The convergence of Internet of Things(IoT),5G,and cloud collaboration offers tailored solutions to the rigorous demands of multi-flow integrated energy aggregation dispatch data processing.While generative adversarial...The convergence of Internet of Things(IoT),5G,and cloud collaboration offers tailored solutions to the rigorous demands of multi-flow integrated energy aggregation dispatch data processing.While generative adversarial networks(GANs)are instrumental in resource scheduling,their application in this domain is impeded by challenges such as convergence speed,inferior optimality searching capability,and the inability to learn from failed decision making feedbacks.Therefore,a cloud-edge collaborative federated GAN-based communication and computing resource scheduling algorithm with long-term constraint violation sensitiveness is proposed to address these challenges.The proposed algorithm facilitates real-time,energy-efficient data processing by optimizing transmission power control,data migration,and computing resource allocation.It employs federated learning for global parameter aggregation to enhance GAN parameter updating and dynamically adjusts GAN learning rates and global aggregation weights based on energy consumption constraint violations.Simulation results indicate that the proposed algorithm effectively reduces data processing latency,energy consumption,and convergence time.展开更多
The designing of reasonable nanocomposite materials and proper introduction of defect engineering are of great significance for the improvement of the poor electronic conductivity and slow reaction kinetics of mangane...The designing of reasonable nanocomposite materials and proper introduction of defect engineering are of great significance for the improvement of the poor electronic conductivity and slow reaction kinetics of manganese-based compounds. Herein, we report manganese-deficient Mn_(3)O_(4) nanoparticles which grow in-situ on highly conductive carbon nanotubes(CNTs)(denoted as DMOC) as an advanced cathode material for aqueous rechargeable zinc-ion batteries(RAZIBs). According to experimental and calculation results, the DMOC cathode integrates the advantages of enriched Mn defects and small particle size. These features not only enhance electronic conductivity but also create more active site and contribute to fast reaction kinetics. Moreover, the structure of DMOC is maintained during the charging and discharging process, thus benefiting for excellent cycle stability. As a result, the DMOC electrode delivers a high specific capacity of 420.6 m A h g^(-1) at 0.1 A g^(-1) and an excellent cycle life of 2800 cycles at 2.0 A g^(-1) with a high-capacity retention of 84.1%. In addition, the soft-packaged battery assembled with DMOC cathode exhibits long cycle life and high energy density of 146.3 Wh kg^(-1) at 1.0 A g^(-1) . The results are beneficial for the development of Zn/Mn_(3)O_(4) battery for practical energy storage.展开更多
This paper presents a new design approach to achieve decentralized optimal control of high-dimension complex singular systems with dynamic uncertainties. Based on robust adaptive dynamic programming(robust ADP) method...This paper presents a new design approach to achieve decentralized optimal control of high-dimension complex singular systems with dynamic uncertainties. Based on robust adaptive dynamic programming(robust ADP) method, controllers for solving the singular systems optimal control problem are designed. The proposed algorithm can work well when the system model is not exactly known but the input and output data can be measured. The policy iteration of each controller only uses their own states and input information for learning,and do not need to know the whole system dynamics. Simulation results on the New England 10-machine 39-bus test system show the effectiveness of the designed controller.展开更多
Background Implementing the current guidelines for leisure-time physical activity(LTPA)provides significant health benefits,especially for middle-aged adults,but it is unclear whether LTPA also translates into cardiov...Background Implementing the current guidelines for leisure-time physical activity(LTPA)provides significant health benefits,especially for middle-aged adults,but it is unclear whether LTPA also translates into cardiovascular health benefits among elderly people.Therefore,we aimed to assess the association of LTPA with the risks of cardiovascular disease(CVD),including coronary heart disease(CHD)and stroke,and all-cause mortality in an elderly population.Methods In this prospective cohort study,32,942 participants aged 60 years or older who participated in a health check-up programme in China between 2010 and 2018 were included.We evaluated the morbidity and mortality risks through the Cox regression model,competing risk model and restricted cubic spline model.Results During a median of 6.84 years of follow-up,there were 6,857 elderly people with incident CVD;a total of 6,324 deaths occurred due to all causes and 2,060 deaths occurred due to CVD.Compared with the inactive group,reductions in CVD morbidity and mortality were observed,with hazard ratios(HRs)of 0.89(95%CI:0.83–0.96)and 0.81(95%CI:0.71–0.92)in the insufficiently active group,0.86(95%CI:0.80–0.92)and 0.79(95%CI:0.69–0.90)in the sufficiently active group,and 0.79(95%CI:0.70–0.89)and 0.58(95%CI:0.45–0.76)in the highly active group,respectively;but no significant reductions were observed in the very highly active group,with HRs of 0.87(95%CI:0.71–1.06)and 0.99(95%CI:0.70–1.40),respectively.Compared with the inactive group,reductions in all-cause mortality were also observed,with a HR of 0.90(95%CI:0.84–0.97)in the insufficiently active group,0.82(95%CI:0.77–0.89)in the sufficiently active group,0.77(95%CI:0.67–0.87)in the highly active group,and 0.80(95%CI:0.64–0.98)in the very highly active group.A restricted cubic spline diagram showed that there was an L-shaped association between LTPA and the risk of all-cause mortality but a U-shaped or reverse J-shaped relationship between LTPA and the risk of CVD morbidity and mortality,especially stroke.In addition,a subgroup analysis showed that elderly population who consistently performed LTPA for ten years or more had a lower risk of morbidity and mortality.Conclusions In an elderly population,even insufficient activity is associated with a decreased risk of all-cause mortality and CVD,and moderate levels of LTPA may be optimal for CVD prevention.In addition,elderly people who consistently perform LTPA over several years may experience greater health benefits.展开更多
Persulfate decontamination technologies utilizing radical‐driven processes are powerful tools for the treatment of a broad range of impurities.However,the design of high‐performance catalytic activators with multi‐...Persulfate decontamination technologies utilizing radical‐driven processes are powerful tools for the treatment of a broad range of impurities.However,the design of high‐performance catalytic activators with multi‐functionality remains a great challenge.Therefore,in this study,three‐dimensional multifunctional FexOy/N‐GN/CNTs(N‐GN:nitrogen‐doped graphene,CNTs:carbon nanotubes)heterojunctions,which can be employed as microwave absorbers and catalysts,were synthesized via a solvothermal method and applied to activate peroxymonosulfate for the degradation of methylene blue(MB).X‐ray diffraction(XRD),Fourier transform infrared spectrometer(FTIR),scanning electron microscope(SEM),and X‐ray photoelectron microscopy(XPS)analyses revealed that the FexOy were anchored in‐situ onto the N‐GN network.Using MB as the model organic dye,various factors,such as degradation systems,PMS loading,initial organic pollutant concentration,and catalyst dosage were optimized.The results revealed that the remarkable efficiency was attributable to the synergistic effects of carbon,nitrogen,and iron‐based species.The oxidation system corresponded to the pseudo‐first‐order kinetic with a k value of^0.33 min^-1.It was demonstrated that both SO4^-and OH^-were the predominant reactive species through quenching experiments.Because these heterojunctions were employed as microwave absorbers and have a semiconductor‐like texture,the Fe/N co‐rich hierarchical porous carbon skeleton favored electron transport and storage.These heterojunctions increase the options for transitional metal catalysts and highlights the importance of designing other heterojunctions for specific applications,such as supercapacitors,energy storage,CO2 capture,and oxygen reduction electrocatalysts.展开更多
A new organo-directed titanium phosphate, [NH3CH2CH2NH3]·[TiO(HPO4)2], was synthesized by the solvothermal method and its structure was determined by single crystal X-ray diffraction. The structure consists of 1-...A new organo-directed titanium phosphate, [NH3CH2CH2NH3]·[TiO(HPO4)2], was synthesized by the solvothermal method and its structure was determined by single crystal X-ray diffraction. The structure consists of 1-D zigzag chains built up from trans-corner-sharing titanium oxo octahedra running along the b axis, with fused Ti2P three-membered rings being attached to the ( Ti ( O ( Ti ( O ( backbone.展开更多
BACKGROUND To examine the association of baseline waist circumference(WC)and changes in WC with cardiovascular disease(CVD)and all-cause mortality among elderly people.METHODS A total of 30,041 eligible participants w...BACKGROUND To examine the association of baseline waist circumference(WC)and changes in WC with cardiovascular disease(CVD)and all-cause mortality among elderly people.METHODS A total of 30,041 eligible participants were included from a retrospective cohort in China.The same questionnaire,anthropometric and laboratory measurements were performed at baseline(2010)and the first follow-up(2013).The percent change in WC between baseline and the first follow-up was calculated to evaluate three years change of WC.We collected the occurrence of CVD and all-cause death from the first follow-up to December 31,2018.Restricted cubic splines and Cox proportionalhazards regression models were used to evaluate the relationship between baseline WC/changes in WC and mortality.RESULTS The dose-response relationships between baseline WC and CVD mortality were U-or J-shaped.In low WC group,compared with stable group,the fully adjusted hazard ratio(aHR)for CVD mortality was 1.60(95%CI:1.24−2.06)in WC gain group among men.In normal WC group,the CVD mortality risk increased with WC gain(men:aHR=1.86,95%CI:1.36−2.56;women:aHR=1.83,95%CI:1.29−2.58).In moderate-high WC group,the CVD mortality risk increased with WC gain(men:aHR=1.76,95%CI:1.08−2.88;women:aHR=1.46,95%CI:1.04−2.05)and risk decreased with WC loss(men:aHR=0.54,95%CI:0.30−0.98;women:aHR=0.59,95%CI:0.37−0.96).CONCLUSIONS For the elderly population,WC gain may increase CVD mortality risk regardless of baseline WC,whereas WC reduction could decrease the risk only in the moderate-high WC group.展开更多
Alkaline water electrolysis is an environmentally friendly and promising approach to produce hydrogen.However,high cost,low efficiency,and poor stability are roadblocks to commercialization of electrocatalysts.This wo...Alkaline water electrolysis is an environmentally friendly and promising approach to produce hydrogen.However,high cost,low efficiency,and poor stability are roadblocks to commercialization of electrocatalysts.This work aims to design and develop a highly efficient,durable,and cost-effective electrocatalyst toward water splitting through modifying metal–organic frameworks.The electrocatalytic performance and stability surpass those of noble metal benchmarks at high current density(1–10 A·cm^(−2)).Theoretical calculations and in situ Raman spectra reveal the electronic structure of the synthesized catalyst and the mechanism of the catalytic reaction process,which rationalizes that the high catalytic activity and stability at high current are attributed to the unique electronic structure of cobalt regulated by copper and the protection provided by carbon nanotubes formed in situ,respectively.In addition,this paper proposes that the desorption ability of the catalyst toward the products(H_(2)and O_(2)),rather than the adsorption ability toward the reactants(H^(+)or OH^(−)),is more important to the sustainable and stable electrochemical water splitting progress at high current density,which is a kinetic rather than thermodynamic dominating process.The findings provide alternative insights to design and employ high performance catalysts to fuel hydrogen production as a clean energy source to tackle the global energy crisis.展开更多
The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 3...The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.展开更多
Developing acid/base-resistant and low-price microwave-absorbing materials with lighter weight is highly desired for practical applications in extreme environments.Herein,we demonstrate the successful synthesis of the...Developing acid/base-resistant and low-price microwave-absorbing materials with lighter weight is highly desired for practical applications in extreme environments.Herein,we demonstrate the successful synthesis of the N-doped porous carbon(NC)material with hierarchical pore structure by the spray pyrolysis method.The large specific surface area(SBET=707.53 m^(2)·g^(−1))of materials enables multiple scattering of incident electromagnetic waves,and N doping greatly enhances the electrical conductivity of the material.Notably,single-atom Zn can adjust the local electronic structure of adjacent sites such as carbon and nitrogen atoms,induce the center of polarization,and thus change the dielectric and electronic properties of the host material.The porous carbon coating of single-atom Zn avoids the deterioration of electromagnetic parameters caused by the accumulation of magnetic particles under high-temperature pyrolysis.At the same time,they can also be used in various complex environments,such as acidic and basic environments.Ultimately,NC-1000,with high surface area,low density,and good chemical stability,obtained a minimum reflection loss(RLmin)of−50.5 dB and an effective absorption bandwidth(EAB)exceeding 5.1 GHz at the thickness of 1.9 mm.After soaking in the strong acid and base solution,the electromagnetic wave absorption performance of the material decreased by<15%.Widely available raw materials and a simple preparation scheme are expected to expedite industrial mass production for this novel type of materials.展开更多
Metal-organic frameworks(MOFs)have shown significant potential as photocatalysts.It has been widely assumed that all catalytic active sites within MOFs are functional in photocatalytic reactions but for a three-dimens...Metal-organic frameworks(MOFs)have shown significant potential as photocatalysts.It has been widely assumed that all catalytic active sites within MOFs are functional in photocatalytic reactions but for a three-dimensional MOF,whether the internal catalytic active sites can effectively absorb light and actively contribute to photocatalytic reactions remains to be explored.In this context,we synthesized a two-dimensional nanosheet MOF(2D-MOF)and a three-dimensional bulk MOF(3D-MOF)composed of Zr^(6) clusters and tetracarboxylic porphyrin(TCPP)by the approach described in the literature.Re(bpy)(CO)^(3)Cl(bpy=2,2’-bipyridine),which has remarkable CO_(2) photoreduction ability,was introduced to the two MOFs to create two new photocatalysts 2D-MOF-Re and 3D-MOF-Re,respectively.Photocatalytic CO_(2) reduction experiments show that based on the equal number of catalytic active sites,the CO turnover number(TON)of 2D-MOF-Re reaches 27.8 in 6 h,which is 50 times that of 3D-MOF-Re.The result shows that certain catalytic active sites inside the bulk MOF are inactive due to the inability to absorb light.This study illuminates the potential of the dimensional reduction approach in the design of photocatalysts to exploit the capabilities fully.展开更多
The classical Ray-Knight theorems for the Brownian motion determine the law of its local time process either at the first hitting time of a given value a by the local time at the origin,or at the first hitting time of...The classical Ray-Knight theorems for the Brownian motion determine the law of its local time process either at the first hitting time of a given value a by the local time at the origin,or at the first hitting time of a given position b by the Brownian motion.We extend these results by describing the local time process jointly for all a and b,by means of the stochastic integral with respect to an appropriate white noise.Our result applies toμ-processes,and has an immediate application:aμ-process is the height process of a Feller continuous-state branching process(CSBP)with immigration(Lambert(2002)),whereas a Feller CSBP with immigration satisfies a stochastic differential equation(SDE)driven by a white noise(Dawson and Li(2012));our result gives an explicit relation between these two descriptions and shows that the SDE in question is a reformulation of Tanaka’s formula.展开更多
Background:Hepatocellular carcinoma(HCC)persists as a dominant cause of cancer-related mortality globally,with a notably rapid escalation in mortality rates.The advent of immunotherapy,particularly immune checkpoint i...Background:Hepatocellular carcinoma(HCC)persists as a dominant cause of cancer-related mortality globally,with a notably rapid escalation in mortality rates.The advent of immunotherapy,particularly immune checkpoint inhibitors(ICIs),has ushered in a new era in the management of liver cancer,albeit with unresolved challenges in the context of treatment beyond progression(TBP)and stratified prognosis in diverse populations.This study aimed to develop and validate a novel nomogram model to identify factors that predict the benefit of continued immunotherapy for hepatocellular carcinoma patients following disease progression in clinical practice.Methods:This study retrospectively analyzed the efficacy of ICIs in TBP,focusing on the Chinese population with advanced liver cancer.A nomogram was constructed based on four independent risk factors identified through Cox multivariate analysis,aiming to predict patient prognosis post-ICI treatment.The model was validated through receiver operating characteristic(ROC)curve analysis and categorized patients into high-,intermediate-,and low-risk groups,with further validation using calibration plots and decision curve analysis(DCA).Results:The low-risk group demonstrated significantly enhanced overall survival(OS)compared to the high-risk group,with the nomogram predictions aligning closely with actual outcomes for 6-and 9-month OS.The model exhibited commendable predictive accuracy,achieving a C-index exceeding 0.7 in both training and validation datasets.The DCA underscored the clinical utility of the nomogram-based prognostic model,further substantiated by the area under the ROC curve(AUC).Conclusions:The developed nomogram presents a potentially valuable tool for predicting the prognosis of HCC patients undergoing ICI therapy beyond progression,particularly within the Chinese demographic.However,the study is constrained by its retrospective,single-center nature and necessitates further validation through large-scale,multicenter clinical studies across varied populations.展开更多
Manganese-based cathode materials are promising candidates for aqueous zinc ion batteries(AZIBs)by reason of their low cost and high energy density.However,their practical applicability is hampered by the intrinsic de...Manganese-based cathode materials are promising candidates for aqueous zinc ion batteries(AZIBs)by reason of their low cost and high energy density.However,their practical applicability is hampered by the intrinsic defects of poor electrical conductivity,sluggish reaction kinetics,and severe structural deterioration.Herein,we constructed a hierarchically porous structure composed of carbon-encapsulated Mn O nanoparticles(MOC)and three-dimensional(3D)nitrogen-doped graphene aerogel(NGA)(denoted as MOC@NGA).The hybrid was synthesized by a facile in-situ coprecipitation and annealing of manganesebased metal-organic framework(Mn-MOF74)and NGA composite(Mn-MOF74@NGA).Specifically,the carbon shells inherited from organic ligand of Mn-MOF74 could restrain the volume changes of Mn O,and the porous NGA prevented the agglomeration of MOC nanoparticles and enriched the types of interfacial chemical bonds.Profiting from the synergistic effect of rich interface chemical bonds and dual-carbon protection,the MOC@NGA hybrids exhibit fast interfacial electron/charge transfer and transport,and outstanding structural stability.Therefore,MOC@NGA cathode delivers an excellent rate performance(270 and 99.8 m Ah g^(-1)at 0.1 and 2.0 A g^(-1))and maintains an excellent specific capacity of 151.6 m Ah g^(-1)after 2,000cycles at 1.0 A g^(-1).Moreover,the fabricated MOC@NGA-based quasi-solid-state battery not only achieves outstanding flexibility but also displays impressive cycling stability,demonstrating a promising potential for portable and flexible equipment.This work provides a feasible strategy for the fabrication of the bridging structure of manganese-based oxides and porous carbon matrix for high-specific capacity and durable AZIBs cathodes.展开更多
MEMS resonators exhibit rich dynamic behaviors under the internal resonance regime. In this work, we present a novel MEMS bifurcation sensor that exploits frequency unlocking due to a 1:3 internal resonance between tw...MEMS resonators exhibit rich dynamic behaviors under the internal resonance regime. In this work, we present a novel MEMS bifurcation sensor that exploits frequency unlocking due to a 1:3 internal resonance between two electrostatically coupled micro-resonators. The proposed detection mechanism allows the sensor to operate in binary (digital) and analog modes, depending on whether the sensor merely detects a significant jump event in the peak frequency upon unlocking or measures the shift in the peak frequency after unlocking and uses it in conjunction with a calibration curve to estimate the corresponding change in stimulus. We validate the success of this sensor paradigm by experimentally demonstrating charge detection. High charge resolutions are achieved in binary mode, up to 0.137 fC, and in analog mode, up to 0.01 fC. The proposed binary sensor enables extraordinarily high detection resolutions due to the excellent frequency stability under internal resonance and the high signal-to-noise ratio of the shift in peak frequency. Our findings offer new opportunities for high-performance ultrasensitive sensors.展开更多
基金supported by China Southern Power Grid Technology Project under Grant 03600KK52220019(GDKJXM20220253).
文摘The convergence of Internet of Things(IoT),5G,and cloud collaboration offers tailored solutions to the rigorous demands of multi-flow integrated energy aggregation dispatch data processing.While generative adversarial networks(GANs)are instrumental in resource scheduling,their application in this domain is impeded by challenges such as convergence speed,inferior optimality searching capability,and the inability to learn from failed decision making feedbacks.Therefore,a cloud-edge collaborative federated GAN-based communication and computing resource scheduling algorithm with long-term constraint violation sensitiveness is proposed to address these challenges.The proposed algorithm facilitates real-time,energy-efficient data processing by optimizing transmission power control,data migration,and computing resource allocation.It employs federated learning for global parameter aggregation to enhance GAN parameter updating and dynamically adjusts GAN learning rates and global aggregation weights based on energy consumption constraint violations.Simulation results indicate that the proposed algorithm effectively reduces data processing latency,energy consumption,and convergence time.
基金financially supported by the National Natural Science Foundation of China (21771084, 21771077, 21621001)the Foundation of Science and Technology Development of Jilin Province,China (20200801004GH)+1 种基金the 111 Project (B17020)financial support by the program for JLU Science and Technology Innovative Research Team (JLUSTIRT)。
文摘The designing of reasonable nanocomposite materials and proper introduction of defect engineering are of great significance for the improvement of the poor electronic conductivity and slow reaction kinetics of manganese-based compounds. Herein, we report manganese-deficient Mn_(3)O_(4) nanoparticles which grow in-situ on highly conductive carbon nanotubes(CNTs)(denoted as DMOC) as an advanced cathode material for aqueous rechargeable zinc-ion batteries(RAZIBs). According to experimental and calculation results, the DMOC cathode integrates the advantages of enriched Mn defects and small particle size. These features not only enhance electronic conductivity but also create more active site and contribute to fast reaction kinetics. Moreover, the structure of DMOC is maintained during the charging and discharging process, thus benefiting for excellent cycle stability. As a result, the DMOC electrode delivers a high specific capacity of 420.6 m A h g^(-1) at 0.1 A g^(-1) and an excellent cycle life of 2800 cycles at 2.0 A g^(-1) with a high-capacity retention of 84.1%. In addition, the soft-packaged battery assembled with DMOC cathode exhibits long cycle life and high energy density of 146.3 Wh kg^(-1) at 1.0 A g^(-1) . The results are beneficial for the development of Zn/Mn_(3)O_(4) battery for practical energy storage.
基金supported in part by the National Natural Science Foundation of China(61473070,61433004,61627809)SAPI Fundamental Research Funds(2018ZCX22)
文摘This paper presents a new design approach to achieve decentralized optimal control of high-dimension complex singular systems with dynamic uncertainties. Based on robust adaptive dynamic programming(robust ADP) method, controllers for solving the singular systems optimal control problem are designed. The proposed algorithm can work well when the system model is not exactly known but the input and output data can be measured. The policy iteration of each controller only uses their own states and input information for learning,and do not need to know the whole system dynamics. Simulation results on the New England 10-machine 39-bus test system show the effectiveness of the designed controller.
基金supported by National Key Research and Development Programme of China(2017YFC1307705&2016YFC0106907)the Science and Technology Development Programme of Henan(No.201403007)。
文摘Background Implementing the current guidelines for leisure-time physical activity(LTPA)provides significant health benefits,especially for middle-aged adults,but it is unclear whether LTPA also translates into cardiovascular health benefits among elderly people.Therefore,we aimed to assess the association of LTPA with the risks of cardiovascular disease(CVD),including coronary heart disease(CHD)and stroke,and all-cause mortality in an elderly population.Methods In this prospective cohort study,32,942 participants aged 60 years or older who participated in a health check-up programme in China between 2010 and 2018 were included.We evaluated the morbidity and mortality risks through the Cox regression model,competing risk model and restricted cubic spline model.Results During a median of 6.84 years of follow-up,there were 6,857 elderly people with incident CVD;a total of 6,324 deaths occurred due to all causes and 2,060 deaths occurred due to CVD.Compared with the inactive group,reductions in CVD morbidity and mortality were observed,with hazard ratios(HRs)of 0.89(95%CI:0.83–0.96)and 0.81(95%CI:0.71–0.92)in the insufficiently active group,0.86(95%CI:0.80–0.92)and 0.79(95%CI:0.69–0.90)in the sufficiently active group,and 0.79(95%CI:0.70–0.89)and 0.58(95%CI:0.45–0.76)in the highly active group,respectively;but no significant reductions were observed in the very highly active group,with HRs of 0.87(95%CI:0.71–1.06)and 0.99(95%CI:0.70–1.40),respectively.Compared with the inactive group,reductions in all-cause mortality were also observed,with a HR of 0.90(95%CI:0.84–0.97)in the insufficiently active group,0.82(95%CI:0.77–0.89)in the sufficiently active group,0.77(95%CI:0.67–0.87)in the highly active group,and 0.80(95%CI:0.64–0.98)in the very highly active group.A restricted cubic spline diagram showed that there was an L-shaped association between LTPA and the risk of all-cause mortality but a U-shaped or reverse J-shaped relationship between LTPA and the risk of CVD morbidity and mortality,especially stroke.In addition,a subgroup analysis showed that elderly population who consistently performed LTPA for ten years or more had a lower risk of morbidity and mortality.Conclusions In an elderly population,even insufficient activity is associated with a decreased risk of all-cause mortality and CVD,and moderate levels of LTPA may be optimal for CVD prevention.In addition,elderly people who consistently perform LTPA over several years may experience greater health benefits.
基金supported by the National Natural Science Foundation of China(21676039)Innovative talents in Liaoning universities and colleges(LR2017045)the Opening Foundation of State Key Laboratory of Inorganic Synthesis and Preparative Chemistry of Jilin University(2016–04)~~
文摘Persulfate decontamination technologies utilizing radical‐driven processes are powerful tools for the treatment of a broad range of impurities.However,the design of high‐performance catalytic activators with multi‐functionality remains a great challenge.Therefore,in this study,three‐dimensional multifunctional FexOy/N‐GN/CNTs(N‐GN:nitrogen‐doped graphene,CNTs:carbon nanotubes)heterojunctions,which can be employed as microwave absorbers and catalysts,were synthesized via a solvothermal method and applied to activate peroxymonosulfate for the degradation of methylene blue(MB).X‐ray diffraction(XRD),Fourier transform infrared spectrometer(FTIR),scanning electron microscope(SEM),and X‐ray photoelectron microscopy(XPS)analyses revealed that the FexOy were anchored in‐situ onto the N‐GN network.Using MB as the model organic dye,various factors,such as degradation systems,PMS loading,initial organic pollutant concentration,and catalyst dosage were optimized.The results revealed that the remarkable efficiency was attributable to the synergistic effects of carbon,nitrogen,and iron‐based species.The oxidation system corresponded to the pseudo‐first‐order kinetic with a k value of^0.33 min^-1.It was demonstrated that both SO4^-and OH^-were the predominant reactive species through quenching experiments.Because these heterojunctions were employed as microwave absorbers and have a semiconductor‐like texture,the Fe/N co‐rich hierarchical porous carbon skeleton favored electron transport and storage.These heterojunctions increase the options for transitional metal catalysts and highlights the importance of designing other heterojunctions for specific applications,such as supercapacitors,energy storage,CO2 capture,and oxygen reduction electrocatalysts.
文摘A new organo-directed titanium phosphate, [NH3CH2CH2NH3]·[TiO(HPO4)2], was synthesized by the solvothermal method and its structure was determined by single crystal X-ray diffraction. The structure consists of 1-D zigzag chains built up from trans-corner-sharing titanium oxo octahedra running along the b axis, with fused Ti2P three-membered rings being attached to the ( Ti ( O ( Ti ( O ( backbone.
基金supported by the National Key Research and Development Programme of China(2017YFC1307705&2016YFC0106907)the Science and Technology Development Programme of Henan(No.201403007).
文摘BACKGROUND To examine the association of baseline waist circumference(WC)and changes in WC with cardiovascular disease(CVD)and all-cause mortality among elderly people.METHODS A total of 30,041 eligible participants were included from a retrospective cohort in China.The same questionnaire,anthropometric and laboratory measurements were performed at baseline(2010)and the first follow-up(2013).The percent change in WC between baseline and the first follow-up was calculated to evaluate three years change of WC.We collected the occurrence of CVD and all-cause death from the first follow-up to December 31,2018.Restricted cubic splines and Cox proportionalhazards regression models were used to evaluate the relationship between baseline WC/changes in WC and mortality.RESULTS The dose-response relationships between baseline WC and CVD mortality were U-or J-shaped.In low WC group,compared with stable group,the fully adjusted hazard ratio(aHR)for CVD mortality was 1.60(95%CI:1.24−2.06)in WC gain group among men.In normal WC group,the CVD mortality risk increased with WC gain(men:aHR=1.86,95%CI:1.36−2.56;women:aHR=1.83,95%CI:1.29−2.58).In moderate-high WC group,the CVD mortality risk increased with WC gain(men:aHR=1.76,95%CI:1.08−2.88;women:aHR=1.46,95%CI:1.04−2.05)and risk decreased with WC loss(men:aHR=0.54,95%CI:0.30−0.98;women:aHR=0.59,95%CI:0.37−0.96).CONCLUSIONS For the elderly population,WC gain may increase CVD mortality risk regardless of baseline WC,whereas WC reduction could decrease the risk only in the moderate-high WC group.
基金support by the program for JLU Science and Technology Innovative Research Team(JLUSTIRT).
文摘Alkaline water electrolysis is an environmentally friendly and promising approach to produce hydrogen.However,high cost,low efficiency,and poor stability are roadblocks to commercialization of electrocatalysts.This work aims to design and develop a highly efficient,durable,and cost-effective electrocatalyst toward water splitting through modifying metal–organic frameworks.The electrocatalytic performance and stability surpass those of noble metal benchmarks at high current density(1–10 A·cm^(−2)).Theoretical calculations and in situ Raman spectra reveal the electronic structure of the synthesized catalyst and the mechanism of the catalytic reaction process,which rationalizes that the high catalytic activity and stability at high current are attributed to the unique electronic structure of cobalt regulated by copper and the protection provided by carbon nanotubes formed in situ,respectively.In addition,this paper proposes that the desorption ability of the catalyst toward the products(H_(2)and O_(2)),rather than the adsorption ability toward the reactants(H^(+)or OH^(−)),is more important to the sustainable and stable electrochemical water splitting progress at high current density,which is a kinetic rather than thermodynamic dominating process.The findings provide alternative insights to design and employ high performance catalysts to fuel hydrogen production as a clean energy source to tackle the global energy crisis.
基金support from diverse funding sources,including the National Key Program for S&T Research and Development of the Ministry of Science and Technology(MOST),Yifang Wang's Science Studio of the Ten Thousand Talents Project,the CAS Key Foreign Cooperation Grant,the National Natural Science Foundation of China(NSFC)Beijing Municipal Science&Technology Commission,the CAS Focused Science Grant,the IHEP Innovation Grant,the CAS Lead Special Training Programthe CAS Center for Excellence in Particle Physics,the CAS International Partnership Program,and the CAS/SAFEA International Partnership Program for Creative Research Teams.
文摘The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.
基金B.X.thanks financial support from the National Natural Science Foundation of China(No.21801133)the Jiangsu Specially Appointed Professorship and Innovation and Entrepreneurship Talents in Jiangsu Province,the State Key Laboratory of Coordination Chemistry,the School of Chemistry and Chemical Engineering,and Collaborative Innovation Center of Advanced Microstructures,Nanjing University.
文摘Developing acid/base-resistant and low-price microwave-absorbing materials with lighter weight is highly desired for practical applications in extreme environments.Herein,we demonstrate the successful synthesis of the N-doped porous carbon(NC)material with hierarchical pore structure by the spray pyrolysis method.The large specific surface area(SBET=707.53 m^(2)·g^(−1))of materials enables multiple scattering of incident electromagnetic waves,and N doping greatly enhances the electrical conductivity of the material.Notably,single-atom Zn can adjust the local electronic structure of adjacent sites such as carbon and nitrogen atoms,induce the center of polarization,and thus change the dielectric and electronic properties of the host material.The porous carbon coating of single-atom Zn avoids the deterioration of electromagnetic parameters caused by the accumulation of magnetic particles under high-temperature pyrolysis.At the same time,they can also be used in various complex environments,such as acidic and basic environments.Ultimately,NC-1000,with high surface area,low density,and good chemical stability,obtained a minimum reflection loss(RLmin)of−50.5 dB and an effective absorption bandwidth(EAB)exceeding 5.1 GHz at the thickness of 1.9 mm.After soaking in the strong acid and base solution,the electromagnetic wave absorption performance of the material decreased by<15%.Widely available raw materials and a simple preparation scheme are expected to expedite industrial mass production for this novel type of materials.
文摘Metal-organic frameworks(MOFs)have shown significant potential as photocatalysts.It has been widely assumed that all catalytic active sites within MOFs are functional in photocatalytic reactions but for a three-dimensional MOF,whether the internal catalytic active sites can effectively absorb light and actively contribute to photocatalytic reactions remains to be explored.In this context,we synthesized a two-dimensional nanosheet MOF(2D-MOF)and a three-dimensional bulk MOF(3D-MOF)composed of Zr^(6) clusters and tetracarboxylic porphyrin(TCPP)by the approach described in the literature.Re(bpy)(CO)^(3)Cl(bpy=2,2’-bipyridine),which has remarkable CO_(2) photoreduction ability,was introduced to the two MOFs to create two new photocatalysts 2D-MOF-Re and 3D-MOF-Re,respectively.Photocatalytic CO_(2) reduction experiments show that based on the equal number of catalytic active sites,the CO turnover number(TON)of 2D-MOF-Re reaches 27.8 in 6 h,which is 50 times that of 3D-MOF-Re.The result shows that certain catalytic active sites inside the bulk MOF are inactive due to the inability to absorb light.This study illuminates the potential of the dimensional reduction approach in the design of photocatalysts to exploit the capabilities fully.
文摘The classical Ray-Knight theorems for the Brownian motion determine the law of its local time process either at the first hitting time of a given value a by the local time at the origin,or at the first hitting time of a given position b by the Brownian motion.We extend these results by describing the local time process jointly for all a and b,by means of the stochastic integral with respect to an appropriate white noise.Our result applies toμ-processes,and has an immediate application:aμ-process is the height process of a Feller continuous-state branching process(CSBP)with immigration(Lambert(2002)),whereas a Feller CSBP with immigration satisfies a stochastic differential equation(SDE)driven by a white noise(Dawson and Li(2012));our result gives an explicit relation between these two descriptions and shows that the SDE in question is a reformulation of Tanaka’s formula.
基金supported by the Jiangsu Provincial Graduate Student Practice Innovation Project(No.JX22013930)the Internal Research Fund Project of Jinling Hospital Affiliated to Nanjing Medical University(No.22LCZLXJS21)the Internal Research Fund Project of Jinling Hospital Affiliated to Nanjing Medical University(No.22LCYY-LH5).
文摘Background:Hepatocellular carcinoma(HCC)persists as a dominant cause of cancer-related mortality globally,with a notably rapid escalation in mortality rates.The advent of immunotherapy,particularly immune checkpoint inhibitors(ICIs),has ushered in a new era in the management of liver cancer,albeit with unresolved challenges in the context of treatment beyond progression(TBP)and stratified prognosis in diverse populations.This study aimed to develop and validate a novel nomogram model to identify factors that predict the benefit of continued immunotherapy for hepatocellular carcinoma patients following disease progression in clinical practice.Methods:This study retrospectively analyzed the efficacy of ICIs in TBP,focusing on the Chinese population with advanced liver cancer.A nomogram was constructed based on four independent risk factors identified through Cox multivariate analysis,aiming to predict patient prognosis post-ICI treatment.The model was validated through receiver operating characteristic(ROC)curve analysis and categorized patients into high-,intermediate-,and low-risk groups,with further validation using calibration plots and decision curve analysis(DCA).Results:The low-risk group demonstrated significantly enhanced overall survival(OS)compared to the high-risk group,with the nomogram predictions aligning closely with actual outcomes for 6-and 9-month OS.The model exhibited commendable predictive accuracy,achieving a C-index exceeding 0.7 in both training and validation datasets.The DCA underscored the clinical utility of the nomogram-based prognostic model,further substantiated by the area under the ROC curve(AUC).Conclusions:The developed nomogram presents a potentially valuable tool for predicting the prognosis of HCC patients undergoing ICI therapy beyond progression,particularly within the Chinese demographic.However,the study is constrained by its retrospective,single-center nature and necessitates further validation through large-scale,multicenter clinical studies across varied populations.
基金supported by the National Natural Science Foundation of China(22271114,21621001)the Foundation of Science and Technology Development of Jilin Province,China(20200801004GH)+1 种基金111 Project(B17020)the financial support by the program for JLU Science and Technology Innovative Research Team(JLUSTIRT)。
文摘Manganese-based cathode materials are promising candidates for aqueous zinc ion batteries(AZIBs)by reason of their low cost and high energy density.However,their practical applicability is hampered by the intrinsic defects of poor electrical conductivity,sluggish reaction kinetics,and severe structural deterioration.Herein,we constructed a hierarchically porous structure composed of carbon-encapsulated Mn O nanoparticles(MOC)and three-dimensional(3D)nitrogen-doped graphene aerogel(NGA)(denoted as MOC@NGA).The hybrid was synthesized by a facile in-situ coprecipitation and annealing of manganesebased metal-organic framework(Mn-MOF74)and NGA composite(Mn-MOF74@NGA).Specifically,the carbon shells inherited from organic ligand of Mn-MOF74 could restrain the volume changes of Mn O,and the porous NGA prevented the agglomeration of MOC nanoparticles and enriched the types of interfacial chemical bonds.Profiting from the synergistic effect of rich interface chemical bonds and dual-carbon protection,the MOC@NGA hybrids exhibit fast interfacial electron/charge transfer and transport,and outstanding structural stability.Therefore,MOC@NGA cathode delivers an excellent rate performance(270 and 99.8 m Ah g^(-1)at 0.1 and 2.0 A g^(-1))and maintains an excellent specific capacity of 151.6 m Ah g^(-1)after 2,000cycles at 1.0 A g^(-1).Moreover,the fabricated MOC@NGA-based quasi-solid-state battery not only achieves outstanding flexibility but also displays impressive cycling stability,demonstrating a promising potential for portable and flexible equipment.This work provides a feasible strategy for the fabrication of the bridging structure of manganese-based oxides and porous carbon matrix for high-specific capacity and durable AZIBs cathodes.
基金The authors gratefully acknowledge the support of the National Natural Science Foundation of China(12032015,12102250,12202263)the Science and Technology Innovation Action Plan of Shanghai(21190760100)+1 种基金the Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-02-E00030)the China Postdoctoral Science Foundation(2021TQ0201,2022M712069).
文摘MEMS resonators exhibit rich dynamic behaviors under the internal resonance regime. In this work, we present a novel MEMS bifurcation sensor that exploits frequency unlocking due to a 1:3 internal resonance between two electrostatically coupled micro-resonators. The proposed detection mechanism allows the sensor to operate in binary (digital) and analog modes, depending on whether the sensor merely detects a significant jump event in the peak frequency upon unlocking or measures the shift in the peak frequency after unlocking and uses it in conjunction with a calibration curve to estimate the corresponding change in stimulus. We validate the success of this sensor paradigm by experimentally demonstrating charge detection. High charge resolutions are achieved in binary mode, up to 0.137 fC, and in analog mode, up to 0.01 fC. The proposed binary sensor enables extraordinarily high detection resolutions due to the excellent frequency stability under internal resonance and the high signal-to-noise ratio of the shift in peak frequency. Our findings offer new opportunities for high-performance ultrasensitive sensors.
