Objective We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.Methods Adults≥65 years old(n=1,973)were interviewed at baseline in 2018 and 1,459 we...Objective We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.Methods Adults≥65 years old(n=1,973)were interviewed at baseline in 2018 and 1,459 were followed up in 2021.General and abdominal obesity were assessed,and serum C-reactive protein(CRP)levels were measured at baseline.Depression status was assessed at baseline and at follow-up.Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms,as well as the relationship between obesity and CRP levels.The associations of CRP levels with the geriatric depression scale,as well as with its three dimensions,were investigated using multiple linear regressions.Results General obesity was associated with worsening depression symptoms and incident depression,with an odds ratio(OR)[95%confidence interval(CI)]of 1.53(1.13-2.12)and 1.80(1.23-2.63),especially among old male subjects,with OR(95%CI)of 2.12(1.25-3.58)and 2.24(1.22-4.11),respectively;however,no significant relationship was observed between abdominal obesity and depression.In addition,general obesity was associated with high levels of CRP,with OR(95%CI)of 2.58(1.75-3.81),especially in subjects free of depression at baseline,with OR(95%CI)of 3.15(1.97-5.04),and CRP levels were positively correlated with a score of specific dimension(life satisfaction)of depression,P<0.05.Conclusion General obesity,rather than abdominal obesity,was associated with worsening depressive symptoms and incident depression,which can be partly explained by the systemic inflammatory response,and the impact of obesity on depression should be taken more seriously in the older male population.展开更多
为研究一种性能更优越的新型聚酰胺材料,以衣康酰氯及对苯二胺为原料,采用低温溶液缩聚法制备出聚衣康酰对苯二胺(PPIA)。通过红外光谱和核磁共振确定了目标产物的分子结构;探究了PPIA的合成工艺,即原料的摩尔比、滴加时间、反应时间、...为研究一种性能更优越的新型聚酰胺材料,以衣康酰氯及对苯二胺为原料,采用低温溶液缩聚法制备出聚衣康酰对苯二胺(PPIA)。通过红外光谱和核磁共振确定了目标产物的分子结构;探究了PPIA的合成工艺,即原料的摩尔比、滴加时间、反应时间、反应温度对PPIA比浓对数黏度的影响。运用X射线衍射、热重分析和差示扫描量热分析研究了其结晶情况与热性能。结果表明,衣康酰氯与对苯二胺的摩尔比为1.05∶1,滴加时间为60 min,反应时间60 min,反应温度-5℃时,得到的产物比浓对数黏度(η)最大,即相对分子质量最大,η能达到1.6 d L/g。通过XRD表明低温下制备的PPIA具有更好的晶型结构;通过DSC和TGA可知PPIA具有良好的热稳定性能;通过拉伸强度和弯曲强度的测定可知PPIA具有较好的力学性能。展开更多
Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity h...Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research.展开更多
The heterogeneous nodes in the Internet of Things(IoT)are relatively weak in the computing power and storage capacity.Therefore,traditional algorithms of network security are not suitable for the IoT.Once these nodes ...The heterogeneous nodes in the Internet of Things(IoT)are relatively weak in the computing power and storage capacity.Therefore,traditional algorithms of network security are not suitable for the IoT.Once these nodes alternate between normal behavior and anomaly behavior,it is difficult to identify and isolate them by the network system in a short time,thus the data transmission accuracy and the integrity of the network function will be affected negatively.Based on the characteristics of IoT,a lightweight local outlier factor detection method is used for node detection.In order to further determine whether the nodes are an anomaly or not,the varying behavior of those nodes in terms of time is considered in this research,and a time series method is used to make the system respond to the randomness and selectiveness of anomaly behavior nodes effectively in a short period of time.Simulation results show that the proposed method can improve the accuracy of the data transmitted by the network and achieve better performance.展开更多
Hebei is one of the most air polluted provinces in China. According to the Ministry of Environmental Protection (MEP) for the severe fog-haze month of Jan. 2013, seven of the top ten most polluted cities in China are ...Hebei is one of the most air polluted provinces in China. According to the Ministry of Environmental Protection (MEP) for the severe fog-haze month of Jan. 2013, seven of the top ten most polluted cities in China are located in Hebei Province. In this study, the air pollution history and status of the Hebei Province are reviewed and discussed, using the governmental published Air Pollution Index (API), the academic observations by various scientific research groups and the long-term statistics of visibility and haze frequencies. It is found that within the Hebei Province, the air pollution in the southern cities is much more severe than the northern cities. Particulate matter (PM) is undoubtedly the major air pollutant, sulfur dioxide (SO2) and nitrogen oxides (NOX) pollutions are also unnegligible. Ozone (O3) pollution in larger cities, such as Shijiazhuang, is significant. Air pollution control history from 1998 is discussed as well. Although Hebei Province has made a great effort on air quality, the pollutant emissions, such as SO2 and fly ash, showed a notable increase in 2001 to 2006. However, after 2006 the emissions started to decrease due to the strict implementation of the national 11th Five Year Plan (FYP). In addition, regional jointly air pollution control and prevention strategies are expected in the future to substantially change the severe air pollution status in Hebei Province.展开更多
To develop suitable nicotine derivatives for potential use in next generation tobacco products,mixtures of nicotine with tartaric acid were prepared.The prepared freeze-dried product was a white powder with good water...To develop suitable nicotine derivatives for potential use in next generation tobacco products,mixtures of nicotine with tartaric acid were prepared.The prepared freeze-dried product was a white powder with good water solubility.The structure of nicotine tartrate was evaluated with X-ray powder diffraction,near infrared diffuse reflectance spectroscopy and solid-state Nuclear Magnetic Resonance(ss-NMR).The crystal structure of nicotine tartrate was analyzed by single-crystal X-ray diffraction.According to the obtained atomic coordinates,equivalent temperature factor,bond length and torsion angles,the chemical formula of nicotine tartrate was proposed as 2(C4H5O6)· C10H16N2·H2O.The relative molecular mass was 480.42,and the crystal density was 1.501 mg/m^3 The crystal structure of nicotine tartrate belongs to the orthorhombic system and the monoclinic space group is P212121.Nicotine tartrate was used in gum-based chewing tobacco to substitute pure nicotine,which showed a sustained nicotine release when compared to traditional ultrafine tobacco powder as assessed by an in situ dissolution method.展开更多
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient hig...The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat plasma.Methotrexate and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with acetonitrile.The analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for methotrexate.Other parameters were all within the acceptance criteria.The validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/2.Results suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine ferulate.The method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.展开更多
目的分析评估日均气温对新疆7个国家级死因监测点人群非意外总死亡(A00-R99)人数的影响,为卫生决策提供科学依据。方法收集2015—2019年新疆7个国家级死因监测点非意外总死亡资料及同期气象和空气质量资料,利用分布滞后非线性模型(distr...目的分析评估日均气温对新疆7个国家级死因监测点人群非意外总死亡(A00-R99)人数的影响,为卫生决策提供科学依据。方法收集2015—2019年新疆7个国家级死因监测点非意外总死亡资料及同期气象和空气质量资料,利用分布滞后非线性模型(distributed lag non-linear model,DLNM)研究日均气温与非意外死亡人数的影响及滞后效应。结果新疆7个监测点日均气温与居民非意外死亡呈“J”型关系,死亡最低风险温度为17℃。高温当天对居民非意外总死亡的RR值(95%CI)为1.031(1.019~1.043),危害效应达到最大,滞后天数为5 d;在不同年龄、性别层中,高温对女性和≥65岁人群非意外死亡风险的影响较大。低温对总死亡及不同年龄、性别层中均未表现出明显的健康风险及滞后效应。结论高温会造成居民非意外死亡风险增加,早期呈明显急性影响,且存在滞后效应,女性和≥65岁人群为敏感人群。展开更多
In the reputation modeling of wireless sensor networks（WSNs） many literatures have proposed creative reputation indirect update methods,such as reputation integration,discounting,aging to eliminate,and filtering mal...In the reputation modeling of wireless sensor networks（WSNs） many literatures have proposed creative reputation indirect update methods,such as reputation integration,discounting,aging to eliminate,and filtering malicious reputation information. However,few have discussed the reputation direct update. In this paper,based on sound statistical theories,a negative binominal distribution method in the reputation direct update for WSNs is proposed. Results show that the proposed method is more suitable and time-saving for the reputation update of the resource constraint WSNs and can improve the computation power efficiency as well.展开更多
In the field of medical equipment and equipment storage work, when we access accessories and equipment, due to the actual conditions, it causes low efficiency. It is often difficult to quickly and efficiently search b...In the field of medical equipment and equipment storage work, when we access accessories and equipment, due to the actual conditions, it causes low efficiency. It is often difficult to quickly and efficiently search by using simple data management software, such as excel. In order to solve the problem, our team used Python development tool to build high-performance retrieval software, which enabled the equipment custodian to maintain or redesign the database according to actual needs. Through actual verification, this system not only can greatly improve the accuracy of device access, but also has good expansion portability, which could manage various multimedia data systems.展开更多
基金supported by the National Key R&D Program of China[2020 YFC2003000]。
文摘Objective We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.Methods Adults≥65 years old(n=1,973)were interviewed at baseline in 2018 and 1,459 were followed up in 2021.General and abdominal obesity were assessed,and serum C-reactive protein(CRP)levels were measured at baseline.Depression status was assessed at baseline and at follow-up.Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms,as well as the relationship between obesity and CRP levels.The associations of CRP levels with the geriatric depression scale,as well as with its three dimensions,were investigated using multiple linear regressions.Results General obesity was associated with worsening depression symptoms and incident depression,with an odds ratio(OR)[95%confidence interval(CI)]of 1.53(1.13-2.12)and 1.80(1.23-2.63),especially among old male subjects,with OR(95%CI)of 2.12(1.25-3.58)and 2.24(1.22-4.11),respectively;however,no significant relationship was observed between abdominal obesity and depression.In addition,general obesity was associated with high levels of CRP,with OR(95%CI)of 2.58(1.75-3.81),especially in subjects free of depression at baseline,with OR(95%CI)of 3.15(1.97-5.04),and CRP levels were positively correlated with a score of specific dimension(life satisfaction)of depression,P<0.05.Conclusion General obesity,rather than abdominal obesity,was associated with worsening depressive symptoms and incident depression,which can be partly explained by the systemic inflammatory response,and the impact of obesity on depression should be taken more seriously in the older male population.
文摘为研究一种性能更优越的新型聚酰胺材料,以衣康酰氯及对苯二胺为原料,采用低温溶液缩聚法制备出聚衣康酰对苯二胺(PPIA)。通过红外光谱和核磁共振确定了目标产物的分子结构;探究了PPIA的合成工艺,即原料的摩尔比、滴加时间、反应时间、反应温度对PPIA比浓对数黏度的影响。运用X射线衍射、热重分析和差示扫描量热分析研究了其结晶情况与热性能。结果表明,衣康酰氯与对苯二胺的摩尔比为1.05∶1,滴加时间为60 min,反应时间60 min,反应温度-5℃时,得到的产物比浓对数黏度(η)最大,即相对分子质量最大,η能达到1.6 d L/g。通过XRD表明低温下制备的PPIA具有更好的晶型结构;通过DSC和TGA可知PPIA具有良好的热稳定性能;通过拉伸强度和弯曲强度的测定可知PPIA具有较好的力学性能。
基金supported by the National Natural Science Foundation of China(Grant Nos.81101143,81572617,and 81630101)the Sichuan Province Science and Technology Support Program(Grant Nos.2019JDRC0019 and 2018SZ0009)+2 种基金1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant No.ZYJC18026)The Science and Technology Project of the Health Planning Committee of Sichuan(Grant No.19PJ242)Chengdu science and technology Support Program(Grant No.2019-YFYF-00090-SN)。
文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research.
基金This work is partially supported by the Ministry of Education of China(www.moe.gov.cn)under grant Nos.201802123091(received by F.W.)and 201802123068(received by Z.W.)Scientific Project of CAFUC(www.cafuc.edu.cn)under grant Nos.F2017KF02 and J2018-3(both received by Z.W.)Teaching Reform Project of CAFUC(www.cafuc.edu.cn)under grant No.E2020044(received by Z.W.).
文摘The heterogeneous nodes in the Internet of Things(IoT)are relatively weak in the computing power and storage capacity.Therefore,traditional algorithms of network security are not suitable for the IoT.Once these nodes alternate between normal behavior and anomaly behavior,it is difficult to identify and isolate them by the network system in a short time,thus the data transmission accuracy and the integrity of the network function will be affected negatively.Based on the characteristics of IoT,a lightweight local outlier factor detection method is used for node detection.In order to further determine whether the nodes are an anomaly or not,the varying behavior of those nodes in terms of time is considered in this research,and a time series method is used to make the system respond to the randomness and selectiveness of anomaly behavior nodes effectively in a short period of time.Simulation results show that the proposed method can improve the accuracy of the data transmitted by the network and achieve better performance.
文摘Hebei is one of the most air polluted provinces in China. According to the Ministry of Environmental Protection (MEP) for the severe fog-haze month of Jan. 2013, seven of the top ten most polluted cities in China are located in Hebei Province. In this study, the air pollution history and status of the Hebei Province are reviewed and discussed, using the governmental published Air Pollution Index (API), the academic observations by various scientific research groups and the long-term statistics of visibility and haze frequencies. It is found that within the Hebei Province, the air pollution in the southern cities is much more severe than the northern cities. Particulate matter (PM) is undoubtedly the major air pollutant, sulfur dioxide (SO2) and nitrogen oxides (NOX) pollutions are also unnegligible. Ozone (O3) pollution in larger cities, such as Shijiazhuang, is significant. Air pollution control history from 1998 is discussed as well. Although Hebei Province has made a great effort on air quality, the pollutant emissions, such as SO2 and fly ash, showed a notable increase in 2001 to 2006. However, after 2006 the emissions started to decrease due to the strict implementation of the national 11th Five Year Plan (FYP). In addition, regional jointly air pollution control and prevention strategies are expected in the future to substantially change the severe air pollution status in Hebei Province.
文摘To develop suitable nicotine derivatives for potential use in next generation tobacco products,mixtures of nicotine with tartaric acid were prepared.The prepared freeze-dried product was a white powder with good water solubility.The structure of nicotine tartrate was evaluated with X-ray powder diffraction,near infrared diffuse reflectance spectroscopy and solid-state Nuclear Magnetic Resonance(ss-NMR).The crystal structure of nicotine tartrate was analyzed by single-crystal X-ray diffraction.According to the obtained atomic coordinates,equivalent temperature factor,bond length and torsion angles,the chemical formula of nicotine tartrate was proposed as 2(C4H5O6)· C10H16N2·H2O.The relative molecular mass was 480.42,and the crystal density was 1.501 mg/m^3 The crystal structure of nicotine tartrate belongs to the orthorhombic system and the monoclinic space group is P212121.Nicotine tartrate was used in gum-based chewing tobacco to substitute pure nicotine,which showed a sustained nicotine release when compared to traditional ultrafine tobacco powder as assessed by an in situ dissolution method.
文摘The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat plasma.Methotrexate and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with acetonitrile.The analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for methotrexate.Other parameters were all within the acceptance criteria.The validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/2.Results suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine ferulate.The method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.
文摘目的分析评估日均气温对新疆7个国家级死因监测点人群非意外总死亡(A00-R99)人数的影响,为卫生决策提供科学依据。方法收集2015—2019年新疆7个国家级死因监测点非意外总死亡资料及同期气象和空气质量资料,利用分布滞后非线性模型(distributed lag non-linear model,DLNM)研究日均气温与非意外死亡人数的影响及滞后效应。结果新疆7个监测点日均气温与居民非意外死亡呈“J”型关系,死亡最低风险温度为17℃。高温当天对居民非意外总死亡的RR值(95%CI)为1.031(1.019~1.043),危害效应达到最大,滞后天数为5 d;在不同年龄、性别层中,高温对女性和≥65岁人群非意外死亡风险的影响较大。低温对总死亡及不同年龄、性别层中均未表现出明显的健康风险及滞后效应。结论高温会造成居民非意外死亡风险增加,早期呈明显急性影响,且存在滞后效应,女性和≥65岁人群为敏感人群。
基金supported by the National Natural Science Foundation of China under Grant No. 6107311
文摘In the reputation modeling of wireless sensor networks（WSNs） many literatures have proposed creative reputation indirect update methods,such as reputation integration,discounting,aging to eliminate,and filtering malicious reputation information. However,few have discussed the reputation direct update. In this paper,based on sound statistical theories,a negative binominal distribution method in the reputation direct update for WSNs is proposed. Results show that the proposed method is more suitable and time-saving for the reputation update of the resource constraint WSNs and can improve the computation power efficiency as well.
文摘In the field of medical equipment and equipment storage work, when we access accessories and equipment, due to the actual conditions, it causes low efficiency. It is often difficult to quickly and efficiently search by using simple data management software, such as excel. In order to solve the problem, our team used Python development tool to build high-performance retrieval software, which enabled the equipment custodian to maintain or redesign the database according to actual needs. Through actual verification, this system not only can greatly improve the accuracy of device access, but also has good expansion portability, which could manage various multimedia data systems.
