We investigate the photoluminescence(PL)emission from InGaN/GaN multiple quantum-well structures before and after 1 MeV electron irradiation.The PL peak intensity exhibits a slight enhancement after low-dose electron ...We investigate the photoluminescence(PL)emission from InGaN/GaN multiple quantum-well structures before and after 1 MeV electron irradiation.The PL peak intensity exhibits a slight enhancement after low-dose electron irradiation(2×10^(13) e/cm^(2)),and then decreases with the cumulative electron dose.Meanwhile,the full width at half maximum of the PL spectrum narrows after low-dose electron irradiation and widens when the irradiation dose is relatively high.With respect to the yellow photoluminescence,there is no significant change until the electron fluence has accumulated up to 10^(14) e/cm^(2).展开更多
近年来,肿瘤免疫治疗逐渐成为恶性肿瘤的前沿疗法。细胞因子IL-33是一种重要的内源性“危险信号”,在肿瘤免疫治疗中显示出潜在的应用价值。IL-33通过与其天然受体肿瘤抑制素2(suppression of tumorigenicity 2,ST2)结合,参与多种生物...近年来,肿瘤免疫治疗逐渐成为恶性肿瘤的前沿疗法。细胞因子IL-33是一种重要的内源性“危险信号”,在肿瘤免疫治疗中显示出潜在的应用价值。IL-33通过与其天然受体肿瘤抑制素2(suppression of tumorigenicity 2,ST2)结合,参与多种生物学效应。但IL-33/ST2信号通路在肿瘤免疫应答中的作用及其机制一直存在争议,目前普遍认为其具有促进肿瘤生长或抑制肿瘤生长的双重作用。随着对IL-33认识的深入,IL-33的临床应用价值更加广泛。该文回顾了IL-33/ST2信号通路对肿瘤发生、发展和调控免疫应答的作用及其机制,及以IL-33/ST2信号轴为靶点的潜在临床应用。展开更多
基金Supported by the National Natural Science Foundation of China under Grant No 11275262.
文摘We investigate the photoluminescence(PL)emission from InGaN/GaN multiple quantum-well structures before and after 1 MeV electron irradiation.The PL peak intensity exhibits a slight enhancement after low-dose electron irradiation(2×10^(13) e/cm^(2)),and then decreases with the cumulative electron dose.Meanwhile,the full width at half maximum of the PL spectrum narrows after low-dose electron irradiation and widens when the irradiation dose is relatively high.With respect to the yellow photoluminescence,there is no significant change until the electron fluence has accumulated up to 10^(14) e/cm^(2).
文摘近年来,肿瘤免疫治疗逐渐成为恶性肿瘤的前沿疗法。细胞因子IL-33是一种重要的内源性“危险信号”,在肿瘤免疫治疗中显示出潜在的应用价值。IL-33通过与其天然受体肿瘤抑制素2(suppression of tumorigenicity 2,ST2)结合,参与多种生物学效应。但IL-33/ST2信号通路在肿瘤免疫应答中的作用及其机制一直存在争议,目前普遍认为其具有促进肿瘤生长或抑制肿瘤生长的双重作用。随着对IL-33认识的深入,IL-33的临床应用价值更加广泛。该文回顾了IL-33/ST2信号通路对肿瘤发生、发展和调控免疫应答的作用及其机制,及以IL-33/ST2信号轴为靶点的潜在临床应用。