针药并用治疗视神经萎缩疗效观察

目的观察针药并用治疗视神经萎缩的临床疗效。方法 64例视神经萎缩患者88只眼,随机分为治疗组(33例46只眼)和药物组(31例42只眼)。药物组予以口服复方银杏胶囊、甲钴胺治疗,治疗组在药物组治疗的基础上联合针刺治疗。观察两组治疗前后视野MD值和视觉诱发电位(P-VEP)值变化,并比较两组临床疗效。结果治疗组总有效率为87.0%,对照组为59.5%,两组比较差异有统计学意义(P<0.05)。两组治疗后视野MD值和P-VEP值与治疗前比较,差异有统计学意义(P<0.05)。两组治疗后视野MD值和P-VEP值比较,差异有统计学意义(P<0.05)。结论针药并用可以改善视神经萎缩患者的视野和视觉诱发电位,效果显著。

电针治疗气阴两虚型干眼症的疗效观察

目的:观察电针治疗对气阴两虚型干眼症患者的影响。方法:将60例该型患者随机分为治疗组和对照组各30例,治疗组采用电针治疗,对照组采用人工泪液治疗,观察各组治疗前后基础泪液分泌试验、泪膜破裂时间、眼部症状评分及中医证候评分的变化情况并比较2组临床疗效。结果:治疗组治疗后基础泪液分泌试验左眼和右眼均显著高于对照组(P<0.01),治疗组泪膜破裂时间左眼和右眼也显著高于对照组(P<0.01)。治疗组治疗后眼部症状评分低于对照组,差异有统计学意义(P<0.05);治疗组总有效率86.7%,对照组13.3%,2组总有效率比较差异有统计学意义(P<0.05)。结论:电针治疗气阴两虚型干眼症可以促进泪液分泌并改善泪膜稳定性,缓解患者眼部干涩感、异物感、视疲劳等不适症状。

天津地铁车站基坑支撑体系机械拆除施工技术

本文以天津地铁某车站工程为依托,在基坑开挖完成进行主体结构施工时,需从下到上逐层对混凝土支撑进行拆除。本文着重对混凝土支撑体系机械拆除的具体操作方法进行阐述,为类似工程提供参考。

基于三维伪连续脉冲动脉自旋标记技术探讨脊柱手法治疗眩晕症的临床研究

目的:筛选适合中医脊柱手法治疗的眩晕症患者。方法:收集存在脊柱“骨错缝、筋出槽”的眩晕患者78例,磁共振扫描并应用三维伪连续脉冲动脉自旋标记(3D-pcASL)技术进行筛选,双侧大脑半球存在灌注峰值不同步者列为观察组,灌注峰值同步者列为对照组,对两组患者应用脊柱手法治疗,应用眩晕障碍量表(DHI)评估眩晕改善状况,再次磁共振3D-pcASL成像扫描观察灌注情况。结果:78例眩晕症患者中观察组患者数为47例,占60.26%,眩晕症状改善有效率为85.11%(40/47);对照组患者数为31例,占39.74%,眩晕症状改善有效率为45.16%(14/31)。观察组总有效率显著高于对照组(P<0.01)。治疗后,观察组灌注峰值同步数为37例,对照组为29例。观察组和对照组治疗前后DHI评分差值分别为(37.53±13.96)、(10.65±8.33)分,差异有统计学意义(P<0.05)。结论:磁共振3D-pcASL成像是评估双侧大脑灌注是否均衡的有效手段;同时存在“骨错缝、筋出槽”和双侧大脑灌注失衡眩晕患者适宜脊柱手法治疗且疗效较好。

逍遥散对慢性束缚应激大肠癌裸鼠肠道菌群代谢产物的影响

目的:探讨逍遥散对慢性束缚应激(CRS)大肠癌裸鼠肠道菌群代谢产物的影响。方法:40只SPF级雄性BALB/c裸鼠随机分为正常组、模型组、逍遥散组、氟西汀组,每组10只。除正常组外,其余3组裸鼠均接受CRS造模,持续2周。CRS造模结束后1周,4组裸鼠全部皮下注射HCT116细胞,建立CRS大肠癌皮下移植瘤模型,逍遥散组和氟西汀组分别给予逍遥散和氟西汀干预。灌胃3周后,无菌条件下收集4组裸鼠粪便,采用LC-MS技术检测肠道菌群代谢产物的种类和含量。结果:4组间共检测出差异代谢物20种,与正常组比较,模型组裸鼠肠道菌群代谢产物中LysoPE(15∶0/0∶0)、PE(16∶0/0∶0)、Oleamide、DL-Phenylalanine和2-Hydroxyphenethylamine的含量均显著减少(P<0.01,P<0.05);与模型组比较,逍遥散组和氟西汀组裸鼠肠道菌群代谢产物中LysoPE(15∶0/0∶0)、PE(16∶0/0∶0)和Oleamide含量均显著增加(P<0.01,P<0.05)。结论:逍遥散可能通过增加肠道菌群代谢产物中LysoPE(15∶0/0∶0)、PE(16∶0/0∶0)和Oleamide含量,从而达到改善CRS裸鼠抑郁状态和抑制CRS大肠癌皮下移植瘤生长的作用。

rherapeutic efficacy observation on acupuncture for persistent allergic rhinitis

Objective： To observe the clinical effect of acupuncture for persistent allergic rhinitis （PAR）. Methods： A total of 154 PAR patients were randomized into a treatment group and a control group, 78 cases in the treatment group received acupuncture at meridian points, while 76 cases in the control group received acupuncture at non-meridian points. The treatment was done every other day, 3 times a week for a total 4 weeks. The total nasal symptom score （TNSS）, the total non-nasal symptom score （TNNSS） and the rhinoconjunctivitis quality of life questionnaire （RO, LQ） were measured before the treatment and after 2 weeks and 4 weeks of treatment, as well as 1 month and 3 months after the treatment to compare the clinical effect between the two groups. Results： After 4 weeks of treatment, the total effective rate in the treatment group was 92.3%, versus 76.3% in the control group, showing a statistically significant difference （P〈0.05）. Intra-group comparisons of TNSS, TNNSS and R0.L0. scores after 4 weeks of treatment showed statistically significant differences （all P〈0.05）. Between-group comparisons of TNSS, TNNSS and RQLQ score after 4 weeks of treatment and in follow-up visits showed statistically significant differences （all P〈0.05）. Conclusion： Acupuncture is effective for PAR, and acupuncture at meridian points can produce a better effect than acupuncture at non-meridian points.

Warm needling moxibustion plus functional exercises for knee osteoarthritis

Objective： To observe the clinical efficacy of warm needling moxibustion plus functional exercises in treating knee osteoarthritis（KOA）. Methods： Totally 108 eligible KOA patients were intervened by warm needling moxibustion plus functional exercises. The warm needling moxibustion was given 3 times a week, successively for 4 weeks. The visual analogue scale（VAS） was adopted to evaluate the pain intensity of the knee joint. After 4-week treatment, the change of VAS score, range of motion（ROM） of knee, and Lysholm score were observed, and the clinical efficacy was also estimated. Results： After treatment, the VAS score dropped obviously, and the ROM and Lysholm score increased markedly; the total effective rate was 83.3%. Conclusion： Warm needling moxibustion plus functional exercises is effective in treating KOA, as it can relieve the knee joint pain and improve the joint motion.

Umbilicus application with Chinese medicine for chronic diarrhea due to food intolerance in kids:a multicenter randomized trial

Objective： To observe the clinical efficacy of umbilicus application with Chinese medicine in treating children＇s chronic diarrhea due to food intolerance and the value of healthy diet education. Methods： Eighty kids with chronic diarrhea due to food intolerance were recruited from multiple centers and divided by using the random number table into a treatment group of 40 cases and a control group of 40 cases. For both groups, based on the level of serum food-specific immunoglobulin G（Ig-G）, the patients were given unified diet following the healthy diet guidance： safe, alternate, and forbidden, while the treatment group was additionally given umbilicus application with Chinese medicine. The therapeutic efficacy and symptom score of traditional Chinese medicine（TCM） were observed and compared respectively after 1-week, 2-week, 4-week, and 12-week treatment. Results： The diarrhea symptoms and coupled symptoms scores dropped significantly in the two groups after treatment（ all P〈0.05）, and the inter-group comparisons also showed statistical significances（P〈0.05）. The total effective rate was 97.5% in the treatment group versus 77.5% in the control group, and the inter-group difference was statistically significant（P〈0.05）. Conclusion： The healthy diet guidance based on the food intolerance test is effective in helping treat diarrhea, while umbilicus application with Chinese medicine works better in treating diarrhea for kids with chronic diarrhea due to food intolerance and can significantly enhance the therapeutic efficacy.

Clinical observation on warm needling moxibustion for erectile dysfunction

Objective： To observe the therapeutic effect of warm needling moxibustion for erectile dysfunction （ED）. Methods： A total of 46 eligible ED patients were randomized into a treatment group （n=24） and a control group （n=22）. The treatment group was intervened by warm needling moxibustion while the control group by conventional acupuncture treatment, for a total of 4 courses. The therapeutic effect was evaluated by the international index of erectile function 5 （IIEF-5）. Results： After 4 courses of treatment, the overall effective rate was 91.3% in the treatment group （23 completed）, versus 75.0% in the control group （20 completed）, with a significant difference （P〈0.05）. After the treatment, the change of IIEF-5 score in the treatment group was significantly different from that in the control group （P〈0.05）. Conclusion： Warm needling moxibustion can produce a more significant efficacy than conventional acupuncture in the treatment of ED.

Clinical progress on moxibustion in preventing and treating adverse effects of surgery or chemoradiotherapy for breast cancer

Breast cancer has the highest incidence rate among all women＇s malignant tumors worldwide.Surgery,radiotherapy and chemotherapy are three major treatments,while most patients showed adverse effects or complications during or after the treatment,including lymphedema,gastrointestinal reactions and leukopenia,which cause severe impact on patients＇ recovery and quality of life.Moxibustion has been used and certified to alleviate adverse effects of surgery or chemoradiotherapy for breast cancer.We have summarized literatures in recent years and suggest more systematic research in the future for the underlying mechanism.

Clinical study of optimizing acupoint combining in treatment of bronchial asthma with acupoint application

Objective:To observe the therapeutic efficacy of acupoint application at different groups of acupoints in treating bronchial asthma in remission stage.Methods:A total of 120 patients with bronchial asthma in remission stage were recruited and divided by the random number table method into acupoint application group 1,acupoint application group 2 and acupoint application group 3,with 40 cases in each group.In all the three groups,Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)were selected,with Dingchuan(EX-B 1)added in acupoint application group 1,Shenshu(BL 23)added in acupoint application group 2,and Gaohuang(BL 43)added in acupoint application group 3.Before intervention,one month and 3 months after intervention,clinical symptoms,peak expiratory flow(PEF)and forced expiratory volume in 1 second percentage of predicted value(FEV1%)of the three groups were observed,and their clinical efficacies were evaluated.Results:Comparing the therapeutic efficacy regarding traditional Chinese medicine symptoms and signs,after 1-month treatment,the total effective rate was 87.5%in acupoint application group 1,versus 62.5%in acupoint application group 2 and 55.0%in acupoint application group 3,and the between-group differences were statistically significant.After 3-month treatment,the total effective rate was 95.0%in acupoint application group 1,versus 70.0%in acupoint application group 2 and 65.0%in acupoint application group 3,and the between-group differences were statistically significant.After intervention,the three groups all showed significant improvements in pulmonary function with statistical significance;among the three groups,the improvement in acupoint application group 1 was more significant than that in the other two groups.Conclusion:Tiantu(CV 22),Dazhui(GV 14)and Feishu(BL 13)as basic prescription plus Dingchuan(EX-B 1)can improve symptoms of bronchial asthma in remission stage,and it works better in improving pulmonary function than the basic prescription plus Shenshu(BL 23)or Gaohuang(BL 43).

Clinical Observation on Acupuncture Plus Acupoint Sticking for Bronchial Asthma in Remissive State

Objective:To observe the clinical efficacy of acupuncture plus acupoint sticking for bronchial asthma in remissive state.Methods:A total of 210 cases with asthma at remissive state were randomly allocated into an acupuncture group of 100 cases and a comprehensive therapy group of 110 cases.Cases in the acupuncture group were treated with acupuncture alone,and cases in the comprehensive therapy group were treated with acupuncture plus acupoint sticking therapy.Then the therapeutic efficacies were compared using observation indexes including wheezing,cough and coughing up phlegm,peak expiratory flow(PEF)and forced expiratory volume in one second(FEV1).In addition,the overall therapeutic efficacies were also analyzed on different traditional Chinese medicine(TCM)patterns.Results:The comprehensive therapy obtained better effects than acupuncture alone in alleviating cough and coughing up phlegm and improving PEF and FEV1;the overall efficacies on asthma due to lung-qi deficiency and spleen-qi deficiency were better than those on asthma due to kidney-qi deficiency.Conclusion:Acupuncture plus acupoint sticking is a convenient and effective therapy for asthma at remissive state and therefore worthy of being popularized.

Therapeutic Efficacy of Tuina in Treating 48 Cases with Knee Osteoarthritis

Objective: To observe the clinical efficacy of tuina in treating knee osteoarthritis(KOA). Methods: Forty-eight cases with KOA who met the inclusion criteria were enrolled and received tuina therapy. Visual analogue scale(VAS) was used to evaluate pain degree. VAS, range of motion(ROM) and Lysholm score were observed before and after intervention to evaluate the clinical efficacy. Results: After treatment, VAS score, ROM and Lysholm score were significantly improved, and the total effective rate was 87.5%. Conclusion: The therapeutic efficacy of tuina in treating KOA was reliable.

Therapeutic Efficacy Observation on Mild Lifting and Superficial Pulling Point-towards-point Needling for Intractable Facial Palsy

Objective: To observe and compare the clinical effects of combining mild lifting and superficial pulling point-towards-point needling and point injection and integrated standard electroacupuncture(EA) with intramuscular injection of Mecobalamin for intractable facial palsy. Methods: Eighty cases with intractable facial palsy were randomized into a treatment group and a control group, 40 in each group. Cases in the treatment group were treated with mild lifting and superficial pulling point-towards-point needling Xiaguan(ST 7) coupled with point injection of Mecobalamin. Cases in the control group were treated with standard EA coupled with intramuscular injection of Mecobalamin. After three courses of treatment, the between-group comparisons of Portmann scores and clinical effects were conducted. Results: After three courses of treatment, the Portmann scores in both groups were higher than the scores before treatment(P<0.01); the Portmann score in the treatment group was higher than that in the control group(P<0.05) and the total effective rate in the treatment group was higher than that in the control group(P<0.05). Conclusion: Combining mild lifting and superficial pulling point-towardspoint needling and point injection of Mecobalamin could obtain better effect for intractable facial palsy than standard EA coupled with intramuscular injection of Mecobalamin.

Clinical Study on Acupoint Injection plus Acupuncture for Insomnia Due to Heart-kidney Disharmony

Objective: To observe the clinical efficacy of acupoint injection at Neiguan(PC 6) plus acupuncture in treating insomnia due to heart-kidney disharmony. Methods: A hundred patients with insomnia due to heart-kidney disharmony were randomized into an observation group and a control group. Fifty-three cases in the observation group were intervened by acupoint injection at Neiguan(PC 6) plus acupuncture; while 54 cases in the control group were intervened by acupuncture alone. The Pittsburgh sleep quality index(PSQI) was evaluated before and after intervention, and the therapeutic efficacies of the two groups were compared. Results: Acupoint injection at Neiguan(PC 6) plus acupuncture produced significantly higher efficacies in improving sleep quality, shortening sleep latency, and enhancing sleep efficiency than acupuncture alone(P<0.05).Conclusion: The two groups both can improve the condition of insomnia; acupoint injection at Neiguan(PC 6) has significant advantages, manifested by a higher therapeutic efficacy for insomnia due to heart-kidney disharmony, higher safety evaluation, efficiency, and less adverse events, thus proper for clinical application.

Study on Burning Temperature Versus Time Graph of Moxa Sticks in a Novel Animal Moxibustion Device

Objective: To invent a novel animal experimentation moxa device and intend to solve temperature fluctuations during moxa stick burning in animal moxibustion test. Methods: Smokeless moxa sticks of 4 mm in diameter and 120 mm in length were selected in this trial. The target temperature was(47±1) ℃. The burning temperature versus time graph of moxa sticks during un-interfered time period were recorded when the distances between moxa sticks and thermometer were 2 mm, 3 mm and 4 mm respectively. In addition, the total lengths of burned moxa stick ashes within 0-5 min were recorded. Then the moxa stick burning temperature versus time graph after intervention was measured. Results: The maximum temperatures during test duration when the distances were 2 mm, 3 mm and 4 mm were(47.37±0.25) ℃,(42.62±2.05) ℃ and(35.50±0.40) ℃respectively the total lengths of burned ashes from 0-5 min were(5.1±0.08) mm,(12.17±0.44) mm,(14.8±0.31) mm,(17.25±0.17) mm and(19.82±0.67) mm respectively with a distance of 2 mm between a moxa stick and the testing area, remove 5 mm ashes every 2 min, then the maximum and minimum temperatures within 10 min were(48.37±0.47) ℃and(47.12±0.25) ℃, showing no statistical significance(P=0.12). Conclusion: The novel animal experimentation moxa device can help to maintain relatively constant moxa stick burning temperature during test period.

Observation on Clinical Effects of Electroacupuncture for Migraine Without Aura

Objective: To observe the clinical effects of electroacupuncture(EA) for migraine without aura. Methods: The migraine patients in conformity with the conditions were randomly divided into two groups, 34 cases in each group. The treatment group was given EA and the control group was given the routine acupuncture treatment, to observe various pain indexes respectively before and one month after the treatment. Results: The general effect was remarkably better in the treatment group than that in the control group(P<0.05). Conclusion: EA is an effective therapy for migraine without aura.

Efficacy Observation of Tuina Therapy for Fibromyalgia Syndrome

Objective： To observe the efficacy of tuina manipulations for fibromyalgia syndrome （FMS）. Methods： Sixty eligible FMS patients were randomized into two groups, 30 in each group. Patients in the observation group were intervened by tuina manipulations to the corresponding segment of the spine based on the detection of disorders of the spine-related bones and tendons; patients in the control group were directed to practice functional exercises. Before and after intervention, the fibromyalgia impact questionnaire （FIQ） and visual analogue scale （VAS） were adopted for evaluation. Results： After intervention, the FIQ and VAS scores dropped significantly in both groups （all P〈O.05）, and there were significant differences between the two groups （both P〈0.05）. The total effective rate was 86.7% in the observation group versus 63.3% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion： Spinal tuina manipulations are effective and safe in treating FMS, for significantly promoting the quality of life of the FMS patients.