BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the com...BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying mechanisms.CASE SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed MODS.The patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital admission.Cantharidin poisoning can cause lifethreatening MODS and is rare clinically.This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.CONCLUSION This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.展开更多
Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomizatio...Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomization(MR).Methods Genome-wide association studies in UK Biobank included 349376 individuals and successfully discovered single-nucleotide polymorphisms linked to consumption of one cup of tea per day.Summary statistics from the Chronic Kidney Disease Genetics consortium included 13179 cases and 750634 controls for gout.Two-sample MR analyses were used to evaluate the relationship between tea consumption and gout risk.The inverse-variance weighted(IVW)method was used for primary analysis,and sensitivity analyses were also conducted to validate the potential causal effect.Results In this study,the genetically predicted increase in tea consumption per cup was associated with a lower risk of gout in the IVW method(OR:0.90;95%CI:0.82–0.98).Similar results were found in weighted median methods(OR:0.88;95%CI:0.78–1.00),while no significant associations were found in MR-Egger(OR:0.89;95%CI:0.71–1.11),weighted mode(OR:0.80;95%CI:0.65–0.99),and simple mode(OR:1.01;95%CI:0.75–1.36).In addition,no evidence of pleiotropy was detected by MR-Egger regression(P=0.95)or MR-PRESSO analysis(P=0.07).Conclusion This study provides evidence for the daily consumption of an extra cup of tea to reduce the risk of gout.展开更多
In this study,CoCrFeMnNi high-entropy alloys(HEAs)with a surface gradient nanostructure were produced using industrial shot blasting,which improved their mechanical properties compared to the untreated alloy.The sever...In this study,CoCrFeMnNi high-entropy alloys(HEAs)with a surface gradient nanostructure were produced using industrial shot blasting,which improved their mechanical properties compared to the untreated alloy.The severely plastically deformed(SPD)surface layer had a multi-scale hierarchical structure with a high density of stacking faults,deformation nanotwins,and amorphous domains.The depth of the SPD layer steadily increased as the shot-blasting time increased.The differences in the microhardness and tensile strength before and after shotblasting demonstrated the significant effect of the SPD layer on the mechanical performance.The microhardness of the homogenized HEA was~5 GPa.In comparison,the maximum microhardness of the specimens after 20 min of shot blasting was~8.0 GPa at the surface.The yield strength also improved by 178%,and a large ductility of~36%was retained.Additional nanograin boundary,stacking fault,and twin strengthening within the gradientnanostructured surface layer caused the strength to increase.During tensile deformation,strain concentration began at the surface of the specimen and gradually spread to the interior.Thus,the gradient-nanostructured surface layer with improved strain hardening can prevent early necking and ensure steady plastic deformation so that high toughness is achieved.展开更多
基金supported by the National Natural Science Foundation of China (No.51901018)the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (Nos.YESS,2019QNRC001)+2 种基金the Fundamental Research Funds for the Central Universities,China (Nos.FRF-AT-20-07,06500119)the Natural Science Foundation of Beijing Municipality,China (No.2212037)the National Science and Technology Resources Investigation Program of China (No.2019FY101400).
基金Supported by Jilin Province Science and Technology Agency Project,No.20210101350JCProject of Jilin Provincial Finance Department,No.JLSWSRCZX2023-60Beijing iGandan Foundation Fund for Artificial Liver,No.iGandanF-1082023-RGG025.
文摘BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying mechanisms.CASE SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed MODS.The patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital admission.Cantharidin poisoning can cause lifethreatening MODS and is rare clinically.This case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt intervention.CONCLUSION This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.
基金supported by grants from the Natural Science Foundation of China(No.82102199)the General Program of Shanghai Municipal Commission of Health and Family Planning(No.202040479).
文摘Objective Evidence from prospective studies on the consumption of tea and risk of gout is conflicting and limited.We aimed to investigate the potential causal effects of tea intake on gout using Mendelian randomization(MR).Methods Genome-wide association studies in UK Biobank included 349376 individuals and successfully discovered single-nucleotide polymorphisms linked to consumption of one cup of tea per day.Summary statistics from the Chronic Kidney Disease Genetics consortium included 13179 cases and 750634 controls for gout.Two-sample MR analyses were used to evaluate the relationship between tea consumption and gout risk.The inverse-variance weighted(IVW)method was used for primary analysis,and sensitivity analyses were also conducted to validate the potential causal effect.Results In this study,the genetically predicted increase in tea consumption per cup was associated with a lower risk of gout in the IVW method(OR:0.90;95%CI:0.82–0.98).Similar results were found in weighted median methods(OR:0.88;95%CI:0.78–1.00),while no significant associations were found in MR-Egger(OR:0.89;95%CI:0.71–1.11),weighted mode(OR:0.80;95%CI:0.65–0.99),and simple mode(OR:1.01;95%CI:0.75–1.36).In addition,no evidence of pleiotropy was detected by MR-Egger regression(P=0.95)or MR-PRESSO analysis(P=0.07).Conclusion This study provides evidence for the daily consumption of an extra cup of tea to reduce the risk of gout.
基金financially supported by Shenzhen Science and Technology Program(No.JCYJ20210324121011031)the National Natural Science Foundation of China(Nos.51871132 and 51971120)+2 种基金the Free Exploring Basic Research Project of Shenzhen Virtual University Park(No.2021Szvup069)the Opening Project of the State Key Laboratory of Explosion Science and Technology(Beijing Institutes of Technology)(No.KFJJ21-08M)the Natural Science Foundation of Shandong Province(No.ZR2020ME002)。
文摘In this study,CoCrFeMnNi high-entropy alloys(HEAs)with a surface gradient nanostructure were produced using industrial shot blasting,which improved their mechanical properties compared to the untreated alloy.The severely plastically deformed(SPD)surface layer had a multi-scale hierarchical structure with a high density of stacking faults,deformation nanotwins,and amorphous domains.The depth of the SPD layer steadily increased as the shot-blasting time increased.The differences in the microhardness and tensile strength before and after shotblasting demonstrated the significant effect of the SPD layer on the mechanical performance.The microhardness of the homogenized HEA was~5 GPa.In comparison,the maximum microhardness of the specimens after 20 min of shot blasting was~8.0 GPa at the surface.The yield strength also improved by 178%,and a large ductility of~36%was retained.Additional nanograin boundary,stacking fault,and twin strengthening within the gradientnanostructured surface layer caused the strength to increase.During tensile deformation,strain concentration began at the surface of the specimen and gradually spread to the interior.Thus,the gradient-nanostructured surface layer with improved strain hardening can prevent early necking and ensure steady plastic deformation so that high toughness is achieved.
