were opposite due to the absence (KK052)or presence (KK073)of a trifluoromethyl group on their phenyl ring.These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying strigolactone perception.展开更多
The mitigation of dephasing poses a significant challenge toimproving the performance of error-prone superconducting quantum computing systems.Here,the dephasing of a transmon qubit ina dispersive readout regime was i...The mitigation of dephasing poses a significant challenge toimproving the performance of error-prone superconducting quantum computing systems.Here,the dephasing of a transmon qubit ina dispersive readout regime was investigated by adopting aJosephson traveling-wave parametric amplifier as the preamplifier.Our findings reveal that the potent pump leakage from the preamplifier may lead to severe dephasing.This could be attributed to amixture of measurement-induced dephasing,ac Stark effect,andheating.It is showed that pulse-mode readout is a promising measurement scheme to mitigate qubit dephasing while minimizing theneed for bulky circulators.Our work provides key insights intomitigating decoherence from microwave-pumped preamplifiers,which will be critical for advancing large-scale quantum computers.展开更多
文摘Strigolactones,a class of plant hormones with multiple functions,mediate plant-plant and plantmicroorganism communications in the rhizosphere.In this study,we developed potent strigolactone antagonists,which covalently bindto the strigolactone receptor D14,by preparing an array of triazole urea compounds.Using yeast two-hybrid and rice-tillering assays,we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors.Liquid chromatography-tandem mass spectrometry analysis and X-ray crystallography revealed that KK094 was hydrolyzed by D14,and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14.Furthermore,we identified two triazole urea compounds KK052 and KK073,whose effects on D14-D53/D14-SLR1 complex formation were opposite due to the absence (KK052)or presence (KK073)of a trifluoromethyl group on their phenyl ring.These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying strigolactone perception.
基金supported by the National Natural Science Foundation of China(NSFC-11890704)the Natural Science Foundation of Beijing(NSFB-Z190012)the Key-Area Research and Development Program of Guangdong Province(Grant No.2018B030326001).
文摘The mitigation of dephasing poses a significant challenge toimproving the performance of error-prone superconducting quantum computing systems.Here,the dephasing of a transmon qubit ina dispersive readout regime was investigated by adopting aJosephson traveling-wave parametric amplifier as the preamplifier.Our findings reveal that the potent pump leakage from the preamplifier may lead to severe dephasing.This could be attributed to amixture of measurement-induced dephasing,ac Stark effect,andheating.It is showed that pulse-mode readout is a promising measurement scheme to mitigate qubit dephasing while minimizing theneed for bulky circulators.Our work provides key insights intomitigating decoherence from microwave-pumped preamplifiers,which will be critical for advancing large-scale quantum computers.
