BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient prognosis.For radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI...BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient prognosis.For radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a challenge.AIM To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable LNs.METHODS In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI matching.Conventional MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were evaluated.Three radiomics models used 3D features from T1WI and T2WI images.Additionally,a nomogram model combining conventional MRI and radiomics features was developed.The model used univariate analysis and multivariable logistic regression.Evaluation employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic performance.Nomogram performance was assessed using calibration and decision curve analysis.RESULTS The nomogram model outperformed conventional MRI and single radiomics models in evaluating LNM.In the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,respectively.In the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),respectively.CONCLUSION The nomogram model showed the best performance in predicting metastasis of evaluable LNs.展开更多
目的了解急诊医生心脏骤停患者脑保护的认知和实践情况。方法通过问卷调查的方式进行,在全国范围内随机选取75家医院,参研医院所有的急诊科医生均参与调查研究。结果共有1473名受访者参与研究,应答率为92.1%。89.4%受访者认为目标温度管...目的了解急诊医生心脏骤停患者脑保护的认知和实践情况。方法通过问卷调查的方式进行,在全国范围内随机选取75家医院,参研医院所有的急诊科医生均参与调查研究。结果共有1473名受访者参与研究,应答率为92.1%。89.4%受访者认为目标温度管理(target temperature management,TTM)有助于改善心脏骤停患者的神经功能,但仅有15.5%的急诊科及27.8%的受访者在临床实践中实施过TTM。对于理论上有脑保护作用,但目前缺乏相关证据支持的药物和措施,绝大多数受访者认为有脑保护作用并应用于临床实践中,应用最为普遍的三磷酸腺苷(85.9%)、减轻脑水肿的药物(73.5%)、自由基清除剂(70.8%)、营养神经药物(66.4%)、高压氧治疗(60.0%)及线粒体保护剂(45.6%)。结论急诊医生对TTM认知程度有很大改观,但实践情况仍然不理想,临床上更多选择理论上有保护作用但目前尚无确切证据的措施。展开更多
基金Supported by the National Natural Science Foundation of China,No.81602145 and No.82072704Jiangsu Province TCM Science and Technology Development Plan Monographic Project,No.ZT202118+6 种基金Jiangsu Provincial Natural Science Foundation,No.BK20171509China Postdoctoral Science Foundation,No.2018M632265The“333 Talents”Program of Jiangsu Province,No.BRA2020390Key R&D Plan of Jiangsu Provincial Department of Science and Technology,No.BE2020723Nanjing Medical University Project,No.NMUC2020046Nanjing Science and Technology Project,No.202110027Elderly Health Research Project of Jiangsu Provincial Health Commission,No.LR2022006.
文摘BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient prognosis.For radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a challenge.AIM To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable LNs.METHODS In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI matching.Conventional MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were evaluated.Three radiomics models used 3D features from T1WI and T2WI images.Additionally,a nomogram model combining conventional MRI and radiomics features was developed.The model used univariate analysis and multivariable logistic regression.Evaluation employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic performance.Nomogram performance was assessed using calibration and decision curve analysis.RESULTS The nomogram model outperformed conventional MRI and single radiomics models in evaluating LNM.In the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,respectively.In the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),respectively.CONCLUSION The nomogram model showed the best performance in predicting metastasis of evaluable LNs.
文摘目的了解急诊医生心脏骤停患者脑保护的认知和实践情况。方法通过问卷调查的方式进行,在全国范围内随机选取75家医院,参研医院所有的急诊科医生均参与调查研究。结果共有1473名受访者参与研究,应答率为92.1%。89.4%受访者认为目标温度管理(target temperature management,TTM)有助于改善心脏骤停患者的神经功能,但仅有15.5%的急诊科及27.8%的受访者在临床实践中实施过TTM。对于理论上有脑保护作用,但目前缺乏相关证据支持的药物和措施,绝大多数受访者认为有脑保护作用并应用于临床实践中,应用最为普遍的三磷酸腺苷(85.9%)、减轻脑水肿的药物(73.5%)、自由基清除剂(70.8%)、营养神经药物(66.4%)、高压氧治疗(60.0%)及线粒体保护剂(45.6%)。结论急诊医生对TTM认知程度有很大改观,但实践情况仍然不理想,临床上更多选择理论上有保护作用但目前尚无确切证据的措施。
