目的 探讨中年男性脂肪肝的患病率及其危险因素。 方法 选取2014年1月至2015年12月该院健康体检中心的中年男性2 760例，年龄30~60岁，平均年龄（45.72±8.8）岁，经超声明确诊断为脂肪肝患者1 074例。分析不同特征中年男性脂肪...目的 探讨中年男性脂肪肝的患病率及其危险因素。 方法 选取2014年1月至2015年12月该院健康体检中心的中年男性2 760例，年龄30~60岁，平均年龄（45.72±8.8）岁，经超声明确诊断为脂肪肝患者1 074例。分析不同特征中年男性脂肪肝的患病情况，比较中年男性脂肪肝与非脂肪肝组血液生化指标的差异，应用多因素logistic分析中年男性脂肪肝的危险因素。 结果 中年男性体检人群中B超共检出脂肪肝1 074例，患病率为38.9%，其中40~50岁年龄层男性脂肪肝患病率最高达42.6%。血压升高组脂肪肝的患病率较血压正常组升高（53.9% vs .32.3%， P 〈0.001）;超重和肥胖人群脂肪肝患病率显著高于体重正常组（49.5% vs .81% vs .15.1%， P 〈0.001），空腹血糖升高组脂肪肝患病率显著高于空腹血糖正常组（67.9% vs. 36.5%， P 〈0.001）；高甘油三酯血症、高胆固醇血症、混合型高脂血症、低HDL-胆固醇血症人群脂肪肝患病率显著高于正常组（55.9% vs .30.8% vs .62.6% vs .39.8% vs .19.7%， P 〈0.001）。脂肪肝组α-L-岩藻糖苷酶（AFU）、总蛋白、结合胆红素、糖化血红蛋白、谷草转氨酶、LDL-胆固醇、r-谷氨酰酶、谷丙转氨酶、尿素、MCHC、血红蛋白、血小板计数、红细胞计数、嗜中性粒细胞%、血小板压积、红细胞压积平均水平均高于非脂肪肝组（ P 均小于 0.05 ）。HDL-胆固醇水平、白球比例均低于非脂肪肝组（ P 均〈0.05）。多因素logistic回归分析提示年龄增长、肥胖、血糖升高、血压升高、高甘油三酯血症、低HDL-胆固醇血症升高是中年男性发生脂肪肝的危险因素（其OR值分别为1.531、12.067、2.230、2.284、1.436、2.987、1.724、 P 均〈0.05）。 结论 40~50岁男性在中年男性中脂肪肝发病率最高，肥胖、糖尿病、高血压、高甘油三酯血症、低HDL-胆固醇血症与脂肪肝发生密切相关。展开更多
In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in th...In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault-terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil-~as fields locate herein.展开更多
Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The U...Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The Upper Paleozoic shales in the northwestern Guizhong Depression, including the Middle Devonian Luofu shale, the Nabiao shale, and the Lower Carboniferous Yanguan shale, were investigated in this study. Mineral composition analysis, organic matter analysis(including total organic carbon(TOC) content, maceral of kerogen and the vitrinite reflection(Ro)), pore characteristic analysis(including porosity and permeability, pore type identification by SEM, and pore size distribution by nitrogen sorption), methane isothermal sorption test were conducted, and the distribution and thickness of the shales were determined, Then the characteristics of the two target shales were illustrated and compared. The results show that the Upper Paleozoic shales have favorable organic matter conditions(mainly moderate to high TOC content, type Ⅰ and Ⅱ_1 kerogen and high to over maturity), good fracability potential(brittleness index(BI) > 40%), multiple pore types, stable distribution and effective thickness, and good methane sorption capacity. Therefore, the Upper Paleozoic shales in the northern Guizhong Depression have good shale gas potential and exploration prospects. Moreover, the average TOC content, average BI, thickness of the organic-rich shale(TOC > 2.0 wt%) and the shale gas resources of the Middle Devonian shales are better than those of the Lower Carboniferous shale. The Middle Devonian shales have better shale gas potential and exploration prospects than the Lower Carboniferous shales.展开更多
文摘目的 探讨中年男性脂肪肝的患病率及其危险因素。 方法 选取2014年1月至2015年12月该院健康体检中心的中年男性2 760例，年龄30~60岁，平均年龄（45.72±8.8）岁，经超声明确诊断为脂肪肝患者1 074例。分析不同特征中年男性脂肪肝的患病情况，比较中年男性脂肪肝与非脂肪肝组血液生化指标的差异，应用多因素logistic分析中年男性脂肪肝的危险因素。 结果 中年男性体检人群中B超共检出脂肪肝1 074例，患病率为38.9%，其中40~50岁年龄层男性脂肪肝患病率最高达42.6%。血压升高组脂肪肝的患病率较血压正常组升高（53.9% vs .32.3%， P 〈0.001）;超重和肥胖人群脂肪肝患病率显著高于体重正常组（49.5% vs .81% vs .15.1%， P 〈0.001），空腹血糖升高组脂肪肝患病率显著高于空腹血糖正常组（67.9% vs. 36.5%， P 〈0.001）；高甘油三酯血症、高胆固醇血症、混合型高脂血症、低HDL-胆固醇血症人群脂肪肝患病率显著高于正常组（55.9% vs .30.8% vs .62.6% vs .39.8% vs .19.7%， P 〈0.001）。脂肪肝组α-L-岩藻糖苷酶（AFU）、总蛋白、结合胆红素、糖化血红蛋白、谷草转氨酶、LDL-胆固醇、r-谷氨酰酶、谷丙转氨酶、尿素、MCHC、血红蛋白、血小板计数、红细胞计数、嗜中性粒细胞%、血小板压积、红细胞压积平均水平均高于非脂肪肝组（ P 均小于 0.05 ）。HDL-胆固醇水平、白球比例均低于非脂肪肝组（ P 均〈0.05）。多因素logistic回归分析提示年龄增长、肥胖、血糖升高、血压升高、高甘油三酯血症、低HDL-胆固醇血症升高是中年男性发生脂肪肝的危险因素（其OR值分别为1.531、12.067、2.230、2.284、1.436、2.987、1.724、 P 均〈0.05）。 结论 40~50岁男性在中年男性中脂肪肝发病率最高，肥胖、糖尿病、高血压、高甘油三酯血症、低HDL-胆固醇血症与脂肪肝发生密切相关。
基金supported jointly by the Open Fund (Grant No. PLC201105 & PLC201002) of the State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Chengdu University of Technology)the National Natural Science Foundation of China (Grant No. 40839902)the National Science & Technology Major Project (Grant No. 2011ZX05005-003-008HZ & 2011ZX05002-006-003HZ)
文摘In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault-terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil-~as fields locate herein.
基金the financial support of the National Science and Technology Major Project of 2011ZX05005-003-008HZthe Science and Technology Project of Zhejiang Geological Survey Bureau(No.201713)the National Natural Science Foundation of China(No.41572110)
文摘Multiple sets of organic-rich shales developed in the Upper Paleozoic of the northwestern Guizhong Depression in South China. However, the exploration of these shales is presently at a relatively immature stage. The Upper Paleozoic shales in the northwestern Guizhong Depression, including the Middle Devonian Luofu shale, the Nabiao shale, and the Lower Carboniferous Yanguan shale, were investigated in this study. Mineral composition analysis, organic matter analysis(including total organic carbon(TOC) content, maceral of kerogen and the vitrinite reflection(Ro)), pore characteristic analysis(including porosity and permeability, pore type identification by SEM, and pore size distribution by nitrogen sorption), methane isothermal sorption test were conducted, and the distribution and thickness of the shales were determined, Then the characteristics of the two target shales were illustrated and compared. The results show that the Upper Paleozoic shales have favorable organic matter conditions(mainly moderate to high TOC content, type Ⅰ and Ⅱ_1 kerogen and high to over maturity), good fracability potential(brittleness index(BI) > 40%), multiple pore types, stable distribution and effective thickness, and good methane sorption capacity. Therefore, the Upper Paleozoic shales in the northern Guizhong Depression have good shale gas potential and exploration prospects. Moreover, the average TOC content, average BI, thickness of the organic-rich shale(TOC > 2.0 wt%) and the shale gas resources of the Middle Devonian shales are better than those of the Lower Carboniferous shale. The Middle Devonian shales have better shale gas potential and exploration prospects than the Lower Carboniferous shales.
